TTYH3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description tweety family member 3|This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 80727)
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Genes

329 genes differentially expressed following the TTYH3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CPNE6 copine VI (neuronal) 2.64705
PGAM4 phosphoglycerate mutase family member 4 2.64705
DNASE1L3 deoxyribonuclease I-like 3 2.64705
TNNI2 troponin I type 2 (skeletal, fast) 2.64705
RAB13 RAB13, member RAS oncogene family 2.64705
TMEM151A transmembrane protein 151A 2.64705
GLYAT glycine-N-acyltransferase 2.64705
OSGIN1 oxidative stress induced growth inhibitor 1 2.64705
TBX18 T-box 18 2.64705
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 2.64705
VSTM2A V-set and transmembrane domain containing 2A 2.64705
PLIN4 perilipin 4 2.64705
EGFL6 EGF-like-domain, multiple 6 2.64705
SLC46A3 solute carrier family 46, member 3 2.64705
TBX20 T-box 20 2.64705
ANGPT4 angiopoietin 4 2.64705
HABP2 hyaluronan binding protein 2 2.64705
TMEM141 transmembrane protein 141 2.64705
TMEM212 transmembrane protein 212 2.64705
FOLR1 folate receptor 1 (adult) 2.64705
ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7 2.64705
SACK1A scaffolding CK1 anchoring protein A 2.64705
SLC26A9 solute carrier family 26 (anion exchanger), member 9 2.64705
FBXL8 F-box and leucine-rich repeat protein 8 2.64705
GJB5 gap junction protein, beta 5, 31.1kDa 2.64705
PAX8 paired box 8 2.64705
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 2.64705
FAM216B family with sequence similarity 216, member B 2.64705
ATOH7 atonal homolog 7 (Drosophila) 2.64705
BMP5 bone morphogenetic protein 5 2.64705
TSHZ1 teashirt zinc finger homeobox 1 2.64705
SPAG6 sperm associated antigen 6 2.64705
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 2.64705
ARSH arylsulfatase family, member H 2.64705
CD33 CD33 molecule 2.64705
APOA5 apolipoprotein A-V 2.64705
C1R complement component 1, r subcomponent 2.64705
FABP12 fatty acid binding protein 12 2.64705
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 2.64705
PAX5 paired box 5 2.64705
ARHGAP36 Rho GTPase activating protein 36 2.64705
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 2.64705
MFAP5 microfibrillar associated protein 5 2.64705
TNIP3 TNFAIP3 interacting protein 3 2.64705
ADGB androglobin 2.64705
RAPSN receptor-associated protein of the synapse 2.64705
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 2.64705
TDRD9 tudor domain containing 9 2.64705
C2ORF80 chromosome 2 open reading frame 80 2.64705
NEUROD1 neuronal differentiation 1 2.64705
DNAI1 dynein, axonemal, intermediate chain 1 2.64705
LOC124909439 uncharacterized LOC124909439 2.64705
ZNF74 zinc finger protein 74 2.64705
OTOF otoferlin 2.64705
ALX1 ALX homeobox 1 2.64705
RHCG Rh family, C glycoprotein 2.64705
FRG2C FSHD region gene 2 family, member C 2.64705
KRT86 keratin 86, type II 2.64705
SRGN serglycin 2.64705
SPRR2A small proline-rich protein 2A 2.64705
PDF peptide deformylase (mitochondrial) 2.64705
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 2.64705
MMUT methylmalonyl-CoA mutase 2.64705
DUSP29 dual specificity phosphatase 29 2.64705
GARIN1A golgi associated RAB2 interactor 1A 2.64705
LOC124900192 uncharacterized LOC124900192 2.64705
NHERF4 NHERF family PDZ scaffold protein 4 2.64705
DEFB109B defensin beta 109B 2.64705
LOC124902436 talanin 2.64705
CTXND1 cortexin domain containing 1 2.64705
GREP1 glycine rich extracellular protein 1 2.64705
RHEX regulator of hemoglobinization and erythroid cell expansion 2.64705
UBE2L5 ubiquitin conjugating enzyme E2 L5 2.64705
TEX13C TEX13 family member C 2.64705
CATSPERZ catsper channel auxiliary subunit zeta 2.64705
FAM228A family with sequence similarity 228, member A 2.64705
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.64705
S100B S100 calcium binding protein B 2.64705
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.64705
SCRT1 scratch family zinc finger 1 2.64705
CD79A CD79a molecule, immunoglobulin-associated alpha 2.64705
