TRIM27 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description tripartite motif containing 27|This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5987)
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Genes

253 genes differentially expressed following the TRIM27 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PXDC1 PX domain containing 1 2.77031
ZNF436 zinc finger protein 436 2.77031
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.77031
ALB albumin 2.77031
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.77031
SLC51B solute carrier family 51, beta subunit 2.77031
PRR35 proline rich 35 2.77031
PTGFR prostaglandin F receptor (FP) 2.77031
PCDHA7 protocadherin alpha 7 2.77031
LRRIQ4 leucine-rich repeats and IQ motif containing 4 2.77031
RUFY4 RUN and FYVE domain containing 4 2.77031
BHMT2 betaine--homocysteine S-methyltransferase 2 2.77031
CST1 cystatin SN 2.77031
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 2.77031
CLDN2 claudin 2 2.77031
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 2.77031
DSG1 desmoglein 1 2.77031
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 2.77031
SMIM45 small integral membrane protein 45 2.77031
SMIM43 small integral membrane protein 43 2.77031
GOLGA6B golgin A6 family, member B 2.77031
SOX14 SRY (sex determining region Y)-box 14 2.6881
CASP5 caspase 5, apoptosis-related cysteine peptidase 2.6881
ZFP57 ZFP57 zinc finger protein 2.6881
FGF21 fibroblast growth factor 21 2.6881
PVRIG poliovirus receptor related immunoglobulin domain containing 2.6881
CARD16 caspase recruitment domain family, member 16 2.6881
DTHD1 death domain containing 1 2.6881
PTPRC protein tyrosine phosphatase, receptor type, C 2.6881
GRXCR2 glutaredoxin, cysteine rich 2 2.6881
CCL5 chemokine (C-C motif) ligand 5 2.6881
TDO2 tryptophan 2,3-dioxygenase 2.6881
MFAP5 microfibrillar associated protein 5 2.6881
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 2.6881
OR4D9 olfactory receptor, family 4, subfamily D, member 9 2.6881
TREML1 triggering receptor expressed on myeloid cells-like 1 2.6881
SHE Src homology 2 domain containing E 2.6881
CLEC5A C-type lectin domain family 5, member A 2.6881
FABP12 fatty acid binding protein 12 2.6881
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 2.6881
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.6881
THRSP thyroid hormone responsive 2.6881
REN renin 2.6881
CA6 carbonic anhydrase VI 2.6881
HCRTR2 hypocretin (orexin) receptor 2 2.6881
LGALS2 lectin, galactoside-binding, soluble, 2 2.6881
PAX3 paired box 3 2.6881
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.6881
ASPA aspartoacylase 2.6881
PCDHB10 protocadherin beta 10 2.6881
ACER1 alkaline ceramidase 1 2.6881
ROPN1L rhophilin associated tail protein 1-like 2.6881
MCHR1 melanin-concentrating hormone receptor 1 2.6881
TMOD4 tropomodulin 4 (muscle) 2.6881
SEPTIN14 septin 14 2.6881
H2BC1 H2B clustered histone 1 2.6881
TLE7 TLE family member 7 2.6881
TCIM transcriptional and immune response regulator 2.6881
PLPP4 phospholipid phosphatase 4 2.6881
DUSP29 dual specificity phosphatase 29 2.6881
PEAK3 PEAK family member 3 2.6881
C17ORF113 chromosome 17 open reading frame 113 2.6881
CIMAP1B ciliary microtubule associated protein 1B 2.6881
LINC02268 long intergenic non-protein coding RNA 2268 2.6881
LOC114841035 uncharacterized LOC114841035 2.6881
LOC128125816 uncharacterized LOC128125816 2.6881
OTOR otoraplin 2.6881
FMOD fibromodulin 2.6881
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 2.6881
CBLN3 cerebellin 3 precursor 2.6881
SLC22A25 solute carrier family 22, member 25 2.6881
C10ORF67 chromosome 10 open reading frame 67 2.6881
F8A2 coagulation factor VIII-associated 2 2.6881
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 2.6881
MIA melanoma inhibitory activity 2.6881
TBX5 T-box 5 2.6881
SAA4 serum amyloid A4, constitutive 2.6881
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 2.6881
LRRC72 leucine rich repeat containing 72 2.6881
PNPLA1 patatin-like phospholipase domain containing 1 2.6881
ACE2 angiotensin I converting enzyme 2 2.6881
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.6881
