TWIST2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description twist family bHLH transcription factor 2|The protein encoded by this gene is a basic helix-loop-helix type transcription factor and shares similarity with Twist. This protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype during osteoblast development. This gene may be upregulated in certain cancers. Mutations in this gene cause focal facial dermal dysplasia 3, Setleis type. Two transcript variants encoding the same protein have been found. [provided by RefSeq, Apr 2014] (NCBI Entrez Gene Database, 117581)
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Genes

307 genes differentially expressed following the TWIST2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
AMBP alpha-1-microglobulin/bikunin precursor 4.28853
CD274 CD274 molecule 4.28853
COLEC10 collectin sub-family member 10 (C-type lectin) 4.28853
KLRK1 killer cell lectin-like receptor subfamily K, member 1 4.28853
CELF3 CUGBP, Elav-like family member 3 4.28853
PRICKLE4 prickle homolog 4 (Drosophila) 4.28853
BTC betacellulin 4.28853
PRSS41 protease, serine, 41 4.28853
PCDHB7 protocadherin beta 7 4.28853
TMEM244 transmembrane protein 244 4.28853
TMEM212 transmembrane protein 212 4.28853
PLVAP plasmalemma vesicle associated protein 4.28853
SYCP2 synaptonemal complex protein 2 4.28853
MAGEB1 melanoma antigen family B1 4.28853
CLDN9 claudin 9 4.28853
VIT vitrin 4.28853
TUBA3E tubulin, alpha 3e 4.28853
PCDHB13 protocadherin beta 13 4.28853
PTPRH protein tyrosine phosphatase, receptor type, H 4.28853
OR2A25 olfactory receptor, family 2, subfamily A, member 25 4.28853
ERAS ES cell expressed Ras 4.28853
FAM153A family with sequence similarity 153, member A 4.28853
OR10A2 olfactory receptor, family 10, subfamily A, member 2 4.28853
GJB5 gap junction protein, beta 5, 31.1kDa 4.28853
C1ORF141 chromosome 1 open reading frame 141 4.28853
UMODL1 uromodulin-like 1 4.28853
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 4.28853
FABP12 fatty acid binding protein 12 4.28853
SYCE3 synaptonemal complex central element protein 3 4.28853
TRPC5OS TRPC5 opposite strand 4.28853
BMP5 bone morphogenetic protein 5 4.28853
SLC39A12 solute carrier family 39 (zinc transporter), member 12 4.28853
ASGR2 asialoglycoprotein receptor 2 4.28853
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 4.28853
IGFL2 IGF-like family member 2 4.28853
UNC45B unc-45 homolog B (C. elegans) 4.28853
MUC5B mucin 5B, oligomeric mucus/gel-forming 4.28853
DSG3 desmoglein 3 4.28853
PAX5 paired box 5 4.28853
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 4.28853
PLCH2 phospholipase C, eta 2 4.28853
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 4.28853
GRIA2 glutamate receptor, ionotropic, AMPA 2 4.28853
SSTR5 somatostatin receptor 5 4.28853
PECAM1 platelet/endothelial cell adhesion molecule 1 4.28853
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 4.28853
LOC128125816 uncharacterized LOC128125816 4.28853
H1-6 H1.6 linker histone, cluster member 4.28853
SPI1 Spi-1 proto-oncogene 4.28853
DNAAF1 dynein, axonemal, assembly factor 1 4.28853
PKD2L1 polycystic kidney disease 2-like 1 4.28853
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 4.28853
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 4.28853
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 4.28853
PROX2 prospero homeobox 2 4.28853
SMPX small muscle protein, X-linked 4.28853
H3-5 H3.5 histone 4.28853
FAM237B family with sequence similarity 237 member B 4.28853
TBXT T-box transcription factor T 4.28853
ZC3H11C zinc finger CCCH-type containing 11C 4.28853
PRR20G proline rich 20G 4.28853
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 4.28853
H3-7 H3.7 histone (putative) 4.28853
UBE2L5 ubiquitin conjugating enzyme E2 L5 4.28853
VXN vexin 4.28853
RTL5 retrotransposon Gag like 5 4.28853
RTL9 retrotransposon Gag like 9 4.28853
ANKRD40CL ANKRD40 C-terminal like 4.28853
LY6K lymphocyte antigen 6 complex, locus K 4.28853
TBX10 T-box 10 4.28853