PSAPL1 prosaposin-like 1 (gene/pseudogene) 2.64705
GOLGA6L4 golgin A6 family-like 4 2.64705
FAM43B family with sequence similarity 43, member B 2.64705
EDAR ectodysplasin A receptor 2.64705
NXPE4 neurexophilin and PC-esterase domain family, member 4 2.64705
STAR steroidogenic acute regulatory protein 2.64705
DDTL D-dopachrome tautomerase-like 2.64705
ROPN1 rhophilin associated tail protein 1 2.64705
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.64705
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 2.64705
GATA2 GATA binding protein 2 2.64705
PRDM7 PR domain containing 7 2.64705
CSAG3 CSAG family, member 3 2.64705
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 2.64705
TUBA4B tubulin, alpha 4b 2.64705
CCDC42 coiled-coil domain containing 42 2.64705
LRRN4CL LRRN4 C-terminal like 2.64705
DLK1 delta-like 1 homolog (Drosophila) 2.64705
WDR93 WD repeat domain 93 2.64705
PRB4 proline-rich protein BstNI subfamily 4 2.64705
NLRP13 NLR family, pyrin domain containing 13 2.64705
PDCD1 programmed cell death 1 2.64705
RBMXL2 RNA binding motif protein, X-linked-like 2 2.64705
TCEA3 transcription elongation factor A (SII), 3 2.64705
NOG noggin 2.64705
DYDC1 DPY30 domain containing 1 2.64705
CLDN34 claudin 34 2.64705
DKK4 dickkopf WNT signaling pathway inhibitor 4 2.64705
EFCAB9 EF-hand calcium binding domain 9 2.64705
GPR12 G protein-coupled receptor 12 2.64705
C11ORF91 chromosome 11 open reading frame 91 2.64705
PRSS3 protease, serine, 3 2.64705
IGFBP7 insulin-like growth factor binding protein 7 2.64705
CCL25 chemokine (C-C motif) ligand 25 2.64705
SPRN shadow of prion protein homolog (zebrafish) 2.64705
ONECUT3 one cut homeobox 3 2.64705
CPO carboxypeptidase O 2.64705
LRRC32 leucine rich repeat containing 32 2.64705
MORC1 MORC family CW-type zinc finger 1 2.64705
CABP7 calcium binding protein 7 2.64705
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 2.64705
PCDHGB6 protocadherin gamma subfamily B, 6 2.64705
CTNNBIP1 catenin, beta interacting protein 1 2.64705
MAU2 MAU2 sister chromatid cohesion factor 2.64705
DEFB107B defensin, beta 107B 2.64705
MKRN2 makorin ring finger protein 2 2.64705
CATIP ciliogenesis associated TTC17 interacting protein 2.64705
KLK5 kallikrein-related peptidase 5 2.64705
KLK3 kallikrein-related peptidase 3 2.64705
FSHR follicle stimulating hormone receptor 2.64705
SLCO2B1 solute carrier organic anion transporter family, member 2B1 2.64705
NT5DC4 5'-nucleotidase domain containing 4 2.64705
USP10 ubiquitin specific peptidase 10 2.64705
ADGRD1 adhesion G protein-coupled receptor D1 2.64705
NCR3 natural cytotoxicity triggering receptor 3 2.64705
NKX6-1 NK6 homeobox 1 2.64705
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 2.64705
IL1B interleukin 1, beta 2.64705
RNASE11 ribonuclease, RNase A family, 11 (non-active) 2.64705
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 2.64705
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 2.64705
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4 2.64705
PAGE4 P antigen family, member 4 (prostate associated) 2.64705
TLR10 toll-like receptor 10 2.64705
CAGE1 cancer antigen 1 2.64705
C2CD4A C2 calcium-dependent domain containing 4A 2.64705
TMEM139 transmembrane protein 139 2.64705
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.64705
LAMB4 laminin, beta 4 2.64705
FIGLA folliculogenesis specific basic helix-loop-helix 2.64705
OR51I2 olfactory receptor, family 51, subfamily I, member 2 2.64705
MAGEA12 melanoma antigen family A12 2.64705
SLC51B solute carrier family 51, beta subunit 2.64705
SDSL serine dehydratase-like 2.64705
AHSG alpha-2-HS-glycoprotein 2.64705
CLCA1 chloride channel accessory 1 2.64705
NLRP6 NLR family, pyrin domain containing 6 2.64705
FGF16 fibroblast growth factor 16 2.64705
NLRP9 NLR family, pyrin domain containing 9 2.64705
ARGFX arginine-fifty homeobox 2.64705
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.64705
SHBG sex hormone-binding globulin 2.64705
DRC1 dynein regulatory complex subunit 1 2.64705
PGM5 phosphoglucomutase 5 2.64705
