| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/1935 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Tacrine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH7 | myosin, heavy chain 7, cardiac muscle, beta | 1.0 |
| ALPK3 | alpha-kinase 3 | 0.95 |
| WNT10B | wingless-type MMTV integration site family, member 10B | 0.69 |
| SYN2 | synapsin II | 0.6 |
| CEP63 | centrosomal protein 63kDa | 0.58 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.55 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | 0.54 |
| SIVA1 | SIVA1, apoptosis-inducing factor | 0.54 |
| SERF2 | small EDRK-rich factor 2 | 0.53 |
| BAIAP2 | BAI1-associated protein 2 | 0.52 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.52 |
| ANKRD39 | ankyrin repeat domain 39 | 0.51 |
| RNF166 | ring finger protein 166 | 0.5 |
| GJB3 | gap junction protein, beta 3, 31kDa | 0.49 |
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | 0.49 |
| SH2D5 | SH2 domain containing 5 | 0.46 |
| ENO1 | enolase 1, (alpha) | 0.44 |
| RMI2 | RecQ mediated genome instability 2 | 0.43 |
| RNF8 | ring finger protein 8, E3 ubiquitin protein ligase | 0.42 |
| MTFR2 | mitochondrial fission regulator 2 | 0.41 |
| RGN | regucalcin | 0.41 |
| SP110 | SP110 nuclear body protein | 0.41 |
| DEDD | death effector domain containing | 0.41 |
| C2CD2L | C2CD2-like | 0.41 |
| BIRC5 | baculoviral IAP repeat containing 5 | 0.4 |
| MACC1 | metastasis associated in colon cancer 1 | 0.4 |
| BMP4 | bone morphogenetic protein 4 | 0.39 |
| ALG12 | ALG12, alpha-1,6-mannosyltransferase | 0.39 |
| FOSL1 | FOS-like antigen 1 | 0.39 |
| C12ORF60 | chromosome 12 open reading frame 60 | 0.39 |
| DEPDC1B | DEP domain containing 1B | 0.38 |
| PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | 0.38 |
| SNRK | SNF related kinase | 0.38 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 0.38 |
| GPATCH3 | G patch domain containing 3 | 0.37 |
| C8ORF76 | chromosome 8 open reading frame 76 | 0.37 |
| HLA-F | major histocompatibility complex, class I, F | 0.37 |
| ZUP1 | zinc finger containing ubiquitin peptidase 1 | 0.37 |
| CCDC82 | coiled-coil domain containing 82 | 0.37 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.37 |
| ODC1 | ornithine decarboxylase 1 | 0.36 |
| SOX7 | SRY (sex determining region Y)-box 7 | 0.36 |
| FAM171A1 | family with sequence similarity 171, member A1 | 0.36 |
| METAP1D | methionyl aminopeptidase type 1D (mitochondrial) | 0.36 |
| DNPH1 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | 0.36 |
| IL6ST | interleukin 6 signal transducer | 0.36 |
| FASTK | Fas-activated serine/threonine kinase | 0.35 |
| KLHL21 | kelch-like family member 21 | 0.35 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 0.35 |
| AMD1 | adenosylmethionine decarboxylase 1 | 0.35 |
| EXPH5 | exophilin 5 | 0.35 |
| CCNB1 | cyclin B1 | 0.35 |
| MID1IP1 | MID1 interacting protein 1 | 0.35 |
| JPH1 | junctophilin 1 | 0.34 |
| C12ORF73 | chromosome 12 open reading frame 73 | 0.34 |
| CEP290 | centrosomal protein 290kDa | 0.34 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.34 |
| ST3GAL4 | ST3 beta-galactoside alpha-2,3-sialyltransferase 4 | 0.33 |
| CCDC112 | coiled-coil domain containing 112 | 0.33 |
| CDC20 | cell division cycle 20 | 0.33 |
| MTRR | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | 0.33 |
| PLK1 | polo-like kinase 1 | 0.33 |
| MTSS2 | MTSS I-BAR domain containing 2 | 0.33 |
| WNT16 | wingless-type MMTV integration site family, member 16 | 0.32 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | 0.32 |
