TYW3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)|Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW3 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008] (NCBI Entrez Gene Database, 127253)
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Genes

319 genes differentially expressed following the TYW3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NPPB natriuretic peptide B 2.96778
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 2.96778
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 2.96778
PTH parathyroid hormone 2.96778
MYL10 myosin, light chain 10, regulatory 2.96778
FAM181B family with sequence similarity 181, member B 2.96778
KLF9 Kruppel-like factor 9 2.96778
GJB1 gap junction protein, beta 1, 32kDa 2.96778
UMOD uromodulin 2.89997
APLN apelin 2.89997
TMEM212 transmembrane protein 212 2.89997
OR2AG2 olfactory receptor, family 2, subfamily AG, member 2 2.89997
CCL5 chemokine (C-C motif) ligand 5 2.89997
PCDHGB3 protocadherin gamma subfamily B, 3 2.89997
HORMAD1 HORMA domain containing 1 2.89997
SOX18 SRY (sex determining region Y)-box 18 2.89997
TM4SF5 transmembrane 4 L six family member 5 2.89997
GLUD2 glutamate dehydrogenase 2 2.89997
LAX1 lymphocyte transmembrane adaptor 1 2.89997
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.89997
MYO7A myosin VIIA 2.89997
RBM11 RNA binding motif protein 11 2.89997
SOX1 SRY (sex determining region Y)-box 1 2.89997
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.89997
PTH2 parathyroid hormone 2 2.89997
CA14 carbonic anhydrase XIV 2.89997
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.89997
PRSS36 protease, serine, 36 2.89997
MUC21 mucin 21, cell surface associated 2.89997
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 2.89997
BFSP2 beaded filament structural protein 2, phakinin 2.89997
THSD1 thrombospondin, type I, domain containing 1 2.89997
RXRG retinoid X receptor, gamma 2.89997
PRSS21 protease, serine, 21 (testisin) 2.89997
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 2.89997
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.89997
PAX5 paired box 5 2.89997
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.89997
SLC15A5 solute carrier family 15, member 5 2.89997
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.89997
ARHGAP36 Rho GTPase activating protein 36 2.89997
TUBB8 tubulin, beta 8 class VIII 2.89997
GPR22 G protein-coupled receptor 22 2.89997
TCAF2 TRPM8 channel-associated factor 2 2.89997
UNC45B unc-45 homolog B (C. elegans) 2.89997
SPDEF SAM pointed domain containing ETS transcription factor 2.89997
SRL sarcalumenin 2.89997
OR1R1 olfactory receptor family 1 subfamily R member 1 2.89997
SQOR sulfide quinone oxidoreductase 2.89997
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.89997
OR10H5 olfactory receptor, family 10, subfamily H, member 5 2.89997
MCHR2 melanin-concentrating hormone receptor 2 2.89997
CCER2 coiled-coil glutamate-rich protein 2 2.89997
VN1R2 vomeronasal 1 receptor 2 2.89997
SRGN serglycin 2.89997
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.89997
PNMA8B PNMA family member 8B 2.89997
TMEM275 transmembrane protein 275 2.89997
FAM240B family with sequence similarity 240 member B 2.89997
CIMIP2B ciliary microtubule inner protein 2B 2.89997
PPIAP39 peptidylprolyl isomerase A pseudogene 39 2.89997
C20ORF204 chromosome 20 open reading frame 204 2.89997
EZHIP EZH inhibitory protein 2.89997
CFAP276 cilia and flagella associated protein 276 2.89997
SPDYE9 speedy/RINGO cell cycle regulator family member E9 2.89997
DUSP29 dual specificity phosphatase 29 2.89997
CGB3 chorionic gonadotropin subunit beta 3 2.89997
FCMR Fc fragment of IgM receptor 2.89997
DYNLRB2 dynein, light chain, roadblock-type 2 2.89997
MROH5 maestro heat-like repeat family member 5 2.89997
EDAR ectodysplasin A receptor 2.89997
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 2.89997
KRABD1 KRAB domain containing 1 2.89997
MAGEB3 melanoma antigen family B3 2.89997
PCDHA2 protocadherin alpha 2 2.89997
TMEM229A transmembrane protein 229A 2.89997