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 2.64705
CASR calcium-sensing receptor 2.64705
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 2.64705
PPP1R3G protein phosphatase 1, regulatory subunit 3G 2.64705
GGN gametogenetin 2.64705
KIF12 kinesin family member 12 2.64705
RNF224 ring finger protein 224 2.64705
PRSS57 protease, serine, 57 2.64705
BATF2 basic leucine zipper transcription factor, ATF-like 2 2.64705
TBC1D28 TBC1 domain family, member 28 2.64705
CARD6 caspase recruitment domain family, member 6 2.64705
SP100 SP100 nuclear antigen 2.64705
PSORS1C2 psoriasis susceptibility 1 candidate 2 2.64705
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.64705
FADS6 fatty acid desaturase 6 2.64705
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 2.64705
POTEC POTE ankyrin domain family, member C 2.64705
AQP10 aquaporin 10 2.64705
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 2.62725
CXCL3 chemokine (C-X-C motif) ligand 3 2.61179
RBX1 ring-box 1, E3 ubiquitin protein ligase 2.51548
F10 coagulation factor X 2.51002
C17ORF114 chromosome 17 open reading frame 114 2.51002
LENG9 leukocyte receptor cluster (LRC) member 9 2.51002
RNF17 ring finger protein 17 2.48782
KIAA0586 KIAA0586 2.46534
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 2.43275
WDR18 WD repeat domain 18 2.38919
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 2.31916
GNMT glycine N-methyltransferase 2.31226
TCTN1 tectonic family member 1 2.29973
VMAC vimentin-type intermediate filament associated coiled-coil protein 2.29973
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa 2.29973
MCM4 minichromosome maintenance complex component 4 2.29973
EHD1 EH-domain containing 1 2.28997
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 2.28414
APOM apolipoprotein M 2.27809
NAE1 NEDD8 activating enzyme E1 subunit 1 2.27809
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 2.2659
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) 2.26492
FAM50B family with sequence similarity 50, member B 2.25903
MTX3 metaxin 3 2.24701
GPATCH4 G patch domain containing 4 2.21624
NOP10 NOP10 ribonucleoprotein 2.20711
AGFG1 ArfGAP with FG repeats 1 2.1942
EML5 echinoderm microtubule associated protein like 5 2.18421
NOP53 NOP53 ribosome biogenesis factor 2.18113
MTPAP mitochondrial poly(A) polymerase 2.16726
KCTD12 potassium channel tetramerization domain containing 12 2.16726
CTNNA3 catenin (cadherin-associated protein), alpha 3 2.16726
ALKBH7 alkB, alkylation repair homolog 7 (E. coli) 2.16315
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 2.14955
TMEM106B transmembrane protein 106B 2.12269
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 2.11751
ZFP36 ZFP36 ring finger protein 2.11421
IQCK IQ motif containing K 2.03264
ATRAID all-trans retinoic acid-induced differentiation factor 2.02931
GLDN gliomedin 2.02847
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 2.00547

decreased expression

Symbol Name Standardized Value
HIC1 hypermethylated in cancer 1 -2.64705
TGM2 transglutaminase 2 -2.64705
SEC31B SEC31 homolog B (S. cerevisiae) -2.64705
CD86 CD86 molecule -2.64705
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 -2.64705
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 -2.64705
TYK2 tyrosine kinase 2 -2.64705
JPH2 junctophilin 2 -2.64705
SOX7 SRY (sex determining region Y)-box 7 -2.64705
FZD1 frizzled class receptor 1 -2.64705
RHBDL2 rhomboid, veinlet-like 2 (Drosophila) -2.64705
ACTL8 actin-like 8 -2.64705
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C) -2.64705
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 -2.64705
ADAM29 ADAM metallopeptidase domain 29 -2.64705
TRAF3IP3 TRAF3 interacting protein 3 -2.64705
CPLX1 complexin 1 -2.64705
NUDT17 nudix (nucleoside diphosphate linked moiety X)-type motif 17 -2.64705
NR4A2 nuclear receptor subfamily 4, group A, member 2 -2.64705
FGF6 fibroblast growth factor 6 -2.64705
FGF8 fibroblast growth factor 8 (androgen-induced) -2.64705
SETD6 SET domain containing 6 -2.64705
KYNU kynureninase -2.64705
