Tadalafil_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tadalafil perturbation in COLO 205 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Tadalafil_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.100125
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0764893
FNDC3B fibronectin type III domain containing 3B 0.0715835
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0667087
NDRG1 N-myc downstream regulated 1 0.0563957
MBNL2 muscleblind-like splicing regulator 2 0.0553678
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0523779
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0457513
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0456328
ATXN1 ataxin 1 0.0441684
STS steroid sulfatase (microsomal), isozyme S 0.0433207
GMDS GDP-mannose 4,6-dehydratase 0.0418686
N4BP2L2 NEDD4 binding protein 2-like 2 0.0409868
INTS6 integrator complex subunit 6 0.0388148
TXNIP thioredoxin interacting protein 0.0380052
FNIP1 folliculin interacting protein 1 0.0367796
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0338056
DSCAM Down syndrome cell adhesion molecule 0.0334931
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0324691
RNF149 ring finger protein 149 0.0323183
YAP1 Yes-associated protein 1 0.0308039
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0289911
MLPH melanophilin 0.0289003
ESYT2 extended synaptotagmin-like protein 2 0.0287182
TSC22D2 TSC22 domain family, member 2 0.0286689
FNDC3A fibronectin type III domain containing 3A 0.0283953
MCTP2 multiple C2 domains, transmembrane 2 0.0279831
ZMYM2 zinc finger, MYM-type 2 0.0270964
TRIO trio Rho guanine nucleotide exchange factor 0.0265774
MED13 mediator complex subunit 13 0.0257942
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0254755
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0246055
TBPL1 TBP-like 1 0.0242603
SREBF2 sterol regulatory element binding transcription factor 2 0.0241347
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0241327
PDLIM5 PDZ and LIM domain 5 0.0241026
LPP LIM domain containing preferred translocation partner in lipoma 0.0240978
RBM26 RNA binding motif protein 26 0.0235598
TMEM39A transmembrane protein 39A 0.0233734
RAB6A RAB6A, member RAS oncogene family 0.0231618
TSPAN3 tetraspanin 3 0.0226557
KDM4C lysine (K)-specific demethylase 4C 0.0226049
AFF1 AF4/FMR2 family, member 1 0.0225914
DSCAML1 Down syndrome cell adhesion molecule like 1 0.0225149
PIAS1 protein inhibitor of activated STAT, 1 0.0223572
PRKCA protein kinase C, alpha 0.0222453
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0221953
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0220107
PLSCR2 phospholipid scramblase 2 0.0218011
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0217541
ZNF292 zinc finger protein 292 0.0211798
TENT2 terminal nucleotidyltransferase 2 0.0210252
ARHGAP26 Rho GTPase activating protein 26 0.020803
SORBS1 sorbin and SH3 domain containing 1 0.0207551
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0206512
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0204299
KDM6A lysine (K)-specific demethylase 6A 0.0202824
ARGLU1 arginine and glutamate rich 1 0.020224
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0199934
EXOC1 exocyst complex component 1 0.0199113
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0197264
PADI1 peptidyl arginine deiminase, type I 0.0196555
ANKRD10 ankyrin repeat domain 10 0.0196353
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.0193446
PTPRJ protein tyrosine phosphatase, receptor type, J 0.019325
ABHD2 abhydrolase domain containing 2 0.0192884
RABGAP1 RAB GTPase activating protein 1 0.0189255
KIF16B kinesin family member 16B 0.0188807
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.0183812
ASPH aspartate beta-hydroxylase 0.0182552
CNOT8 CCR4-NOT transcription complex, subunit 8 0.0182397
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0182129
TBC1D22A TBC1 domain family, member 22A 0.0180451
CEMIP2 cell migration inducing hyaluronidase 2 0.018025
UBE2H ubiquitin-conjugating enzyme E2H 0.0179615
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 0.017747
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0175661
FOXO3 forkhead box O3 0.0175439
WAPL WAPL cohesin release factor 0.0175022
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0173702
OGA O-GlcNAcase 0.0172487
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.0172035
ZBTB20 zinc finger and BTB domain containing 20 0.0170778
ANO6 anoctamin 6 0.0169702
PCM1 pericentriolar material 1 0.0168091
PDIA6 protein disulfide isomerase family A, member 6 0.0165109
MBD5 methyl-CpG binding domain protein 5 0.0164672
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0164455
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.016421
SH3PXD2A SH3 and PX domains 2A 0.0163396
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0162739
HELZ helicase with zinc finger 0.0161925
PDCD10 programmed cell death 10 0.0161303
SH3RF1 SH3 domain containing ring finger 1 0.0161245
LRRC1 leucine rich repeat containing 1 0.0161155
TAS2R14 taste receptor, type 2, member 14 0.0159954
