TRAM1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description translocation associated membrane protein 1|This gene encodes a multi-pass membrane protein that is part of the mammalian endoplasmic reticulum. The encoded protein influences glycosylation and facilitates the translocation of secretory proteins across the endoplasmic reticulum membrane by regulating which domains of the nascent polypeptide chain are visible to the cytosol during a translocational pause. [provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 23471)
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Genes

314 genes differentially expressed following the TRAM1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CCR6 chemokine (C-C motif) receptor 6 2.70926
EDDM3A epididymal protein 3A 2.70926
CRYBA1 crystallin, beta A1 2.70926
ITGB7 integrin, beta 7 2.70926
DRP2 dystrophin related protein 2 2.70926
NRROS negative regulator of reactive oxygen species 2.70926
TGM4 transglutaminase 4 2.70926
RSPO3 R-spondin 3 2.70926
TACR2 tachykinin receptor 2 2.70926
HES7 hes family bHLH transcription factor 7 2.70926
WFDC6 WAP four-disulfide core domain 6 2.70926
OR11A1 olfactory receptor, family 11, subfamily A, member 1 2.70926
C8ORF48 chromosome 8 open reading frame 48 2.70926
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.70926
NPR3 natriuretic peptide receptor 3 2.70926
KLK11 kallikrein-related peptidase 11 2.70926
SPON2 spondin 2, extracellular matrix protein 2.70926
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.70926
ANGPTL8 angiopoietin like 8 2.70926
GALR3 galanin receptor 3 2.69222
FETUB fetuin B 2.69222
GJB3 gap junction protein, beta 3, 31kDa 2.69222
GSTM5 glutathione S-transferase mu 5 2.69222
DSG3 desmoglein 3 2.69222
SPP2 secreted phosphoprotein 2, 24kDa 2.69222
STEAP4 STEAP family member 4 2.69222
CASP1 caspase 1, apoptosis-related cysteine peptidase 2.69222
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.69222
ZNF467 zinc finger protein 467 2.69222
TEX13B testis expressed 13B 2.69222
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.69222
SPINK4 serine peptidase inhibitor, Kazal type 4 2.69222
ACOT12 acyl-CoA thioesterase 12 2.69222
OLIG3 oligodendrocyte transcription factor 3 2.69222
LCN10 lipocalin 10 2.69222
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 2.69222
TAS2R13 taste receptor, type 2, member 13 2.69222
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 2.69222
UMODL1 uromodulin-like 1 2.69222
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 2.69222
LRRC63 leucine rich repeat containing 63 2.69222
SFTPB surfactant protein B 2.69222
RFPL3 ret finger protein-like 3 2.69222
BFSP2 beaded filament structural protein 2, phakinin 2.69222
UNC45B unc-45 homolog B (C. elegans) 2.69222
SLC39A1 solute carrier family 39 (zinc transporter), member 1 2.69222
GIMAP8 GTPase, IMAP family member 8 2.69222
C19ORF67 chromosome 19 open reading frame 67 2.69222
DIRAS3 DIRAS family, GTP-binding RAS-like 3 2.69222
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.69222
COLEC10 collectin sub-family member 10 (C-type lectin) 2.69222
FGD2 FYVE, RhoGEF and PH domain containing 2 2.69222
WNT16 wingless-type MMTV integration site family, member 16 2.69222
MYEOV myeloma overexpressed 2.69222
SRPK3 SRSF protein kinase 3 2.69222
SRGN serglycin 2.69222
FFAR1 free fatty acid receptor 1 2.69222
OR10H5 olfactory receptor, family 10, subfamily H, member 5 2.69222
ERVW-1 endogenous retrovirus group W, member 1 2.69222
H3-5 H3.5 histone 2.69222
BNIP5 BCL2 interacting protein 5 2.69222
PCARE photoreceptor cilium actin regulator 2.69222
GSTT4 glutathione S-transferase theta 4 2.69222
EZHIP EZH inhibitory protein 2.69222
LHFPL7 LHFPL tetraspan subfamily member 7 2.69222
REELD1 reeler domain containing 1 2.69222
SPEGNB SPEG neighbor 2.69222
C3ORF85 chromosome 3 open reading frame 85 2.69222
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 2.69222
OR52E6 olfactory receptor, family 52, subfamily E, member 6 2.69222