LOC390937 Ets2 repressor factor-like 2.89997
SYCP2 synaptonemal complex protein 2 2.89997
CLEC3A C-type lectin domain family 3, member A 2.89997
OR51B2 olfactory receptor, family 51, subfamily B, member 2 (gene/pseudogene) 2.89997
SCRT2 scratch family zinc finger 2 2.89997
LRRN4CL LRRN4 C-terminal like 2.89997
OOSP1 oocyte secreted protein 1, pseudogene 2.89997
IL1R1 interleukin 1 receptor, type I 2.89997
UTS2 urotensin 2 2.89997
PRR4 proline rich 4 (lacrimal) 2.89997
SLAMF9 SLAM family member 9 2.89997
BHLHA9 basic helix-loop-helix family, member a9 2.89997
DMBX1 diencephalon/mesencephalon homeobox 1 2.89997
HNF4A hepatocyte nuclear factor 4, alpha 2.89997
KCNK7 potassium channel, two pore domain subfamily K, member 7 2.89997
HAVCR1 hepatitis A virus cellular receptor 1 2.89997
FAM177B family with sequence similarity 177, member B 2.89997
CPA5 carboxypeptidase A5 2.89997
PAGE4 P antigen family, member 4 (prostate associated) 2.89997
CASP8AP2 caspase 8 associated protein 2 2.89997
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) 2.89997
TEX19 testis expressed 19 2.89997
PCDH12 protocadherin 12 2.89997
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B 2.89997
HOXD1 homeobox D1 2.89997
RNASE11 ribonuclease, RNase A family, 11 (non-active) 2.89997
CH25H cholesterol 25-hydroxylase 2.89997
BRDT bromodomain, testis-specific 2.89997
KLHL6 kelch-like family member 6 2.89997
S100A14 S100 calcium binding protein A14 2.89997
AQP7 aquaporin 7 2.89997
CXCR4 chemokine (C-X-C motif) receptor 4 2.89997
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.89997
TIGD3 tigger transposable element derived 3 2.89997
JAKMIP1 janus kinase and microtubule interacting protein 1 2.89997
GTF2A1L general transcription factor IIA, 1-like 2.89997
RELN reelin 2.89997
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 2.89997
GBX1 gastrulation brain homeobox 1 2.89997
ETV3L ets variant 3-like 2.89997
WNT2 wingless-type MMTV integration site family member 2 2.89997
LRRC24 leucine rich repeat containing 24 2.89997
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.89997
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 2.89997
GSDMC gasdermin C 2.89997
CFH complement factor H 2.89997
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 2.89997
NMBR neuromedin B receptor 2.89997
PRPH peripherin 2.89997
SPATA9 spermatogenesis associated 9 2.89997
LAMB4 laminin, beta 4 2.89997
FGB fibrinogen beta chain 2.89997
SIGLEC11 sialic acid binding Ig-like lectin 11 2.89997
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 2.89997
VAV1 vav 1 guanine nucleotide exchange factor 2.89997
PRSS38 protease, serine, 38 2.89997
PRH2 proline-rich protein HaeIII subfamily 2 2.89997
PHOX2A paired-like homeobox 2a 2.89997
FNDC9 fibronectin type III domain containing 9 2.89997
GP1BA glycoprotein Ib (platelet), alpha polypeptide 2.89997
NUTM2B NUT family member 2B 2.89997
ZPLD1 zona pellucida-like domain containing 1 2.89997
GREM1 gremlin 1, DAN family BMP antagonist 2.89997
EPX eosinophil peroxidase 2.89997
TTC36 tetratricopeptide repeat domain 36 2.89997
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.89997
TMPRSS13 transmembrane protease, serine 13 2.89997
CHRM4 cholinergic receptor, muscarinic 4 2.89997
MMP3 matrix metallopeptidase 3 2.89997
LRRC74A leucine rich repeat containing 74A 2.89997
LRRC38 leucine rich repeat containing 38 2.89997
PPP1R3G protein phosphatase 1, regulatory subunit 3G 2.89997
IL37 interleukin 37 2.89997
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.89997
CD22 CD22 molecule 2.89997
PLA2G4D phospholipase A2, group IVD (cytosolic) 2.89997
NRGN neurogranin (protein kinase C substrate, RC3) 2.89997
APOL3 apolipoprotein L, 3 2.89997
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 2.89997
ECM1 extracellular matrix protein 1 2.89997
NLRP8 NLR family, pyrin domain containing 8 2.89997
CSF3R colony stimulating factor 3 receptor (granulocyte) 2.89997
ZNF648 zinc finger protein 648 2.89997
VENTX VENT homeobox 2.85087
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 2.85087