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 4.28853
CCR3 chemokine (C-C motif) receptor 3 4.28853
AMY2A amylase, alpha 2A (pancreatic) 4.28853
KLRF2 killer cell lectin-like receptor subfamily F, member 2 4.28853
SLAMF1 signaling lymphocytic activation molecule family member 1 4.28853
MIP major intrinsic protein of lens fiber 4.28853
IL6 interleukin 6 4.28853
SIM2 single-minded family bHLH transcription factor 2 4.28853
TMEM235 transmembrane protein 235 4.28853
C7ORF57 chromosome 7 open reading frame 57 4.28853
C7 complement component 7 4.28853
BLNK B-cell linker 4.28853
ZNF705D zinc finger protein 705D 4.28853
GATA3 GATA binding protein 3 4.28853
GATA2 GATA binding protein 2 4.28853
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) 4.28853
MOV10L1 Mov10 RISC complex RNA helicase like 1 4.28853
LRRC72 leucine rich repeat containing 72 4.28853
HAL histidine ammonia-lyase 4.28853
FGFBP1 fibroblast growth factor binding protein 1 4.28853
ARHGAP15 Rho GTPase activating protein 15 4.28853
UROC1 urocanate hydratase 1 4.28853
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 4.28853
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 4.28853
CTAGE9 CTAGE family, member 9 4.28853
SCML4 sex comb on midleg-like 4 (Drosophila) 4.28853
RNASE12 ribonuclease, RNase A family, 12 (non-active) 4.28853
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 4.28853
WFDC9 WAP four-disulfide core domain 9 4.28853
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 4.28853
NPBWR1 neuropeptides B/W receptor 1 4.28853
RANBP3L RAN binding protein 3-like 4.28853
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 4.28853
FATE1 fetal and adult testis expressed 1 4.28853
KCNK4 potassium channel, two pore domain subfamily K, member 4 4.28853
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 4.28853
DBX2 developing brain homeobox 2 4.28853
OR13A1 olfactory receptor, family 13, subfamily A, member 1 4.28853
SPATA32 spermatogenesis associated 32 4.28853
TBPL2 TATA box binding protein like 2 4.28853
ALAS2 5'-aminolevulinate synthase 2 4.28853
PCDHGB5 protocadherin gamma subfamily B, 5 4.28853
PCDHGB1 protocadherin gamma subfamily B, 1 4.28853
CCL27 chemokine (C-C motif) ligand 27 4.28853
FOXE3 forkhead box E3 4.28853
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 4.28853
NKX6-2 NK6 homeobox 2 4.28853
CFB complement factor B 4.28853
GPR142 G protein-coupled receptor 142 4.28853
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 4.28853
PCDHAC2 protocadherin alpha subfamily C, 2 4.28853
IL25 interleukin 25 4.28853
FKBP1C FK506 binding protein 1C 4.28853
DRC1 dynein regulatory complex subunit 1 4.28853
GCNT7 glucosaminyl (N-acetyl) transferase family member 7 4.28853
LGALS12 lectin, galactoside-binding, soluble, 12 4.28853
LYPD5 LY6/PLAUR domain containing 5 4.28853
IL19 interleukin 19 4.28853
FSHR follicle stimulating hormone receptor 4.28853
SIGLEC15 sialic acid binding Ig-like lectin 15 4.28853
CDH17 cadherin 17, LI cadherin (liver-intestine) 4.28853
RETN resistin 4.28853
IP6K3 inositol hexakisphosphate kinase 3 4.28853
GPR65 G protein-coupled receptor 65 4.28853
CTSS cathepsin S 4.28853
SLC38A3 solute carrier family 38, member 3 4.28853
FOXS1 forkhead box S1 4.28853
LVRN laeverin 4.28853
IL10RA interleukin 10 receptor, alpha 4.28853
LRRC38 leucine rich repeat containing 38 4.28853
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 4.28853
PITX2 paired-like homeodomain 2 4.28853
AMPD1 adenosine monophosphate deaminase 1 4.28853
IRX1 iroquois homeobox 1 4.28853
RAB7B RAB7B, member RAS oncogene family 4.28853
TEX38 testis expressed 38 4.28853
ANGPTL3 angiopoietin-like 3 4.28853
TGM4 transglutaminase 4 4.28853
PADI3 peptidyl arginine deiminase, type III 4.28853
NR2F1 nuclear receptor subfamily 2, group F, member 1 4.28853
ZPLD1 zona pellucida-like domain containing 1 4.28853
SLC51B solute carrier family 51, beta subunit 4.28853
FAM9C family with sequence similarity 9, member C 4.28853
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 4.28853
