TYK2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description tyrosine kinase 2|This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7297)
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Genes

310 genes differentially expressed following the TYK2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.97006
CD27 CD27 molecule 2.97006
CD1D CD1d molecule 2.97006
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 2.97006
TMEM156 transmembrane protein 156 2.97006
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 2.97006
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.97006
LRRC63 leucine rich repeat containing 63 2.97006
F5 coagulation factor V (proaccelerin, labile factor) 2.97006
PCDHGA4 protocadherin gamma subfamily A, 4 2.97006
EVPLL envoplakin-like 2.97006
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.97006
NXPE1 neurexophilin and PC-esterase domain family, member 1 2.97006
MAGEB17 melanoma antigen family B17 2.97006
CCDC9B coiled-coil domain containing 9B 2.97006
NEUROD4 neuronal differentiation 4 2.97006
GIPC3 GIPC PDZ domain containing family, member 3 2.97006
ASXL3 additional sex combs like transcriptional regulator 3 2.97006
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.97006
AADACL4 arylacetamide deacetylase-like 4 2.89744
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.89744
MAP3K7CL MAP3K7 C-terminal like 2.89744
LIPN lipase, family member N 2.89744
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 2.89744
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.89744
PNMA5 paraneoplastic Ma antigen family member 5 2.89744
ASPDH aspartate dehydrogenase domain containing 2.89744
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.89744
TSGA13 testis specific, 13 2.89744
DUXB double homeobox B 2.89744
SLC46A2 solute carrier family 46, member 2 2.89744
TEX13B testis expressed 13B 2.89744
CD19 CD19 molecule 2.89744
KLHL30 kelch-like family member 30 2.89744
PDYN prodynorphin 2.89744
ADAM33 ADAM metallopeptidase domain 33 2.89744
SLC9C2 solute carrier family 9, member C2 (putative) 2.89744
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 2.89744
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1 2.89744
HIC1 hypermethylated in cancer 1 2.89744
TDO2 tryptophan 2,3-dioxygenase 2.89744
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 2.89744
TPRX1 tetra-peptide repeat homeobox 1 2.89744
TWIST1 twist family bHLH transcription factor 1 2.89744
OR5A2 olfactory receptor, family 5, subfamily A, member 2 2.89744
HMX1 H6 family homeobox 1 2.89744
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.89744
SLC39A12 solute carrier family 39 (zinc transporter), member 12 2.89744
KIAA2012 KIAA2012 2.89744
RLN1 relaxin 1 2.89744
NEUROG3 neurogenin 3 2.89744
TCP11 t-complex 11, testis-specific 2.89744
PTK6 protein tyrosine kinase 6 2.89744
BFSP2 beaded filament structural protein 2, phakinin 2.89744
ATOH1 atonal homolog 1 (Drosophila) 2.89744
TRPC5OS TRPC5 opposite strand 2.89744
ABRA actin binding Rho activating protein 2.89744
TEKTL1 tektin like 1 2.89744
TCERG1L transcription elongation regulator 1-like 2.89744
ELOVL3 ELOVL fatty acid elongase 3 2.89744
STX11 syntaxin 11 2.89744
MYEOV myeloma overexpressed 2.89744
TTR transthyretin 2.89744
FCMR Fc fragment of IgM receptor 2.89744
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 2.89744
LY6H lymphocyte antigen 6 complex, locus H 2.89744
HNF1B HNF1 homeobox B 2.89744
SPEM1 spermatid maturation 1 2.89744
HTRA4 HtrA serine peptidase 4 2.89744
MYH1 myosin, heavy chain 1, skeletal muscle, adult 2.89744
EXOC1L exocyst complex component 1 like 2.89744
H3-7 H3.7 histone (putative) 2.89744
CFAP97D1 CFAP97 domain containing 1 2.89744
RNF227 ring finger protein 227 2.89744
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.89744
