TSPO Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description translocator protein (18kDa)|Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided by RefSeq, Feb 2012] (NCBI Entrez Gene Database, 706)
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Genes

293 genes differentially expressed following the TSPO gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GIGYF1 GRB10 interacting GYF protein 1 2.25941
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 2.25941
FGL2 fibrinogen-like 2 2.25941
TSGA13 testis specific, 13 2.25941
SOX18 SRY (sex determining region Y)-box 18 2.25941
RUNDC3A RUN domain containing 3A 2.25941
CASP5 caspase 5, apoptosis-related cysteine peptidase 2.25941
GRXCR2 glutaredoxin, cysteine rich 2 2.25941
TCHH trichohyalin 2.25941
CXORF65 chromosome X open reading frame 65 2.25941
NANOS3 nanos homolog 3 (Drosophila) 2.25941
OR51A7 olfactory receptor, family 51, subfamily A, member 7 2.25941
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa 2.25941
PLVAP plasmalemma vesicle associated protein 2.25941
FOLR1 folate receptor 1 (adult) 2.25941
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.25941
FGF23 fibroblast growth factor 23 2.25941
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 2.25941
UCN urocortin 2.25941
NPAP1 nuclear pore associated protein 1 2.25941
ALOX15 arachidonate 15-lipoxygenase 2.25941
GJB1 gap junction protein, beta 1, 32kDa 2.25941
HBA1 hemoglobin, alpha 1 2.25941
OXT oxytocin/neurophysin I prepropeptide 2.25941
CSNK2A3 casein kinase 2, alpha 3 polypeptide 2.25941
SNTG2 syntrophin, gamma 2 2.25941
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 2.25941
TDO2 tryptophan 2,3-dioxygenase 2.25941
FAM9B family with sequence similarity 9, member B 2.25941
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 2.25941
MRGPRX3 MAS-related GPR, member X3 2.25941
DCST1 DC-STAMP domain containing 1 2.25941
PGBDF plakoglobin binding and degradation factor 2.25941
LCN15 lipocalin 15 2.25941
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2 2.25941
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.25941
PAX7 paired box 7 2.25941
KSR1 kinase suppressor of ras 1 2.25941
TUBB8 tubulin, beta 8 class VIII 2.25941
RSPO1 R-spondin 1 2.25941
SHCBP1L SHC SH2-domain binding protein 1-like 2.25941
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 2.25941
MROH2B maestro heat-like repeat family member 2B 2.25941
ASCL3 achaete-scute family bHLH transcription factor 3 2.25941
TEX53 testis expressed 53 2.25941
AVPR1B arginine vasopressin receptor 1B 2.25941
MYH7 myosin, heavy chain 7, cardiac muscle, beta 2.25941
ELOVL3 ELOVL fatty acid elongase 3 2.25941
KRT86 keratin 86, type II 2.25941
ZMYM2 zinc finger, MYM-type 2 2.25941
OR1C1 olfactory receptor, family 1, subfamily C, member 1 2.25941
SAG S-antigen; retina and pineal gland (arrestin) 2.25941
MIOX myo-inositol oxygenase 2.25941
SPATA25 spermatogenesis associated 25 2.25941
MT3 metallothionein 3 2.25941
ALDOB aldolase B, fructose-bisphosphate 2.25941
FAM237A family with sequence similarity 237 member A 2.25941
IRF2-DT IRF2 divergent transcript 2.25941
C1ORF232 chromosome 1 open reading frame 230 2.25941
CIMIP3 ciliary microtubule inner protein 3 2.25941
MYMK myomaker, myoblast fusion factor 2.25941
TMEM270 transmembrane protein 270 2.25941
CATSPERZ catsper channel auxiliary subunit zeta 2.25941
PLPP4 phospholipid phosphatase 4 2.25941
FYB1 FYN binding protein 1 2.25941
LY6H lymphocyte antigen 6 complex, locus H 2.25941
LY6K lymphocyte antigen 6 complex, locus K 2.25941
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 2.25941
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.25941