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 2.69222
DYNLRB2 dynein, light chain, roadblock-type 2 2.69222
CEMP1 cementum protein 1 2.69222
GPR75 G protein-coupled receptor 75 2.69222
CFHR3 complement factor H-related 3 2.69222
GUCA1C guanylate cyclase activator 1C 2.69222
SLC22A10 solute carrier family 22, member 10 2.69222
FRMD7 FERM domain containing 7 2.69222
MAG myelin associated glycoprotein 2.69222
TLR4 toll-like receptor 4 2.69222
MIP major intrinsic protein of lens fiber 2.69222
CFAP45 cilia and flagella associated protein 45 2.69222
BARHL1 BarH-like homeobox 1 2.69222
RGS21 regulator of G-protein signaling 21 2.69222
C9 complement component 9 2.69222
FGFBP1 fibroblast growth factor binding protein 1 2.69222
NPIPB8 nuclear pore complex interacting protein family, member B8 2.69222
KL klotho 2.69222
GATA3 GATA binding protein 3 2.69222
LRTM3 leucine rich repeat transmembrane protein 3 2.69222
CCDC170 coiled-coil domain containing 170 2.69222
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 2.69222
KLF2 Kruppel-like factor 2 2.69222
LCN1 lipocalin 1 2.69222
OR9A2 olfactory receptor, family 9, subfamily A, member 2 2.69222
NOG noggin 2.69222
KCNK3 potassium channel, two pore domain subfamily K, member 3 2.69222
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.69222
ENDOU endonuclease, polyU-specific 2.69222
PCDHGB5 protocadherin gamma subfamily B, 5 2.69222
KRT17 keratin 17, type I 2.69222
PDCD1 programmed cell death 1 2.69222
TMEM132D transmembrane protein 132D 2.69222
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.69222
C9ORF57 chromosome 9 open reading frame 57 2.69222
ACKR2 atypical chemokine receptor 2 2.69222
SLITRK1 SLIT and NTRK-like family, member 1 2.69222
BPIFB1 BPI fold containing family B, member 1 2.69222
PKDREJ polycystin (PKD) family receptor for egg jelly 2.69222
GJC2 gap junction protein, gamma 2, 47kDa 2.69222
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 2.69222
PPP1R27 protein phosphatase 1, regulatory subunit 27 2.69222
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 2.69222
OSR1 odd-skipped related transciption factor 1 2.69222
NYX nyctalopin 2.69222
NT5C1A 5'-nucleotidase, cytosolic IA 2.69222
DLX2 distal-less homeobox 2 2.69222
AMN amnion associated transmembrane protein 2.69222
CFAP61 cilia and flagella associated protein 61 2.69222
IL9R interleukin 9 receptor 2.69222
FBXO40 F-box protein 40 2.69222
NGB neuroglobin 2.69222
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.69222
MAB21L2 mab-21-like 2 (C. elegans) 2.69222
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.69222
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 2.69222
MMP1 matrix metallopeptidase 1 2.69222
CDCP2 CUB domain containing protein 2 2.69222
TEX35 testis expressed 35 2.69222
AMIGO3 adhesion molecule with Ig-like domain 3 2.69222
OR5A1 olfactory receptor, family 5, subfamily A, member 1 2.69222
ANKRD30B ankyrin repeat domain 30B 2.69222
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.69222
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 2.69222
ICAM2 intercellular adhesion molecule 2 2.69222
NLRP5 NLR family, pyrin domain containing 5 2.69222
DNAH8 dynein, axonemal, heavy chain 8 2.69222
CGA glycoprotein hormones, alpha polypeptide 2.69222
PRAP1 proline-rich acidic protein 1 2.69222
EMCN endomucin 2.69222
GPR179 G protein-coupled receptor 179 2.69222
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 2.69222
WFDC10A WAP four-disulfide core domain 10A 2.69222
KIAA1755 KIAA1755 2.69222
GRAPL GRB2-related adaptor protein-like 2.69222
C10ORF90 chromosome 10 open reading frame 90 2.69222
ZNF70 zinc finger protein 70 2.63246
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.60742
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 2.57786
PHF11 PHD finger protein 11 2.5764
MOCS3 molybdenum cofactor synthesis 3 2.5764
MARCHF8 membrane associated ring-CH-type finger 8 2.5764
KCNMB2 potassium channel subfamily M regulatory beta subunit 2 2.5764
