TRIM25 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description tripartite motif containing 25|The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7706)
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Genes

344 genes differentially expressed following the TRIM25 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PNCK pregnancy up-regulated nonubiquitous CaM kinase 3.29819
OR2A5 olfactory receptor, family 2, subfamily A, member 5 3.29819
FAM178B family with sequence similarity 178, member B 3.29819
LYNX1 Ly6/neurotoxin 1 3.29819
C3AR1 complement component 3a receptor 1 3.29819
ALG10B ALG10B, alpha-1,2-glucosyltransferase 3.29819
CDH19 cadherin 19, type 2 3.29819
DYNLRB2 dynein, light chain, roadblock-type 2 3.29819
CHIT1 chitinase 1 (chitotriosidase) 3.29819
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 3.29819
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 3.29819
ANKRD33 ankyrin repeat domain 33 3.29819
PRCD progressive rod-cone degeneration 3.29819
GRIA2 glutamate receptor, ionotropic, AMPA 2 3.29819
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 3.29819
ANXA1 annexin A1 3.29819
TGM3 transglutaminase 3 3.29819
PDZD9 PDZ domain containing 9 3.29819
CELF6 CUGBP, Elav-like family member 6 3.29819
IYD iodotyrosine deiodinase 3.29819
SPRR2F small proline-rich protein 2F 3.29819
CCDC9B coiled-coil domain containing 9B 3.29819
MYADML2 myeloid-associated differentiation marker-like 2 3.29819
LOC124904542 uncharacterized LOC124904542 3.29819
CATSPERZ catsper channel auxiliary subunit zeta 3.29819
CDH22 cadherin 22, type 2 3.29819
PRR35 proline rich 35 3.29819
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 3.29819
DEFB109B defensin beta 109B 3.19522
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 3.19522
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 3.19522
SLC15A5 solute carrier family 15, member 5 3.19522
CCL5 chemokine (C-C motif) ligand 5 3.19522
CIMIP3 ciliary microtubule inner protein 3 3.19522
PCDHB1 protocadherin beta 1 3.19522
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 3.19522
ADGRE1 adhesion G protein-coupled receptor E1 3.19522
SIGLECL1 SIGLEC family like 1 3.19522
CFAP97D2 CFAP97 domain containing 2 3.19522
UCN urocortin 3.19522
SMIM45 small integral membrane protein 45 3.19522
ZBTB9 zinc finger and BTB domain containing 9 3.19522
H3-7 H3.7 histone (putative) 3.19522
CIMIP7 ciliary microtubule inner protein 7 3.19522
CIMAP2 ciliary microtubule associated protein 2 3.19522
JCHAIN joining chain of multimeric IgA and IgM 3.19522
BMP3 bone morphogenetic protein 3 3.19522
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 3.19522
FABP12 fatty acid binding protein 12 3.19522
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 3.19522
MS4A18 membrane-spanning 4-domains, subfamily A, member 18 3.19522
HAS1 hyaluronan synthase 1 3.19522
TRPV5 transient receptor potential cation channel, subfamily V, member 5 3.19522
TRPV6 transient receptor potential cation channel, subfamily V, member 6 3.19522
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 3.19522
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 3.19522
ZNF575 zinc finger protein 575 3.19522
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 3.19522
C19ORF67 chromosome 19 open reading frame 67 3.19522
SPMAP1 sperm microtubule associated protein 1 3.19522
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 3.19522
TUBB8 tubulin, beta 8 class VIII 3.19522
GRP gastrin-releasing peptide 3.19522
SIX1 SIX homeobox 1 3.19522
SRL sarcalumenin 3.19522
IL16 interleukin 16 3.19522
DUSP29 dual specificity phosphatase 29 3.19522
LTB lymphotoxin beta (TNF superfamily, member 3) 3.19522
SYT15 synaptotagmin XV 3.19522
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 3.19522
C15ORF62 chromosome 15 open reading frame 62 3.19522
PLAAT4 phospholipase A and acyltransferase 4 3.19522
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 3.19522
ZNF446 zinc finger protein 446 3.19522
OR1C1 olfactory receptor, family 1, subfamily C, member 1 3.19522
PROZ protein Z, vitamin K-dependent plasma glycoprotein 3.19522
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) 3.19522
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 3.19522
AVPR1A arginine vasopressin receptor 1A 3.19522
IL6 interleukin 6 3.19522
GBP4 guanylate binding protein 4 3.19522
ROPN1 rhophilin associated tail protein 1 3.19522
