TRIB3 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description tribbles pseudokinase 3|The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014] (NCBI Entrez Gene Database, 57761)
External Link http://www.ncbi.nlm.nih.gov/gene/57761
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Genes

97 interacting proteins for TRIB3 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
APP amyloid beta (A4) precursor protein
ARHGAP35 Rho GTPase activating protein 35
ARID1A AT rich interactive domain 1A (SWI-like)
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATF4 activating transcription factor 4
ATF5 activating transcription factor 5
ATF7 activating transcription factor 7
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL6 B-cell CLL/lymphoma 6
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CDC25A cell division cycle 25A
COPS6 COP9 signalosome subunit 6
CSMD1 CUB and Sushi multiple domains 1
CSNK2B casein kinase 2, beta polypeptide
DDIT3 DNA-damage-inducible transcript 3
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DNAH9 dynein, axonemal, heavy chain 9
DROSHA drosha, ribonuclease type III
E2F3 E2F transcription factor 3
EBF1 early B-cell factor 1
EEF1G eukaryotic translation elongation factor 1 gamma
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
ELF1 E74-like factor 1 (ets domain transcription factor)
EPHB6 EPH receptor B6
ERCC5 excision repair cross-complementation group 5
FN1 fibronectin 1
GDF9 growth differentiation factor 9
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GRN granulin
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HDAC9 histone deacetylase 9
HELZ2 helicase with zinc finger 2, transcriptional coactivator
HLA-B major histocompatibility complex, class I, B
HNF1A HNF1 homeobox A
HRSP12 heat-responsive protein 12
HSF4 heat shock transcription factor 4
IDI2 isopentenyl-diphosphate delta isomerase 2
KAT5 K(lysine) acetyltransferase 5
KDM2A lysine (K)-specific demethylase 2A
KIF13B kinesin family member 13B
KMT2B lysine (K)-specific methyltransferase 2B
LPAR2 lysophosphatidic acid receptor 2
LPAR4 lysophosphatidic acid receptor 4
LSM1 LSM1, U6 small nuclear RNA associated
LTBP4 latent transforming growth factor beta binding protein 4
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K7 mitogen-activated protein kinase kinase 7
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MCM3AP minichromosome maintenance complex component 3 associated protein
MED23 mediator complex subunit 23
MTMR6 myotubularin related protein 6
NCOR2 nuclear receptor corepressor 2
NKRF NFKB repressing factor
OLA1 Obg-like ATPase 1
OSBPL1A oxysterol binding protein-like 1A
PANX3 pannexin 3
PARP12 poly (ADP-ribose) polymerase family, member 12
PCDH9 protocadherin 9
POU2F3 POU class 2 homeobox 3
PPAP2B phosphatidic acid phosphatase type 2B
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRMT5 protein arginine methyltransferase 5
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
RBM4 RNA binding motif protein 4
RBM48 RNA binding motif protein 48
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RPSA ribosomal protein SA
SAE1 SUMO1 activating enzyme subunit 1
SENP7 SUMO1/sentrin specific peptidase 7
SETDB1 SET domain, bifurcated 1
SIAH1 siah E3 ubiquitin protein ligase 1
SIN3A SIN3 transcription regulator family member A
SMAD3 SMAD family member 3
SMO smoothened, frizzled class receptor
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SPEN spen family transcriptional repressor
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TIAF1 TGFB1-induced anti-apoptotic factor 1
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TRAF3IP3 TRAF3 interacting protein 3
UBC ubiquitin C
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast)
WDR35 WD repeat domain 35
WNK4 WNK lysine deficient protein kinase 4
WNT16 wingless-type MMTV integration site family, member 16
YY1 YY1 transcription factor
ZMYND8 zinc finger, MYND-type containing 8
ZNF443 zinc finger protein 443