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 2.25941
REC114 REC114 meiotic recombination protein 2.25941
MYH10 myosin, heavy chain 10, non-muscle 2.25941
TLR8 toll-like receptor 8 2.25941
HSFX4 heat shock transcription factor family, X-linked member 4 2.25941
TMEM235 transmembrane protein 235 2.25941
UROC1 urocanate hydratase 1 2.25941
XRN1 5'-3' exoribonuclease 1 2.25941
GLIPR1L2 GLI pathogenesis-related 1 like 2 2.25941
GATA4 GATA binding protein 4 2.25941
MLANA melan-A 2.25941
CSAG3 CSAG family, member 3 2.25941
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 2.25941
LTK leukocyte receptor tyrosine kinase 2.25941
DLK2 delta-like 2 homolog (Drosophila) 2.25941
BEST3 bestrophin 3 2.25941
FGFBP2 fibroblast growth factor binding protein 2 2.25941
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 2.25941
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 2.25941
IL17B interleukin 17B 2.25941
LRRC32 leucine rich repeat containing 32 2.25941
WDR48 WD repeat domain 48 2.25941
WFDC6 WAP four-disulfide core domain 6 2.25941
WFDC9 WAP four-disulfide core domain 9 2.25941
CREG1 cellular repressor of E1A-stimulated genes 1 2.25941
FAM209A family with sequence similarity 209, member A 2.25941
CAGE1 cancer antigen 1 2.25941
TTC9B tetratricopeptide repeat domain 9B 2.25941
DRD3 dopamine receptor D3 2.25941
WWC2 WW and C2 domain containing 2 2.25941
LHFPL1 lipoma HMGIC fusion partner-like 1 2.25941
EMX2 empty spiracles homeobox 2 2.25941
FBXO39 F-box protein 39 2.25941
LRCOL1 leucine rich colipase-like 1 2.25941
GLYATL3 glycine-N-acyltransferase-like 3 2.25941
ERICH4 glutamate-rich 4 2.25941
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 2.25941
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 2.25941
EMP1 epithelial membrane protein 1 2.25941
AQP9 aquaporin 9 2.25941
CXCR6 chemokine (C-X-C motif) receptor 6 2.25941
LMOD3 leiomodin 3 (fetal) 2.25941
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 2.25941
C1ORF105 chromosome 1 open reading frame 105 2.25941
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase 2.25941
OTP orthopedia homeobox 2.25941
OPALIN oligodendrocytic myelin paranodal and inner loop protein 2.25941
MEPE matrix extracellular phosphoglycoprotein 2.25941
WNT2 wingless-type MMTV integration site family member 2 2.25941
FOXN1 forkhead box N1 2.25941
GJC3 gap junction protein, gamma 3, 30.2kDa 2.25941
GOLGA8M golgin A8 family, member M 2.25941
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 2.25941
NCR3 natural cytotoxicity triggering receptor 3 2.25941
IL1B interleukin 1, beta 2.25941
UTS2R urotensin 2 receptor 2.25941
SPEF1 sperm flagellar 1 2.25941
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 2.25941
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 2.25941
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2.25941
NT5C1B 5'-nucleotidase, cytosolic IB 2.25941
CTSZ cathepsin Z 2.25941
DAW1 dynein assembly factor with WDR repeat domains 1 2.25941
LRRC46 leucine rich repeat containing 46 2.25941
IL17D interleukin 17D 2.25941
CHRM4 cholinergic receptor, muscarinic 4 2.25941
USP33 ubiquitin specific peptidase 33 2.25941
RERGL RERG/RAS-like 2.25941
CLCA1 chloride channel accessory 1 2.25941
TRPM1 transient receptor potential cation channel, subfamily M, member 1 2.25941
RTN4RL1 reticulon 4 receptor-like 1 2.25941
ANGPTL6 angiopoietin-like 6 2.25941
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 2.25941
TMPRSS12 transmembrane (C-terminal) protease, serine 12 2.25941
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.25941
FGF10 fibroblast growth factor 10 2.25941
TGM5 transglutaminase 5 2.25941