GPR85 G protein-coupled receptor 85 3.19522
FGFBP1 fibroblast growth factor binding protein 1 3.19522
SMIM35 small integral membrane protein 35 3.19522
GUCA1C guanylate cyclase activator 1C 3.19522
USH1G Usher syndrome 1G (autosomal recessive) 3.19522
OR5H6 olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene) 3.19522
ACTL10 actin-like 10 3.19522
PCDHB14 protocadherin beta 14 3.19522
IRF8 interferon regulatory factor 8 3.19522
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 3.19522
CFAP276 cilia and flagella associated protein 276 3.19522
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 3.19522
GARIN6 golgi associated RAB2 interactor family member 6 3.19522
TLR4 toll-like receptor 4 3.19522
TFEC transcription factor EC 3.19522
PGC progastricsin (pepsinogen C) 3.19522
CELA2A chymotrypsin-like elastase family, member 2A 3.19522
TIMD4 T-cell immunoglobulin and mucin domain containing 4 3.19522
MT3 metallothionein 3 3.19522
SP6 Sp6 transcription factor 3.19522
FITM1 fat storage-inducing transmembrane protein 1 3.19522
KCNK3 potassium channel, two pore domain subfamily K, member 3 3.19522
CLDN34 claudin 34 3.19522
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 3.19522
SPATA31E1 SPATA31 subfamily E, member 1 3.19522
ANKRD61 ankyrin repeat domain 61 3.19522
KLF2 Kruppel-like factor 2 3.19522
MKRN3 makorin ring finger protein 3 3.19522
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 3.19522
LRRC43 leucine rich repeat containing 43 3.19522
LRRC46 leucine rich repeat containing 46 3.19522
CCDC154 coiled-coil domain containing 154 3.19522
EPO erythropoietin 3.19522
SUN5 Sad1 and UNC84 domain containing 5 3.19522
AGR3 anterior gradient 3 3.19522
RUFY4 RUN and FYVE domain containing 4 3.19522
CALML5 calmodulin-like 5 3.19522
ZMYND10 zinc finger, MYND-type containing 10 3.19522
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 3.19522
ERMN ermin, ERM-like protein 3.19522
NPFFR1 neuropeptide FF receptor 1 3.19522
SPATA3 spermatogenesis associated 3 3.19522
SLC36A3 solute carrier family 36, member 3 3.19522
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 3.19522
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 3.19522
TM4SF19 transmembrane 4 L six family member 19 3.19522
C1ORF185 chromosome 1 open reading frame 185 3.19522
TEX26 testis expressed 26 3.19522
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 3.19522
BHLHA15 basic helix-loop-helix family, member a15 3.19522
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 3.19522
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 3.19522
MORN5 MORN repeat containing 5 3.19522
TREH trehalase (brush-border membrane glycoprotein) 3.19522
MAGEE2 melanoma antigen family E2 3.19522
CRHR1 corticotropin releasing hormone receptor 1 3.19522
IFITM5 interferon induced transmembrane protein 5 3.19522
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 3.19522
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 3.19522
BSPH1 binder of sperm protein homolog 1 3.19522
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 3.19522
FOXS1 forkhead box S1 3.19522
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 3.19522
LRRC31 leucine rich repeat containing 31 3.19522
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 3.19522
TGM6 transglutaminase 6 3.19522
OR5A2 olfactory receptor, family 5, subfamily A, member 2 3.19522
CLCF1 cardiotrophin-like cytokine factor 1 3.19522
TGM7 transglutaminase 7 3.19522
SDSL serine dehydratase-like 3.19522
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 3.19522
SSX1 synovial sarcoma, X breakpoint 1 3.19522
RTP2 receptor (chemosensory) transporter protein 2 3.19522
CIB3 calcium and integrin binding family member 3 3.19522
MNX1 motor neuron and pancreas homeobox 1 3.19522
HMX3 H6 family homeobox 3 3.19522
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 3.19522
ANGPTL3 angiopoietin-like 3 3.19522
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 3.19522
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 3.19522
SETD2 SET domain containing 2 3.19522
IGSF22 immunoglobulin superfamily, member 22 3.08274
MFAP4 microfibrillar-associated protein 4 3.08274
ZEB2 zinc finger E-box binding homeobox 2 3.08274
MRPL19 mitochondrial ribosomal protein L19 3.03242
C2 complement component 2 2.99337
WDR3 WD repeat domain 3 2.8606
SNX2 sorting nexin 2 2.855
