| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tadalafil perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tadalafil_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.131771 |
| ATP13A3 | ATPase type 13A3 | 0.116015 |
| CADM1 | cell adhesion molecule 1 | 0.111458 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0900106 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0658557 |
| SPAG9 | sperm associated antigen 9 | 0.0623461 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0513289 |
| ZNF292 | zinc finger protein 292 | 0.047615 |
| SMAD3 | SMAD family member 3 | 0.0463778 |
| QKI | QKI, KH domain containing, RNA binding | 0.0463213 |
| PTK2 | protein tyrosine kinase 2 | 0.0460639 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0439627 |
| PDE10A | phosphodiesterase 10A | 0.0435784 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0416852 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0413606 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0373687 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0371189 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0367916 |
| ARRDC3 | arrestin domain containing 3 | 0.0366381 |
| TSC22D2 | TSC22 domain family, member 2 | 0.03629 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0357304 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0346267 |
| RNF145 | ring finger protein 145 | 0.0341189 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0336588 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0327949 |
| USP3 | ubiquitin specific peptidase 3 | 0.0327163 |
| RASA2 | RAS p21 protein activator 2 | 0.0324663 |
| POSTN | periostin, osteoblast specific factor | 0.0324322 |
| RLF | rearranged L-myc fusion | 0.03223 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.031864 |
| CCNL1 | cyclin L1 | 0.0316538 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0316489 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0312031 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0311734 |
| MRTFA | myocardin related transcription factor A | 0.031166 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0308425 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0306737 |
| GOLGA4 | golgin A4 | 0.0304496 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0301416 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0299795 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0294953 |
| RYBP | RING1 and YY1 binding protein | 0.0289784 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0279446 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0278045 |
| FMNL2 | formin-like 2 | 0.0277472 |
| COG5 | component of oligomeric golgi complex 5 | 0.0272832 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0270516 |
| GRB10 | growth factor receptor-bound protein 10 | 0.026782 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0267243 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0267197 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0266846 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0263808 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0262472 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.025788 |
| NDRG1 | N-myc downstream regulated 1 | 0.0256553 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0255166 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0250729 |
| CLINT1 | clathrin interactor 1 | 0.0245829 |
| SETD5 | SET domain containing 5 | 0.024205 |
| MYO1B | myosin IB | 0.0241863 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0240704 |
| HELZ | helicase with zinc finger | 0.0238896 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0236613 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0235765 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0234941 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0227486 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0219063 |
| NAV2 | neuron navigator 2 | 0.0217797 |
| DENND5A | DENN/MADD domain containing 5A | 0.0217696 |
| PDS5B | PDS5 cohesin associated factor B | 0.0217629 |
| FOXJ3 | forkhead box J3 | 0.0217003 |
| TNPO1 | transportin 1 | 0.0215317 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0208278 |
| FAT1 | FAT atypical cadherin 1 | 0.0206581 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0206036 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0204967 |
| RBM39 | RNA binding motif protein 39 | 0.0204128 |
| PDE8A | phosphodiesterase 8A | 0.0203935 |
| RHEB | Ras homolog enriched in brain | 0.0203538 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0201715 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0201211 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0200655 |
| TFG | TRK-fused gene | 0.0198045 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.0197908 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0195655 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0195474 |
| ANLN | anillin, actin binding protein | 0.0194841 |
| MED13L | mediator complex subunit 13-like | 0.0194136 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0193744 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0193677 |
| AZIN1 | antizyme inhibitor 1 | 0.01925 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0191866 |
| COPA | coatomer protein complex, subunit alpha | 0.0189117 |
| RAB8B | RAB8B, member RAS oncogene family | 0.018884 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0188246 |
| RNF24 | ring finger protein 24 | 0.0188135 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0187806 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0187677 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0187507 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0187089 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.2892 |
| VIM | vimentin | -0.144404 |
| FN1 | fibronectin 1 | -0.142494 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.126914 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.116756 |
| CDH13 | cadherin 13 | -0.105224 |
| COL1A1 | collagen, type I, alpha 1 | -0.0974116 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0926619 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0840869 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0788604 |
| MT2A | metallothionein 2A | -0.0786942 |
| FBN1 | fibrillin 1 | -0.0719278 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0706246 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0692956 |
| ASPH | aspartate beta-hydroxylase | -0.0590359 |
| TMSB10 | thymosin beta 10 | -0.0588503 |
| CALR | calreticulin | -0.0534602 |
| COL1A2 | collagen, type I, alpha 2 | -0.0527134 |
| COL5A1 | collagen, type V, alpha 1 | -0.0524752 |
| STC1 | stanniocalcin 1 | -0.05201 |
| CANX | calnexin | -0.0470771 |
| HMGA2 | high mobility group AT-hook 2 | -0.0454364 |
| ENO1 | enolase 1, (alpha) | -0.0435902 |
| LOX | lysyl oxidase | -0.0416299 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0397198 |
| ACTG1 | actin gamma 1 | -0.0386915 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0369628 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0367781 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0363271 |
| GLIS3 | GLIS family zinc finger 3 | -0.0353808 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0350436 |
| RPS8 | ribosomal protein S8 | -0.0345089 |
| RRBP1 | ribosome binding protein 1 | -0.0337626 |
| CAVIN1 | caveolae associated protein 1 | -0.0330176 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0329837 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0327216 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0318076 |
| NAV1 | neuron navigator 1 | -0.0317438 |
| GOLGB1 | golgin B1 | -0.03127 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0311048 |
| TMSB4X | thymosin beta 4, X-linked | -0.0310832 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0307253 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0302312 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0301075 |
| LDHA | lactate dehydrogenase A | -0.0291401 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0285232 |
| TPM4 | tropomyosin 4 | -0.0278583 |
| HLA-B | major histocompatibility complex, class I, B | -0.0273747 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0261491 |
| OXR1 | oxidation resistance 1 | -0.0259648 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0258337 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0257437 |
| RND3 | Rho family GTPase 3 | -0.0252016 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0251869 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0251698 |
| NEK10 | NIMA-related kinase 10 | -0.0249325 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0247272 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0246629 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0243731 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0243384 |
| RPL30 | ribosomal protein L30 | -0.0242812 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0234967 |
| OSMR | oncostatin M receptor | -0.0233724 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.023026 |
| RPL26 | ribosomal protein L26 | -0.0228732 |
| RPS3 | ribosomal protein S3 | -0.0226628 |
| AHNAK | AHNAK nucleoprotein | -0.0226197 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0221628 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0218504 |
| RACK1 | receptor for activated C kinase 1 | -0.0216359 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0213952 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0212255 |
| HDLBP | high density lipoprotein binding protein | -0.0207253 |
| FOXP1 | forkhead box P1 | -0.0204088 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0202232 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0199581 |
| S100A9 | S100 calcium binding protein A9 | -0.0199211 |
| MT1X | metallothionein 1X | -0.0198672 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0197067 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.019669 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0196572 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0194548 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0191517 |
| RPL12 | ribosomal protein L12 | -0.0189443 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0189244 |
| EFNA5 | ephrin-A5 | -0.0189061 |
| CNTN5 | contactin 5 | -0.0188678 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0188424 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.018756 |
| CUX1 | cut-like homeobox 1 | -0.0187257 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0186781 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.0186299 |
| GNAS | GNAS complex locus | -0.018617 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0184068 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0183503 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0182119 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0181219 |
| PTMA | prothymosin, alpha | -0.0181049 |
| MTDH | metadherin | -0.0179329 |
| EGR1 | early growth response 1 | -0.0178258 |
