Tadalafil_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tadalafil perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tadalafil_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.244026
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.21591
IGFBP3 insulin-like growth factor binding protein 3 0.130419
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.120335
AUTS2 autism susceptibility candidate 2 0.108862
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.100076
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0984851
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0930458
ZFP36L1 ZFP36 ring finger protein-like 1 0.0767175
AHNAK AHNAK nucleoprotein 0.0716122
ATP13A3 ATPase type 13A3 0.0700789
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0672101
CDH13 cadherin 13 0.0657124
TMSB10 thymosin beta 10 0.0620302
BHLHE40 basic helix-loop-helix family, member e40 0.0588513
MSI2 musashi RNA-binding protein 2 0.0575728
COL8A1 collagen, type VIII, alpha 1 0.0567797
ELL2 elongation factor, RNA polymerase II, 2 0.0532757
DLG1 discs, large homolog 1 (Drosophila) 0.0525567
ABI3BP ABI family, member 3 (NESH) binding protein 0.0523293
WTAP Wilms tumor 1 associated protein 0.0516967
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.047209
SDK1 sidekick cell adhesion molecule 1 0.0466502
ANKRD11 ankyrin repeat domain 11 0.0460799
WAC WW domain containing adaptor with coiled-coil 0.0458557
FNDC3B fibronectin type III domain containing 3B 0.0456066
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0455794
SOD2 superoxide dismutase 2, mitochondrial 0.0453435
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0434892
ADAM17 ADAM metallopeptidase domain 17 0.0426661
ZEB1 zinc finger E-box binding homeobox 1 0.0421857
NT5C2 5'-nucleotidase, cytosolic II 0.0409948
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0407549
FGF13 fibroblast growth factor 13 0.040286
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0399199
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0393236
TFG TRK-fused gene 0.0390429
ZEB2 zinc finger E-box binding homeobox 2 0.0377712
MB21D2 Mab-21 domain containing 2 0.0374696
LPCAT2 lysophosphatidylcholine acyltransferase 2 0.0372769
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.037187
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0371442
CYLD cylindromatosis (turban tumor syndrome) 0.0370286
ARL15 ADP-ribosylation factor-like 15 0.0369224
MED13L mediator complex subunit 13-like 0.0368137
KMT2C lysine (K)-specific methyltransferase 2C 0.0367958
CD109 CD109 molecule 0.0367106
PGK1 phosphoglycerate kinase 1 0.0363655
RICTOR RPTOR independent companion of MTOR, complex 2 0.0359341
RNF145 ring finger protein 145 0.0358402
DENND5A DENN/MADD domain containing 5A 0.0355653
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.035357
KDM6A lysine (K)-specific demethylase 6A 0.0349251
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0347709
SLC39A11 solute carrier family 39, member 11 0.0345318
ENO2 enolase 2 (gamma, neuronal) 0.0344521
FMNL2 formin-like 2 0.0342016
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0340896
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.034061
SPAG9 sperm associated antigen 9 0.0339665
B2M beta-2-microglobulin 0.0333814
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0332781
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0331839
GLS2 glutaminase 2 (liver, mitochondrial) 0.0330234
MT2A metallothionein 2A 0.0327345
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0327007
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0318724
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0317371
FAM162A family with sequence similarity 162, member A 0.0316321
MMP12 matrix metallopeptidase 12 0.0307224
LPP LIM domain containing preferred translocation partner in lipoma 0.0307135
HELZ helicase with zinc finger 0.0306359
MRPS6 mitochondrial ribosomal protein S6 0.0305137
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0298894
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0296627
PIAS1 protein inhibitor of activated STAT, 1 0.029637
RUNX1 runt-related transcription factor 1 0.0294897
GPBP1 GC-rich promoter binding protein 1 0.0293364
XPO1 exportin 1 0.0291625
KIF13A kinesin family member 13A 0.0288921
NDRG1 N-myc downstream regulated 1 0.0288286
GARS1 glycyl-tRNA synthetase 1 0.0287346
HMBOX1 homeobox containing 1 0.0286451
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.028359
KDM3A lysine (K)-specific demethylase 3A 0.0283325
RAB18 RAB18, member RAS oncogene family 0.028321
VEGFC vascular endothelial growth factor C 0.0282276
PCGF5 polycomb group ring finger 5 0.0280785
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0279375
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0277801
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0275713
SEC24A SEC24 family member A 0.0274619
NAMPT nicotinamide phosphoribosyltransferase 0.027327
KMT2E lysine (K)-specific methyltransferase 2E 0.0271374
FBN1 fibrillin 1 0.027121
FAM13B family with sequence similarity 13, member B 0.0270285