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 2.84739
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 2.80207
CTDNEP1 CTD nuclear envelope phosphatase 1 2.78282
CDH18 cadherin 18, type 2 2.71346
CCDC82 coiled-coil domain containing 82 2.68571
RNF13 ring finger protein 13 2.6602
TMEM39A transmembrane protein 39A 2.53888
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 2.53888
NT5C1B 5'-nucleotidase, cytosolic IB 2.53888
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.53888
NFIA nuclear factor I/A 2.51126
EMC6 ER membrane protein complex subunit 6 2.51126
MACROD1 MACRO domain containing 1 2.49527
ALKBH2 alkB, alkylation repair homolog 2 (E. coli) 2.47148
LIPT2 lipoyl(octanoyl) transferase 2 (putative) 2.45624
LRRC37A2 leucine rich repeat containing 37, member A2 2.45421
STK39 serine threonine kinase 39 2.41862
SCN1B sodium channel, voltage gated, type I beta subunit 2.38758
F2RL1 coagulation factor II (thrombin) receptor-like 1 2.38431
CFAP68 cilia and flagella associated protein 68 2.38427
MAP3K13 mitogen-activated protein kinase kinase kinase 13 2.38427
CALU calumenin 2.37975
FBXL19 F-box and leucine-rich repeat protein 19 2.37526
CAV2 caveolin 2 2.37206
IMMP1L IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) 2.37202
LPCAT4 lysophosphatidylcholine acyltransferase 4 2.37202
STAG1 stromal antigen 1 2.36819
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 2.35893
PDZD4 PDZ domain containing 4 2.35619
NKAPD1 NKAP domain containing 1 2.35406
LOC114841035 uncharacterized LOC114841035 2.33535
INSYN1 inhibitory synaptic factor 1 2.33535
SH3D19 SH3 domain containing 19 2.33524
CORO1A coronin, actin binding protein, 1A 2.23959
KALRN kalirin, RhoGEF kinase 2.21336
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.15673
C11ORF42 chromosome 11 open reading frame 42 2.15673
RIMS1 regulating synaptic membrane exocytosis 1 2.14839
THSD4 thrombospondin, type I, domain containing 4 2.14569
GARIN1B golgi associated RAB2 interactor 1B 2.1449
KATNAL1 katanin p60 subunit A-like 1 2.13553
MZT2A mitotic spindle organizing protein 2A 2.13553
PUS7 pseudouridylate synthase 7 (putative) 2.13132
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 2.12257
SMIM10L1 small integral membrane protein 10 like 1 2.11553
PPP1R18 protein phosphatase 1, regulatory subunit 18 2.09803
AKAP3 A kinase (PRKA) anchor protein 3 2.09803
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 2.09803
DNAI7 dynein axonemal intermediate chain 7 2.09803
TMEM171 transmembrane protein 171 2.09803
TMPRSS11D transmembrane protease, serine 11D 2.09803
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 2.09392
ECSIT ECSIT signalling integrator 2.07616
RING1 ring finger protein 1 2.05226
ETFBKMT electron transfer flavoprotein subunit beta lysine methyltransferase 2.03824
MACC1 metastasis associated in colon cancer 1 2.03572
LPAR6 lysophosphatidic acid receptor 6 2.03419
PFDN2 prefoldin subunit 2 2.02187
ADCY9 adenylate cyclase 9 2.00465

decreased expression

Symbol Name Standardized Value
SSUH2 ssu-2 homolog (C. elegans) -3.29819
DPYSL5 dihydropyrimidinase-like 5 -3.29819
SMAD9 SMAD family member 9 -3.29819
SCNN1D sodium channel, non voltage gated 1 delta subunit -3.29819
MEIS1 Meis homeobox 1 -3.29819
BARX1 BARX homeobox 1 -3.29819
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 -3.19522
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 -3.19522
TAS2R19 taste receptor, type 2, member 19 -3.19522
ACSM1 acyl-CoA synthetase medium-chain family member 1 -3.19522
NPIPA8 nuclear pore complex interacting protein family, member A8 -3.19522
COL15A1 collagen, type XV, alpha 1 -3.19522
NGFR nerve growth factor receptor -3.19522
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 -3.19522
TRPV3 transient receptor potential cation channel, subfamily V, member 3 -3.19522
SP7 Sp7 transcription factor -3.19522
DEFB134 defensin, beta 134 -3.19522
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 -3.19522
CNTN2 contactin 2 (axonal) -3.19522
ANKRD40 ankyrin repeat domain 40 -3.19522
GRM6 glutamate receptor, metabotropic 6 -3.19522
FXYD3 FXYD domain containing ion transport regulator 3 -3.19522
GGN gametogenetin -3.19522
CLNK cytokine-dependent hematopoietic cell linker -3.19522
GPRC5D G protein-coupled receptor, class C, group 5, member D -3.19522
ADAM29 ADAM metallopeptidase domain 29 -3.19522
