TRIB3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description tribbles pseudokinase 3|The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014] (NCBI Entrez Gene Database, 57761)
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Genes

344 genes differentially expressed following the TRIB3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
MIGA1 mitoguardin 1 2.16135
MAP1A microtubule-associated protein 1A 2.16135
RIN1 Ras and Rab interactor 1 2.16135
GPA33 glycoprotein A33 (transmembrane) 2.15762
IL17D interleukin 17D 2.14418
H2BC8 H2B clustered histone 8 2.14418
CD276 CD276 molecule 2.10702
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 2.10702
SACK1B scaffolding CK1 anchoring protein B 2.10702
SCGN secretagogin, EF-hand calcium binding protein 2.10702
SPINK6 serine peptidase inhibitor, Kazal type 6 2.10702
SCGB3A1 secretoglobin, family 3A, member 1 2.10702
PDIA2 protein disulfide isomerase family A, member 2 2.10702
GLUD2 glutamate dehydrogenase 2 2.10702
PKP1 plakophilin 1 2.10702
HGD homogentisate 1,2-dioxygenase 2.10702
HES7 hes family bHLH transcription factor 7 2.10702
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.10702
NAPSA napsin A aspartic peptidase 2.10702
MYBPHL myosin binding protein H-like 2.10702
ZNF92 zinc finger protein 92 2.10702
ZNF90 zinc finger protein 90 2.10702
FFAR2 free fatty acid receptor 2 2.10702
KBTBD11 kelch repeat and BTB (POZ) domain containing 11 2.10702
SCARA5 scavenger receptor class A, member 5 2.10702
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 2.10702
NCBP2L nuclear cap binding protein subunit 2-like 2.10702
SLCO1B3 solute carrier organic anion transporter family, member 1B3 2.10702
SRL sarcalumenin 2.10702
MAMSTR MEF2 activating motif and SAP domain containing transcriptional regulator 2.10702
GPR75 G protein-coupled receptor 75 2.10702
LY86 lymphocyte antigen 86 2.10702
PCDHGB3 protocadherin gamma subfamily B, 3 2.10702
C8ORF48 chromosome 8 open reading frame 48 2.10702
ZNF185 zinc finger protein 185 (LIM domain) 2.10702
ACVRL1 activin A receptor type II-like 1 2.10702
C11ORF86 chromosome 11 open reading frame 86 2.10702
CXCL2 chemokine (C-X-C motif) ligand 2 2.10702
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.10702
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 2.10702
SFTPB surfactant protein B 2.10702
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.10702
USP50 ubiquitin specific peptidase 50 2.10702
C1ORF141 chromosome 1 open reading frame 141 2.10702
TMEM217 transmembrane protein 217 2.10702
TNIP3 TNFAIP3 interacting protein 3 2.10702
ALPK2 alpha-kinase 2 2.10702
PLXNB3 plexin B3 2.10702
EPC2 enhancer of polycomb homolog 2 (Drosophila) 2.10702
GJA10 gap junction protein, alpha 10, 62kDa 2.10702
GJB5 gap junction protein, beta 5, 31.1kDa 2.10702
GJB3 gap junction protein, beta 3, 31kDa 2.10702
AADACL3 arylacetamide deacetylase-like 3 2.10702
DSG3 desmoglein 3 2.10702
OLIG2 oligodendrocyte lineage transcription factor 2 2.10702
ASB14 ankyrin repeat and SOCS box containing 14 2.10702
NFAM1 NFAT activating protein with ITAM motif 1 2.10702
TUBB1 tubulin, beta 1 class VI 2.10702
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 2.10702
CPB2 carboxypeptidase B2 (plasma) 2.10702
FAM153A family with sequence similarity 153, member A 2.10702
CIMIP2C ciliary microtubule inner protein 2C 2.10702
PCDHGA9 protocadherin gamma subfamily A, 9 2.10702
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 2.10702
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.10702
MAN2C1 mannosidase, alpha, class 2C, member 1 2.10702
PNLIPRP3 pancreatic lipase-related protein 3 2.10702
PNLIPRP1 pancreatic lipase-related protein 1 2.10702
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.10702
SIM1 single-minded family bHLH transcription factor 1 2.10702
ACER3 alkaline ceramidase 3 2.10702
POM121L2 POM121 transmembrane nucleoporin-like 2 2.10702
FMOD fibromodulin 2.10702
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.10702
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.10702
ALDOB aldolase B, fructose-bisphosphate 2.10702
SPEGNB SPEG neighbor 2.10702
FAM240A family with sequence similarity 240 member A 2.10702
LRRC8C-DT LRRC8C divergent transcript 2.10702
