TYKNU Gene Set

Dataset Achilles Cell Line Gene Essentiality Profiles
Category disease or phenotype associations
Type cell line
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Genes

473 gene knockdowns changing fitness of TYKNU relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.

increased fitness

Symbol Name Standardized Value
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 3.19303
NMRAL1 NmrA-like family domain containing 1 3.18457
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 3.18385
ZBTB22 zinc finger and BTB domain containing 22 3.1494
MUC7 mucin 7, secreted 2.98848
RNF25 ring finger protein 25 2.84956
KLRC2 killer cell lectin-like receptor subfamily C, member 2 2.64028
ERCC6 excision repair cross-complementation group 6 2.56328
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 2.50685
EPHA8 EPH receptor A8 2.49508
SFPQ splicing factor proline/glutamine-rich 2.43886
ALAS1 5'-aminolevulinate synthase 1 2.40427
TP73 tumor protein p73 2.38226
COMT catechol-O-methyltransferase 2.37677
MXRA5 matrix-remodelling associated 5 2.33511
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 2.29791
IFT57 intraflagellar transport 57 2.25275
FBN2 fibrillin 2 2.24702
LPPR2 lipid phosphate phosphatase-related protein type 2 2.17513
HHEX hematopoietically expressed homeobox 2.15553
APOA5 apolipoprotein A-V 2.15437
TSHZ2 teashirt zinc finger homeobox 2 2.12486
RGS19 regulator of G-protein signaling 19 2.12203
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 2.0689
TCF20 transcription factor 20 (AR1) 2.05062
MED1 mediator complex subunit 1 2.03495
ZNF672 zinc finger protein 672 2.02799
GTF2A1L general transcription factor IIA, 1-like 2.02639
KRT28 keratin 28, type I 1.9842
STON1-GTF2A1L STON1-GTF2A1L readthrough 1.97668
MUSK muscle, skeletal, receptor tyrosine kinase 1.95111
DLG2 discs, large homolog 2 (Drosophila) 1.93526
ZNF773 zinc finger protein 773 1.92479
MBIP MAP3K12 binding inhibitory protein 1 1.919
GCLC glutamate-cysteine ligase, catalytic subunit 1.89898
ACO2 aconitase 2, mitochondrial 1.88968
NAA20 N(alpha)-acetyltransferase 20, NatB catalytic subunit 1.88633
SEC23B Sec23 homolog B (S. cerevisiae) 1.88085
PCSK4 proprotein convertase subtilisin/kexin type 4 1.87866
MECP2 methyl CpG binding protein 2 1.86071
PTPRU protein tyrosine phosphatase, receptor type, U 1.85199
KCNIP4 Kv channel interacting protein 4 1.84957
EIF3E eukaryotic translation initiation factor 3, subunit E 1.82509
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 1.81958
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 1.81684
ZFP64 ZFP64 zinc finger protein 1.81063
POLR2J4 polymerase (RNA) II (DNA directed) polypeptide J4, pseudogene 1.80751
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.78971
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 1.78877
RBM26 RNA binding motif protein 26 1.78525
BAZ1B bromodomain adjacent to zinc finger domain, 1B 1.78212
HRH2 histamine receptor H2 1.76856
RCN1 reticulocalbin 1, EF-hand calcium binding domain 1.76772
LEFTY1 left-right determination factor 1 1.75643
TXNL4A thioredoxin-like 4A 1.74475
GJB1 gap junction protein, beta 1, 32kDa 1.71755
CBS cystathionine-beta-synthase 1.71452
OGG1 8-oxoguanine DNA glycosylase 1.70929
LIPE lipase, hormone-sensitive 1.69779
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit 1.69444
KLRAP1 killer cell lectin-like receptor subfamily A pseudogene 1 1.68227
UIMC1 ubiquitin interaction motif containing 1 1.6797
FAS Fas cell surface death receptor 1.67066
CST11 cystatin 11 1.66989
HAUS1 HAUS augmin-like complex, subunit 1 1.65414
ACTL6A actin-like 6A 1.65282
POLRMT polymerase (RNA) mitochondrial (DNA directed) 1.65099
ENC1 ectodermal-neural cortex 1 (with BTB domain) 1.64878
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 1.63732
MGAT4C MGAT4 family, member C 1.63461
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 1.63185
RNF7 ring finger protein 7 1.62866
NCS1 neuronal calcium sensor 1 1.621
LGI1 leucine-rich, glioma inactivated 1 1.61215
