| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | An organochlorine compound that has formula C22H17ClN2. (Chemical Entities of Biological Interest Ontology, CHEBI_34990) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/656734 |
| Similar Terms | |
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198 proteins with high or low expression in TRAM-34 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 1.52 |
| BORA | bora, aurora kinase A activator | 0.59 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.57 |
| DOCK11 | dedicator of cytokinesis 11 | 0.54 |
| TOB1 | transducer of ERBB2, 1 | 0.54 |
| GLI2 | GLI family zinc finger 2 | 0.52 |
| COA5 | cytochrome c oxidase assembly factor 5 | 0.52 |
| ITGA7 | integrin, alpha 7 | 0.5 |
| ANKS6 | ankyrin repeat and sterile alpha motif domain containing 6 | 0.5 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 0.48 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | 0.45 |
| ZNF226 | zinc finger protein 226 | 0.43 |
| FKBPL | FK506 binding protein like | 0.41 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.4 |
| CLASP1 | cytoplasmic linker associated protein 1 | 0.39 |
| TMC4 | transmembrane channel-like 4 | 0.39 |
| SLC38A2 | solute carrier family 38, member 2 | 0.39 |
| ITGB8 | integrin, beta 8 | 0.38 |
| RNF130 | ring finger protein 130 | 0.37 |
| C2CD3 | C2 calcium-dependent domain containing 3 | 0.37 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | 0.37 |
| NAA38 | N(alpha)-acetyltransferase 38, NatC auxiliary subunit | 0.36 |
| CA8 | carbonic anhydrase VIII | 0.35 |
| RNF13 | ring finger protein 13 | 0.35 |
| SMAD1 | SMAD family member 1 | 0.35 |
| LMO4 | LIM domain only 4 | 0.35 |
| HMCN1 | hemicentin 1 | 0.34 |
| HTD2 | hydroxyacyl-thioester dehydratase type 2 | 0.34 |
| ALDOA | aldolase A, fructose-bisphosphate | 0.34 |
| COL6A3 | collagen, type VI, alpha 3 | 0.34 |
| STYK1 | serine/threonine/tyrosine kinase 1 | 0.32 |
| PPP4R4 | protein phosphatase 4, regulatory subunit 4 | 0.32 |
| BOK | BCL2-related ovarian killer | 0.32 |
| BMP4 | bone morphogenetic protein 4 | 0.31 |
| RGN | regucalcin | 0.31 |
| MYO15B | myosin XVB | 0.3 |
| SH2B3 | SH2B adaptor protein 3 | 0.3 |
| COX16 | COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) | 0.3 |
| IGSF8 | immunoglobulin superfamily, member 8 | 0.3 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.3 |
| LIME1 | Lck interacting transmembrane adaptor 1 | 0.3 |
| ZKSCAN2 | zinc finger with KRAB and SCAN domains 2 | 0.3 |
| ZNF367 | zinc finger protein 367 | 0.3 |
| DPP4 | dipeptidyl-peptidase 4 | 0.3 |
| HAPLN3 | hyaluronan and proteoglycan link protein 3 | 0.29 |
| HRH1 | histamine receptor H1 | 0.29 |
| ZNF611 | zinc finger protein 611 | 0.28 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.28 |
| TUFT1 | tuftelin 1 | 0.28 |
| FAT2 | FAT atypical cadherin 2 | 0.28 |
| RGS12 | regulator of G-protein signaling 12 | 0.28 |
| VWA5B2 | von Willebrand factor A domain containing 5B2 | 0.28 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.28 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | 0.27 |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 | 0.27 |
| ZNF808 | zinc finger protein 808 | 0.27 |
| TFAP2E | transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) | 0.27 |
| ZNF428 | zinc finger protein 428 | 0.27 |
| CCDC91 | coiled-coil domain containing 91 | 0.26 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.26 |
| TMEM64 | transmembrane protein 64 | 0.26 |
| GALT | galactose-1-phosphate uridylyltransferase | 0.26 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.26 |
| GCSH | glycine cleavage system protein H (aminomethyl carrier) | 0.26 |
| CCP110 | centriolar coiled coil protein 110kDa | 0.26 |