TMPRSS4 transmembrane protease, serine 4 2.6881
ANO3 anoctamin 3 2.6881
TBC1D3L TBC1 domain family, member 3L 2.6881
LOC124909439 uncharacterized LOC124909439 2.6881
PCDHGA12 protocadherin gamma subfamily A, 12 2.6881
GOLGA8K golgin A8 family, member K 2.6881
SPINK9 serine peptidase inhibitor, Kazal type 9 2.6881
CDH19 cadherin 19, type 2 2.6881
PRIMPOL primase and polymerase (DNA-directed) 2.6881
RPS27 ribosomal protein S27 2.6881
IFITM5 interferon induced transmembrane protein 5 2.6881
IL19 interleukin 19 2.6881
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2.6881
RAB40AL RAB40A, member RAS oncogene family-like 2.6881
ERICH6B glutamate-rich 6B 2.6881
BPIFB4 BPI fold containing family B, member 4 2.6881
AKR1B15 aldo-keto reductase family 1, member B15 2.6881
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 2.6881
RFX8 RFX family member 8, lacking RFX DNA binding domain 2.6881
CDC20B cell division cycle 20B 2.6881
ADGRA1 adhesion G protein-coupled receptor A1 2.6881
PRSS2 protease, serine, 2 (trypsin 2) 2.6881
CXCR6 chemokine (C-X-C motif) receptor 6 2.6881
C2ORF66 chromosome 2 open reading frame 66 2.6881
FBXO47 F-box protein 47 2.6881
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.6881
CTSW cathepsin W 2.6881
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 2.6881
OR4D2 olfactory receptor, family 4, subfamily D, member 2 2.6881
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 2.6881
MYLK2 myosin light chain kinase 2 2.6881
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 2.6881
ESPNL espin-like 2.6881
PLA2G5 phospholipase A2, group V 2.6881
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 2.6881
ZIM2 zinc finger, imprinted 2 2.6881
KLK8 kallikrein-related peptidase 8 2.6881
KLK4 kallikrein-related peptidase 4 2.6881
TH tyrosine hydroxylase 2.6881
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.6881
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.6881
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 2.6881
PRSS38 protease, serine, 38 2.6881
NT5C1A 5'-nucleotidase, cytosolic IA 2.6881
ZNF132 zinc finger protein 132 2.6881
PXT1 peroxisomal, testis specific 1 2.6881
NUTM2A NUT family member 2A 2.6881
CARNS1 carnosine synthase 1 2.6881
RNF224 ring finger protein 224 2.6881
BCAS1 breast carcinoma amplified sequence 1 2.6881
ZBED6 zinc finger, BED-type containing 6 2.6881
CLCNKA chloride channel, voltage-sensitive Ka 2.6881
LYZL1 lysozyme-like 1 2.6881
IFNE interferon, epsilon 2.6881
ADRA1B adrenoceptor alpha 1B 2.6881
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 2.6881
GPRC5D G protein-coupled receptor, class C, group 5, member D 2.6881
NKPD1 NTPase, KAP family P-loop domain containing 1 2.6881
RAB7B RAB7B, member RAS oncogene family 2.6881
STOML3 stomatin (EPB72)-like 3 2.6881
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.6881
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.6881
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.6881
FRS3 fibroblast growth factor receptor substrate 3 2.6881
PLA2G4E phospholipase A2, group IVE 2.6881
DMTN dematin actin binding protein 2.6881
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.6881
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 2.6881
ESAM endothelial cell adhesion molecule 2.6881
GCKR glucokinase (hexokinase 4) regulator 2.54854
RDH13 retinol dehydrogenase 13 (all-trans/9-cis) 2.53757
CHDH choline dehydrogenase 2.52408
ZC3HAV1 zinc finger CCCH-type, antiviral 1 2.52078
SUGP1 SURP and G patch domain containing 1 2.47141
TAGLN3 transgelin 3 2.42946
TIGD3 tigger transposable element derived 3 2.42441
SNN stannin 2.39392
HLA-B major histocompatibility complex, class I, B 2.39392
SH3GL1 SH3-domain GRB2-like 1 2.38508
FSD2 fibronectin type III and SPRY domain containing 2 2.31693
CC2D2A coiled-coil and C2 domain containing 2A 2.30298
H4C2 H4 clustered histone 2 2.27996
PRRT3 proline-rich transmembrane protein 3 2.2651
PRPF31 pre-mRNA processing factor 31 2.23736
TLN2 talin 2 2.23736
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 2.21096
MBD5 methyl-CpG binding domain protein 5 2.1895
IFT52 intraflagellar transport 52 2.18606
TULP4 tubby like protein 4 2.18602