PCDHA2 protocadherin alpha 2 1.61024
ZNF141 zinc finger protein 141 1.59759
IFNA6 interferon, alpha 6 1.58731
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 1.58339
NCBP2 nuclear cap binding protein subunit 2, 20kDa 1.57145
CAMK1 calcium/calmodulin-dependent protein kinase I 1.5646
KDM5D lysine (K)-specific demethylase 5D 1.54407
CLCN1 chloride channel, voltage-sensitive 1 1.54295
SOX5 SRY (sex determining region Y)-box 5 1.53097
MPPE1 metallophosphoesterase 1 1.521
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 1.51954
DBN1 drebrin 1 1.51841
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 1.50686
TMPO thymopoietin 1.49947
RAB19 RAB19, member RAS oncogene family 1.48782
CCNT2 cyclin T2 1.48356
SUZ12 SUZ12 polycomb repressive complex 2 subunit 1.47991
RPS3 ribosomal protein S3 1.47955
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 1.47388
OSTM1 osteopetrosis associated transmembrane protein 1 1.47106
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 1.46929
F9 coagulation factor IX 1.45717
ZNF433 zinc finger protein 433 1.45599
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 1.45277
GMPR guanosine monophosphate reductase 1.44444
PLXNB2 plexin B2 1.43892
CIB3 calcium and integrin binding family member 3 1.43861
TRPV3 transient receptor potential cation channel, subfamily V, member 3 1.43782
CDH20 cadherin 20, type 2 1.43647
NCAPD2 non-SMC condensin I complex, subunit D2 1.43646
ZNF568 zinc finger protein 568 1.43489
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 1.43444
SFXN2 sideroflexin 2 1.42419
FH fumarate hydratase 1.42418
OR51V1 olfactory receptor, family 51, subfamily V, member 1 1.4203
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase 1.41055
SALL1 spalt-like transcription factor 1 1.40855
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 1.4081
PDLIM5 PDZ and LIM domain 5 1.40468
HCRTR2 hypocretin (orexin) receptor 2 1.40227
ELP4 elongator acetyltransferase complex subunit 4 1.39941
ZRANB1 zinc finger, RAN-binding domain containing 1 1.38095
BCORL1 BCL6 corepressor-like 1 1.37552
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C 1.36923
ZNF702P zinc finger protein 702, pseudogene 1.36576
ZNF143 zinc finger protein 143 1.36115
NEK11 NIMA-related kinase 11 1.34286
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa 1.33699
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.33285
ACOT4 acyl-CoA thioesterase 4 1.33252
STK17B serine/threonine kinase 17b 1.32596
FOXR1 forkhead box R1 1.3218
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 1.31718
CD200R1 CD200 receptor 1 1.31287
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 1.30958
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 1.30889
GCLM glutamate-cysteine ligase, modifier subunit 1.30795
ZNF423 zinc finger protein 423 1.30601
DMRT3 doublesex and mab-3 related transcription factor 3 1.30402
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial 1.29476
LPAR4 lysophosphatidic acid receptor 4 1.29144
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2 1.29042
ZNF680 zinc finger protein 680 1.2869
SCARA3 scavenger receptor class A, member 3 1.28493
KCMF1 potassium channel modulatory factor 1 1.28065
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 1.27783
MAB21L2 mab-21-like 2 (C. elegans) 1.27236
SLC26A9 solute carrier family 26 (anion exchanger), member 9 1.2658
PLAG1 pleiomorphic adenoma gene 1 1.26516
ZNF420 zinc finger protein 420 1.25515
EIF3I eukaryotic translation initiation factor 3, subunit I 1.25377
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 1.2527
IGF1 insulin-like growth factor 1 (somatomedin C) 1.24719
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 1.24128
CDH3 cadherin 3, type 1, P-cadherin (placental) 1.23868
GJA5 gap junction protein, alpha 5, 40kDa 1.23684
CYP21A1P cytochrome P450, family 21, subfamily A, polypeptide 1 pseudogene 1.23083
GAMT guanidinoacetate N-methyltransferase 1.23014
KIF17 kinesin family member 17 1.22785
