TYK2 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description tyrosine kinase 2|This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7297)
External Link http://www.ncbi.nlm.nih.gov/gene/7297
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6 substrates of the kinase TYK2 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IL13RA1 interleukin 13 receptor, alpha 1
KLF10 Kruppel-like factor 10
SIVA1 SIVA1, apoptosis-inducing factor
TYK2 tyrosine kinase 2