| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/110635 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Tadalafil relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| YPEL5 | yippee-like 5 (Drosophila) | 1.64 |
| SETD9 | SET domain containing 9 | 1.12 |
| ITGB5 | integrin, beta 5 | 1.1 |
| CHST3 | carbohydrate (chondroitin 6) sulfotransferase 3 | 1.08 |
| ZNF646 | zinc finger protein 646 | 1.07 |
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | 1.06 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | 0.81 |
| RNF139 | ring finger protein 139 | 0.64 |
| TYRO3 | TYRO3 protein tyrosine kinase | 0.61 |
| PLEKHN1 | pleckstrin homology domain containing, family N member 1 | 0.61 |
| PJA1 | praja ring finger 1, E3 ubiquitin protein ligase | 0.6 |
| NEK4 | NIMA-related kinase 4 | 0.56 |
| FGFR1OP2 | FGFR1 oncogene partner 2 | 0.56 |
| EWSR1 | EWS RNA-binding protein 1 | 0.55 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | 0.5 |
| F13A1 | coagulation factor XIII, A1 polypeptide | 0.5 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.5 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 0.5 |
| TNNC2 | troponin C type 2 (fast) | 0.5 |
| NMI | N-myc (and STAT) interactor | 0.48 |
| MAN2C1 | mannosidase, alpha, class 2C, member 1 | 0.46 |
| RNF181 | ring finger protein 181 | 0.46 |
| FGF2 | fibroblast growth factor 2 (basic) | 0.45 |
| FBXW2 | F-box and WD repeat domain containing 2 | 0.44 |
| ABHD5 | abhydrolase domain containing 5 | 0.44 |
| FBXO41 | F-box protein 41 | 0.44 |
| H2AZ1 | H2A.Z variant histone 1 | 0.44 |
| SLC16A7 | solute carrier family 16 (monocarboxylate transporter), member 7 | 0.43 |
| RANBP10 | RAN binding protein 10 | 0.43 |
| ZFP64 | ZFP64 zinc finger protein | 0.43 |
| CCDC170 | coiled-coil domain containing 170 | 0.42 |
| TANGO2 | transport and golgi organization 2 homolog (Drosophila) | 0.42 |
| FN1 | fibronectin 1 | 0.41 |
| RCOR1 | REST corepressor 1 | 0.4 |
| SLC4A11 | solute carrier family 4, sodium borate transporter, member 11 | 0.4 |
| CCDC43 | coiled-coil domain containing 43 | 0.39 |
| PPP1R3D | protein phosphatase 1, regulatory subunit 3D | 0.38 |
| MAGEA12 | melanoma antigen family A12 | 0.38 |
| BCAS2 | breast carcinoma amplified sequence 2 | 0.38 |
| RPS19BP1 | ribosomal protein S19 binding protein 1 | 0.38 |
| AP5S1 | adaptor-related protein complex 5, sigma 1 subunit | 0.37 |
| TSPAN9 | tetraspanin 9 | 0.37 |
| UQCR10 | ubiquinol-cytochrome c reductase, complex III subunit X | 0.37 |
| HSPG2 | heparan sulfate proteoglycan 2 | 0.36 |
| LRFN3 | leucine rich repeat and fibronectin type III domain containing 3 | 0.36 |
| ADIRF | adipogenesis regulatory factor | 0.35 |
| HYLS1 | hydrolethalus syndrome 1 | 0.35 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | 0.35 |
| PISD | phosphatidylserine decarboxylase | 0.34 |
| ANAPC16 | anaphase promoting complex subunit 16 | 0.34 |
| GTF3C6 | general transcription factor IIIC, polypeptide 6, alpha 35kDa | 0.33 |
| CD320 | CD320 molecule | 0.33 |
| DST | dystonin | 0.33 |
| MRC2 | mannose receptor, C type 2 | 0.33 |
| ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | 0.32 |
| FIG4 | FIG4 phosphoinositide 5-phosphatase | 0.32 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.32 |
| BIRC5 | baculoviral IAP repeat containing 5 | 0.32 |
| TRMO | tRNA methyltransferase O | 0.32 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.32 |
| RPL36AL | ribosomal protein L36a-like | 0.32 |
| ZBTB1 | zinc finger and BTB domain containing 1 | 0.31 |
| RNASEH2C | ribonuclease H2, subunit C | 0.31 |