H3-5 H3.5 histone 2.89744
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 2.89744
SFTPA2 surfactant protein A2 2.89744
ARX aristaless related homeobox 2.89744
DLK1 delta-like 1 homolog (Drosophila) 2.89744
PRG4 proteoglycan 4 2.89744
ASIC3 acid sensing (proton gated) ion channel 3 2.89744
CD79A CD79a molecule, immunoglobulin-associated alpha 2.89744
IL31RA interleukin 31 receptor A 2.89744
IRF7 interferon regulatory factor 7 2.89744
ARL5C ADP-ribosylation factor-like 5C 2.89744
KLHL38 kelch-like family member 38 2.89744
AVPR1B arginine vasopressin receptor 1B 2.89744
SLC35D3 solute carrier family 35, member D3 2.89744
RS1 retinoschisin 1 2.89744
FABP9 fatty acid binding protein 9, testis 2.89744
ULBP3 UL16 binding protein 3 2.89744
SCRT1 scratch family zinc finger 1 2.89744
DNASE2B deoxyribonuclease II beta 2.89744
GPR83 G protein-coupled receptor 83 2.89744
PLEK2 pleckstrin 2 2.89744
VCX3A variable charge, X-linked 3A 2.89744
CCR3 chemokine (C-C motif) receptor 3 2.89744
PIWIL3 piwi-like RNA-mediated gene silencing 3 2.89744
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.89744
KLRF2 killer cell lectin-like receptor subfamily F, member 2 2.89744
ADGRG1 adhesion G protein-coupled receptor G1 2.89744
TLR1 toll-like receptor 1 2.89744
SOX1 SRY (sex determining region Y)-box 1 2.89744
PRR15L proline rich 15-like 2.89744
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 2.89744
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 2.89744
CYSLTR1 cysteinyl leukotriene receptor 1 2.89744
OAZ3 ornithine decarboxylase antizyme 3 2.89744
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 2.89744
CDH10 cadherin 10, type 2 (T2-cadherin) 2.89744
EMP1 epithelial membrane protein 1 2.89744
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 2.89744
EBLN1 endogenous Bornavirus-like nucleoprotein 1 2.89744
MOS v-mos Moloney murine sarcoma viral oncogene homolog 2.89744
ARHGAP20 Rho GTPase activating protein 20 2.89744
TRIM29 tripartite motif containing 29 2.89744
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.89744
WNT2B wingless-type MMTV integration site family, member 2B 2.89744
PLA2G4E phospholipase A2, group IVE 2.89744
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 2.89744
FOXP2 forkhead box P2 2.89744
PCDHGB2 protocadherin gamma subfamily B, 2 2.89744
LRCOL1 leucine rich colipase-like 1 2.89744
IFITM5 interferon induced transmembrane protein 5 2.89744
RGCC regulator of cell cycle 2.89744
KLHL15 kelch-like family member 15 2.89744
CPN2 carboxypeptidase N, polypeptide 2 2.89744
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.89744
PLA2G5 phospholipase A2, group V 2.89744
SFTA2 surfactant associated 2 2.89744
SYT3 synaptotagmin III 2.89744
VMO1 vitelline membrane outer layer 1 homolog (chicken) 2.89744
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.89744
ORM2 orosomucoid 2 2.89744
BCL2L15 BCL2-like 15 2.89744
TAGAP T-cell activation RhoGTPase activating protein 2.89744
KLK6 kallikrein-related peptidase 6 2.89744
TBX1 T-box 1 2.89744
UTS2B urotensin 2B 2.89744
CALR3 calreticulin 3 2.89744
CFAP61 cilia and flagella associated protein 61 2.89744
ANKRD55 ankyrin repeat domain 55 2.89744
CLEC9A C-type lectin domain family 9, member A 2.89744
VAV1 vav 1 guanine nucleotide exchange factor 2.89744
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.89744
IRX5 iroquois homeobox 5 2.89744
MT1G metallothionein 1G 2.89744
GRAP2 GRB2-related adaptor protein 2 2.89744
MMP1 matrix metallopeptidase 1 2.89744
CD80 CD80 molecule 2.89744
PTCRA pre T-cell antigen receptor alpha 2.89744
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 2.89744
NXF3 nuclear RNA export factor 3 2.89744
ANGPTL6 angiopoietin-like 6 2.89744
NPC1L1 NPC1-like 1 2.89744
KCNK15 potassium channel, two pore domain subfamily K, member 15 2.89744