FGF11 fibroblast growth factor 11 2.80718
CCK cholecystokinin 2.79993
FSCN3 fascin actin-bundling protein 3, testicular 2.68453
H2AC13 H2A clustered histone 13 2.64934
TATDN3 TatD DNase domain containing 3 2.62582
PIMREG PICALM interacting mitotic regulator 2.60755
SQSTM1 sequestosome 1 2.57403
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 2.57403
IFI27L1 interferon, alpha-inducible protein 27-like 1 2.4825
DYNC2I2 dynein 2 intermediate chain 2 2.47282
TRAPPC2 trafficking protein particle complex 2 2.43164
MFSD1 major facilitator superfamily domain containing 1 2.37515
ZNF268 zinc finger protein 268 2.36863
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 2.34343
KRIT1 KRIT1, ankyrin repeat containing 2.34094
DIPK1C divergent protein kinase domain 1C 2.32271
DOCK5 dedicator of cytokinesis 5 2.32154
LRRC27 leucine rich repeat containing 27 2.31458
COL5A3 collagen, type V, alpha 3 2.31458
UBE2F ubiquitin-conjugating enzyme E2F (putative) 2.31178
NEDD1 neural precursor cell expressed, developmentally down-regulated 1 2.30234
FUNDC2 FUN14 domain containing 2 2.29985
SYNPO2L synaptopodin 2-like 2.29985
FAM184B family with sequence similarity 184, member B 2.29421
AHNAK AHNAK nucleoprotein 2.27451
RPL34 ribosomal protein L34 2.25346
CTCF CCCTC-binding factor (zinc finger protein) 2.24829
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.24673
C2ORF68 chromosome 2 open reading frame 68 2.21042
STX16 syntaxin 16 2.16899
SH3GL1 SH3-domain GRB2-like 1 2.10878
RARS2 arginyl-tRNA synthetase 2, mitochondrial 2.0982
MTMR1 myotubularin related protein 1 2.0982
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 2.09618
PFDN6 prefoldin subunit 6 2.09512
AP2M1 adaptor-related protein complex 2, mu 1 subunit 2.08074
BTN2A1 butyrophilin, subfamily 2, member A1 2.07947
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) 2.07897
GORASP1 golgi reassembly stacking protein 1, 65kDa 2.07836
SAMD3 sterile alpha motif domain containing 3 2.06991
PAQR3 progestin and adipoQ receptor family member III 2.06467
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 2.05342
PJVK pejvakin 2.04857
NME9 NME/NM23 family member 9 2.03151
TTC19 tetratricopeptide repeat domain 19 2.0308
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 2.02134
FZD5 frizzled class receptor 5 2.01899
CRYAB crystallin, alpha B 2.00771
FAM53A family with sequence similarity 53, member A 2.00026

decreased expression

Symbol Name Standardized Value
PNCK pregnancy up-regulated nonubiquitous CaM kinase -2.96778
ATXN7L2 ataxin 7-like 2 -2.92567
TXLNB taxilin beta -2.89997
IL2RA interleukin 2 receptor, alpha -2.89997
TSGA10IP testis specific, 10 interacting protein -2.89997
HRG histidine-rich glycoprotein -2.89997
CATSPERD catsper channel auxiliary subunit delta -2.89997
OR2A14 olfactory receptor, family 2, subfamily A, member 14 -2.89997
C1QTNF1 C1q and tumor necrosis factor related protein 1 -2.89997
PCDHB4 protocadherin beta 4 -2.89997
PROZ protein Z, vitamin K-dependent plasma glycoprotein -2.89997
TTC23L tetratricopeptide repeat domain 23-like -2.89997
ST18 suppression of tumorigenicity 18, zinc finger -2.89997
DUSP9 dual specificity phosphatase 9 -2.89997
RHOXF1 Rhox homeobox family, member 1 -2.89997
NPIPA8 nuclear pore complex interacting protein family, member A8 -2.89997
USP50 ubiquitin specific peptidase 50 -2.89997
TMPRSS11E transmembrane protease, serine 11E -2.89997
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 -2.89997
FAM167A family with sequence similarity 167, member A -2.89997
TBX22 T-box 22 -2.89997
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 -2.89997
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) -2.89997
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.89997
OPRL1 opiate receptor-like 1 -2.89997
ACOT1 acyl-CoA thioesterase 1 -2.89997
RFPL2 ret finger protein-like 2 -2.89997
PCDHA1 protocadherin alpha 1 -2.89997
NPAS4 neuronal PAS domain protein 4 -2.89997
FADS6 fatty acid desaturase 6 -2.89997
PCDHGA7 protocadherin gamma subfamily A, 7 -2.89997
