TYSND1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description trypsin domain containing 1|This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome. The encoded protein is also capable of removing the C-terminal peroxisomal targeting signal (PTS1) from proteins in the peroxisomal matrix. The full-length protein undergoes self-cleavage to produce shorter, potentially inactive, peptides. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013] (NCBI Entrez Gene Database, 219743)
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Genes

320 genes differentially expressed following the TYSND1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SCNN1G sodium channel, non voltage gated 1 gamma subunit 2.63663
CD68 CD68 molecule 2.63663
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 2.63663
PNPLA1 patatin-like phospholipase domain containing 1 2.63663
GDF9 growth differentiation factor 9 2.63663
TMEM121 transmembrane protein 121 2.63663
GATA6 GATA binding protein 6 2.63663
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.63663
C21ORF140 chromosome 21 open reading frame 140 2.63663
FSCN2 fascin actin-bundling protein 2, retinal 2.63663
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.63663
SLC30A2 solute carrier family 30 (zinc transporter), member 2 2.63663
LBP lipopolysaccharide binding protein 2.63663
C9 complement component 9 2.63663
GPR20 G protein-coupled receptor 20 2.63663
GPR22 G protein-coupled receptor 22 2.63663
FBLN7 fibulin 7 2.63663
NT5C2 5'-nucleotidase, cytosolic II 2.63663
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.63663
HTR3D 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic 2.63663
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 2.63663
CRYAA crystallin, alpha A 2.63663
SPI1 Spi-1 proto-oncogene 2.63663
ZG16 zymogen granule protein 16 2.63663
MNX1 motor neuron and pancreas homeobox 1 2.63663
LKAAEAR1 LKAAEAR motif containing 1 2.63663
NLRP3 NLR family, pyrin domain containing 3 2.63663
NLRP7 NLR family, pyrin domain containing 7 2.63663
POPDC2 popeye domain containing 2 2.63663
ZNF726 zinc finger protein 726 2.63663
IL23R interleukin 23 receptor 2.63663
PCDHGA11 protocadherin gamma subfamily A, 11 2.63663
KCNU1 potassium channel, subfamily U, member 1 2.63663
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 2.63663
ACSL5 acyl-CoA synthetase long-chain family member 5 2.63663
NOMO2 NODAL modulator 2 2.63663
OR6F1 olfactory receptor, family 6, subfamily F, member 1 2.63663
PLCZ1 phospholipase C, zeta 1 2.63663
FFAR1 free fatty acid receptor 1 2.63663
CCDC80 coiled-coil domain containing 80 2.63663
GPRC5A G protein-coupled receptor, class C, group 5, member A 2.63663
MSC musculin 2.63663
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.63663
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.63663
GOLGA6L4 golgin A6 family-like 4 2.63663
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.63663
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 2.63663
COLEC10 collectin sub-family member 10 (C-type lectin) 2.63663
ADGRE3 adhesion G protein-coupled receptor E3 2.63663
IZUMO3 IZUMO family member 3 2.63663
ALKBH4 alkB, alkylation repair homolog 4 (E. coli) 2.63663
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 2.63663
SLFN11 schlafen family member 11 2.63663
PVRIG poliovirus receptor related immunoglobulin domain containing 2.63663
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 2.63663
ACOT1 acyl-CoA thioesterase 1 2.63663
FPR2 formyl peptide receptor 2 2.63663
MTNR1B melatonin receptor 1B 2.63663
SPATA31F3 SPATA31 subfamily F member 3 2.63663
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 2.63663
RNF17 ring finger protein 17 2.63663
KLRK1 killer cell lectin-like receptor subfamily K, member 1 2.63663
PTX3 pentraxin 3, long 2.63663
CELF3 CUGBP, Elav-like family member 3 2.63663
NPIPB9 nuclear pore complex interacting protein family, member B9 2.63663
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.63663
MTTP microsomal triglyceride transfer protein 2.63663
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 2.63663
APOA2 apolipoprotein A-II 2.63663
