TYK2 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description tyrosine kinase 2|This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7297)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_TYK2
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Genes

33 co-expressed genes for TYK2 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADPGK ADP-dependent glucokinase
ARHGAP4 Rho GTPase activating protein 4
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2
C17ORF62 chromosome 17 open reading frame 62
CDV3 CDV3 homolog (mouse)
CHD1 chromodomain helicase DNA binding protein 1
CORO1A coronin, actin binding protein, 1A
CORO7 coronin 7
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DOCK2 dedicator of cytokinesis 2
EIF1 eukaryotic translation initiation factor 1
ELF4 E74-like factor 4 (ets domain transcription factor)
FAM120A family with sequence similarity 120A
GDI2 GDP dissociation inhibitor 2
GRK6 G protein-coupled receptor kinase 6
HCLS1 hematopoietic cell-specific Lyn substrate 1
HEATR3 HEAT repeat containing 3
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MANBA mannosidase, beta A, lysosomal
MOB1A MOB kinase activator 1A
NCKAP1L NCK-associated protein 1-like
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PAPOLA poly(A) polymerase alpha
PHF21A PHD finger protein 21A
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TYK2 tyrosine kinase 2
USP3 ubiquitin specific peptidase 3