CPNE8-AS1 CPNE8 antisense RNA 1 2.10702
ANKRD42-DT ANKRD42 divergent transcript 2.10702
SMIM35 small integral membrane protein 35 2.10702
GSG1L2 GSG1 like 2 2.10702
IHO1 interactor of HORMAD1 1 2.10702
ELOA2 elongin A2 2.10702
AJM1 apical junction component 1 homolog 2.10702
LOC122539214 Zinc finger protein LOC122539214 2.10702
CYBC1 cytochrome b-245 chaperone 1 2.10702
PDF peptide deformylase (mitochondrial) 2.10702
C1QTNF9B C1q and tumor necrosis factor related protein 9B 2.10702
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.10702
PIWIL3 piwi-like RNA-mediated gene silencing 3 2.10702
MYOT myotilin 2.10702
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 2.10702
CFAP45 cilia and flagella associated protein 45 2.10702
NPIPB9 nuclear pore complex interacting protein family, member B9 2.10702
CATSPER1 cation channel, sperm associated 1 2.10702
ANXA10 annexin A10 2.10702
GUSB glucuronidase, beta 2.10702
TRIM60 tripartite motif containing 60 2.10702
PTPRG protein tyrosine phosphatase, receptor type, G 2.10702
KLHL36 kelch-like family member 36 2.10702
CCR7 chemokine (C-C motif) receptor 7 2.10702
CCR8 chemokine (C-C motif) receptor 8 2.10702
MYPN myopalladin 2.10702
LY6K lymphocyte antigen 6 complex, locus K 2.10702
ATP4B ATPase, H+/K+ exchanging, beta polypeptide 2.10702
CSAG3 CSAG family, member 3 2.10702
HSD11B1L hydroxysteroid (11-beta) dehydrogenase 1-like 2.10702
ACE2 angiotensin I converting enzyme 2 2.10702
GDF9 growth differentiation factor 9 2.10702
FGFBP1 fibroblast growth factor binding protein 1 2.10702
STARD6 StAR-related lipid transfer (START) domain containing 6 2.10702
ALG10B ALG10B, alpha-1,2-glucosyltransferase 2.10702
SBSN suprabasin 2.10702
CLDN24 claudin 24 2.10702
ECT2L epithelial cell transforming 2 like 2.10702
TMEM82 transmembrane protein 82 2.10702
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 2.10702
LCN2 lipocalin 2 2.10702
KLHL41 kelch-like family member 41 2.10702
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.10702
HPD 4-hydroxyphenylpyruvate dioxygenase 2.10702
TDRD10 tudor domain containing 10 2.10702
NIPAL4 NIPA-like domain containing 4 2.10702
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.10702
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.10702
IL36R interleukin 36 receptor 2.10702
POU2AF1 POU class 2 associating factor 1 2.10702
KCTD21 potassium channel tetramerization domain containing 21 2.10702
CCDC27 coiled-coil domain containing 27 2.10702
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 2.10702
CYSLTR1 cysteinyl leukotriene receptor 1 2.10702
APOB apolipoprotein B 2.10702
GAL3ST2 galactose-3-O-sulfotransferase 2 2.10702
ICMT isoprenylcysteine carboxyl methyltransferase 2.10702
SBDS Shwachman-Bodian-Diamond syndrome 2.10702
OPRK1 opioid receptor, kappa 1 2.10702
ACCSL 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like 2.10702
CSTA cystatin A (stefin A) 2.10702
MYBBP1A MYB binding protein (P160) 1a 2.10702
GPR12 G protein-coupled receptor 12 2.10702
KLHL1 kelch-like family member 1 2.10702
CLRN2 clarin 2 2.10702
KRT222 keratin 222, type II 2.10702
FAM209A family with sequence similarity 209, member A 2.10702
ODF4 outer dense fiber of sperm tails 4 2.10702
SH2D1A SH2 domain containing 1A 2.10702
MOS v-mos Moloney murine sarcoma viral oncogene homolog 2.10702
CYTH4 cytohesin 4 2.10702
TRIM7 tripartite motif containing 7 2.10702
RFC2 replication factor C (activator 1) 2, 40kDa 2.10702
NYX nyctalopin 2.10702
LGALS14 lectin, galactoside-binding, soluble, 14 2.10702
GBX1 gastrulation brain homeobox 1 2.10702
LMX1B LIM homeobox transcription factor 1, beta 2.10702
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 2.10702
C22ORF31 chromosome 22 open reading frame 31 2.10702
BEX4 brain expressed, X-linked 4 2.10702
RGS8 regulator of G-protein signaling 8 2.10702
SLC38A8 solute carrier family 38, member 8 2.10702
TTC9B tetratricopeptide repeat domain 9B 2.10702
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2.10702
FOXE1 forkhead box E1 2.10702
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.10702
IL11 interleukin 11 2.10702
IL1A interleukin 1, alpha 2.10702
COL6A5 collagen, type VI, alpha 5 2.10702
NT5DC4 5'-nucleotidase domain containing 4 2.10702
MORN5 MORN repeat containing 5 2.10702