| DAPK2 | death-associated protein kinase 2 | 0.25 |
| DOP1A | DOP1 leucine zipper like protein A | 0.25 |
| CLGN | calmegin | 0.25 |
| SUPT4H1 | suppressor of Ty 4 homolog 1 (S. cerevisiae) | 0.25 |
| MYO15A | myosin XVA | 0.25 |
| CDC34 | cell division cycle 34 | 0.24 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.24 |
| STYX | serine/threonine/tyrosine interacting protein | 0.24 |
| RCAN3 | RCAN family member 3 | 0.24 |
| NPTXR | neuronal pentraxin receptor | 0.24 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.24 |
| SBNO2 | strawberry notch homolog 2 (Drosophila) | 0.24 |
| ADAM22 | ADAM metallopeptidase domain 22 | 0.24 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | 0.24 |
| AKT1S1 | AKT1 substrate 1 (proline-rich) | 0.24 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | 0.24 |
| RNF8 | ring finger protein 8, E3 ubiquitin protein ligase | 0.24 |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 | 0.24 |
| B4GALT3 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 | 0.24 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | 0.24 |
| RCN2 | reticulocalbin 2, EF-hand calcium binding domain | 0.24 |
| LARGE2 | LARGE xylosyl- and glucuronyltransferase 2 | 0.23 |
| FBXO10 | F-box protein 10 | 0.23 |
| CALB2 | calbindin 2 | 0.23 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.23 |
| SEMA4G | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G | 0.23 |
| S100A2 | S100 calcium binding protein A2 | 0.23 |
| PEG10 | paternally expressed 10 | 0.23 |
| NRBP2 | nuclear receptor binding protein 2 | 0.23 |
| GTSF1 | gametocyte specific factor 1 | 0.23 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.23 |
| RMDN2 | regulator of microtubule dynamics 2 | 0.23 |
| ERCC6L2 | excision repair cross-complementation group 6-like 2 | 0.23 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TEN1 | TEN1 CST complex subunit | -1.83 |
| APLP1 | amyloid beta (A4) precursor-like protein 1 | -1.54 |
| B2M | beta-2-microglobulin | -1.37 |
| MYO3A | myosin IIIA | -1.04 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -1.02 |
| NPHP3 | nephronophthisis 3 (adolescent) | -1.02 |
| SGSH | N-sulfoglucosamine sulfohydrolase | -0.95 |
| KSR2 | kinase suppressor of ras 2 | -0.9 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | -0.87 |
| TRAF3 | TNF receptor-associated factor 3 | -0.85 |
| ABCA3 | ATP-binding cassette, sub-family A (ABC1), member 3 | -0.78 |
| ARMCX5 | armadillo repeat containing, X-linked 5 | -0.77 |
| RAD54L | RAD54-like (S. cerevisiae) | -0.67 |
| SOX12 | SRY (sex determining region Y)-box 12 | -0.62 |
| STOML1 | stomatin (EPB72)-like 1 | -0.6 |
| GATA2 | GATA binding protein 2 | -0.57 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.55 |
| HLA-E | major histocompatibility complex, class I, E | -0.5 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.48 |
| CNTLN | centlein, centrosomal protein | -0.48 |
| ANKRD36C | ankyrin repeat domain 36C | -0.47 |
| PRKD3 | protein kinase D3 | -0.46 |
| RNF145 | ring finger protein 145 | -0.45 |
| XRCC2 | X-ray repair complementing defective repair in Chinese hamster cells 2 | -0.41 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | -0.41 |
| NOS1 | nitric oxide synthase 1 (neuronal) | -0.4 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | -0.4 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | -0.39 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.38 |
| POMT1 | protein-O-mannosyltransferase 1 | -0.38 |
| PAQR7 | progestin and adipoQ receptor family member VII | -0.37 |
| UPP1 | uridine phosphorylase 1 | -0.37 |
| RNF5 | ring finger protein 5, E3 ubiquitin protein ligase | -0.37 |
| WNT10B | wingless-type MMTV integration site family, member 10B | -0.37 |