ZNF257 zinc finger protein 257 2.63663
MANSC4 MANSC domain containing 4 2.63663
TSPO2 translocator protein 2 2.63663
TMEM235 transmembrane protein 235 2.63663
OR2AG2 olfactory receptor, family 2, subfamily AG, member 2 2.63663
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 2.63663
LYST lysosomal trafficking regulator 2.63663
PEAR1 platelet endothelial aggregation receptor 1 2.63663
SPDYE4 speedy/RINGO cell cycle regulator family member E4 2.63663
OR10A6 olfactory receptor, family 10, subfamily A, member 6 (gene/pseudogene) 2.63663
OR10A4 olfactory receptor, family 10, subfamily A, member 4 2.63663
SH2D7 SH2 domain containing 7 2.63663
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 2.63663
FOLR3 folate receptor 3 (gamma) 2.63663
UBQLNL ubiquilin-like 2.63663
SPATA4 spermatogenesis associated 4 2.63663
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 2.63663
C1ORF232 chromosome 1 open reading frame 230 2.63663
BCO1 beta-carotene oxygenase 1 2.63663
VWA7 von Willebrand factor A domain containing 7 2.63663
COL17A1 collagen, type XVII, alpha 1 2.63663
RGCC regulator of cell cycle 2.63663
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.63663
PRRT1B proline rich transmembrane protein 1B 2.63663
SPINK9 serine peptidase inhibitor, Kazal type 9 2.63663
AKAIN1 A-kinase anchor inhibitor 1 2.63663
KLHL6 kelch-like family member 6 2.63663
GRK1 G protein-coupled receptor kinase 1 2.63663
CRYBB2 crystallin, beta B2 2.63663
MYPOP Myb-related transcription factor, partner of profilin 2.63663
DUOX2 dual oxidase 2 2.63663
LCN1 lipocalin 1 2.63663
CCN5 cellular communication network factor 5 2.63663
SPATA46 spermatogenesis associated 46 2.63663
TEX11 testis expressed 11 2.63663
ZNF596 zinc finger protein 596 2.63663
ORM2 orosomucoid 2 2.63663
HLA-G major histocompatibility complex, class I, G 2.63663
PCDHAC2 protocadherin alpha subfamily C, 2 2.63663
EPCIP exosomal polycystin 1 interacting protein 2.63663
WNT2 wingless-type MMTV integration site family member 2 2.63663
PLA2G5 phospholipase A2, group V 2.63663
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 2.63663
LRRC24 leucine rich repeat containing 24 2.63663
CCNI2 cyclin I family, member 2 2.63663
ZIM2 zinc finger, imprinted 2 2.63663
PRSS33 protease, serine, 33 2.63663
FAM240A family with sequence similarity 240 member A 2.63663
CFAP47 cilia and flagella associated protein 47 2.63663
LRRC15 leucine rich repeat containing 15 2.63663
TBX1 T-box 1 2.63663
DMRTA2 DMRT-like family A2 2.63663
IL9R interleukin 9 receptor 2.63663
ARL13A ADP-ribosylation factor-like 13A 2.63663
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 2.63663
ART1 ADP-ribosyltransferase 1 2.63663
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria 2.63663
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 2.63663
C9ORF50 chromosome 9 open reading frame 50 2.63663
PTGDR prostaglandin D2 receptor (DP) 2.63663
ABHD1 abhydrolase domain containing 1 2.63663
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.63663
CPO carboxypeptidase O 2.63663
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 2.63663
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 2.63663
SMIM22 small integral membrane protein 22 2.63663
ROM1 retinal outer segment membrane protein 1 2.63663
RNF222 ring finger protein 222 2.63663
TRAF3IP3 TRAF3 interacting protein 3 2.63663
IFITM10 interferon induced transmembrane protein 10 2.63663
DBF4B DBF4 zinc finger B 2.63663
IFNE interferon, epsilon 2.63663
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.63663
SLC7A6OS solute carrier family 7, member 6 opposite strand 2.63663
GPRC5D G protein-coupled receptor, class C, group 5, member D 2.63663
CLCNKA chloride channel, voltage-sensitive Ka 2.63663
MT3 metallothionein 3 2.63663
APOB apolipoprotein B 2.63663
RGS11 regulator of G-protein signaling 11 2.63663
EDN3 endothelin 3 2.63663
PF4V1 platelet factor 4 variant 1 2.63663
ZNF541 zinc finger protein 541 2.63663
CSTA cystatin A (stefin A) 2.63663
NECTIN1 nectin cell adhesion molecule 1 2.63663
SOWAHA sosondowah ankyrin repeat domain family member A 2.63663
PMIS2 PMIS2 transmembrane protein 2.63663
