TTF1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description transcription termination factor, RNA polymerase I|This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011] (NCBI Entrez Gene Database, 7270)
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Genes

234 genes differentially expressed following the TTF1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
LRP2 low density lipoprotein receptor-related protein 2 2.34512
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 2.22841
TTC8 tetratricopeptide repeat domain 8 2.22841
DRC2 dynein regulatory complex subunit 2 2.22841
POMT1 protein-O-mannosyltransferase 1 2.22841
RNF141 ring finger protein 141 2.22841
GEMIN4 gem (nuclear organelle) associated protein 4 2.22841
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) 2.22841
ANGEL1 angel homolog 1 (Drosophila) 2.22841
ACTN3 actinin, alpha 3 (gene/pseudogene) 2.22841
ZNF107 zinc finger protein 107 2.22521
MMP23B matrix metallopeptidase 23B 2.20493
TCAIM T cell activation inhibitor, mitochondrial 2.20493
ROGDI rogdi homolog (Drosophila) 2.20493
NT5M 5',3'-nucleotidase, mitochondrial 2.20493
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 2.20493
AGBL2 ATP/GTP binding protein-like 2 2.20493
ZNF318 zinc finger protein 318 2.20493
ALG11 ALG11, alpha-1,2-mannosyltransferase 2.20493
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5 2.20493
IFT122 intraflagellar transport 122 2.20493
ASGR1 asialoglycoprotein receptor 1 2.20493
TSHZ3 teashirt zinc finger homeobox 3 2.20493
MYO1C myosin IC 2.20493
KIF2C kinesin family member 2C 2.20493
FAM89B family with sequence similarity 89, member B 2.20493
TLCD3A TLC domain containing 3A 2.20493
GPAT4 glycerol-3-phosphate acyltransferase 4 2.20493
ZNF664 zinc finger protein 664 2.20493
ALDOC aldolase C, fructose-bisphosphate 2.20493
NUP205 nucleoporin 205kDa 2.20493
CDK5 cyclin-dependent kinase 5 2.20493
TMEM200A transmembrane protein 200A 2.20493
MTMR1 myotubularin related protein 1 2.20493
TOR3A torsin family 3, member A 2.20493
ANXA11 annexin A11 2.20493
ERVMER34-1 endogenous retrovirus group MER34, member 1 2.20493
TMEM59L transmembrane protein 59-like 2.20493
MLH3 mutL homolog 3 2.20493
ST14 suppression of tumorigenicity 14 (colon carcinoma) 2.20493
MEF2D myocyte enhancer factor 2D 2.20493
TSC22D3 TSC22 domain family, member 3 2.20493
PGAP4 post-GPI attachment to proteins GalNAc transferase 4 2.20493
ZNF133 zinc finger protein 133 2.20493
UBXN11 UBX domain protein 11 2.20493
STK16 serine/threonine kinase 16 2.20493
TTC26 tetratricopeptide repeat domain 26 2.20493
NOX4 NADPH oxidase 4 2.20493
NODAL nodal growth differentiation factor 2.20493
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12 2.20493
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD) 2.20493
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 2.20493
RNASEH2A ribonuclease H2, subunit A 2.20493
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 2.20493
UVSSA UV-stimulated scaffold protein A 2.20493
ZNF333 zinc finger protein 333 2.20493
GPC1 glypican 1 2.20493
DHRS12 dehydrogenase/reductase (SDR family) member 12 2.20493
PHLDA2 pleckstrin homology-like domain, family A, member 2 2.20493
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 2.20493
FKBP15 FK506 binding protein 15, 133kDa 2.20493
TST thiosulfate sulfurtransferase (rhodanese) 2.20493
TPK1 thiamin pyrophosphokinase 1 2.20493
SH2D3A SH2 domain containing 3A 2.20493
RIC8A RIC8 guanine nucleotide exchange factor A 2.20493
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 2.20493
TRIM25 tripartite motif containing 25 2.20493
CHAC2 ChaC, cation transport regulator homolog 2 (E. coli) 2.20493
TTYH1 tweety family member 1 2.20493
COL28A1 collagen, type XXVIII, alpha 1 2.20493
CUZD1 CUB and zona pellucida-like domains 1 2.20493
ZNF512 zinc finger protein 512 2.19996
INAVA innate immunity activator 2.19996
DOCK2 dedicator of cytokinesis 2 2.19996
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) 2.19996
