| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/445643 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Tacrolimus relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PRELID3B | PRELI domain containing 3B | 0.84 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.79 |
| ZBED2 | zinc finger, BED-type containing 2 | 0.59 |
| PRELID1 | PRELI domain containing 1 | 0.57 |
| MMADHC | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria | 0.55 |
| RCAN1 | regulator of calcineurin 1 | 0.54 |
| FAN1 | FANCD2/FANCI-associated nuclease 1 | 0.52 |
| CREBZF | CREB/ATF bZIP transcription factor | 0.46 |
| ORMDL1 | ORMDL sphingolipid biosynthesis regulator 1 | 0.44 |
| ZDHHC23 | zinc finger, DHHC-type containing 23 | 0.44 |
| ATP23 | ATP23 metallopeptidase and ATP synthase assembly factor homolog | 0.42 |
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | 0.41 |
| SAPCD2 | suppressor APC domain containing 2 | 0.41 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.39 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.39 |
| SH3BGRL2 | SH3 domain binding glutamate-rich protein like 2 | 0.37 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.37 |
| SYTL2 | synaptotagmin-like 2 | 0.36 |
| STYK1 | serine/threonine/tyrosine kinase 1 | 0.36 |
| KLHL29 | kelch-like family member 29 | 0.33 |
| MYH8 | myosin, heavy chain 8, skeletal muscle, perinatal | 0.33 |
| TMEM41B | transmembrane protein 41B | 0.33 |
| C6ORF47 | chromosome 6 open reading frame 47 | 0.33 |
| TIMM8B | translocase of inner mitochondrial membrane 8 homolog B (yeast) | 0.33 |
| GDE1 | glycerophosphodiester phosphodiesterase 1 | 0.31 |
| WDR90 | WD repeat domain 90 | 0.31 |
| MPV17L2 | MPV17 mitochondrial membrane protein-like 2 | 0.31 |
| GATA2 | GATA binding protein 2 | 0.3 |
| LTO1 | LTO1 maturation factor of ABCE1 | 0.29 |
| F10 | coagulation factor X | 0.29 |
| ZNF12 | zinc finger protein 12 | 0.28 |
| SLC25A28 | solute carrier family 25 (mitochondrial iron transporter), member 28 | 0.28 |
| ARHGEF37 | Rho guanine nucleotide exchange factor (GEF) 37 | 0.27 |
| TNNC2 | troponin C type 2 (fast) | 0.27 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.27 |
| ADM | adrenomedullin | 0.27 |
| CLTA | clathrin, light chain A | 0.27 |
| SDR16C5 | short chain dehydrogenase/reductase family 16C, member 5 | 0.26 |
| SH3TC1 | SH3 domain and tetratricopeptide repeats 1 | 0.26 |
| MLX | MLX, MAX dimerization protein | 0.26 |
| MFSD8 | major facilitator superfamily domain containing 8 | 0.26 |
| RTN2 | reticulon 2 | 0.26 |
| HSCB | HscB mitochondrial iron-sulfur cluster co-chaperone | 0.26 |
| CASC4 | cancer susceptibility candidate 4 | 0.26 |
| GPATCH2L | G patch domain containing 2-like | 0.26 |
| DNAJC22 | DnaJ (Hsp40) homolog, subfamily C, member 22 | 0.26 |
| AGPAT1 | 1-acylglycerol-3-phosphate O-acyltransferase 1 | 0.26 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | 0.25 |
| IQCG | IQ motif containing G | 0.25 |
| ZNF91 | zinc finger protein 91 | 0.25 |
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 0.25 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.25 |
| VWA1 | von Willebrand factor A domain containing 1 | 0.25 |
| CYB5A | cytochrome b5 type A (microsomal) | 0.25 |
| ABCF1 | ATP-binding cassette, sub-family F (GCN20), member 1 | 0.25 |
| GRSF1 | G-rich RNA sequence binding factor 1 | 0.25 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | 0.24 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | 0.24 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | 0.24 |
| PIF1 | PIF1 5'-to-3' DNA helicase | 0.24 |
| DUSP14 | dual specificity phosphatase 14 | 0.24 |
| ROGDI | rogdi homolog (Drosophila) | 0.24 |
| SMAP1 | small ArfGAP 1 | 0.24 |
| TAF1B | TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa | 0.23 |