PLA2G12B phospholipase A2, group XIIB 2.10702
DLX5 distal-less homeobox 5 2.10702
PRH2 proline-rich protein HaeIII subfamily 2 2.10702
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 2.10702
EPHB3 EPH receptor B3 2.10702
OR6B1 olfactory receptor, family 6, subfamily B, member 1 2.10702
ZNF641 zinc finger protein 641 2.10702
OR4M2 olfactory receptor, family 4, subfamily M, member 2 2.10702
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.10702
PF4V1 platelet factor 4 variant 1 2.10702
NTAN1 N-terminal asparagine amidase 2.10702
PADI1 peptidyl arginine deiminase, type I 2.10702
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 2.10702
GREM1 gremlin 1, DAN family BMP antagonist 2.10702
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.10702
TMEM52B transmembrane protein 52B 2.10702
CPLX3 complexin 3 2.10702
WFDC11 WAP four-disulfide core domain 11 2.10702
RAMP1 receptor (G protein-coupled) activity modifying protein 1 2.10702
EXOC3 exocyst complex component 3 2.10702
TLDC2 TBC/LysM-associated domain containing 2 2.10702
SPACA1 sperm acrosome associated 1 2.10702
PANO1 proapoptotic nucleolar protein 1 2.10702
NABP1 nucleic acid binding protein 1 2.10702
SYNGR1 synaptogyrin 1 2.10702
ELL3 elongation factor RNA polymerase II-like 3 2.10702
MEIG1 meiosis/spermiogenesis associated 1 2.10702
SP6 Sp6 transcription factor 2.10702
SYNRG synergin, gamma 2.10702
CLCNKA chloride channel, voltage-sensitive Ka 2.10702
CDH8 cadherin 8, type 2 2.10702
WDFY4 WDFY family member 4 2.10702
PTGDS prostaglandin D2 synthase 21kDa (brain) 2.10702
ASGR2 asialoglycoprotein receptor 2 2.10702
DNAJC25 DnaJ (Hsp40) homolog, subfamily C , member 25 2.10702
ACSM4 acyl-CoA synthetase medium-chain family member 4 2.10702
IL12A interleukin 12A 2.10702
ANKRD62 ankyrin repeat domain 62 2.10702
PLEKHS1 pleckstrin homology domain containing, family S member 1 2.10702
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.10702
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.10702
NUTM2D NUT family member 2D 2.10702
NUTM2B NUT family member 2B 2.10702
MUC22 mucin 22 2.10702
SVIL supervillin 2.10702
LRRC38 leucine rich repeat containing 38 2.10702
IL10RA interleukin 10 receptor, alpha 2.10702
OR51I2 olfactory receptor, family 51, subfamily I, member 2 2.10702
MMP20 matrix metallopeptidase 20 2.10702
CHAD chondroadherin 2.10702
TMEM86A transmembrane protein 86A 2.10702
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 2.10702
CEP76 centrosomal protein 76kDa 2.10702
CPO carboxypeptidase O 2.10702
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 2.09176
GSN gelsolin 2.09023
KIF26B kinesin family member 26B 2.08072
TMEM151B transmembrane protein 151B 2.07999
THRB thyroid hormone receptor, beta 2.06913
ARID5A AT rich interactive domain 5A (MRF1-like) 2.06913
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 2.06913
CWC27 CWC27 spliceosome-associated protein homolog (S. cerevisiae) 2.06336
EVC2 Ellis van Creveld syndrome 2 2.05935
HMCN1 hemicentin 1 2.05381
DSC3 desmocollin 3 2.03361
ALYREF Aly/REF export factor 2.02738
NINJ1 ninjurin 1 2.00705
CARD10 caspase recruitment domain family, member 10 2.00705
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 2.00603
MKRN2 makorin ring finger protein 2 2.00603

decreased expression

Symbol Name Standardized Value
MKX mohawk homeobox -2.16135
FICD FIC domain containing -2.16135
CHP2 calcineurin-like EF-hand protein 2 -2.15762
SPMIP6 sperm microtubule inner protein 6 -2.14418
CLUL1 clusterin-like 1 (retinal) -2.14418
CASP8 caspase 8, apoptosis-related cysteine peptidase -2.14418
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 -2.11887
PTX3 pentraxin 3, long -2.10702
SLC35D3 solute carrier family 35, member D3 -2.10702
MED20 mediator complex subunit 20 -2.10702
RENBP renin binding protein -2.10702
ANKRD29 ankyrin repeat domain 29 -2.10702
PDLIM1 PDZ and LIM domain 1 -2.10702
CD200R1L CD200 receptor 1-like -2.10702
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2 -2.10702
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 -2.10702
RHD Rh blood group, D antigen -2.10702
LATS2 large tumor suppressor kinase 2 -2.10702
RLN1 relaxin 1 -2.10702
WSB1 WD repeat and SOCS box containing 1 -2.10702