MCM9 minichromosome maintenance complex component 9 2.16433
H1-2 H1.2 linker histone, cluster member 2.14385
KLHL22 kelch-like family member 22 2.11592
IGF1 insulin-like growth factor 1 (somatomedin C) 2.11592
TMEM154 transmembrane protein 154 2.0779
CCDC88C coiled-coil domain containing 88C 2.0779
CSNK2A1 casein kinase 2, alpha 1 polypeptide 2.04157
TBC1D10B TBC1 domain family, member 10B 2.04022
RHBDD1 rhomboid domain containing 1 2.035

decreased expression

Symbol Name Standardized Value
CPEB1 cytoplasmic polyadenylation element binding protein 1 -2.77031
CBY3 chibby homolog 3 (Drosophila) -2.77031
LOX lysyl oxidase -2.77031
PCDHGA1 protocadherin gamma subfamily A, 1 -2.77031
TTC29 tetratricopeptide repeat domain 29 -2.77031
ANKRD42-DT ANKRD42 divergent transcript -2.6881
NWD1 NACHT and WD repeat domain containing 1 -2.6881
IL18R1 interleukin 18 receptor 1 -2.6881
SPX spexin hormone -2.6881
TMC2 transmembrane channel-like 2 -2.6881
GID8 GID complex subunit 8 -2.6881
LGI1 leucine-rich, glioma inactivated 1 -2.6881
TMEM140 transmembrane protein 140 -2.6881
TMEM82 transmembrane protein 82 -2.6881
LOC107985101 uncharacterized LOC107985101 -2.6881
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 -2.6881
TNS4 tensin 4 -2.6881
NRROS negative regulator of reactive oxygen species -2.6881
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -2.6881
LBP lipopolysaccharide binding protein -2.6881
RAB9B RAB9B, member RAS oncogene family -2.6881
CHADL chondroadherin-like -2.6881
LRRN4CL LRRN4 C-terminal like -2.6881
GBX1 gastrulation brain homeobox 1 -2.6881
LTB lymphotoxin beta (TNF superfamily, member 3) -2.6881
CELA2A chymotrypsin-like elastase family, member 2A -2.6881
CHGB chromogranin B -2.6881
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -2.6881
TRIM27 tripartite motif containing 27 -2.6881
PPP1R3A protein phosphatase 1, regulatory subunit 3A -2.6881
SLC67A1 solute carrier family 67 member 1 -2.6881
TOR3A torsin family 3, member A -2.6881
ACMSD aminocarboxymuconate semialdehyde decarboxylase -2.6881
IRF8 interferon regulatory factor 8 -2.6881
KBTBD12 kelch repeat and BTB (POZ) domain containing 12 -2.6881
GCLC glutamate-cysteine ligase, catalytic subunit -2.6881
FAM3C family with sequence similarity 3, member C -2.6881
SHROOM4 shroom family member 4 -2.60458
ETFRF1 electron transfer flavoprotein regulatory factor 1 -2.58532
PPP1R16A protein phosphatase 1, regulatory subunit 16A -2.52627
ZNF25 zinc finger protein 25 -2.49902
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 -2.44279
TSPAN15 tetraspanin 15 -2.39836
GHRHR growth hormone releasing hormone receptor -2.39392
MCM3AP minichromosome maintenance complex component 3 associated protein -2.39392
SLC25A29 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 -2.38476
ATAD2B ATPase family, AAA domain containing 2B -2.33582
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 -2.30298
CD101 CD101 molecule -2.30085
IQSEC2 IQ motif and Sec7 domain 2 -2.17124
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 -2.16771
WNT5B wingless-type MMTV integration site family, member 5B -2.16433
DCP1B decapping mRNA 1B -2.15815
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 -2.14995
PPP1R18 protein phosphatase 1, regulatory subunit 18 -2.14688
C3ORF52 chromosome 3 open reading frame 52 -2.13641
INPP5F inositol polyphosphate-5-phosphatase F -2.13641
DNAAF10 dynein axonemal assembly factor 10 -2.1267
DAPK1 death-associated protein kinase 1 -2.12663
KAT14 lysine acetyltransferase 14 -2.11592
MEX3C mex-3 RNA binding family member C -2.11592
TMED3 transmembrane emp24 protein transport domain containing 3 -2.11592
HROB homologous recombination factor with OB-fold -2.10127
DEF8 differentially expressed in FDCP 8 homolog (mouse) -2.10127
EPHA3 EPH receptor A3 -2.10127
FOXN2 forkhead box N2 -2.10127
ZFYVE16 zinc finger, FYVE domain containing 16 -2.09511
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) -2.08893
SETDB1 SET domain, bifurcated 1 -2.04903
ADM adrenomedullin -2.02275
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.01614
DNAH9 dynein, axonemal, heavy chain 9 -2.01364
MAT2A methionine adenosyltransferase II, alpha -2.00629