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 1.20383
NUMBL numb homolog (Drosophila)-like 1.1958
MOCS2 molybdenum cofactor synthesis 2 1.18273
C15ORF38-AP3S2 C15orf38-AP3S2 readthrough 1.17923
PRDX3 peroxiredoxin 3 1.17403
ZNF613 zinc finger protein 613 1.17167
TRIM7 tripartite motif containing 7 1.17077
ADAT3 adenosine deaminase, tRNA-specific 3 1.16941
KIAA0195 KIAA0195 1.16673
SOX10 SRY (sex determining region Y)-box 10 1.16559
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 1.15792
MAT2B methionine adenosyltransferase II, beta 1.15738
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 1.15609
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.15465
ALYREF Aly/REF export factor 1.15416
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 1.15337
MMP8 matrix metallopeptidase 8 1.1516
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa 1.14785
LEFTY2 left-right determination factor 2 1.14782
PPP1R12B protein phosphatase 1, regulatory subunit 12B 1.14561
THOC7 THO complex 7 1.14491
PKN3 protein kinase N3 1.14478
PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) 1.14169
SLC26A2 solute carrier family 26 (anion exchanger), member 2 1.1391
HOXA13 homeobox A13 1.13752
DUS3L dihydrouridine synthase 3-like (S. cerevisiae) 1.13658
IFNA13 interferon, alpha 13 1.13624
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) 1.13177
HES4 hes family bHLH transcription factor 4 1.1308
RPS3A ribosomal protein S3A 1.1286
USP37 ubiquitin specific peptidase 37 1.12783
FAF1 Fas (TNFRSF6) associated factor 1 1.12474
ZMIZ1 zinc finger, MIZ-type containing 1 1.12359
SEC13 SEC13 homolog (S. cerevisiae) 1.12315
OR3A2 olfactory receptor, family 3, subfamily A, member 2 1.12271
L3MBTL2 l(3)mbt-like 2 (Drosophila) 1.11825
MADD MAP-kinase activating death domain 1.1094
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 1.10931
CDC37 cell division cycle 37 1.10763
PCDH11X protocadherin 11 X-linked 1.10527
ZMYND11 zinc finger, MYND-type containing 11 1.10426
PLSCR2 phospholipid scramblase 2 1.09833
GFPT1 glutamine--fructose-6-phosphate transaminase 1 1.09804
RIC8B RIC8 guanine nucleotide exchange factor B 1.09794
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 1.09744
ETV6 ets variant 6 1.09744
AIF1L allograft inflammatory factor 1-like 1.09658
PPIE peptidylprolyl isomerase E (cyclophilin E) 1.0955
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.09318
ARHGAP24 Rho GTPase activating protein 24 1.09235
RUFY1 RUN and FYVE domain containing 1 1.0911
UBE2J2 ubiquitin-conjugating enzyme E2, J2 1.09076
RAB9A RAB9A, member RAS oncogene family 1.09006
GJA4 gap junction protein, alpha 4, 37kDa 1.08867
PCDH15 protocadherin-related 15 1.08822
MED28 mediator complex subunit 28 1.08277
DARS aspartyl-tRNA synthetase 1.08261
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 1.08231
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 1.08204
OR2J2 olfactory receptor, family 2, subfamily J, member 2 1.08055
ZNF721 zinc finger protein 721 1.07982
CLTA clathrin, light chain A 1.07765
TRIM54 tripartite motif containing 54 1.07736
GFOD2 glucose-fructose oxidoreductase domain containing 2 1.0771
BRD2 bromodomain containing 2 1.07316
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 1.07228
TMED2 transmembrane emp24 domain trafficking protein 2 1.07188
ZNFX1 zinc finger, NFX1-type containing 1 1.07188
PGM5 phosphoglucomutase 5 1.07105
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 1.06547
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 1.0649
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 1.06179
TRIM50 tripartite motif containing 50 1.06014
PCDHA4 protocadherin alpha 4 1.05825
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 1.05695
KRT19 keratin 19, type I 1.05572
TNFAIP8L2-SCNM1 TNFAIP8L2-SCNM1 readthrough 1.05552
MRPS28 mitochondrial ribosomal protein S28 1.05545
RGS18 regulator of G-protein signaling 18 1.05416
DOCK5 dedicator of cytokinesis 5 1.04756
NACA2 nascent polypeptide-associated complex alpha subunit 2 1.04176