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) -2.10702
CA9 carbonic anhydrase IX -2.10702
HIST1H2BI histone cluster 1, H2bi -2.10702
FSD2 fibronectin type III and SPRY domain containing 2 -2.10702
GRHL3 grainyhead-like 3 (Drosophila) -2.10702
LDHD lactate dehydrogenase D -2.10702
SAMD11 sterile alpha motif domain containing 11 -2.10702
ACSL1 acyl-CoA synthetase long-chain family member 1 -2.10702
GOT1 glutamic-oxaloacetic transaminase 1, soluble -2.10702
STMN2 stathmin 2 -2.10702
HTRA3 HtrA serine peptidase 3 -2.10702
VGLL3 vestigial-like family member 3 -2.10702
PANK4 pantothenate kinase 4 -2.10702
PLPPR3 phospholipid phosphatase related 3 -2.10702
MARCHF10 membrane associated ring-CH-type finger 10 -2.10702
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 -2.10702
FBXW10 F-box and WD repeat domain containing 10 -2.10702
HRH4 histamine receptor H4 -2.10702
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) -2.10702
MYCBP MYC binding protein -2.10702
NDRG1 N-myc downstream regulated 1 -2.10702
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -2.10702
CCDC13 coiled-coil domain containing 13 -2.10702
COL6A6 collagen, type VI, alpha 6 -2.10702
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -2.10702
ARID4B AT rich interactive domain 4B (RBP1-like) -2.10702
AGA-DT AGA divergent transcript -2.10702
GPC3 glypican 3 -2.10702
NUTM1 NUT midline carcinoma, family member 1 -2.10702
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 -2.10702
MRAP melanocortin 2 receptor accessory protein -2.10702
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 -2.10702
TMEM139 transmembrane protein 139 -2.10702
CNGB3 cyclic nucleotide gated channel beta 3 -2.10702
PCSK4 proprotein convertase subtilisin/kexin type 4 -2.10702
FSHR follicle stimulating hormone receptor -2.10702
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -2.10702
TICRR TOPBP1-interacting checkpoint and replication regulator -2.10702
AGER advanced glycosylation end product-specific receptor -2.10702
TMEM31 transmembrane protein 31 -2.10702
ZNF414 zinc finger protein 414 -2.10702
CDH24 cadherin 24, type 2 -2.10702
SLC38A3 solute carrier family 38, member 3 -2.10702
LDLRAD2 low density lipoprotein receptor class A domain containing 2 -2.10702
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G -2.10702
CEP350 centrosomal protein 350kDa -2.10702
SLA2 Src-like-adaptor 2 -2.10702
CLK3 CDC-like kinase 3 -2.10702
TRAF3IP3 TRAF3 interacting protein 3 -2.10702
ICAM1 intercellular adhesion molecule 1 -2.10702
SGCZ sarcoglycan, zeta -2.10702
NPB neuropeptide B -2.10702
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 -2.10702
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit -2.10702
MAP2K7 mitogen-activated protein kinase kinase 7 -2.10702
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 -2.10702
URGCP upregulator of cell proliferation -2.10702
CERCAM cerebral endothelial cell adhesion molecule -2.10702
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.10702
UPK2 uroplakin 2 -2.10702
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -2.10702
LRRC26 leucine rich repeat containing 26 -2.10702
MGST1 microsomal glutathione S-transferase 1 -2.10702
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -2.09176
PIAS4 protein inhibitor of activated STAT, 4 -2.07516
THAP4 THAP domain containing 4 -2.06913
MRPS17 mitochondrial ribosomal protein S17 -2.06913
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 -2.06876
INTS4 integrator complex subunit 4 -2.05848
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.05848
SPMIP9 sperm microtubule inner protein 9 -2.05848
JAZF1 JAZF zinc finger 1 -2.04775
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -2.04272
LCTL lactase-like -2.04172
SAT2 spermidine/spermine N1-acetyltransferase family member 2 -2.04172
STEAP1B STEAP family member 1B -2.02868
FGGY FGGY carbohydrate kinase domain containing -2.02868
GMDS GDP-mannose 4,6-dehydratase -2.02624
MAOB monoamine oxidase B -2.01589
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 -2.01363
ATP23 ATP23 metallopeptidase and ATP synthase assembly factor homolog -2.00705
RELT RELT tumor necrosis factor receptor -2.00705
ACTR5 ARP5 actin-related protein 5 homolog (yeast) -2.00705
ELOB elongin B -2.00705