LCOR ligand dependent nuclear receptor corepressor 0.0269462
CNOT8 CCR4-NOT transcription complex, subunit 8 0.0268785
WSB1 WD repeat and SOCS box containing 1 0.026559
RAB8B RAB8B, member RAS oncogene family 0.0258936

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.192199
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.173454
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.12376
PODXL podocalyxin-like -0.0905977
CD44 CD44 molecule (Indian blood group) -0.0889581
LDHA lactate dehydrogenase A -0.0721407
STC1 stanniocalcin 1 -0.068001
AKAP12 A kinase (PRKA) anchor protein 12 -0.0670726
TMSB4X thymosin beta 4, X-linked -0.0666753
VIM vimentin -0.0649755
COL1A2 collagen, type I, alpha 2 -0.0597351
LOC112694756 uncharaterized LOC112694756 -0.0593621
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0585752
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.055013
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.054908
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0510677
COL5A2 collagen, type V, alpha 2 -0.0506753
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0492722
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0477363
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0468479
POTEF POTE ankyrin domain family, member F -0.0466483
PKM pyruvate kinase, muscle -0.0455108
ERRFI1 ERBB receptor feedback inhibitor 1 -0.045487
CTSB cathepsin B -0.0446008
FLNA filamin A, alpha -0.0430511
EEF2 eukaryotic translation elongation factor 2 -0.042397
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0399788
ASPH aspartate beta-hydroxylase -0.0391888
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0387858
ANXA2 annexin A2 -0.0384263
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0383657
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0370853
SMYD3 SET and MYND domain containing 3 -0.036341
OPTN optineurin -0.0363297
RPS24 ribosomal protein S24 -0.0356507
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0355362
S100A6 S100 calcium binding protein A6 -0.0355282
ADAR adenosine deaminase, RNA-specific -0.0355031
CAVIN1 caveolae associated protein 1 -0.0347727
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0347603
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0347366
AKAP9 A kinase (PRKA) anchor protein 9 -0.0346996
CANX calnexin -0.0346982
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0342782
MYO9A myosin IXA -0.0342525
SQSTM1 sequestosome 1 -0.0341474
AHNAK2 AHNAK nucleoprotein 2 -0.0335573
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0334542
TPT1 tumor protein, translationally-controlled 1 -0.0332191
MYH9 myosin, heavy chain 9, non-muscle -0.0331541
ARFGEF3 ARFGEF family member 3 -0.0327463
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.03259
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0322151
SMC4 structural maintenance of chromosomes 4 -0.03198
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0319001
ARF1 ADP-ribosylation factor 1 -0.0317886
AVL9 AVL9 homolog (S. cerevisiase) -0.0314835
S100A4 S100 calcium binding protein A4 -0.0314553
WWTR1 WW domain containing transcription regulator 1 -0.0313494
MAP1B microtubule-associated protein 1B -0.0306193
ARRDC3 arrestin domain containing 3 -0.0305297
CENPF centromere protein F, 350/400kDa -0.0304358
COL3A1 collagen, type III, alpha 1 -0.0303689
TXNRD1 thioredoxin reductase 1 -0.0296306
CLU clusterin -0.029466
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0294286
ANXA4 annexin A4 -0.0291901
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0290432
IFI16 interferon, gamma-inducible protein 16 -0.0289462
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0287296
OSMR oncostatin M receptor -0.028593
DPYSL2 dihydropyrimidinase-like 2 -0.028466
FSTL1 follistatin-like 1 -0.0283544
FBXL7 F-box and leucine-rich repeat protein 7 -0.028352
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.028309
DSPP dentin sialophosphoprotein -0.0283045
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0280235
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0277862
TPM4 tropomyosin 4 -0.0277627
DPYSL3 dihydropyrimidinase-like 3 -0.0277433
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0276763
TPM3 tropomyosin 3 -0.0272573
LOX lysyl oxidase -0.0272517
VEGFA vascular endothelial growth factor A -0.0269602
GOLM2 golgi membrane protein 2 -0.0265424
FADS2 fatty acid desaturase 2 -0.0264759
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0263027
TAGLN2 transgelin 2 -0.0258732
BPTF bromodomain PHD finger transcription factor -0.0255652
SET SET nuclear proto-oncogene -0.0255378
NID1 nidogen 1 -0.0254522
PNISR PNN-interacting serine/arginine-rich protein -0.0252605
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0251984
SMC5 structural maintenance of chromosomes 5 -0.025158
DDB2 damage-specific DNA binding protein 2, 48kDa -0.0250277
CDK6 cyclin-dependent kinase 6 -0.0248633
EGFR epidermal growth factor receptor -0.024797
PRKCE protein kinase C, epsilon -0.0247143
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.024466
HLA-C major histocompatibility complex, class I, C -0.0241713