| CFAP97 | cilia and flagella associated protein 97 | 0.32 |
| SETMAR | SET domain and mariner transposase fusion gene | 0.32 |
| FOXM1 | forkhead box M1 | 0.32 |
| SEMA7A | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) | 0.32 |
| VIM | vimentin | 0.32 |
| UBE2C | ubiquitin-conjugating enzyme E2C | 0.32 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 0.31 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | 0.31 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.31 |
| PUS10 | pseudouridylate synthase 10 | 0.31 |
| AAGAB | alpha- and gamma-adaptin binding protein | 0.31 |
| SYTL3 | synaptotagmin-like 3 | 0.31 |
| PDRG1 | p53 and DNA-damage regulated 1 | 0.31 |
| NPRL3 | nitrogen permease regulator-like 3 (S. cerevisiae) | 0.31 |
| ZGRF1 | zinc finger, GRF-type containing 1 | 0.31 |
| KIFC3 | kinesin family member C3 | 0.3 |
| ZNF354B | zinc finger protein 354B | 0.3 |
| TNS4 | tensin 4 | 0.3 |
| DUSP7 | dual specificity phosphatase 7 | 0.3 |
| NFYB | nuclear transcription factor Y, beta | 0.3 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | 0.3 |
| TPM2 | tropomyosin 2 (beta) | 0.3 |
| CDC6 | cell division cycle 6 | 0.3 |
| METTL6 | methyltransferase like 6 | 0.3 |
| PHF20 | PHD finger protein 20 | 0.3 |
| DSE | dermatan sulfate epimerase | 0.3 |
| PRC1 | protein regulator of cytokinesis 1 | 0.3 |
| TM2D3 | TM2 domain containing 3 | 0.3 |
| GUCD1 | guanylyl cyclase domain containing 1 | 0.3 |
| GIGYF1 | GRB10 interacting GYF protein 1 | 0.29 |
| ERVMER34-1 | endogenous retrovirus group MER34, member 1 | 0.29 |
| GAS2L3 | growth arrest-specific 2 like 3 | 0.29 |
| HYLS1 | hydrolethalus syndrome 1 | 0.29 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.29 |
| CDCA4 | cell division cycle associated 4 | 0.29 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -1.24 |
| PLXNA3 | plexin A3 | -0.96 |
| TTN | titin | -0.94 |
| SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | -0.79 |
| POLR2M | polymerase (RNA) II (DNA directed) polypeptide M | -0.76 |
| PMF1 | polyamine-modulated factor 1 | -0.67 |
| ADGRL1 | adhesion G protein-coupled receptor L1 | -0.66 |
| XTBD1 | XRN2 binding domain containing 1 | -0.64 |
| DBNL | drebrin-like | -0.62 |
| SIRAL1 | SIR2 antiphage like 1 | -0.61 |
| E2F8 | E2F transcription factor 8 | -0.59 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -0.56 |
| ANO8 | anoctamin 8 | -0.56 |
| CARD8 | caspase recruitment domain family, member 8 | -0.53 |
| DEPTOR | DEP domain containing MTOR-interacting protein | -0.51 |
| AASS | aminoadipate-semialdehyde synthase | -0.51 |
| ZBTB49 | zinc finger and BTB domain containing 49 | -0.51 |
| RAB40C | RAB40C, member RAS oncogene family | -0.5 |
| TMEM64 | transmembrane protein 64 | -0.49 |
| CLGN | calmegin | -0.47 |
| MXRA7 | matrix-remodelling associated 7 | -0.45 |
| HBA1 | hemoglobin, alpha 1 | -0.44 |
| PCDH1 | protocadherin 1 | -0.44 |
| ACE | angiotensin I converting enzyme | -0.43 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.41 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | -0.41 |
| ACVR2A | activin A receptor, type IIA | -0.4 |
| RABAC1 | Rab acceptor 1 (prenylated) | -0.4 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.39 |
| KIAA1107 | KIAA1107 | -0.39 |
| MT1F | metallothionein 1F | -0.39 |
| NEBL | nebulette | -0.39 |
| SLC25A28 | solute carrier family 25 (mitochondrial iron transporter), member 28 | -0.38 |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 | -0.38 |