| MT1L | metallothionein 1L (gene/pseudogene) | 0.23 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.23 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.22 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | 0.22 |
| DUSP22 | dual specificity phosphatase 22 | 0.22 |
| CCDC150 | coiled-coil domain containing 150 | 0.22 |
| FAM241B | family with sequence similarity 241 member B | 0.22 |
| BEND7 | BEN domain containing 7 | 0.22 |
| PDE7A | phosphodiesterase 7A | 0.22 |
| COBLL1 | cordon-bleu WH2 repeat protein-like 1 | 0.22 |
| FRRS1 | ferric-chelate reductase 1 | 0.22 |
| PSEN2 | presenilin 2 | 0.22 |
| FSD1L | fibronectin type III and SPRY domain containing 1-like | 0.21 |
| UBE2G2 | ubiquitin-conjugating enzyme E2G 2 | 0.21 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.21 |
| CNEP1R1 | CTD nuclear envelope phosphatase 1 regulatory subunit 1 | 0.21 |
| ERVK3-1 | endogenous retrovirus group K3, member 1 | 0.21 |
| UBXN8 | UBX domain protein 8 | 0.21 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.21 |
| TMEM143 | transmembrane protein 143 | 0.21 |
| CALU | calumenin | 0.2 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.2 |
| FANCF | Fanconi anemia, complementation group F | 0.2 |
| MT1E | metallothionein 1E | 0.2 |
| DBF4 | DBF4 zinc finger | 0.2 |
| CEP70 | centrosomal protein 70kDa | 0.2 |
| IER5 | immediate early response 5 | 0.2 |
| PAQR4 | progestin and adipoQ receptor family member IV | 0.2 |
| NECAB3 | N-terminal EF-hand calcium binding protein 3 | 0.2 |
| CHSY3 | chondroitin sulfate synthase 3 | 0.2 |
| GABPB1 | GA binding protein transcription factor, beta subunit 1 | 0.2 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.2 |
| HMOX1 | heme oxygenase 1 | 0.2 |
| GTSF1 | gametocyte specific factor 1 | 0.2 |
| FNTB | farnesyltransferase, CAAX box, beta | 0.2 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC29A2 | solute carrier family 29 (equilibrative nucleoside transporter), member 2 | -1.27 |
| ALPK3 | alpha-kinase 3 | -1.03 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | -1.0 |
| TMEM126B | transmembrane protein 126B | -0.82 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | -0.78 |
| EVA1C | eva-1 homolog C (C. elegans) | -0.72 |
| MTERF2 | mitochondrial transcription termination factor 2 | -0.69 |
| COL6A6 | collagen, type VI, alpha 6 | -0.68 |
| TMEM106C | transmembrane protein 106C | -0.65 |
| ADCY10 | adenylate cyclase 10 (soluble) | -0.65 |
| PET100 | PET100 homolog (S. cerevisiae) | -0.65 |
| HRH1 | histamine receptor H1 | -0.62 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -0.6 |
| ABCB4 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | -0.59 |
| MTFMT | mitochondrial methionyl-tRNA formyltransferase | -0.58 |
| SCN11A | sodium channel, voltage gated, type XI alpha subunit | -0.58 |
| COX7A2L | cytochrome c oxidase subunit VIIa polypeptide 2 like | -0.57 |
| NUDT6 | nudix (nucleoside diphosphate linked moiety X)-type motif 6 | -0.57 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.57 |
| CFAP58 | cilia and flagella associated protein 58 | -0.56 |
| CRTC1 | CREB regulated transcription coactivator 1 | -0.55 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.54 |
| POF1B | premature ovarian failure, 1B | -0.54 |
| MICU1 | mitochondrial calcium uptake 1 | -0.54 |
| COL13A1 | collagen, type XIII, alpha 1 | -0.53 |
| MTRF1L | mitochondrial translational release factor 1-like | -0.53 |
| ULK1 | unc-51 like autophagy activating kinase 1 | -0.52 |
| MTRF1 | mitochondrial translational release factor 1 | -0.52 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.52 |
| ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | -0.51 |