RHOV ras homolog family member V -2.64705
GSTM3 glutathione S-transferase mu 3 (brain) -2.64705
CD101 CD101 molecule -2.64705
PON3 paraoxonase 3 -2.64705
ZNF404 zinc finger protein 404 -2.64705
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B -2.64705
TMEM17 transmembrane protein 17 -2.64705
DTX4 deltex 4, E3 ubiquitin ligase -2.64705
ACADL acyl-CoA dehydrogenase, long chain -2.64705
EPHA3 EPH receptor A3 -2.64705
GLRB glycine receptor, beta -2.64705
CAPN3 calpain 3, (p94) -2.64705
KIFC2 kinesin family member C2 -2.64705
SLC38A3 solute carrier family 38, member 3 -2.64705
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 -2.64705
IGSF10 immunoglobulin superfamily, member 10 -2.64705
INSL3 insulin-like 3 (Leydig cell) -2.64705
PWWP3B PWWP domain containing 3B -2.64705
ERVV-2 endogenous retrovirus group V, member 2 -2.64705
MUCL3 mucin like 3 -2.64705
CCNA1 cyclin A1 -2.64705
SPATA9 spermatogenesis associated 9 -2.64705
TTC19 tetratricopeptide repeat domain 19 -2.64705
CLIC5 chloride intracellular channel 5 -2.64705
CMKLR1 chemerin chemokine-like receptor 1 -2.64705
MYO3B myosin IIIB -2.64705
NLRC3 NLR family, CARD domain containing 3 -2.64705
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 -2.64705
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2 -2.64705
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 -2.64705
NIPAL1 NIPA-like domain containing 1 -2.64705
TMED6 transmembrane emp24 protein transport domain containing 6 -2.64705
CLEC4G C-type lectin domain family 4, member G -2.64705
COMMD3 COMM domain containing 3 -2.64705
AHCYL2 adenosylhomocysteinase-like 2 -2.64705
LRRC37A leucine rich repeat containing 37A -2.64292
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 -2.61179
DCLK3 doublecortin-like kinase 3 -2.58004
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -2.56662
CPNE2 copine II -2.56416
H3C11 H3 clustered histone 11 -2.54627
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 -2.54211
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B -2.53359
PXDNL peroxidasin-like -2.44413
SMIM14 small integral membrane protein 14 -2.41861
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 -2.31226
TPCN2 two pore segment channel 2 -2.29117
CDC40 cell division cycle 40 -2.2748
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 -2.23042
ZNF396 zinc finger protein 396 -2.2253
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A -2.2253
ZBTB16 zinc finger and BTB domain containing 16 -2.2253
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 -2.2253
PCDHGA5 protocadherin gamma subfamily A, 5 -2.2253
AVEN apoptosis, caspase activation inhibitor -2.2253
C1ORF21 chromosome 1 open reading frame 21 -2.223
SPAG5 sperm associated antigen 5 -2.22215
RABGAP1L RAB GTPase activating protein 1-like -2.21381
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 -2.20995
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3 -2.20995
AMPD3 adenosine monophosphate deaminase 3 -2.20995
PAMR1 peptidase domain containing associated with muscle regeneration 1 -2.20935
SAYSD1 SAYSVFN motif domain containing 1 -2.20913
BATF3 basic leucine zipper transcription factor, ATF-like 3 -2.20585
FLT4 fms-related tyrosine kinase 4 -2.20585
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 -2.1942
RAB8A RAB8A, member RAS oncogene family -2.1942
ATP13A3 ATPase type 13A3 -2.18274
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 -2.16726
RERG RAS-like, estrogen-regulated, growth inhibitor -2.16726
CRB2 crumbs family member 2 -2.16726
DLAT dihydrolipoamide S-acetyltransferase -2.16726
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) -2.14449
GAK cyclin G associated kinase -2.1047
HIRA histone cell cycle regulator -2.1047
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D -2.04319
TTC31 tetratricopeptide repeat domain 31 -2.03146
CDC37 cell division cycle 37 -2.03146
CEP76 centrosomal protein 76kDa -2.03033
SPATS2L spermatogenesis associated, serine-rich 2-like -2.02833
AJAP1 adherens junctions associated protein 1 -2.02833
ZNF485 zinc finger protein 485 -2.02833