| KCTD18 | potassium channel tetramerization domain containing 18 | -0.38 |
| ELK1 | ELK1, member of ETS oncogene family | -0.37 |
| PLA2G6 | phospholipase A2, group VI (cytosolic, calcium-independent) | -0.37 |
| PYGM | phosphorylase, glycogen, muscle | -0.37 |
| CGNL1 | cingulin-like 1 | -0.37 |
| AHI1 | Abelson helper integration site 1 | -0.36 |
| DNAJC6 | DnaJ (Hsp40) homolog, subfamily C, member 6 | -0.36 |
| SLC25A39 | solute carrier family 25, member 39 | -0.36 |
| CD63 | CD63 molecule | -0.36 |
| TEC | tec protein tyrosine kinase | -0.36 |
| ARSD | arylsulfatase D | -0.36 |
| RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) | -0.36 |
| WWOX | WW domain containing oxidoreductase | -0.36 |
| ABCA7 | ATP-binding cassette, sub-family A (ABC1), member 7 | -0.36 |
| ABHD3 | abhydrolase domain containing 3 | -0.36 |
| GPRASP2 | G protein-coupled receptor associated sorting protein 2 | -0.36 |
| FIG4 | FIG4 phosphoinositide 5-phosphatase | -0.35 |
| GRN | granulin | -0.35 |
| SCARB2 | scavenger receptor class B, member 2 | -0.35 |
| GDF15 | growth differentiation factor 15 | -0.35 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.35 |
| TMSB10 | thymosin beta 10 | -0.34 |
| ATP9B | ATPase, class II, type 9B | -0.34 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.34 |
| CCDC158 | coiled-coil domain containing 158 | -0.34 |
| DST | dystonin | -0.34 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | -0.34 |
| DOLPP1 | dolichyldiphosphatase 1 | -0.33 |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | -0.33 |
| METTL26 | methyltransferase like 26 | -0.33 |
| NENF | neudesin neurotrophic factor | -0.33 |
| ZRSR2 | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 | -0.32 |
| RNF185 | ring finger protein 185 | -0.31 |
| THBS1 | thrombospondin 1 | -0.31 |
| IQCE | IQ motif containing E | -0.31 |
| CERS4 | ceramide synthase 4 | -0.31 |
| ADIRF | adipogenesis regulatory factor | -0.31 |
| GALNT12 | polypeptide N-acetylgalactosaminyltransferase 12 | -0.31 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | -0.31 |
| S100A6 | S100 calcium binding protein A6 | -0.31 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | -0.31 |
| MYOM3 | myomesin 3 | -0.31 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -0.3 |
| H1-0 | H1.0 linker histone | -0.3 |
| C18ORF32 | chromosome 18 open reading frame 32 | -0.3 |
| C6ORF136 | chromosome 6 open reading frame 136 | -0.3 |
| MTUS2 | microtubule associated tumor suppressor candidate 2 | -0.3 |
| SH3TC2 | SH3 domain and tetratricopeptide repeats 2 | -0.3 |
| MOSPD3 | motile sperm domain containing 3 | -0.3 |
| FN1 | fibronectin 1 | -0.3 |
| BBS2 | Bardet-Biedl syndrome 2 | -0.3 |
| AMPD1 | adenosine monophosphate deaminase 1 | -0.29 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | -0.29 |
| RBL2 | retinoblastoma-like 2 | -0.29 |
| ABHD13 | abhydrolase domain containing 13 | -0.29 |
| NUDT14 | nudix (nucleoside diphosphate linked moiety X)-type motif 14 | -0.28 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.28 |
| TMC4 | transmembrane channel-like 4 | -0.28 |
| SLC66A2 | solute carrier family 66 member 2 | -0.28 |
| CUX1 | cut-like homeobox 1 | -0.28 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | -0.28 |
| RBKS | ribokinase | -0.28 |
| TEX15 | testis expressed 15 | -0.28 |
| APOE | apolipoprotein E | -0.27 |
| ENPP4 | ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) | -0.27 |