| CLCN3 | chloride channel, voltage-sensitive 3 | -0.51 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.5 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.5 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.5 |
| KLC1 | kinesin light chain 1 | -0.49 |
| COA1 | cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) | -0.48 |
| NSUN3 | NOP2/Sun domain family, member 3 | -0.48 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | -0.47 |
| ACAD10 | acyl-CoA dehydrogenase family, member 10 | -0.47 |
| ZBTB4 | zinc finger and BTB domain containing 4 | -0.46 |
| NAA38 | N(alpha)-acetyltransferase 38, NatC auxiliary subunit | -0.45 |
| FASTKD3 | FAST kinase domains 3 | -0.45 |
| FER1L5 | fer-1-like family member 5 | -0.45 |
| ZNF107 | zinc finger protein 107 | -0.45 |
| XBP1 | X-box binding protein 1 | -0.43 |
| MTFP1 | mitochondrial fission process 1 | -0.43 |
| NME6 | NME/NM23 nucleoside diphosphate kinase 6 | -0.43 |
| BMPR1B | bone morphogenetic protein receptor, type IB | -0.43 |
| ACTL8 | actin-like 8 | -0.43 |
| RECK | reversion-inducing-cysteine-rich protein with kazal motifs | -0.43 |
| PLIN2 | perilipin 2 | -0.42 |
| SPATA7 | spermatogenesis associated 7 | -0.42 |
| PUSL1 | pseudouridylate synthase-like 1 | -0.42 |
| RGN | regucalcin | -0.42 |
| HDHD3 | haloacid dehalogenase-like hydrolase domain containing 3 | -0.41 |
| ACVR1 | activin A receptor, type I | -0.41 |
| COA3 | cytochrome c oxidase assembly factor 3 | -0.41 |
| KLF13 | Kruppel-like factor 13 | -0.41 |
| SUOX | sulfite oxidase | -0.41 |
| AADAT | aminoadipate aminotransferase | -0.4 |
| MLYCD | malonyl-CoA decarboxylase | -0.4 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | -0.4 |
| PROSER3 | proline and serine rich 3 | -0.38 |
| CACNA1E | calcium channel, voltage-dependent, R type, alpha 1E subunit | -0.38 |
| TMEM70 | transmembrane protein 70 | -0.38 |
| SLC25A15 | solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 | -0.37 |
| SFXN2 | sideroflexin 2 | -0.37 |
| DCHS1 | dachsous cadherin-related 1 | -0.37 |
| NEU3 | sialidase 3 (membrane sialidase) | -0.37 |
| SLC25A22 | solute carrier family 25 (mitochondrial carrier: glutamate), member 22 | -0.36 |
| MICU2 | mitochondrial calcium uptake 2 | -0.36 |
| MMAA | methylmalonic aciduria (cobalamin deficiency) cblA type | -0.36 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.36 |
| LETMD1 | LETM1 domain containing 1 | -0.36 |
| CPOX | coproporphyrinogen oxidase | -0.36 |
| CISD3 | CDGSH iron sulfur domain 3 | -0.35 |
| ZNF239 | zinc finger protein 239 | -0.35 |
| TAF10 | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa | -0.34 |
| PNKD | paroxysmal nonkinesigenic dyskinesia | -0.34 |
| DYNC2LI1 | dynein, cytoplasmic 2, light intermediate chain 1 | -0.34 |
| COQ7 | coenzyme Q7 homolog, ubiquinone (yeast) | -0.34 |
| MCUR1 | mitochondrial calcium uniporter regulator 1 | -0.33 |
| TGFBR1 | transforming growth factor, beta receptor 1 | -0.33 |
| SDR39U1 | short chain dehydrogenase/reductase family 39U, member 1 | -0.33 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.33 |
| MCEE | methylmalonyl CoA epimerase | -0.33 |
| PRXL2B | peroxiredoxin like 2B | -0.33 |
| FANCL | Fanconi anemia, complementation group L | -0.33 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | -0.32 |
| CRTC2 | CREB regulated transcription coactivator 2 | -0.32 |
| TMEM126A | transmembrane protein 126A | -0.32 |
| DNAJC30 | DnaJ (Hsp40) homolog, subfamily C, member 30 | -0.31 |
| MTG1 | mitochondrial ribosome-associated GTPase 1 | -0.31 |
| PLEC | plectin | -0.31 |
| MRPL55 | mitochondrial ribosomal protein L55 | -0.31 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.3 |
| COQ2 | coenzyme Q2 4-hydroxybenzoate polyprenyltransferase | -0.3 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.3 |
| COQ9 | coenzyme Q9 | -0.3 |
| MBP | myelin basic protein | -0.3 |