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0159579
PNISR PNN-interacting serine/arginine-rich protein 0.0159389
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0159165
GPBP1 GC-rich promoter binding protein 1 0.0158766

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.198237
TPT1 tumor protein, translationally-controlled 1 -0.177157
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.132072
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.112523
HLA-B major histocompatibility complex, class I, B -0.111098
LCN2 lipocalin 2 -0.109033
B2M beta-2-microglobulin -0.106372
PTMA prothymosin, alpha -0.0977229
EZR ezrin -0.0781645
PDIA3 protein disulfide isomerase family A, member 3 -0.0694268
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0690213
H1-0 H1.0 linker histone -0.0637482
GCLC glutamate-cysteine ligase, catalytic subunit -0.0618951
HLA-E major histocompatibility complex, class I, E -0.0574672
LOC102724023 ES1 protein homolog, mitochondrial -0.0570543
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.057032
HLA-C major histocompatibility complex, class I, C -0.053839
PERP PERP, TP53 apoptosis effector -0.0531219
LYZ lysozyme -0.0519151
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0488601
EPHB2 EPH receptor B2 -0.0479838
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0476576
CANX calnexin -0.0463455
LOC112694756 uncharaterized LOC112694756 -0.0462766
CALR calreticulin -0.0461645
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0460066
FTL ferritin, light polypeptide -0.0440383
JUN jun proto-oncogene -0.0440226
RRBP1 ribosome binding protein 1 -0.0434658
MACC1 metastasis associated in colon cancer 1 -0.0430986
TM4SF1 transmembrane 4 L six family member 1 -0.0429654
NAMPT nicotinamide phosphoribosyltransferase -0.0425084
GCC2 GRIP and coiled-coil domain containing 2 -0.0417931
DSTN destrin (actin depolymerizing factor) -0.0415228
RAB7A RAB7A, member RAS oncogene family -0.0414844
NCOA7 nuclear receptor coactivator 7 -0.0413536
UBC ubiquitin C -0.0413276
LMO7 LIM domain 7 -0.0410349
SPATA13 spermatogenesis associated 13 -0.0408205
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0405224
RPS24 ribosomal protein S24 -0.0396251
RUNX1 runt-related transcription factor 1 -0.0393558
PLSCR1 phospholipid scramblase 1 -0.0388331
ACTG1 actin gamma 1 -0.0388292
XAF1 XIAP associated factor 1 -0.0385735
ABLIM1 actin binding LIM protein 1 -0.0378377
RHOBTB3 Rho-related BTB domain containing 3 -0.0377773
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0377381
HM13 histocompatibility (minor) 13 -0.0376821
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0376385
EIF1 eukaryotic translation initiation factor 1 -0.0374376
SP100 SP100 nuclear antigen -0.036954
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0368305
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0367832
RPLP1 ribosomal protein, large, P1 -0.0363643
CALU calumenin -0.0359355
S100A6 S100 calcium binding protein A6 -0.0353359
HLA-A major histocompatibility complex, class I, A -0.0352839
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0342649
VDAC1 voltage-dependent anion channel 1 -0.0337786
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0336301
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0332896
SLC38A1 solute carrier family 38, member 1 -0.0331516
NKD1 naked cuticle homolog 1 (Drosophila) -0.0329911
TPM4 tropomyosin 4 -0.032928
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0328611
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0327018
TMSB10 thymosin beta 10 -0.0326124
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0325803
TMC5 transmembrane channel-like 5 -0.0324781
H3-3B H3.3 histone B -0.0323937
IFI27 interferon, alpha-inducible protein 27 -0.0323549
MUC20 mucin 20, cell surface associated -0.032242
IRS2 insulin receptor substrate 2 -0.031029
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0306871
GNAS GNAS complex locus -0.0306101
FTH1 ferritin, heavy polypeptide 1 -0.0303461
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0300643
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0300538
MKI67 marker of proliferation Ki-67 -0.0297219
KLF6 Kruppel-like factor 6 -0.0296313
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0296205
PTGR1 prostaglandin reductase 1 -0.0293774
C6ORF132 chromosome 6 open reading frame 132 -0.0291736
RAB10 RAB10, member RAS oncogene family -0.0291582
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0290324
MX1 MX dynamin-like GTPase 1 -0.0289986
EPCAM epithelial cell adhesion molecule -0.0289023
SQSTM1 sequestosome 1 -0.0281275
LDHA lactate dehydrogenase A -0.0280204
MT2A metallothionein 2A -0.0277417
ARF1 ADP-ribosylation factor 1 -0.0275361
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0274973
RPL7L1 ribosomal protein L7-like 1 -0.0274157
IRF1 interferon regulatory factor 1 -0.0273218
ZFP36L1 ZFP36 ring finger protein-like 1 -0.027286
SDC4 syndecan 4 -0.02724
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0271243
RNF43 ring finger protein 43 -0.026832
SEC31A SEC31 homolog A (S. cerevisiae) -0.0268058