GAGE10 G antigen 10 2.63663
KCNK4 potassium channel, two pore domain subfamily K, member 4 2.63663
CCDC152 coiled-coil domain containing 152 2.63663
ENDOU endonuclease, polyU-specific 2.63663
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 2.63663
GP1BB glycoprotein Ib (platelet), beta polypeptide 2.63663
MYOCOS myocilin opposite strand 2.63663
MMS22L MMS22-like, DNA repair protein 2.60534
HYAL3 hyaluronoglucosaminidase 3 2.55933
CRYGS crystallin, gamma S 2.55933
LYG1 lysozyme G-like 1 2.55933
PRMT2 protein arginine methyltransferase 2 2.55933
MOGAT1 monoacylglycerol O-acyltransferase 1 2.55933
SREBF2 sterol regulatory element binding transcription factor 2 2.55933
BHLHA15 basic helix-loop-helix family, member a15 2.49819
LCNL1 lipocalin-like 1 2.49819
STARD3 StAR-related lipid transfer (START) domain containing 3 2.43693
BRI3BP BRI3 binding protein 2.43693
FPR3 formyl peptide receptor 3 2.43035
ADRB1 adrenoceptor beta 1 2.40853
COPS7B COP9 signalosome subunit 7B 2.40853
LMO2 LIM domain only 2 (rhombotin-like 1) 2.40853
RBPMS2 RNA binding protein with multiple splicing 2 2.37014
MUC16 mucin 16, cell surface associated 2.35752
SGCE sarcoglycan, epsilon 2.34262
DYDC2 DPY30 domain containing 2 2.34262
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase 2.31324
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) 2.30625
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 2.30583
ADGRG3 adhesion G protein-coupled receptor G3 2.30394
LAMP5 lysosomal-associated membrane protein family, member 5 2.30394
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) 2.29436
ZNF624 zinc finger protein 624 2.27582
PNP purine nucleoside phosphorylase 2.27582
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 2.25878
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 2.23808
PCIF1 PDX1 C-terminal inhibiting factor 1 2.22978
NKTR natural killer cell triggering receptor 2.21349
ATG2A autophagy related 2A 2.21349
ANKRD36B ankyrin repeat domain 36B 2.20969
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 2.18895
FN3KRP fructosamine 3 kinase related protein 2.17623
SLC7A14 solute carrier family 7, member 14 2.17416
ARF3 ADP-ribosylation factor 3 2.15247
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 2.13665
MESD mesoderm development LRP chaperone 2.1319
TMEM41B transmembrane protein 41B 2.13175
RPL19 ribosomal protein L19 2.11766
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 2.10825
C6ORF52 chromosome 6 open reading frame 52 2.10289
MLF2 myeloid leukemia factor 2 2.09676
ZNF75A zinc finger protein 75a 2.09495
MITD1 MIT, microtubule interacting and transport, domain containing 1 2.08608
ZNF592 zinc finger protein 592 2.07943
IRF1 interferon regulatory factor 1 2.07943
CNRIP1 cannabinoid receptor interacting protein 1 2.07457
SLC10A7 solute carrier family 10, member 7 2.0654
AGGF1 angiogenic factor with G patch and FHA domains 1 2.06208
NDRG3 NDRG family member 3 2.06208
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.05567
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 2.05222
TMT1A thiol methyltransferase 1A 2.04646
MAP3K5 mitogen-activated protein kinase kinase kinase 5 2.04154
LHFPL2 lipoma HMGIC fusion partner-like 2 2.02166
PLEKHM3 pleckstrin homology domain containing, family M, member 3 2.00407

decreased expression

Symbol Name Standardized Value
CCDC194 coiled-coil domain containing 194 -2.63663
JMJD7 jumonji domain containing 7 -2.63663
TAC1 tachykinin, precursor 1 -2.63663
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 -2.63663
FOXJ1 forkhead box J1 -2.63663
ZNF597 zinc finger protein 597 -2.63663
SYT15 synaptotagmin XV -2.63663
POMC proopiomelanocortin -2.63663
PRB3 proline-rich protein BstNI subfamily 3 -2.63663
H2AC16 H2A clustered histone 16 -2.63663
MOB1B MOB kinase activator 1B -2.63663
PIWIL2 piwi-like RNA-mediated gene silencing 2 -2.63663
COMMD1 copper metabolism (Murr1) domain containing 1 -2.63663
PLPPR4 phospholipid phosphatase related 4 -2.63663
H1-1 H1.1 linker histone, cluster member -2.63663
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor -2.60534
SPINT4 serine peptidase inhibitor, Kunitz type 4 -2.55933