| TMEM248 | transmembrane protein 248 | 0.31 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.31 |
| TIGD5 | tigger transposable element derived 5 | 0.31 |
| FBLIM1 | filamin binding LIM protein 1 | 0.3 |
| FZD1 | frizzled class receptor 1 | 0.3 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.3 |
| CLTA | clathrin, light chain A | 0.29 |
| OPHN1 | oligophrenin 1 | 0.29 |
| INTS5 | integrator complex subunit 5 | 0.29 |
| CHTF8 | CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) | 0.29 |
| GPATCH2L | G patch domain containing 2-like | 0.28 |
| SGMS1 | sphingomyelin synthase 1 | 0.28 |
| TAF12 | TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa | 0.28 |
| SERPINC1 | serpin peptidase inhibitor, clade C (antithrombin), member 1 | 0.28 |
| TMEM219 | transmembrane protein 219 | 0.28 |
| SON | SON DNA binding protein | 0.28 |
| BNIP2 | BCL2/adenovirus E1B 19kDa interacting protein 2 | 0.28 |
| GID8 | GID complex subunit 8 | 0.27 |
| GRID1 | glutamate receptor, ionotropic, delta 1 | 0.27 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 0.27 |
| GLB1L2 | galactosidase, beta 1-like 2 | 0.27 |
| COA7 | cytochrome c oxidase assembly factor 7 (putative) | 0.27 |
| RABEP2 | rabaptin, RAB GTPase binding effector protein 2 | 0.27 |
| CPOX | coproporphyrinogen oxidase | 0.27 |
| ZNF408 | zinc finger protein 408 | 0.27 |
| ZNF580 | zinc finger protein 580 | 0.27 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 0.27 |
| PAIP2 | poly(A) binding protein interacting protein 2 | 0.26 |
| BORCS5 | BLOC-1 related complex subunit 5 | 0.26 |
| HSPA8 | heat shock 70kDa protein 8 | 0.26 |
| ERVMER34-1 | endogenous retrovirus group MER34, member 1 | 0.26 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.26 |
| AMDHD2 | amidohydrolase domain containing 2 | 0.26 |
| CGNL1 | cingulin-like 1 | 0.26 |
| CAB39L | calcium binding protein 39-like | 0.26 |
| CYBRD1 | cytochrome b reductase 1 | 0.26 |
| ISCA2 | iron-sulfur cluster assembly 2 | 0.26 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CCNDBP1 | cyclin D-type binding-protein 1 | -0.96 |
| DCHS1 | dachsous cadherin-related 1 | -0.66 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | -0.52 |
| ZNF35 | zinc finger protein 35 | -0.49 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.48 |
| MYH6 | myosin, heavy chain 6, cardiac muscle, alpha | -0.47 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.46 |
| CUL7 | cullin 7 | -0.46 |
| SLC35A4 | solute carrier family 35, member A4 | -0.45 |
| ENO1 | enolase 1, (alpha) | -0.45 |
| PRKD3 | protein kinase D3 | -0.44 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.44 |
| MFHAS1 | malignant fibrous histiocytoma amplified sequence 1 | -0.43 |
| CHST12 | carbohydrate (chondroitin 4) sulfotransferase 12 | -0.43 |
| MATR3 | matrin 3 | -0.43 |
| PLXNA3 | plexin A3 | -0.43 |
| UNKL | unkempt family zinc finger-like | -0.42 |
| GUCD1 | guanylyl cyclase domain containing 1 | -0.42 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | -0.42 |
| HGFAC | HGF activator | -0.42 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.4 |
| LYST | lysosomal trafficking regulator | -0.39 |
| ZNF672 | zinc finger protein 672 | -0.38 |
| ZFYVE28 | zinc finger, FYVE domain containing 28 | -0.38 |
| ZNF440 | zinc finger protein 440 | -0.38 |
| LRRIQ1 | leucine-rich repeats and IQ motif containing 1 | -0.37 |
| ATP9B | ATPase, class II, type 9B | -0.37 |
| LYPD3 | LY6/PLAUR domain containing 3 | -0.37 |
| PLPP6 | phospholipid phosphatase 6 | -0.36 |
| PTBP1 | polypyrimidine tract binding protein 1 | -0.36 |