PVALB parvalbumin 2.57547
FBXO33 F-box protein 33 2.55264
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 2.4832
GTF2IRD2 GTF2I repeat domain containing 2 2.4832
INTS9 integrator complex subunit 9 2.47802
MYO16 myosin XVI 2.47802
FBXO8 F-box protein 8 2.47759
VPS33B vacuolar protein sorting 33 homolog B (yeast) 2.44001
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 2.41524
TMPRSS11E transmembrane protease, serine 11E 2.39068
PCDHB2 protocadherin beta 2 2.3782
ACBD5 acyl-CoA binding domain containing 5 2.35825
WASHC2C WASH complex subunit 2C 2.31352
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa 2.312
DZIP1 DAZ interacting zinc finger protein 1 2.312
PTPRE protein tyrosine phosphatase, receptor type, E 2.312
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 2.31175
SPMIP3 sperm microtubule inner protein 3 2.31175
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 2.29299
CASD1 CAS1 domain containing 1 2.2858
RBP7 retinol binding protein 7, cellular 2.2858
SLC25A27 solute carrier family 25, member 27 2.2858
FAM91A1 family with sequence similarity 91, member A1 2.26354
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 2.24669
PLAAT4 phospholipase A and acyltransferase 4 2.23439
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.18099
GSTO2 glutathione S-transferase omega 2 2.17695
ZSWIM5 zinc finger, SWIM-type containing 5 2.16928
PIGU phosphatidylinositol glycan anchor biosynthesis, class U 2.14839
WDR33 WD repeat domain 33 2.1398
MFSD8 major facilitator superfamily domain containing 8 2.1398
LRRC9 leucine rich repeat containing 9 2.13704
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 2.10774
LEF1 lymphoid enhancer-binding factor 1 2.10531
NCOA7 nuclear receptor coactivator 7 2.0897
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 2.0798
CUL7 cullin 7 2.07741
FNIP1 folliculin interacting protein 1 2.07741
TMEM163 transmembrane protein 163 2.07038
HLA-E major histocompatibility complex, class I, E 2.06523
C19ORF12 chromosome 19 open reading frame 12 2.05893
BAHCC1 BAH domain and coiled-coil containing 1 2.0573
SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12 2.03988
PTAR1 protein prenyltransferase alpha subunit repeat containing 1 2.03988
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1 2.03753
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 2.03691
H2BC5 H2B clustered histone 5 2.03691
TFAP2E transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) 2.03691
PEX26 peroxisomal biogenesis factor 26 2.02886
APELA apelin receptor early endogenous ligand 2.02259
DCLRE1B DNA cross-link repair 1B 2.01412
SRP54 signal recognition particle 54kDa 2.01109
DHRS7B dehydrogenase/reductase (SDR family) member 7B 2.00754
GGNBP2 gametogenetin binding protein 2 2.00152

decreased expression

Symbol Name Standardized Value
TRAM1 translocation associated membrane protein 1 -2.70926
IRAK1 interleukin-1 receptor-associated kinase 1 -2.70926
OXTR oxytocin receptor -2.69222
MEIKIN meiotic kinetochore factor -2.69222
GJA9 gap junction protein, alpha 9, 59kDa -2.69222
MYOT myotilin -2.69222
NEK2 NIMA-related kinase 2 -2.69222
TCEAL8 transcription elongation factor A (SII)-like 8 -2.69222
OR2H2 olfactory receptor, family 2, subfamily H, member 2 -2.69222
RHEB Ras homolog enriched in brain -2.69222
MMP3 matrix metallopeptidase 3 -2.69222
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -2.69222
COL20A1 collagen, type XX, alpha 1 -2.69222
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 -2.69222
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 -2.69222
SANBR SANT and BTB domain regulator of CSR -2.69222
FAM178B family with sequence similarity 178, member B -2.69222
MTREX Mtr4 exosome RNA helicase -2.66679
ARMC9 armadillo repeat containing 9 -2.58789
COL9A1 collagen, type IX, alpha 1 -2.58789
AMOTL1 angiomotin like 1 -2.58789
RPL26 ribosomal protein L26 -2.58012
THUMPD2 THUMP domain containing 2 -2.5764
TBC1D26 TBC1 domain family, member 26 -2.5764