PRDM1 PR domain containing 1, with ZNF domain 4.28853
GCSAML germinal center-associated, signaling and motility-like 4.28853
CCDC83 coiled-coil domain containing 83 4.28853
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 4.28853
NLRP7 NLR family, pyrin domain containing 7 4.26453
FCRL5 Fc receptor-like 5 4.26453
PANO1 proapoptotic nucleolar protein 1 4.26453
C7ORF25 chromosome 7 open reading frame 25 4.10189
DPYSL4 dihydropyrimidinase-like 4 3.88418
TNNC1 troponin C type 1 (slow) 3.79041
ZKSCAN8 zinc finger with KRAB and SCAN domains 8 3.49516
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 3.44676
LOC122526780 uncharacterized LOC122526780 3.24219
SPACA9 sperm acrosome associated 9 3.24219
GLRA3 glycine receptor, alpha 3 3.24219
DND1 DND microRNA-mediated repression inhibitor 1 3.24219
DYDC1 DPY30 domain containing 1 3.24219
CA7 carbonic anhydrase VII 3.24219
LUC7L2 LUC7-like 2 (S. cerevisiae) 3.20181
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 3.11045
UTP11 UTP11 small subunit processome component 3.05213
CST3 cystatin C 3.04417
AARS2 alanyl-tRNA synthetase 2, mitochondrial 3.02965
CABLES1 Cdk5 and Abl enzyme substrate 1 2.95916
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 2.92214
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 2.89835
APC adenomatous polyposis coli 2.86771
RUMY3 RUMY family member 3 2.85592
LAPTM4B lysosomal protein transmembrane 4 beta 2.81444
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 2.81267
REEP5 receptor accessory protein 5 2.8078
GNG11 guanine nucleotide binding protein (G protein), gamma 11 2.80561
FOXO3 forkhead box O3 2.80561
BCO2 beta-carotene oxygenase 2 2.7165
FARSB phenylalanyl-tRNA synthetase, beta subunit 2.69044
MBLAC2 metallo-beta-lactamase domain containing 2 2.60472
EXOSC3 exosome component 3 2.5107
DUSP23 dual specificity phosphatase 23 2.42176
RALGDS ral guanine nucleotide dissociation stimulator 2.39309
EQTN equatorin, sperm acrosome associated 2.35754
ELAVL2 ELAV like neuron-specific RNA binding protein 2 2.34466
CELF5 CUGBP, Elav-like family member 5 2.32722
NPIPB7 nuclear pore complex interacting protein family, member B7 2.31556
ROM1 retinal outer segment membrane protein 1 2.31556
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 2.25462
FER1L6 fer-1-like family member 6 2.23246
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 2.23073
GPSM2 G-protein signaling modulator 2 2.2244
ZNF414 zinc finger protein 414 2.20254
JPT1 Jupiter microtubule associated homolog 1 2.17739
GHRL ghrelin/obestatin prepropeptide 2.13312
DDX55 DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 2.12658
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 2.08372
SPATA20 spermatogenesis associated 20 2.05562
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 2.04876
MCTP2 multiple C2 domains, transmembrane 2 2.03694
ANXA2 annexin A2 2.03081
ATP5F1E ATP synthase F1 subunit epsilon 2.0299
CCDC112 coiled-coil domain containing 112 2.02648
ACSF3 acyl-CoA synthetase family member 3 2.02607
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 2.00606
CFAP298 cilia and flagella associated protein 298 2.00606
KLHL25 kelch-like family member 25 2.00125

decreased expression

Symbol Name Standardized Value
BIRC3 baculoviral IAP repeat containing 3 -4.28853
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) -4.28853
ZC3H11A zinc finger CCCH-type containing 11A -4.28853
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 -4.28853
PRSS50 protease, serine, 50 -4.28853
CARD6 caspase recruitment domain family, member 6 -4.28853
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial -4.28853
TMPRSS15 transmembrane protease, serine 15 -4.28853
MAGEA4 melanoma antigen family A4 -4.28853
SOX30 SRY (sex determining region Y)-box 30 -4.28853
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) -4.28853
FXYD2 FXYD domain containing ion transport regulator 2 -4.28853
RBP2 retinol binding protein 2, cellular -4.28853