| SLC25A29 | solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 | -0.36 |
| CTSA | cathepsin A | -0.35 |
| ALS2CL | ALS2 C-terminal like | -0.35 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.35 |
| LETMD1 | LETM1 domain containing 1 | -0.35 |
| PDE9A | phosphodiesterase 9A | -0.35 |
| SBSN | suprabasin | -0.35 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | -0.34 |
| COL7A1 | collagen, type VII, alpha 1 | -0.34 |
| AFG1L | AFG1 like ATPase | -0.34 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | -0.33 |
| CCPG1 | cell cycle progression 1 | -0.33 |
| TRADD | TNFRSF1A-associated via death domain | -0.33 |
| MSMO1 | methylsterol monooxygenase 1 | -0.33 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.33 |
| PROSER1 | proline and serine rich 1 | -0.33 |
| CYB5R1 | cytochrome b5 reductase 1 | -0.32 |
| ATE1 | arginyltransferase 1 | -0.32 |
| MOCS1 | molybdenum cofactor synthesis 1 | -0.32 |
| DCHS2 | dachsous cadherin-related 2 | -0.31 |
| DPP4 | dipeptidyl-peptidase 4 | -0.31 |
| SYVN1 | synovial apoptosis inhibitor 1, synoviolin | -0.3 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.3 |
| TRHDE | thyrotropin-releasing hormone degrading enzyme | -0.3 |
| TMEM128 | transmembrane protein 128 | -0.29 |
| TTC7A | tetratricopeptide repeat domain 7A | -0.29 |
| ADGRL1 | adhesion G protein-coupled receptor L1 | -0.29 |
| EPB41L4B | erythrocyte membrane protein band 4.1 like 4B | -0.29 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | -0.29 |
| MARS2 | methionyl-tRNA synthetase 2, mitochondrial | -0.29 |
| EPM2AIP1 | EPM2A (laforin) interacting protein 1 | -0.29 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | -0.28 |
| RAB5IF | RAB5 interacting factor | -0.28 |
| KDM6B | lysine (K)-specific demethylase 6B | -0.28 |
| FADS1 | fatty acid desaturase 1 | -0.28 |
| CCNI | cyclin I | -0.28 |
| SERINC3 | serine incorporator 3 | -0.28 |
| KALRN | kalirin, RhoGEF kinase | -0.27 |
| SCNM1 | sodium channel modifier 1 | -0.27 |
| CLN8 | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) | -0.27 |
| SLC25A21 | solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 | -0.27 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | -0.27 |
| MEST | mesoderm specific transcript | -0.27 |
| CDK14 | cyclin-dependent kinase 14 | -0.27 |
| PPCDC | phosphopantothenoylcysteine decarboxylase | -0.27 |
| DNAH12 | dynein, axonemal, heavy chain 12 | -0.27 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | -0.27 |
| TLR3 | toll-like receptor 3 | -0.26 |
| ZFYVE1 | zinc finger, FYVE domain containing 1 | -0.26 |
| CLDND1 | claudin domain containing 1 | -0.26 |
| KBTBD8 | kelch repeat and BTB (POZ) domain containing 8 | -0.26 |
| USP53 | ubiquitin specific peptidase 53 | -0.26 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.26 |
| E2F7 | E2F transcription factor 7 | -0.25 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.25 |
| FBXO17 | F-box protein 17 | -0.25 |
| CCNA1 | cyclin A1 | -0.25 |
| PIK3CD | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta | -0.25 |
| NDFIP2 | Nedd4 family interacting protein 2 | -0.25 |
| PRELID1 | PRELI domain containing 1 | -0.25 |
| ZFP36 | ZFP36 ring finger protein | -0.25 |
| S100A10 | S100 calcium binding protein A10 | -0.25 |
| RAB27B | RAB27B, member RAS oncogene family | -0.25 |
| RNF115 | ring finger protein 115 | -0.25 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.24 |
| NOTCH3 | notch 3 | -0.24 |
| FRS2 | fibroblast growth factor receptor substrate 2 | -0.24 |
| FMNL1 | formin-like 1 | -0.24 |
| KCNK5 | potassium channel, two pore domain subfamily K, member 5 | -0.24 |