| DNASE1L1 | deoxyribonuclease I-like 1 | -0.37 |
| LMBR1 | limb development membrane protein 1 | -0.36 |
| TM2D3 | TM2 domain containing 3 | -0.35 |
| GATA6 | GATA binding protein 6 | -0.34 |
| ZNF524 | zinc finger protein 524 | -0.33 |
| CCDC110 | coiled-coil domain containing 110 | -0.33 |
| SET | SET nuclear proto-oncogene | -0.32 |
| COX10 | COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor | -0.32 |
| MGLL | monoglyceride lipase | -0.31 |
| TMEM219 | transmembrane protein 219 | -0.31 |
| CHCHD2P9 | coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9 | -0.31 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.31 |
| SIGMAR1 | sigma non-opioid intracellular receptor 1 | -0.31 |
| SMTN | smoothelin | -0.3 |
| PPP1R26 | protein phosphatase 1, regulatory subunit 26 | -0.3 |
| BLOC1S5 | biogenesis of lysosomal organelles complex-1, subunit 5, muted | -0.29 |
| GLT8D1 | glycosyltransferase 8 domain containing 1 | -0.29 |
| CUX2 | cut-like homeobox 2 | -0.29 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | -0.29 |
| TPGS2 | tubulin polyglutamylase complex subunit 2 | -0.29 |
| ARL13B | ADP-ribosylation factor-like 13B | -0.29 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -0.29 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | -0.28 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | -0.28 |
| BCL3 | B-cell CLL/lymphoma 3 | -0.28 |
| ALG10B | ALG10B, alpha-1,2-glucosyltransferase | -0.27 |
| UNKL | unkempt family zinc finger-like | -0.27 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.27 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | -0.27 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | -0.27 |
| PLAUR | plasminogen activator, urokinase receptor | -0.26 |
| FAM241A | family with sequence similarity 241 member A | -0.26 |
| GRAMD1A | GRAM domain containing 1A | -0.26 |
| TRIM7 | tripartite motif containing 7 | -0.26 |
| TTC9C | tetratricopeptide repeat domain 9C | -0.26 |
| TOMM5 | translocase of outer mitochondrial membrane 5 homolog (yeast) | -0.26 |
| SNTA1 | syntrophin, alpha 1 | -0.25 |
| SIAH2 | siah E3 ubiquitin protein ligase 2 | -0.25 |
| STK25 | serine/threonine kinase 25 | -0.25 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.25 |
| RRAGC | Ras-related GTP binding C | -0.25 |
| FBXO44 | F-box protein 44 | -0.25 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | -0.25 |
| ACVR2A | activin A receptor, type IIA | -0.25 |
| CD81 | CD81 molecule | -0.25 |
| CNEP1R1 | CTD nuclear envelope phosphatase 1 regulatory subunit 1 | -0.25 |
| ZSCAN20 | zinc finger and SCAN domain containing 20 | -0.25 |
| SESN1 | sestrin 1 | -0.25 |
| PHLPP2 | PH domain and leucine rich repeat protein phosphatase 2 | -0.25 |
| ARFRP1 | ADP-ribosylation factor related protein 1 | -0.24 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | -0.24 |
| BHLHA15 | basic helix-loop-helix family, member a15 | -0.24 |
| PLCB4 | phospholipase C, beta 4 | -0.24 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | -0.24 |
| S100A16 | S100 calcium binding protein A16 | -0.24 |
| DES | desmin | -0.24 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.24 |
| PTBP1 | polypyrimidine tract binding protein 1 | -0.24 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | -0.23 |
| BCL2L12 | BCL2-like 12 (proline rich) | -0.23 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.23 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -0.23 |
| BET1L | Bet1 golgi vesicular membrane trafficking protein-like | -0.23 |
| C18ORF32 | chromosome 18 open reading frame 32 | -0.22 |
| CHST3 | carbohydrate (chondroitin 6) sulfotransferase 3 | -0.22 |
| ABRAXAS1 | abraxas 1, BRCA1 A complex subunit | -0.22 |