FIBCD1 fibrinogen C domain containing 1 -4.28853
CCNB3 cyclin B3 -4.28853
OXT oxytocin/neurophysin I prepropeptide -4.28853
NPIPA8 nuclear pore complex interacting protein family, member A8 -4.28853
CD300A CD300a molecule -4.28853
PIH1D2 PIH1 domain containing 2 -4.28853
INSM1 insulinoma-associated 1 -4.28853
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 -4.28853
ITGA10 integrin, alpha 10 -4.28853
DUSP29 dual specificity phosphatase 29 -4.28853
COL17A1 collagen, type XVII, alpha 1 -4.28853
SQOR sulfide quinone oxidoreductase -4.28853
FAM131C family with sequence similarity 131, member C -4.28853
ALX1 ALX homeobox 1 -4.28853
GLRB glycine receptor, beta -4.28853
ISM2 isthmin 2 -4.28853
NKX3-1 NK3 homeobox 1 -4.28853
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 -4.28853
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 -4.21855
SSPN sarcospan -4.21855
MSH4 mutS homolog 4 -4.21855
PARP8 poly (ADP-ribose) polymerase family, member 8 -3.46274
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) -3.45578
AOX1 aldehyde oxidase 1 -3.34445
SLC45A1 solute carrier family 45, member 1 -3.3342
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 -3.14299
CCDC158 coiled-coil domain containing 158 -3.14299
SMIM10 small integral membrane protein 10 -3.14299
C17ORF107 chromosome 17 open reading frame 107 -3.14299
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -3.12875
SAMD8 sterile alpha motif domain containing 8 -2.96936
SLC44A5 solute carrier family 44, member 5 -2.95143
TRIL TLR4 interactor with leucine-rich repeats -2.88168
METTL2A methyltransferase like 2A -2.85282
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) -2.84519
PIGM phosphatidylinositol glycan anchor biosynthesis, class M -2.79017
PDLIM1 PDZ and LIM domain 1 -2.69351
BMP7 bone morphogenetic protein 7 -2.68729
FAM131B family with sequence similarity 131, member B -2.60923
ZNF865 zinc finger protein 865 -2.58004
LARS1 leucyl-tRNA synthetase 1 -2.57982
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -2.55855
GVQW3 GVQW motif containing 3 -2.49976
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -2.42319
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 -2.41274
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 -2.33311
C1QTNF12 C1q and TNF related 12 -2.29748
CLEC2L C-type lectin domain family 2, member L -2.29417
MOCS3 molybdenum cofactor synthesis 3 -2.28101
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -2.281
TRAPPC6B trafficking protein particle complex 6B -2.24116
MRAP melanocortin 2 receptor accessory protein -2.23708
FSCN3 fascin actin-bundling protein 3, testicular -2.23708
B9D1 B9 protein domain 1 -2.2244
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 -2.20401
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -2.20254
FAM222A family with sequence similarity 222, member A -2.20254
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -2.20254
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C -2.19961
SASS6 spindle assembly 6 homolog (C. elegans) -2.19365
CPS1 carbamoyl-phosphate synthase 1, mitochondrial -2.19182
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 -2.19182
C16ORF86 chromosome 16 open reading frame 86 -2.19018
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon -2.18421
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) -2.17093
XKR7 XK, Kell blood group complex subunit-related family, member 7 -2.16795
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) -2.16077
NUDT14 nudix (nucleoside diphosphate linked moiety X)-type motif 14 -2.12268
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -2.10574
MTFMT mitochondrial methionyl-tRNA formyltransferase -2.10295
TASOR transcription activation suppressor -2.09554
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -2.09554
SYT1 synaptotagmin I -2.07048
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -2.04876
GCSH glycine cleavage system protein H (aminomethyl carrier) -2.03472
TSPAN11 tetraspanin 11 -2.00606
CCNL1 cyclin L1 -2.00606