CCDC183 coiled-coil domain containing 183 -2.89997
MUC16 mucin 16, cell surface associated -2.89997
RBBP8NL RBBP8 N-terminal like -2.89997
GARIN1A golgi associated RAB2 interactor 1A -2.89997
ATP10B ATPase, class V, type 10B -2.89997
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C -2.89997
FLRT3 fibronectin leucine rich transmembrane protein 3 -2.89997
CDH17 cadherin 17, LI cadherin (liver-intestine) -2.89997
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) -2.89997
AMH anti-Mullerian hormone -2.89997
JAML junction adhesion molecule like -2.89997
ADAM29 ADAM metallopeptidase domain 29 -2.89997
ITPRID1 ITPR interacting domain containing 1 -2.89997
BTNL8 butyrophilin-like 8 -2.89997
ANKRD63 ankyrin repeat domain 63 -2.89997
HLA-DMB major histocompatibility complex, class II, DM beta -2.89997
CD300LF CD300 molecule-like family member f -2.89997
PPP1R27 protein phosphatase 1, regulatory subunit 27 -2.89997
MEGF11 multiple EGF-like-domains 11 -2.89997
PPP1R9B protein phosphatase 1, regulatory subunit 9B -2.86395
CA4 carbonic anhydrase IV -2.77258
MOGS mannosyl-oligosaccharide glucosidase -2.77258
AVIL advillin -2.66092
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 -2.6571
ZFP82 ZFP82 zinc finger protein -2.6571
MAP1S microtubule-associated protein 1S -2.64934
TMC6 transmembrane channel-like 6 -2.59465
IFRD1 interferon-related developmental regulator 1 -2.58318
ALG9 ALG9, alpha-1,2-mannosyltransferase -2.54555
RAB6A RAB6A, member RAS oncogene family -2.52665
CREBL2 cAMP responsive element binding protein-like 2 -2.52665
SYNPO2 synaptopodin 2 -2.5049
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 -2.48612
DPYSL5 dihydropyrimidinase-like 5 -2.4822
PRMT2IP PRMT2 interacting protein -2.47546
DNAH8 dynein, axonemal, heavy chain 8 -2.45759
WDR74 WD repeat domain 74 -2.43919
TMEM147 transmembrane protein 147 -2.4225
PCDHB5 protocadherin beta 5 -2.41511
FAM111A family with sequence similarity 111, member A -2.38667
XKR4 XK, Kell blood group complex subunit-related family, member 4 -2.38667
TP73 tumor protein p73 -2.38477
TYW3 tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) -2.37515
THRB thyroid hormone receptor, beta -2.35863
FUBP3 far upstream element (FUSE) binding protein 3 -2.33794
SLC35E1 solute carrier family 35, member E1 -2.33709
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -2.31458
CRLF2 cytokine receptor-like factor 2 -2.30059
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -2.29985
RIMS2 regulating synaptic membrane exocytosis 2 -2.2604
RNF31 ring finger protein 31 -2.25346
ARHGAP4 Rho GTPase activating protein 4 -2.25127
PSPH phosphoserine phosphatase -2.24982
EOLA1 endothelium and lymphocyte associated ASCH domain 1 -2.24913
CUTA cutA divalent cation tolerance homolog (E. coli) -2.23251
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) -2.23197
LARP1B La ribonucleoprotein domain family, member 1B -2.21531
KIN Kin17 DNA and RNA binding protein -2.21042
WDPCP WD repeat containing planar cell polarity effector -2.21042
SLC35E4 solute carrier family 35, member E4 -2.20839
IFNAR2 interferon (alpha, beta and omega) receptor 2 -2.20141
RIPOR1 RHO family interacting cell polarization regulator 1 -2.16646
SAE1 SUMO1 activating enzyme subunit 1 -2.1536
NPAS3 neuronal PAS domain protein 3 -2.11295
BRAT1 BRCA1-associated ATM activator 1 -2.11015
SPINT1 serine peptidase inhibitor, Kunitz type 1 -2.10878
NUP42 nucleoporin 42 -2.10339
CDK16 cyclin-dependent kinase 16 -2.07897
GRID2 glutamate receptor, ionotropic, delta 2 -2.07897
RNPC3 RNA-binding region (RNP1, RRM) containing 3 -2.06772
BICRA BRD4 interacting chromatin remodeling complex associated protein -2.05546
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa -2.05342
HIP1R huntingtin interacting protein 1 related -2.03571
OR2A7 olfactory receptor, family 2, subfamily A, member 7 -2.02611
CCDC196 coiled-coil domain containing 196 -2.01718
ZNF25 zinc finger protein 25 -2.01718
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) -2.01718
FGF20 fibroblast growth factor 20 -2.00433