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) 2.19996
HIC2 hypermethylated in cancer 2 2.19996
TBCE tubulin folding cofactor E 2.18256
PCNX1 pecanex 1 2.13249
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 2.12829
PIGBOS1 PIGB opposite strand 1 2.12829
STK17A serine/threonine kinase 17a 2.12829
WHR1 winged helix repair factor 1 2.12829
STK11 serine/threonine kinase 11 2.12829
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 2.12829
ACAT2 acetyl-CoA acetyltransferase 2 2.07446
ZC3H18 zinc finger CCCH-type containing 18 2.07168
SHISAL2B shisa like 2B 2.06749
TMX3 thioredoxin-related transmembrane protein 3 2.06749
OLFM1 olfactomedin 1 2.06749
SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2.06749
CA5B carbonic anhydrase VB, mitochondrial 2.06749
SIPA1L2 signal-induced proliferation-associated 1 like 2 2.05826
IL17RD interleukin 17 receptor D 2.05826
NEURL1B neuralized E3 ubiquitin protein ligase 1B 2.05826
KCNMB2 potassium channel subfamily M regulatory beta subunit 2 2.04651
NCSTN nicastrin 2.04651

decreased expression

Symbol Name Standardized Value
EXOSC10 exosome component 10 -2.34512
CISD1 CDGSH iron sulfur domain 1 -2.34512
METTL3 methyltransferase like 3 -2.34512
ZFP42 ZFP42 zinc finger protein -2.34512
TRIP10 thyroid hormone receptor interactor 10 -2.22841
TMEM51 transmembrane protein 51 -2.22841
CEP250 centrosomal protein 250kDa -2.22841
SAP30BP SAP30 binding protein -2.22841
PREP prolyl endopeptidase -2.22841
MKKS McKusick-Kaufman syndrome -2.22841
CCDC141 coiled-coil domain containing 141 -2.22841
GXYLT1 glucoside xylosyltransferase 1 -2.22841
SRA1 steroid receptor RNA activator 1 -2.22841
P4HB prolyl 4-hydroxylase, beta polypeptide -2.22841
SLC39A3 solute carrier family 39 (zinc transporter), member 3 -2.22841
MOB1A MOB kinase activator 1A -2.22841
AKT2 v-akt murine thymoma viral oncogene homolog 2 -2.22841
ELAPOR2 endosome-lysosome associated apoptosis and autophagy regulator family member 2 -2.22841
SPRED2 sprouty-related, EVH1 domain containing 2 -2.22841
PALS1 protein associated with LIN7 1, MAGUK p55 family member -2.22841
TEDC2 tubulin epsilon and delta complex 2 -2.22841
ANAPC5 anaphase promoting complex subunit 5 -2.22841
UGT3A2 UDP glycosyltransferase 3 family, polypeptide A2 -2.22841
NAAA N-acylethanolamine acid amidase -2.22841
LRATD2 LRAT domain containing 2 -2.22841
COQ10A coenzyme Q10 homolog A (S. cerevisiae) -2.20493
RELL2 RELT-like 2 -2.20493
MEGF6 multiple EGF-like-domains 6 -2.20493
ZNF586 zinc finger protein 586 -2.20493
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -2.20493
BCAR1 breast cancer anti-estrogen resistance 1 -2.20493
GSKIP GSK3B interacting protein -2.20493
MMP25 matrix metallopeptidase 25 -2.20493
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 -2.20493
ADAT2 adenosine deaminase, tRNA-specific 2 -2.20493
NUDT14 nudix (nucleoside diphosphate linked moiety X)-type motif 14 -2.20493
RAB26 RAB26, member RAS oncogene family -2.20493
ANKS3 ankyrin repeat and sterile alpha motif domain containing 3 -2.20493
SIRT5 sirtuin 5 -2.20493
LBH limb bud and heart development -2.20493
PHKG2 phosphorylase kinase, gamma 2 (testis) -2.20493
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase -2.20493
NRBF2 nuclear receptor binding factor 2 -2.20493
MTERF3 mitochondrial transcription termination factor 3 -2.20493
ZDHHC5 zinc finger, DHHC-type containing 5 -2.20493
TAS2R4 taste receptor, type 2, member 4 -2.20493
RAB11B RAB11B, member RAS oncogene family -2.20493
ZSCAN32 zinc finger and SCAN domain containing 32 -2.20493
COMMD5 COMM domain containing 5 -2.20493
HS1BP3 HCLS1 binding protein 3 -2.20493
BKGD beta-keto-L-gulonate decarboxylase -2.20493
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.20493
NCKIPSD NCK interacting protein with SH3 domain -2.20493
STAT2 signal transducer and activator of transcription 2, 113kDa -2.20493
MRM2 mitochondrial rRNA methyltransferase 2 -2.20493
POGLUT3 protein O-glucosyltransferase 3 -2.20493
PIERCE1 piercer of microtubule wall 1 -2.20493