LRRC56 leucine rich repeat containing 56 -2.55933
BTLA B and T lymphocyte associated -2.55933
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 -2.55933
CRB1 crumbs family member 1, photoreceptor morphogenesis associated -2.55933
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 -2.55933
PRDM12 PR domain containing 12 -2.55933
SLC10A4 solute carrier family 10, member 4 -2.55933
ADRB2 adrenoceptor beta 2, surface -2.55933
BTK Bruton agammaglobulinemia tyrosine kinase -2.55933
H3C13 H3 clustered histone 13 -2.55933
BNC1 basonuclin 1 -2.55933
HSPB6 heat shock protein, alpha-crystallin-related, B6 -2.55933
FAM153A family with sequence similarity 153, member A -2.55933
MYT1L myelin transcription factor 1-like -2.55933
TXLNB taxilin beta -2.55933
C1ORF53 chromosome 1 open reading frame 53 -2.55933
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 -2.55933
LRRTM2 leucine rich repeat transmembrane neuronal 2 -2.55933
OR8A1 olfactory receptor, family 8, subfamily A, member 1 -2.55933
ICAM5 intercellular adhesion molecule 5, telencephalin -2.55933
BTNL8 butyrophilin-like 8 -2.55933
KLK4 kallikrein-related peptidase 4 -2.55933
EGR2 early growth response 2 -2.55933
IL11 interleukin 11 -2.55933
PLA2G2C phospholipase A2, group IIC -2.55933
LY6G5C lymphocyte antigen 6 complex, locus G5C -2.55933
IZUMO1 izumo sperm-egg fusion 1 -2.55933
STS steroid sulfatase (microsomal), isozyme S -2.55933
VWA3A von Willebrand factor A domain containing 3A -2.55933
TMEM132D transmembrane protein 132D -2.55933
VAV1 vav 1 guanine nucleotide exchange factor -2.55933
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -2.54249
MTO1 mitochondrial tRNA translation optimization 1 -2.52538
NOXO1 NADPH oxidase organizer 1 -2.49819
LRRC66 leucine rich repeat containing 66 -2.49819
PDGFRA platelet-derived growth factor receptor, alpha polypeptide -2.49819
MAN2B2 mannosidase, alpha, class 2B, member 2 -2.49675
SRPK2 SRSF protein kinase 2 -2.45816
IRAK1 interleukin-1 receptor-associated kinase 1 -2.44778
TMEM62 transmembrane protein 62 -2.44778
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2 -2.41949
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -2.41609
POU5F2 POU domain class 5, transcription factor 2 -2.41044
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) -2.40589
GPATCH2 G patch domain containing 2 -2.38661
SLC30A10 solute carrier family 30, member 10 -2.38259
THOC3 THO complex 3 -2.36506
ZNF620 zinc finger protein 620 -2.36245
SALL1 spalt-like transcription factor 1 -2.34262
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 -2.34262
RNF113A ring finger protein 113A -2.32056
TMEM216 transmembrane protein 216 -2.26622
ZNF106 zinc finger protein 106 -2.2584
GADD45A growth arrest and DNA-damage-inducible, alpha -2.24472
ZNF486 zinc finger protein 486 -2.23808
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase -2.22303
PAPOLG poly(A) polymerase gamma -2.20969
BKGD beta-keto-L-gulonate decarboxylase -2.18895
GAPVD1 GTPase activating protein and VPS9 domains 1 -2.18895
MKX mohawk homeobox -2.18428
RPUSD3 RNA pseudouridylate synthase domain containing 3 -2.18428
ANGPTL4 angiopoietin-like 4 -2.17623
PCNX3 pecanex 3 -2.15683
JPH3 junctophilin 3 -2.15509
GTPBP3 GTP binding protein 3 (mitochondrial) -2.12974
EFNA2 ephrin-A2 -2.12974
LOC105378220 macrophage receptor MARCO-like -2.12965
TUBA1C tubulin, alpha 1c -2.10713
FXYD6 FXYD domain containing ion transport regulator 6 -2.10713
SZT2 seizure threshold 2 homolog (mouse) -2.09436
OXTR oxytocin receptor -2.08608
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 -2.07943
CHERP calcium homeostasis endoplasmic reticulum protein -2.05257
BAZ1B bromodomain adjacent to zinc finger domain, 1B -2.04646
TNPO3 transportin 3 -2.04646
EBF3 early B-cell factor 3 -2.03984
TMT1B thiol methyltransferase 1B -2.03984
CSNK1G2 casein kinase 1, gamma 2 -2.02373
CHD4 chromodomain helicase DNA binding protein 4 -2.02186
GNPDA1 glucosamine-6-phosphate deaminase 1 -2.01706
PTTG1IP pituitary tumor-transforming 1 interacting protein -2.01686
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 -2.01203
VMP1 vacuole membrane protein 1 -2.00407