| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tadalafil perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tadalafil_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0598968 |
| MGAT4C | MGAT4 family, member C | 0.0565405 |
| CCNL1 | cyclin L1 | 0.0456722 |
| MED13L | mediator complex subunit 13-like | 0.0428613 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0427183 |
| XPO1 | exportin 1 | 0.0420246 |
| ECT2 | epithelial cell transforming 2 | 0.0392903 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0363617 |
| CDK17 | cyclin-dependent kinase 17 | 0.0358214 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.03582 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0335423 |
| TNPO1 | transportin 1 | 0.0328621 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0325536 |
| ZNF292 | zinc finger protein 292 | 0.0323153 |
| NEK7 | NIMA-related kinase 7 | 0.031549 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0312922 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0295891 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.029543 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0289783 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0289159 |
| TMEM41B | transmembrane protein 41B | 0.0283143 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0283091 |
| CPOX | coproporphyrinogen oxidase | 0.0281997 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0273397 |
| MATR3 | matrin 3 | 0.0271146 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0270348 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0266368 |
| CEP192 | centrosomal protein 192kDa | 0.0266151 |
| EPHA6 | EPH receptor A6 | 0.0254743 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0251503 |
| THOC1 | THO complex 1 | 0.0250697 |
| GASK1B | golgi associated kinase 1B | 0.0239979 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.023885 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0238348 |
| NCKAP1 | NCK-associated protein 1 | 0.0237452 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0237173 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.02357 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0235232 |
| OGA | O-GlcNAcase | 0.0233286 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0230509 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0227955 |
| TXNRD1 | thioredoxin reductase 1 | 0.022571 |
| ETNK1 | ethanolamine kinase 1 | 0.0225302 |
| KIF5B | kinesin family member 5B | 0.0223395 |
| CDK19 | cyclin-dependent kinase 19 | 0.0216082 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0214354 |
| SPAG9 | sperm associated antigen 9 | 0.0213176 |
| ZNF217 | zinc finger protein 217 | 0.0209383 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0205129 |
| TFG | TRK-fused gene | 0.0201436 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.019839 |
| RBM39 | RNA binding motif protein 39 | 0.0198218 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | 0.0197116 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0195887 |
| QKI | QKI, KH domain containing, RNA binding | 0.0195399 |
| CEP95 | centrosomal protein 95kDa | 0.0193412 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0192967 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0191968 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0190291 |
| TBK1 | TANK-binding kinase 1 | 0.018609 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0185534 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0185374 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0185028 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0179625 |
| ATL2 | atlastin GTPase 2 | 0.017884 |
| ARRDC3 | arrestin domain containing 3 | 0.0177974 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0174423 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0171057 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0169549 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0168998 |
| MEMO1 | mediator of cell motility 1 | 0.0168319 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0168238 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0167209 |
| ATAD2B | ATPase family, AAA domain containing 2B | 0.0166447 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0165655 |
| CLDND1 | claudin domain containing 1 | 0.0165137 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0164219 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0163332 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0163025 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0161512 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0161054 |
| AREG | amphiregulin | 0.0160318 |
| CDC73 | cell division cycle 73 | 0.0160008 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0158061 |
| ZBTB11 | zinc finger and BTB domain containing 11 | 0.0156895 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0156723 |
| RNF145 | ring finger protein 145 | 0.0154959 |
| KLHL24 | kelch-like family member 24 | 0.0154868 |
| USP15 | ubiquitin specific peptidase 15 | 0.0154617 |
| U2SURP | U2 snRNP-associated SURP domain containing | 0.0153538 |
| PREPL | prolyl endopeptidase-like | 0.0153184 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0152976 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0151846 |
| DNAJC13 | DnaJ (Hsp40) homolog, subfamily C, member 13 | 0.0151478 |
| CAND1 | cullin-associated and neddylation-dissociated 1 | 0.0151402 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0150716 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.015062 |
| NBAS | neuroblastoma amplified sequence | 0.0149941 |
