TYK2 Gene Set

Dataset Kinase Library Tyrosine Kinome Atlas
Category proteomics
Type kinase
Description tyrosine kinase 2|This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7297)
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100 substrates of the kinase TYK2 from the Kinase Library Tyrosine Kinome Atlas dataset.

Symbol Name Standardized Value
PLPPR4 phospholipid phosphatase related 4 100.0
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 99.98
EIF3I eukaryotic translation initiation factor 3, subunit I 99.96
THRB thyroid hormone receptor, beta 99.89
MIS18BP1 MIS18 binding protein 1 99.87
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa 99.85
PM20D2 peptidase M20 domain containing 2 99.82
EIF1 eukaryotic translation initiation factor 1 99.8
EIF1B eukaryotic translation initiation factor 1B 99.8
RASGRP4 RAS guanyl releasing protein 4 99.69
USP31 ubiquitin specific peptidase 31 99.65
ESYT2 extended synaptotagmin-like protein 2 99.45
EML4 echinoderm microtubule associated protein like 4 99.43
SNAP23 synaptosomal-associated protein, 23kDa 99.23
WWP2 WW domain containing E3 ubiquitin protein ligase 2 99.21
SEC14L1 SEC14-like 1 (S. cerevisiae) 99.19
TIGIT T cell immunoreceptor with Ig and ITIM domains 99.12
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A 99.12
NOX5 NADPH oxidase, EF-hand calcium binding domain 5 99.045
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 99.04
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 98.88
FCHO1 FCH domain only 1 98.8
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 98.75
TFRC transferrin receptor 98.73
PTPN7 protein tyrosine phosphatase, non-receptor type 7 98.71
MKNK1 MAP kinase interacting serine/threonine kinase 1 98.69
SEC14L2 SEC14-like 2 (S. cerevisiae) 98.47
SEC14L3 SEC14-like 3 (S. cerevisiae) 98.47
FKBP10 FK506 binding protein 10, 65 kDa 98.42
MAK male germ cell-associated kinase 98.4
ITSN1 intersectin 1 (SH3 domain protein) 98.36
SHROOM1 shroom family member 1 98.27
CUEDC2 CUE domain containing 2 98.18
MPL MPL proto-oncogene, thrombopoietin receptor 98.09
LHX3 LIM homeobox 3 98.09
CRYZ crystallin, zeta (quinone reductase) 98.09
TRPC6 transient receptor potential cation channel, subfamily C, member 6 98.01
MOK MOK protein kinase 97.99
SNRPA1 small nuclear ribonucleoprotein polypeptide A' 97.94
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 97.77
CHAF1B chromatin assembly factor 1, subunit B (p60) 97.72
EARS2 glutamyl-tRNA synthetase 2, mitochondrial 97.66
GRAMD4 GRAM domain containing 4 97.64
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 97.57
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 97.53
PRUNE2 prune homolog 2 (Drosophila) 97.5
N4BP3 NEDD4 binding protein 3 97.39
WDR62 WD repeat domain 62 97.37
BAG4 BCL2-associated athanogene 4 97.24
CKS1B CDC28 protein kinase regulatory subunit 1B 97.16
CYB5R1 cytochrome b5 reductase 1 97.11
C8A complement component 8, alpha polypeptide 96.94
LRP11 low density lipoprotein receptor-related protein 11 96.94
SH2D3C SH2 domain containing 3C 96.81
CD300LB CD300 molecule-like family member b 96.8
SMC4 structural maintenance of chromosomes 4 96.74
IRS4 insulin receptor substrate 4 96.655
PHB2 prohibitin 2 96.59
AURKA aurora kinase A 96.58
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 96.56
PTPRE protein tyrosine phosphatase, receptor type, E 96.45
PTPRA protein tyrosine phosphatase, receptor type, A 96.43
HSPB1 heat shock 27kDa protein 1 96.39
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 96.37
MAPK1 mitogen-activated protein kinase 1 96.35
CBARP CACN subunit beta associated regulatory protein 96.28
PPP1R18 protein phosphatase 1, regulatory subunit 18 96.24
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 96.21
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 96.21
MOV10 Mov10 RISC complex RNA helicase 96.19
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 96.04
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 95.93
CCT8 chaperonin containing TCP1, subunit 8 (theta) 95.86
SPATS2L spermatogenesis associated, serine-rich 2-like 95.82
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 95.78
AAK1 AP2 associated kinase 1 95.77
RASA3 RAS p21 protein activator 3 95.73
NKX3-1 NK3 homeobox 1 95.67
EIF5A eukaryotic translation initiation factor 5A 95.64
STAT1 signal transducer and activator of transcription 1, 91kDa 95.62
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 95.6
DENND1A DENN/MADD domain containing 1A 95.58
HYAL2 hyaluronoglucosaminidase 2 95.58
TTC4 tetratricopeptide repeat domain 4 95.53
IL10RA interleukin 10 receptor, alpha 95.51
KLHDC3 kelch domain containing 3 95.51
FBXO11 F-box protein 11 95.49
ERCC6L excision repair cross-complementation group 6-like 95.46
IRS1 insulin receptor substrate 1 95.45
RHOG ras homolog family member G 95.43
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 95.42
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 95.4
ZNF579 zinc finger protein 579 95.23
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 95.175
PVRIG poliovirus receptor related immunoglobulin domain containing 95.1
THADA thyroid adenoma associated 95.08
GSK3A glycogen synthase kinase 3 alpha 95.07
CMKLR1 chemerin chemokine-like receptor 1 95.03
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 95.03
EGR1 early growth response 1 94.99