BANF2 barrier to autointegration factor 2 2.89744
AOC1 amine oxidase, copper containing 1 2.89744
ASCL2 achaete-scute family bHLH transcription factor 2 2.89744
ASCL1 achaete-scute family bHLH transcription factor 1 2.89744
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 2.89744
DCSTAMP dendrocyte expressed seven transmembrane protein 2.89744
SLC7A4 solute carrier family 7, member 4 2.89744
DCAF8L2 DDB1 and CUL4 associated factor 8-like 2 2.89744
CARD9 caspase recruitment domain family, member 9 2.89744
POTEI POTE ankyrin domain family, member I 2.89744
ZMYND15 zinc finger, MYND-type containing 15 2.776
PHOX2A paired-like homeobox 2a 2.776
CD200R1 CD200 receptor 1 2.776
APOA1 apolipoprotein A-I 2.776
EHD2 EH-domain containing 2 2.75146
SSRP1 structure specific recognition protein 1 2.72889
SLCO5A1 solute carrier organic anion transporter family, member 5A1 2.67009
ZFP30 ZFP30 zinc finger protein 2.66824
DOCK2 dedicator of cytokinesis 2 2.66676
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 2.64285
SLC14A2 solute carrier family 14 (urea transporter), member 2 2.58052
TMEM256 transmembrane protein 256 2.56996
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 2.56374
SDHAF3 succinate dehydrogenase complex assembly factor 3 2.55065
TMEM240 transmembrane protein 240 2.53053
PDGFA platelet-derived growth factor alpha polypeptide 2.52199
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 2.47075
CCDC59 coiled-coil domain containing 59 2.4252
OGFRL1 opioid growth factor receptor-like 1 2.39097
GOLPH3 golgi phosphoprotein 3 (coat-protein) 2.38215
GADD45A growth arrest and DNA-damage-inducible, alpha 2.37096
RTN4IP1 reticulon 4 interacting protein 1 2.32901
SIT1 signaling threshold regulating transmembrane adaptor 1 2.32901
SLC45A4 solute carrier family 45, member 4 2.32321
KDM5A lysine (K)-specific demethylase 5A 2.30199
NT5C1B 5'-nucleotidase, cytosolic IB 2.29467
BTNL2 butyrophilin-like 2 2.28829
FITM2 fat storage-inducing transmembrane protein 2 2.274
DESI2 desumoylating isopeptidase 2 2.26927
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 2.22753
SYT4 synaptotagmin IV 2.22304
IRF3 interferon regulatory factor 3 2.21286
SLC39A6 solute carrier family 39 (zinc transporter), member 6 2.20009
EPHA7 EPH receptor A7 2.19973
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 2.19934
PXN paxillin 2.19737
ACVR1 activin A receptor, type I 2.18444
PHETA2 PH domain containing endocytic trafficking adaptor 2 2.17307
ZNF587B zinc finger protein 587B 2.16745
MT2A metallothionein 2A 2.164
PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1 2.14489
FABP5 fatty acid binding protein 5 (psoriasis-associated) 2.0959
TRIB2 tribbles pseudokinase 2 2.07612
SH3PXD2B SH3 and PX domains 2B 2.07162
POLR3H polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) 2.0649
SPDYE16 speedy/RINGO cell cycle regulator family member E16 2.0645
TP63 tumor protein p63 2.05132
TUSC3 tumor suppressor candidate 3 2.04088
WTAP Wilms tumor 1 associated protein 2.03848
ZDHHC11B zinc finger, DHHC-type containing 11B 2.03391
SGTB small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta 2.03361
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 2.03361
CSNK1E casein kinase 1, epsilon 2.03219
ZNF438 zinc finger protein 438 2.02039
SUMO3 small ubiquitin-like modifier 3 2.01233
MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B 2.00912
USP38 ubiquitin specific peptidase 38 2.00808
EXOSC9 exosome component 9 2.0058

decreased expression

Symbol Name Standardized Value
TAS2R31 taste receptor, type 2, member 31 -2.97006
TSNAXIP1 translin-associated factor X interacting protein 1 -2.97006
GALR1 galanin receptor 1 -2.97006
ADAP1 ArfGAP with dual PH domains 1 -2.97006
PLN phospholamban -2.97006
TBKBP1 TBK1 binding protein 1 -2.97006