RPA2 replication protein A2, 32kDa 1.04085
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A 1.03705
PUF60 poly-U binding splicing factor 60KDa 1.03623
L3MBTL1 l(3)mbt-like 1 (Drosophila) 1.03431
VRK3 vaccinia related kinase 3 1.03146
LARS leucyl-tRNA synthetase 1.02917
TIPRL TOR signaling pathway regulator 1.02748
RPA3 replication protein A3, 14kDa 1.02612
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa 1.02517
ECEL1 endothelin converting enzyme-like 1 1.02476
TMF1 TATA element modulatory factor 1 1.0226
ARF4 ADP-ribosylation factor 4 1.02199
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 1.01864
YEATS4 YEATS domain containing 4 1.01714
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 1.01621
CHEK1 checkpoint kinase 1 1.01616
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 1.01478
RANBP1 RAN binding protein 1 1.01144
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 1.011
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 1.01094
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa 1.01036
SRRM1 serine/arginine repetitive matrix 1 1.00847
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 1.00698
ADCY2 adenylate cyclase 2 (brain) 1.00659
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 1.0053
RPP40 ribonuclease P/MRP 40kDa subunit 1.00502
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase 1.0033
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 1.00143
NFRKB nuclear factor related to kappaB binding protein 1.00018

decreased fitness

Symbol Name Standardized Value
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) -2.66692
DEC1 deleted in esophageal cancer 1 -2.4993
BMP6 bone morphogenetic protein 6 -2.38659
VILL villin-like -2.37946
PRSS35 protease, serine, 35 -2.28461
RETSAT retinol saturase (all-trans-retinol 13,14-reductase) -2.2615
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) -2.25951
POFUT1 protein O-fucosyltransferase 1 -2.23762
METTL4 methyltransferase like 4 -2.1749
PRKG1 protein kinase, cGMP-dependent, type I -2.12219
CYB5A cytochrome b5 type A (microsomal) -2.08714
ZNF79 zinc finger protein 79 -2.06458
TWIST1 twist family bHLH transcription factor 1 -1.96703
AK2 adenylate kinase 2 -1.96668
ZNF362 zinc finger protein 362 -1.96219
BCL2L2 BCL2-like 2 -1.89646
AMDHD2 amidohydrolase domain containing 2 -1.84162
TAS2R50 taste receptor, type 2, member 50 -1.83403
ATN1 atrophin 1 -1.82315
JMJD7-PLA2G4B JMJD7-PLA2G4B readthrough -1.79411
PHF1 PHD finger protein 1 -1.79355
TBP TATA box binding protein -1.78682
NCAN neurocan -1.78599
EIF4B eukaryotic translation initiation factor 4B -1.76639
SP3 Sp3 transcription factor -1.76531
SLC18B1 solute carrier family 18, subfamily B, member 1 -1.75524
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 -1.74299
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 -1.72915
LIG3 ligase III, DNA, ATP-dependent -1.72801
PAQR6 progestin and adipoQ receptor family member VI -1.70444
NRBP1 nuclear receptor binding protein 1 -1.6956
AGAP6 ArfGAP with GTPase domain, ankyrin repeat and PH domain 6 -1.69325
TOM1 target of myb1 (chicken) -1.69284
FCGBP Fc fragment of IgG binding protein -1.67886
DNM1L dynamin 1-like -1.66154
NME7 NME/NM23 family member 7 -1.62255
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -1.60947
CDKL3 cyclin-dependent kinase-like 3 -1.60767
ZFP28 ZFP28 zinc finger protein -1.60747
SRSF2 serine/arginine-rich splicing factor 2 -1.59873
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 -1.59796
RNF144B ring finger protein 144B -1.59181
PLK4 polo-like kinase 4 -1.58518
ERP44 endoplasmic reticulum protein 44 -1.56012
AGPAT6 1-acylglycerol-3-phosphate O-acyltransferase 6 -1.53668
POR P450 (cytochrome) oxidoreductase -1.52872
EDA ectodysplasin A -1.52308
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -1.51464
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -1.51052
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) -1.48881
TRPM4 transient receptor potential cation channel, subfamily M, member 4 -1.48859