| PNN | pinin, desmosome associated protein | 0.0146816 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0146131 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.149863 |
| NLGN1 | neuroligin 1 | -0.137033 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.119757 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.10287 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0950651 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0789045 |
| PCDH7 | protocadherin 7 | -0.0692841 |
| HMGA2 | high mobility group AT-hook 2 | -0.0657061 |
| ACTG1 | actin gamma 1 | -0.0553053 |
| EHBP1 | EH domain binding protein 1 | -0.051986 |
| TMSB10 | thymosin beta 10 | -0.0407711 |
| DPYD | dihydropyrimidine dehydrogenase | -0.038242 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0373904 |
| NEBL | nebulette | -0.0334358 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0316815 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0313655 |
| INTS6 | integrator complex subunit 6 | -0.0301781 |
| EGR1 | early growth response 1 | -0.0299877 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0298928 |
| RASAL2 | RAS protein activator like 2 | -0.0298729 |
| CMIP | c-Maf inducing protein | -0.0284912 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0279443 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0273351 |
| HMGA1 | high mobility group AT-hook 1 | -0.026924 |
| ZNF804A | zinc finger protein 804A | -0.0267922 |
| CCN2 | cellular communication network factor 2 | -0.0267738 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0267608 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0264012 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0263435 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0259696 |
| R3HDM2 | R3H domain containing 2 | -0.0256752 |
| TUBA1B | tubulin, alpha 1b | -0.0252189 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.0252126 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.025045 |
| BPTF | bromodomain PHD finger transcription factor | -0.0249924 |
| TPI1 | triosephosphate isomerase 1 | -0.0245417 |
| CUX1 | cut-like homeobox 1 | -0.0243219 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0241951 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0239263 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0237694 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0233242 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0232465 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0231816 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0226742 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.021538 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0209993 |
| CCND1 | cyclin D1 | -0.0209046 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0205508 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.020282 |
| EXOC4 | exocyst complex component 4 | -0.0197418 |
| RNF213 | ring finger protein 213 | -0.0195066 |
| MAP1B | microtubule-associated protein 1B | -0.0194085 |
| CEP112 | centrosomal protein 112kDa | -0.0192841 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0191958 |
| DST | dystonin | -0.0191386 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0189771 |
| PFN1 | profilin 1 | -0.0188614 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.018785 |
| TGM2 | transglutaminase 2 | -0.018748 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0186544 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0185291 |
| POTEF | POTE ankyrin domain family, member F | -0.0182889 |
| DOCK1 | dedicator of cytokinesis 1 | -0.0179441 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0172116 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0171989 |
| PTMA | prothymosin, alpha | -0.0169508 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | -0.016839 |
| DTNA | dystrobrevin, alpha | -0.0165977 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0165274 |
| LRRC23 | leucine rich repeat containing 23 | -0.0163273 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | -0.0161413 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.015867 |
| BCHE | butyrylcholinesterase | -0.0155011 |
| FTL | ferritin, light polypeptide | -0.0154474 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0150763 |
| FOXP1 | forkhead box P1 | -0.0150062 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0150032 |
| ADIPOR2 | adiponectin receptor 2 | -0.014904 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0148861 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0146798 |
| NABP1 | nucleic acid binding protein 1 | -0.0146421 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0146421 |
| EGFR | epidermal growth factor receptor | -0.0144643 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0143607 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0143114 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0142801 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0142736 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.0141976 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0140718 |
| MTAP | methylthioadenosine phosphorylase | -0.0140518 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0140461 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.013927 |
| CALR | calreticulin | -0.0138687 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0138491 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.013685 |
| ANKRD12 | ankyrin repeat domain 12 | -0.01362 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0134807 |
| STAU2 | staufen double-stranded RNA binding protein 2 | -0.0133396 |
| PCDH9 | protocadherin 9 | -0.0132492 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0132286 |