ZNG1A Zn regulated GTPase metalloprotein activator 1A -2.20493
FHIP2A FHF complex subunit HOOK interacting protein 2A -2.20493
ASB1 ankyrin repeat and SOCS box containing 1 -2.20493
RBMS2 RNA binding motif, single stranded interacting protein 2 -2.20493
PNPLA4 patatin-like phospholipase domain containing 4 -2.20493
ZBTB11 zinc finger and BTB domain containing 11 -2.20493
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog -2.20493
HMCN1 hemicentin 1 -2.20493
DEPDC5 DEP domain containing 5 -2.20493
GPN2 GPN-loop GTPase 2 -2.20493
CAPRIN2 caprin family member 2 -2.20493
TATDN3 TatD DNase domain containing 3 -2.20493
GSTK1 glutathione S-transferase kappa 1 -2.20493
OSGEP O-sialoglycoprotein endopeptidase -2.20493
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -2.20493
PTS 6-pyruvoyltetrahydropterin synthase -2.20493
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 -2.20493
RLIG1 RNA 5'-phosphate and 3'-OH ligase 1 -2.20493
TERF2 telomeric repeat binding factor 2 -2.20493
LPAR1 lysophosphatidic acid receptor 1 -2.20493
FAM219B family with sequence similarity 219, member B -2.20493
CHSY3 chondroitin sulfate synthase 3 -2.20493
PHF7 PHD finger protein 7 -2.20493
SARM1 sterile alpha and TIR motif containing 1 -2.20493
SLAIN1 SLAIN motif family, member 1 -2.20493
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -2.20493
FAM20B family with sequence similarity 20, member B -2.20493
NIPAL1 NIPA-like domain containing 1 -2.20493
CDK11B cyclin-dependent kinase 11B -2.20493
SCRN2 secernin 2 -2.20493
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -2.20493
KIF9 kinesin family member 9 -2.20493
FHL1 four and a half LIM domains 1 -2.20493
DENND1B DENN/MADD domain containing 1B -2.20493
INF2 inverted formin, FH2 and WH2 domain containing -2.20493
FTCDNL1 formiminotransferase cyclodeaminase N-terminal like -2.20493
TMEM164 transmembrane protein 164 -2.20493
FBXO10 F-box protein 10 -2.20493
DAGLB diacylglycerol lipase, beta -2.20493
RASA3 RAS p21 protein activator 3 -2.20493
FECH ferrochelatase -2.20493
QPCT glutaminyl-peptide cyclotransferase -2.20493
CYTH1 cytohesin 1 -2.20493
CYTH2 cytohesin 2 -2.20493
FANCE Fanconi anemia, complementation group E -2.20493
DCTN5 dynactin 5 (p25) -2.20493
USP36 ubiquitin specific peptidase 36 -2.20493
PRR36 proline rich 36 -2.20493
RAD51C RAD51 paralog C -2.20493
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma -2.20493
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 -2.20493
FAM114A1 family with sequence similarity 114, member A1 -2.20493
TBXAS1 thromboxane A synthase 1 (platelet) -2.20493
TSC1 tuberous sclerosis 1 -2.20493
DCAF10 DDB1 and CUL4 associated factor 10 -2.20493
TMEM80 transmembrane protein 80 -2.20493
ARL4D ADP-ribosylation factor-like 4D -2.20493
ACAD9 acyl-CoA dehydrogenase family, member 9 -2.20493
POLR1E polymerase (RNA) I polypeptide E, 53kDa -2.20493
SETD6 SET domain containing 6 -2.20493
PITRM1 pitrilysin metallopeptidase 1 -2.20493
BLOC1S5 biogenesis of lysosomal organelles complex-1, subunit 5, muted -2.20493
CENPT centromere protein T -2.20493
SHMT1 serine hydroxymethyltransferase 1 (soluble) -2.20493
DNAH11 dynein, axonemal, heavy chain 11 -2.20493
MALT1 MALT1 paracaspase -2.20493
ZC3H13 zinc finger CCCH-type containing 13 -2.20493
FYCO1 FYVE and coiled-coil domain containing 1 -2.20493
BFAR bifunctional apoptosis regulator -2.20493
ALAS1 5'-aminolevulinate synthase 1 -2.20493
ACBD7 acyl-CoA binding domain containing 7 -2.20493
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -2.20493
CCDC8 coiled-coil domain containing 8 -2.20493
UGT3A1 UDP glycosyltransferase 3 family, polypeptide A1 -2.20493
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 -2.20493
ABHD8 abhydrolase domain containing 8 -2.20493
GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 -2.20493
HIPK2 homeodomain interacting protein kinase 2 -2.17693
PIEZO1 piezo-type mechanosensitive ion channel component 1 -2.07168
NGDN neuroguidin, EIF4E binding protein -2.07168