IGBP1 immunoglobulin (CD79A) binding protein 1 -1.47018
CXCR2 chemokine (C-X-C motif) receptor 2 -1.46573
PPAP2A phosphatidic acid phosphatase type 2A -1.45827
POLN polymerase (DNA directed) nu -1.44465
ADCK3 aarF domain containing kinase 3 -1.44449
SENP5 SUMO1/sentrin specific peptidase 5 -1.42889
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa -1.41664
CTSC cathepsin C -1.41255
HMOX2 heme oxygenase 2 -1.40735
ASF1B anti-silencing function 1B histone chaperone -1.39513
GK5 glycerol kinase 5 (putative) -1.39159
IGBP1P1 immunoglobulin (CD79A) binding protein 1 pseudogene 1 -1.39154
PPIA peptidylprolyl isomerase A (cyclophilin A) -1.38454
HIST1H2BM histone cluster 1, H2bm -1.3845
RTEL1-TNFRSF6B RTEL1-TNFRSF6B readthrough (NMD candidate) -1.37819
SLC30A1 solute carrier family 30 (zinc transporter), member 1 -1.37629
XAB2 XPA binding protein 2 -1.37326
PIP5KL1 phosphatidylinositol-4-phosphate 5-kinase-like 1 -1.37099
TASP1 taspase, threonine aspartase, 1 -1.36985
PRPF3 pre-mRNA processing factor 3 -1.36324
EDAR ectodysplasin A receptor -1.36057
MOB3A MOB kinase activator 3A -1.35892
SASH3 SAM and SH3 domain containing 3 -1.35846
CD46 CD46 molecule, complement regulatory protein -1.35386
MORC3 MORC family CW-type zinc finger 3 -1.33151
RHOT2 ras homolog family member T2 -1.32858
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -1.32718
BAZ2B bromodomain adjacent to zinc finger domain, 2B -1.32531
PCDHGC3 protocadherin gamma subfamily C, 3 -1.32215
KAT6A K(lysine) acetyltransferase 6A -1.31384
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog -1.31384
PCSK1 proprotein convertase subtilisin/kexin type 1 -1.312
LMNB1 lamin B1 -1.31143
ACAA1 acetyl-CoA acyltransferase 1 -1.30947
WT1 Wilms tumor 1 -1.30771
CD96 CD96 molecule -1.30757
USP20 ubiquitin specific peptidase 20 -1.30087
ALDH1B1 aldehyde dehydrogenase 1 family, member B1 -1.29914
MTMR1 myotubularin related protein 1 -1.29589
TGFB2 transforming growth factor, beta 2 -1.29452
PTS 6-pyruvoyltetrahydropterin synthase -1.28803
NLRP3 NLR family, pyrin domain containing 3 -1.28726
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 -1.28018
HOXA4 homeobox A4 -1.27437
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide -1.27233
HDAC10 histone deacetylase 10 -1.27077
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -1.27065
NLN neurolysin (metallopeptidase M3 family) -1.26322
MORC1 MORC family CW-type zinc finger 1 -1.25958
ZNF684 zinc finger protein 684 -1.2519
BCL2 B-cell CLL/lymphoma 2 -1.23881
CAND1 cullin-associated and neddylation-dissociated 1 -1.23096
MMP19 matrix metallopeptidase 19 -1.2202
TARBP1 TAR (HIV-1) RNA binding protein 1 -1.21601
TSPO translocator protein (18kDa) -1.21435
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide -1.21228
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -1.21042
POLR2H polymerase (RNA) II (DNA directed) polypeptide H -1.20553
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 -1.19944
CRELD1 cysteine-rich with EGF-like domains 1 -1.19779
AWAT2 acyl-CoA wax alcohol acyltransferase 2 -1.19776
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A -1.19177
MTM1 myotubularin 1 -1.19093
TSKU tsukushi, small leucine rich proteoglycan -1.18696
GPX6 glutathione peroxidase 6 -1.1865
CETP cholesteryl ester transfer protein, plasma -1.18349
NCLN nicalin -1.1804
HPCA hippocalcin -1.17929
FGFR1 fibroblast growth factor receptor 1 -1.17825
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -1.17551
ZBTB33 zinc finger and BTB domain containing 33 -1.17496
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha -1.17273
TSC22D4 TSC22 domain family, member 4 -1.17258
TAS2R38 taste receptor, type 2, member 38 -1.17254
COL11A1 collagen, type XI, alpha 1 -1.1692
UBE4B ubiquitination factor E4B -1.1689
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -1.16881
GRM8 glutamate receptor, metabotropic 8 -1.16819
ACSL4 acyl-CoA synthetase long-chain family member 4 -1.16702
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 -1.16691