PPP1R3C protein phosphatase 1, regulatory subunit 3C 2.25941
ANXA8 annexin A8 2.25941
MMP10 matrix metallopeptidase 10 2.25941
PXT1 peroxisomal, testis specific 1 2.25941
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 2.25941
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 2.25941
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 2.25941
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 2.25941
HCAR1 hydroxycarboxylic acid receptor 1 2.25941
FZD9 frizzled class receptor 9 2.25941
TOP2A topoisomerase (DNA) II alpha 170kDa 2.25829
SIDT2 SID1 transmembrane family, member 2 2.25829
TMEM52 transmembrane protein 52 2.23911
TLNRD1 talin rod domain containing 1 2.23368
KDM4B lysine (K)-specific demethylase 4B 2.23368
SMC6 structural maintenance of chromosomes 6 2.23368
S1PR1 sphingosine-1-phosphate receptor 1 2.23368
POM121 POM121 transmembrane nucleoporin 2.22388
GRID2 glutamate receptor, ionotropic, delta 2 2.21338
GJB3 gap junction protein, beta 3, 31kDa 2.19498
ZBTB39 zinc finger and BTB domain containing 39 2.19031
RUSC2 RUN and SH3 domain containing 2 2.19031
GEMIN4 gem (nuclear organelle) associated protein 4 2.16672
LMF2 lipase maturation factor 2 2.16384
FASTK Fas-activated serine/threonine kinase 2.13331
KLKB1 kallikrein B, plasma (Fletcher factor) 1 2.12774
TCTA T-cell leukemia translocation altered 2.12077
OARD1 O-acyl-ADP-ribose deacylase 1 2.1069
TICAM2 toll-like receptor adaptor molecule 2 2.09605
GTF2A1 general transcription factor IIA, 1, 19/37kDa 2.09337
PDK3 pyruvate dehydrogenase kinase, isozyme 3 2.09337
TOR1AIP2 torsin A interacting protein 2 2.09232
PWWP3B PWWP domain containing 3B 2.08738
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 2.08738
G6PD glucose-6-phosphate dehydrogenase 2.08738
ZNF518B zinc finger protein 518B 2.08738
C19ORF38 chromosome 19 open reading frame 38 2.08738
DHODH dihydroorotate dehydrogenase (quinone) 2.07642
STRN4 striatin, calmodulin binding protein 4 2.06191
INPP5B inositol polyphosphate-5-phosphatase, 75kDa 2.06191
E2F3 E2F transcription factor 3 2.06191
NR1H3 nuclear receptor subfamily 1, group H, member 3 2.05969
RAB22A RAB22A, member RAS oncogene family 2.05709
ALG2 ALG2, alpha-1,3/1,6-mannosyltransferase 2.05709
ALG11 ALG11, alpha-1,2-mannosyltransferase 2.05709
NARF nuclear prelamin A recognition factor 2.04315
DIXDC1 DIX domain containing 1 2.04205
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 2.04184
BBOF1 basal body orientation factor 1 2.04123
CFL2 cofilin 2 (muscle) 2.0402
CRIP3 cysteine-rich protein 3 2.03804
BCAS3 breast carcinoma amplified sequence 3 2.03795
GON4L gon-4-like (C. elegans) 2.0125
AHSP alpha hemoglobin stabilizing protein 2.00268
TOM1 target of myb1 (chicken) 2.00153

decreased expression

Symbol Name Standardized Value
SETD7 SET domain containing (lysine methyltransferase) 7 -2.25941
ZSCAN16 zinc finger and SCAN domain containing 16 -2.25941
DKC1 dyskeratosis congenita 1, dyskerin -2.25941
TUBB2A tubulin, beta 2A class IIa -2.25941
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -2.25941
TSPO translocator protein (18kDa) -2.25941
GPR3 G protein-coupled receptor 3 -2.25941
FITM2 fat storage-inducing transmembrane protein 2 -2.25941
C19ORF73 chromosome 19 open reading frame 73 -2.25941
SLC16A14 solute carrier family 16, member 14 -2.25941
METTL21A methyltransferase like 21A -2.25941
PLXNB2 plexin B2 -2.25941
GLB1L galactosidase, beta 1-like -2.25941
ACO2 aconitase 2, mitochondrial -2.25941
RASD2 RASD family, member 2 -2.25941
KCP kielin/chordin-like protein -2.25941
DAGLB diacylglycerol lipase, beta -2.25941
LSMEM2 leucine-rich single-pass membrane protein 2 -2.25941
