TRIM63 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description tripartite motif containing 63, E3 ubiquitin protein ligase|This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012] (NCBI Entrez Gene Database, 84676)
External Link http://www.ncbi.nlm.nih.gov/gene/84676
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Genes

88 interacting proteins for TRIM63 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
ACTC1 actin, alpha, cardiac muscle 1
AK1 adenylate kinase 1
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDOA aldolase A, fructose-bisphosphate
APP amyloid beta (A4) precursor protein
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATXN3 ataxin 3
ATXN3L ataxin 3-like
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
CCAR1 cell division cycle and apoptosis regulator 1
CKM creatine kinase, muscle
DCAF6 DDB1 and CUL4 associated factor 6
DES desmin
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial
EEF1G eukaryotic translation elongation factor 1 gamma
EIF3E eukaryotic translation initiation factor 3, subunit E
ENO3 enolase 3 (beta, muscle)
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FHL2 four and a half LIM domains 2
FLNC filamin C, gamma
GFM1 G elongation factor, mitochondrial 1
GMEB1 glucocorticoid modulatory element binding protein 1
HIBADH 3-hydroxyisobutyrate dehydrogenase
JOSD1 Josephin domain containing 1
LAMA2 laminin, alpha 2
LMCD1 LIM and cysteine-rich domains 1
MRPL19 mitochondrial ribosomal protein L19
MRPL2 mitochondrial ribosomal protein L2
MRPL41 mitochondrial ribosomal protein L41
MYBPC2 myosin binding protein C, fast type
MYBPC3 myosin binding protein C, cardiac
MYL2 myosin, light chain 2, regulatory, cardiac, slow
MYOT myotilin
MYOZ1 myozenin 1
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
NEB nebulin
NEBL nebulette
NOMO1 NODAL modulator 1
NRAP nebulin-related anchoring protein
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PDHB pyruvate dehydrogenase (lipoamide) beta
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PKM pyruvate kinase, muscle
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PYGM phosphorylase, glycogen, muscle
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SNAPIN SNAP-associated protein
SQSTM1 sequestosome 1
SRF serum response factor (c-fos serum response element-binding transcription factor)
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
SUMO2 small ubiquitin-like modifier 2
TCAP titin-cap
TNNC1 troponin C type 1 (slow)
TNNI1 troponin I type 1 (skeletal, slow)
TNNI2 troponin I type 2 (skeletal, fast)
TNNI3 troponin I type 3 (cardiac)
TNNT1 troponin T type 1 (skeletal, slow)
TNNT3 troponin T type 3 (skeletal, fast)
TRIM54 tripartite motif containing 54
TRIM55 tripartite motif containing 55
TTN titin
UBC ubiquitin C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2D2 ubiquitin-conjugating enzyme E2D 2
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2I ubiquitin-conjugating enzyme E2I
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UBE2U ubiquitin-conjugating enzyme E2U (putative)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
UQCRC1 ubiquinol-cytochrome c reductase core protein I
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
USP15 ubiquitin specific peptidase 15
USP2 ubiquitin specific peptidase 2
USP21 ubiquitin specific peptidase 21
USP28 ubiquitin specific peptidase 28
USP33 ubiquitin specific peptidase 33
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
USP8 ubiquitin specific peptidase 8
UXT ubiquitously-expressed, prefoldin-like chaperone
YOD1 YOD1 deubiquitinase