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) -1.16671
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -1.16523
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -1.16357
DEFA3 defensin, alpha 3, neutrophil-specific -1.16038
LMO7 LIM domain 7 -1.15995
OR51T1 olfactory receptor, family 51, subfamily T, member 1 -1.15733
COPS2 COP9 signalosome subunit 2 -1.1572
LSM1 LSM1, U6 small nuclear RNA associated -1.15507
TAS2R60 taste receptor, type 2, member 60 -1.15475
IFT54 intraflagellar transport 54 -1.15048
ZNF213 zinc finger protein 213 -1.14772
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -1.14031
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -1.13468
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 -1.12864
GPR155 G protein-coupled receptor 155 -1.12724
SLAMF1 signaling lymphocytic activation molecule family member 1 -1.12538
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -1.12412
RASD2 RASD family, member 2 -1.12264
PLA2G4B phospholipase A2, group IVB (cytosolic) -1.12225
ZP3 zona pellucida glycoprotein 3 (sperm receptor) -1.1221
ZNF497 zinc finger protein 497 -1.12181
IFNGR1 interferon gamma receptor 1 -1.11883
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) -1.11544
XPOT exportin, tRNA -1.11202
NCBP1 nuclear cap binding protein subunit 1, 80kDa -1.11069
U2AF1 U2 small nuclear RNA auxiliary factor 1 -1.10831
MSRA methionine sulfoxide reductase A -1.10612
ZNF347 zinc finger protein 347 -1.1061
SPATA8 spermatogenesis associated 8 -1.10524
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -1.10465
GPS1 G protein pathway suppressor 1 -1.10454
ONECUT1 one cut homeobox 1 -1.10355
CCNT1 cyclin T1 -1.10227
EDN1 endothelin 1 -1.09859
USP34 ubiquitin specific peptidase 34 -1.09634
MMP14 matrix metallopeptidase 14 (membrane-inserted) -1.09522
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein -1.09333
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 -1.09258
COBL cordon-bleu WH2 repeat protein -1.09076
CHD1 chromodomain helicase DNA binding protein 1 -1.09063
CSAD cysteine sulfinic acid decarboxylase -1.08748
KIF5B kinesin family member 5B -1.08639
PCGF6 polycomb group ring finger 6 -1.0857
TLX1 T-cell leukemia homeobox 1 -1.08521
CBR1 carbonyl reductase 1 -1.08303
CHGA chromogranin A -1.08128
CIB4 calcium and integrin binding family member 4 -1.08076
RAB5B RAB5B, member RAS oncogene family -1.08073
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -1.07299
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -1.06738
ENSA endosulfine alpha -1.06268
ABHD11 abhydrolase domain containing 11 -1.05931
ALG1L2 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like 2 -1.05667
DUSP18 dual specificity phosphatase 18 -1.056
NGB neuroglobin -1.05358
DTX2 deltex 2, E3 ubiquitin ligase -1.05268
APLP1 amyloid beta (A4) precursor-like protein 1 -1.05033
FKBP1A FK506 binding protein 1A, 12kDa -1.04909
ZNF628 zinc finger protein 628 -1.04691
KRT12 keratin 12, type I -1.04608
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -1.04094
UVRAG UV radiation resistance associated -1.04015
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) -1.0338
ART5 ADP-ribosyltransferase 5 -1.03213
GPR132 G protein-coupled receptor 132 -1.03034
HPR haptoglobin-related protein -1.02897
ATF7IP2 activating transcription factor 7 interacting protein 2 -1.02663
ZNF230 zinc finger protein 230 -1.02352
TRIM58 tripartite motif containing 58 -1.02157
ZNF432 zinc finger protein 432 -1.01976
SKAP1 src kinase associated phosphoprotein 1 -1.01678
RPP25 ribonuclease P/MRP 25kDa subunit -1.01238
ACSL3 acyl-CoA synthetase long-chain family member 3 -1.01155
OR7A5 olfactory receptor, family 7, subfamily A, member 5 -1.01011
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -1.00492
RAX retina and anterior neural fold homeobox -1.00246
MIB2 mindbomb E3 ubiquitin protein ligase 2 -1.00236
CIITA class II, major histocompatibility complex, transactivator -1.00156
SYT4 synaptotagmin IV -1.00083