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 -2.97006
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -2.97006
USP26 ubiquitin specific peptidase 26 -2.89744
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 -2.89744
CHRND cholinergic receptor, nicotinic, delta (muscle) -2.89744
RSAD2 radical S-adenosyl methionine domain containing 2 -2.89744
UNC13C unc-13 homolog C (C. elegans) -2.89744
CRYGN crystallin, gamma N -2.89744
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -2.89744
NWD1 NACHT and WD repeat domain containing 1 -2.89744
ROM1 retinal outer segment membrane protein 1 -2.89744
CCDC178 coiled-coil domain containing 178 -2.89744
GRM6 glutamate receptor, metabotropic 6 -2.89744
DNAAF11 dynein axonemal assembly factor 11 -2.89744
CCN1 cellular communication network factor 1 -2.89744
GPR146 G protein-coupled receptor 146 -2.89744
PKD2L1 polycystic kidney disease 2-like 1 -2.89744
TBC1D3L TBC1 domain family, member 3L -2.89744
PCP4L1 Purkinje cell protein 4 like 1 -2.89744
GPR12 G protein-coupled receptor 12 -2.89744
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 -2.89744
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 -2.89744
PCDHA11 protocadherin alpha 11 -2.89744
SFRP5 secreted frizzled-related protein 5 -2.89744
CLEC4G C-type lectin domain family 4, member G -2.89744
ZAR1L zygote arrest 1-like -2.89744
SNX4 sorting nexin 4 -2.84714
CCDC127 coiled-coil domain containing 127 -2.84714
CALD1 caldesmon 1 -2.82746
FMO4 flavin containing monooxygenase 4 -2.75388
RNF44 ring finger protein 44 -2.71716
SAMD12 sterile alpha motif domain containing 12 -2.66676
CNTN3 contactin 3 (plasmacytoma associated) -2.63725
TRIM36 tripartite motif containing 36 -2.61686
KLHDC8A kelch domain containing 8A -2.57694
ZNF845 zinc finger protein 845 -2.56851
CLSTN3 calsyntenin 3 -2.5621
EXOC2 exocyst complex component 2 -2.5579
PDGFRL platelet-derived growth factor receptor-like -2.53802
KMT2A lysine (K)-specific methyltransferase 2A -2.5257
EPS8 epidermal growth factor receptor pathway substrate 8 -2.52199
KIFC3 kinesin family member C3 -2.46121
GVQW3 GVQW motif containing 3 -2.43785
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 -2.41302
PAQR4 progestin and adipoQ receptor family member IV -2.41302
CORIN corin, serine peptidase -2.36197
NCOA1 nuclear receptor coactivator 1 -2.33544
SWSAP1 SWIM-type zinc finger 7 associated protein 1 -2.3121
TFEB transcription factor EB -2.29926
BAIAP3 BAI1-associated protein 3 -2.29926
PPP1R8 protein phosphatase 1, regulatory subunit 8 -2.26561
STBD1 starch binding domain 1 -2.22466
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 -2.20758
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 -2.17103
ZNF404 zinc finger protein 404 -2.17103
TTLL12 tubulin tyrosine ligase-like family member 12 -2.16634
TMEM147 transmembrane protein 147 -2.15771
TMEM74 transmembrane protein 74 -2.14153
MOV10 Mov10 RISC complex RNA helicase -2.12554
MTERF4 mitochondrial transcription termination factor 4 -2.1139
SNAP25 synaptosomal-associated protein, 25kDa -2.11313
FBXO31 F-box protein 31 -2.0925
ZNF627 zinc finger protein 627 -2.09114
KIAA2026 KIAA2026 -2.09037
ZNF628 zinc finger protein 628 -2.07612
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 -2.04477
STAMBPL1 STAM binding protein-like 1 -2.04244
CDC27 cell division cycle 27 -2.03848
GAS2L1 growth arrest-specific 2 like 1 -2.03361
ZNF410 zinc finger protein 410 -2.03361
C17ORF49 chromosome 17 open reading frame 49 -2.03361
ADORA2B adenosine A2b receptor -2.03361
TP53TG5 TP53 target 5 -2.03361
MMP28 matrix metallopeptidase 28 -2.03248
MYO15A myosin XVA -2.03248
GLIS1 GLIS family zinc finger 1 -2.03248
TMEM121B transmembrane protein 121B -2.03248
FZD3 frizzled class receptor 3 -2.02039
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -2.01233