PCP4L1 Purkinje cell protein 4 like 1 -2.5764
TTC36 tetratricopeptide repeat domain 36 -2.5764
SCG2 secretogranin II -2.5764
CLEC19A C-type lectin domain family 19, member A -2.5764
SPHK1 sphingosine kinase 1 -2.5764
METTL6 methyltransferase like 6 -2.5764
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 -2.5764
MSX2 msh homeobox 2 -2.5764
LRG1 leucine-rich alpha-2-glycoprotein 1 -2.5764
THRSP thyroid hormone responsive -2.5764
CIITA class II, major histocompatibility complex, transactivator -2.5764
TICAM1 toll-like receptor adaptor molecule 1 -2.5764
LRRC36 leucine rich repeat containing 36 -2.5764
RPA4 replication protein A4, 30kDa -2.5764
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 -2.5764
ALX4 ALX homeobox 4 -2.5764
CLDN16 claudin 16 -2.5764
ALOXE3 arachidonate lipoxygenase 3 -2.5764
YPEL4 yippee-like 4 (Drosophila) -2.5764
HBA1 hemoglobin, alpha 1 -2.5764
ETV3L ets variant 3-like -2.5764
OR52E5 olfactory receptor, family 52, subfamily E, member 5 -2.5764
MYPN myopalladin -2.5764
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial -2.5764
STEEP1 STING1 ER exit protein 1 -2.57547
PMP22 peripheral myelin protein 22 -2.55864
XIRP2 xin actin binding repeat containing 2 -2.55264
ATG9B autophagy related 9B -2.55264
PSD4 pleckstrin and Sec7 domain containing 4 -2.55264
POU2F2 POU class 2 homeobox 2 -2.47802
ADAM17 ADAM metallopeptidase domain 17 -2.47759
MSANTD3 Myb/SANT-like DNA-binding domain containing 3 -2.47411
HYPK huntingtin interacting protein K -2.47411
TMEM170A transmembrane protein 170A -2.45417
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -2.44538
KRT18 keratin 18, type I -2.43865
NAP1L5 nucleosome assembly protein 1-like 5 -2.42611
LUZP2 leucine zipper protein 2 -2.4233
BEGAIN brain-enriched guanylate kinase-associated -2.42225
BDH2 3-hydroxybutyrate dehydrogenase, type 2 -2.41557
H2BC11 H2B clustered histone 11 -2.41524
PCGF5 polycomb group ring finger 5 -2.40437
RGS5 regulator of G-protein signaling 5 -2.3782
IK IK cytokine, down-regulator of HLA II -2.31399
DOC2A double C2-like domains, alpha -2.31041
MPG N-methylpurine-DNA glycosylase -2.29468
COMMD1 copper metabolism (Murr1) domain containing 1 -2.2858
DUT deoxyuridine triphosphatase -2.2858
MAGEA4 melanoma antigen family A4 -2.26259
KYNU kynureninase -2.24811
C10ORF88 chromosome 10 open reading frame 88 -2.22939
IQCE IQ motif containing E -2.22618
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 -2.20387
LIMA1 LIM domain and actin binding 1 -2.18296
SHF Src homology 2 domain containing F -2.17593
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) -2.16842
PLAUR plasminogen activator, urokinase receptor -2.14384
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) -2.1398
DNAJC19 DnaJ (Hsp40) homolog, subfamily C, member 19 -2.11558
TMEM272 transmembrane protein 272 -2.10913
RAD9A RAD9 homolog A (S. pombe) -2.0897
TCTN1 tectonic family member 1 -2.07997
ERF Ets2 repressor factor -2.07741
RPL22L1 ribosomal protein L22-like 1 -2.07741
SELENOH selenoprotein H -2.06904
KCTD16 potassium channel tetramerization domain containing 16 -2.06904
LIMD1 LIM domains containing 1 -2.06904
CHKB choline kinase beta -2.06408
GLMP glycosylated lysosomal membrane protein -2.05645
NUDT8 nudix (nucleoside diphosphate linked moiety X)-type motif 8 -2.03988
JPH3 junctophilin 3 -2.03753
ANKRD13A ankyrin repeat domain 13A -2.03691
MPZ myelin protein zero -2.03691
C1ORF202 chromosome 1 open reading frame 202 -2.03691
CFAP119 cilia and flagella associated protein 119 -2.03691
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) -2.03691
TMED6 transmembrane emp24 protein transport domain containing 6 -2.03691
MYCBP MYC binding protein -2.02689
SLC33A2 solute carrier family 33 member 2 -2.02604
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa -2.01796
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -2.01474
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -2.01077
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.01077