TMPRSS15 transmembrane protease, serine 15 -3.19522
BIN2 bridging integrator 2 -3.19522
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 -3.19522
MFAP5 microfibrillar associated protein 5 -3.19522
GFI1B growth factor independent 1B transcription repressor -3.19522
PRR19 proline rich 19 -3.19522
TPPP2 tubulin polymerization-promoting protein family member 2 -3.19522
FAM107A family with sequence similarity 107, member A -3.19522
SF3B6 splicing factor 3b, subunit 6, 14kDa -3.19522
OTOA otoancorin -3.19522
PCDHAC2 protocadherin alpha subfamily C, 2 -3.19522
CCNA1 cyclin A1 -3.19522
MYOCOS myocilin opposite strand -3.19522
NTMT2 N-terminal Xaa-Pro-Lys N-methyltransferase 2 -3.19522
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 -3.19522
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 -3.19522
KRTAP5-11 keratin associated protein 5-11 -3.19522
C1ORF162 chromosome 1 open reading frame 162 -3.19522
PAGE4 P antigen family, member 4 (prostate associated) -3.19522
SH2D6 SH2 domain containing 6 -3.19522
SAMD11 sterile alpha motif domain containing 11 -3.19522
GIGYF1 GRB10 interacting GYF protein 1 -3.19522
AQP6 aquaporin 6, kidney specific -3.19522
TDRD10 tudor domain containing 10 -3.19522
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa -3.18494
KLHL32 kelch-like family member 32 -3.04056
MPZL3 myelin protein zero-like 3 -2.99102
DCBLD1 discoidin, CUB and LCCL domain containing 1 -2.94866
RAB9B RAB9B, member RAS oncogene family -2.9174
PUSL1 pseudouridylate synthase-like 1 -2.86639
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) -2.86076
BCR breakpoint cluster region -2.81506
RLF rearranged L-myc fusion -2.80207
COX5A cytochrome c oxidase subunit Va -2.78282
SNN stannin -2.76898
GLO1 glyoxalase I -2.76793
PIGX phosphatidylinositol glycan anchor biosynthesis, class X -2.7588
NT5C3B 5'-nucleotidase, cytosolic IIIB -2.70388
RNF175 ring finger protein 175 -2.64431
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -2.61526
AURKB aurora kinase B -2.58195
ODF2L outer dense fiber of sperm tails 2-like -2.57774
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 -2.57632
DYDC1 DPY30 domain containing 1 -2.55352
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -2.51171
STAMBPL1 STAM binding protein-like 1 -2.43393
CD276 CD276 molecule -2.43393
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma -2.43043
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) -2.41862
SPC25 SPC25, NDC80 kinetochore complex component -2.40855
LDAH lipid droplet associated hydrolase -2.40703
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -2.40703
ARMH1 armadillo like helical domain containing 1 -2.39506
CATSPERD catsper channel auxiliary subunit delta -2.38427
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase -2.38427
RAB17 RAB17, member RAS oncogene family -2.38427
DHDDS dehydrodolichyl diphosphate synthase -2.38403
NT5C3A 5'-nucleotidase, cytosolic IIIA -2.37975
MOK MOK protein kinase -2.37975
NEURL1 neuralized E3 ubiquitin protein ligase 1 -2.37755
TLK1 tousled-like kinase 1 -2.37202
PIGBOS1 PIGB opposite strand 1 -2.37202
FEZF1 FEZ family zinc finger 1 -2.37202
REPIN1 replication initiator 1 -2.37202
RAMACL RNA guanine-7 methyltransferase activating subunit like -2.36029
GH2 growth hormone 2 -2.36029
SMTNL1 smoothelin-like 1 -2.30679
REC114 REC114 meiotic recombination protein -2.30679
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 -2.30679
ACER2 alkaline ceramidase 2 -2.20571
SCPEP1 serine carboxypeptidase 1 -2.19949
SNRPA1 small nuclear ribonucleoprotein polypeptide A' -2.18303
SWI5 SWI5 recombination repair homolog (yeast) -2.1717
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.14156
FAM151B family with sequence similarity 151, member B -2.13329
DOCK8 dedicator of cytokinesis 8 -2.13329
SYPL1 synaptophysin-like 1 -2.13031
TMEM38A transmembrane protein 38A -2.13
ZNF385C zinc finger protein 385C -2.12398
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa -2.12109
FLT4 fms-related tyrosine kinase 4 -2.10481
CGRRF1 cell growth regulator with ring finger domain 1 -2.09803
FGD5 FYVE, RhoGEF and PH domain containing 5 -2.09803
GTSE1 G-2 and S-phase expressed 1 -2.09515
GK5 glycerol kinase 5 (putative) -2.08331
THBS1 thrombospondin 1 -2.07882
MEX3D mex-3 RNA binding family member D -2.06465
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) -2.02784
PDZD7 PDZ domain containing 7 -2.02148