TTN Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description titin|This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma. [provided by RefSeq, Feb 2012] (NCBI Entrez Gene Database, 7273)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MORF_TTN
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Genes

76 co-expressed genes for TTN from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10
ACTN3 actinin, alpha 3 (gene/pseudogene)
ADAMTSL3 ADAMTS-like 3
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
CADM4 cell adhesion molecule 4
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle)
CDC73 cell division cycle 73
CKM creatine kinase, muscle
CLCN3 chloride channel, voltage-sensitive 3
COL14A1 collagen, type XIV, alpha 1
COL8A1 collagen, type VIII, alpha 1
CXCL5 chemokine (C-X-C motif) ligand 5
DBT dihydrolipoamide branched chain transacylase E2
ENO3 enolase 3 (beta, muscle)
FAM153B family with sequence similarity 153, member B
FBXL4 F-box and leucine-rich repeat protein 4
FSHR follicle stimulating hormone receptor
GCA grancalcin, EF-hand calcium binding protein
GJB5 gap junction protein, beta 5, 31.1kDa
GLRA3 glycine receptor, alpha 3
GPR171 G protein-coupled receptor 171
GUCY2F guanylate cyclase 2F, retinal
HCG8 HLA complex group 8
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
IFNA1 interferon, alpha 1
IFNA10 interferon, alpha 10
IFNA8 interferon, alpha 8
IGKV7-3 immunoglobulin kappa variable 7-3 (pseudogene)
JADE3 jade family PHD finger 3
JRKL JRK-like
KLHL41 kelch-like family member 41
KRT2 keratin 2, type II
KRT34 keratin 34, type I
LDB3 LIM domain binding 3
MAGEA8 melanoma antigen family A8
MAP2 microtubule-associated protein 2
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MYBPC1 myosin binding protein C, slow type
MYBPC2 myosin binding protein C, fast type
MYH1 myosin, heavy chain 1, skeletal muscle, adult
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYL1 myosin, light chain 1, alkali; skeletal, fast
MYOT myotilin
MYOZ1 myozenin 1
NEB nebulin
NR1I2 nuclear receptor subfamily 1, group I, member 2
NTNG2 netrin G2
PGM3 phosphoglucomutase 3
PHOX2B paired-like homeobox 2b
PTPRB protein tyrosine phosphatase, receptor type, B
PYGM phosphorylase, glycogen, muscle
R3HCC1L R3H domain and coiled-coil containing 1-like
RAD51D RAD51 paralog D
RORB RAR-related orphan receptor B
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RREB1 ras responsive element binding protein 1
RYR1 ryanodine receptor 1 (skeletal)
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
SLN sarcolipin
SPA17 sperm autoantigenic protein 17
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
TMEM26 transmembrane protein 26
TNNC2 troponin C type 2 (fast)
TNNI1 troponin I type 1 (skeletal, slow)
TNNI2 troponin I type 2 (skeletal, fast)
TNNT1 troponin T type 1 (skeletal, slow)
TNNT3 troponin T type 3 (skeletal, fast)
TPM3 tropomyosin 3
TSSK2 testis-specific serine kinase 2
TTN titin
ZBTB40 zinc finger and BTB domain containing 40
ZNF141 zinc finger protein 141
ZNF266 zinc finger protein 266
ZSCAN26 zinc finger and SCAN domain containing 26