| Dataset | PhosphoSitePlus Substrates of Kinases |
| Category | physical interactions |
| Type | kinase |
| Description | tyrosine kinase 2|This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7297) |
| External Link | http://www.ncbi.nlm.nih.gov/gene/7297 |
| Similar Terms | |
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6 substrates of the kinase TYK2 from the curated PhosphoSitePlus Substrates of Kinases dataset.