COL24A1 collagen, type XXIV, alpha 1 -2.25941
KLK14 kallikrein-related peptidase 14 -2.25941
MAMLD1 mastermind-like domain containing 1 -2.25941
MTO1 mitochondrial tRNA translation optimization 1 -2.25015
MBD1 methyl-CpG binding domain protein 1 -2.2419
ALX3 ALX homeobox 3 -2.23368
C17ORF113 chromosome 17 open reading frame 113 -2.23368
UBA7 ubiquitin-like modifier activating enzyme 7 -2.23368
MPPED1 metallophosphoesterase domain containing 1 -2.23368
ANKK1 ankyrin repeat and kinase domain containing 1 -2.23368
MSC musculin -2.23368
MPL MPL proto-oncogene, thrombopoietin receptor -2.23368
CELF6 CUGBP, Elav-like family member 6 -2.23368
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) -2.23368
CTXND1 cortexin domain containing 1 -2.23368
OR2B6 olfactory receptor, family 2, subfamily B, member 6 -2.23368
CLDN9 claudin 9 -2.23368
LMNTD1 lamin tail domain containing 1 -2.23368
TLE6 transducin-like enhancer of split 6 -2.23368
ZNF436 zinc finger protein 436 -2.23368
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 -2.23368
TMPRSS11A transmembrane protease, serine 11A -2.23368
TMEM40 transmembrane protein 40 -2.23368
SCG2 secretogranin II -2.23368
NECTIN4 nectin cell adhesion molecule 4 -2.23368
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) -2.23368
RIBC1 RIB43A domain with coiled-coils 1 -2.23368
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 -2.23368
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 -2.23368
NIM1K NIM1 serine/threonine protein kinase -2.23368
EDN1 endothelin 1 -2.23368
CXCR5 chemokine (C-X-C motif) receptor 5 -2.23368
LCN2 lipocalin 2 -2.23368
AFAP1L1 actin filament associated protein 1-like 1 -2.23368
TMEM132D transmembrane protein 132D -2.23368
ZNF85 zinc finger protein 85 -2.23368
COL9A2 collagen, type IX, alpha 2 -2.23368
AHSG alpha-2-HS-glycoprotein -2.23368
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 -2.23368
TMEM88 transmembrane protein 88 -2.23368
EMCN endomucin -2.23368
TP53INP2 tumor protein p53 inducible nuclear protein 2 -2.23368
CLN5 ceroid-lipofuscinosis, neuronal 5 -2.23368
GPR179 G protein-coupled receptor 179 -2.23368
B2M beta-2-microglobulin -2.21262
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -2.19498
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide -2.16384
ATRAID all-trans retinoic acid-induced differentiation factor -2.16341
RMDN3 regulator of microtubule dynamics 3 -2.16047
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 -2.15851
ZNF205 zinc finger protein 205 -2.1094
CCDC15 coiled-coil domain containing 15 -2.10779
CD79B CD79b molecule, immunoglobulin-associated beta -2.1069
RARS1 arginyl-tRNA synthetase 1 -2.09435
FZD5 frizzled class receptor 5 -2.09337
ANPEP alanyl (membrane) aminopeptidase -2.09337
ZNF222 zinc finger protein 222 -2.08738
USP44 ubiquitin specific peptidase 44 -2.08738
AP1S1 adaptor-related protein complex 1, sigma 1 subunit -2.08738
OSBPL10 oxysterol binding protein-like 10 -2.08738
LYPLA2 lysophospholipase II -2.08738
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -2.08738
FAS Fas cell surface death receptor -2.08738
TMEM158 transmembrane protein 158 (gene/pseudogene) -2.08738
RIPK2 receptor-interacting serine-threonine kinase 2 -2.06084
SLC4A3 solute carrier family 4 (anion exchanger), member 3 -2.04269
MOB3B MOB kinase activator 3B -2.04269
GPNMB glycoprotein (transmembrane) nmb -2.04184
ZNF680 zinc finger protein 680 -2.04184
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide -2.04139
PALD1 phosphatase domain containing, paladin 1 -2.0402
OPRM1 opioid receptor, mu 1 -2.03572
FOS FBJ murine osteosarcoma viral oncogene homolog -2.03572
CCR5AS CCR5 antisense RNA -2.00268