| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tadalafil perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tadalafil_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.107834 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.103843 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.102878 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0951912 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0937618 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0604779 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0553218 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0537136 |
| DTNA | dystrobrevin, alpha | 0.0520086 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0466095 |
| FMNL2 | formin-like 2 | 0.0421941 |
| INSIG2 | insulin induced gene 2 | 0.0386653 |
| AFDN | afadin, adherens junction formation factor | 0.0386604 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0368719 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0350017 |
| RBM39 | RNA binding motif protein 39 | 0.0346954 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.034589 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0333354 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0327024 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0320052 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0298336 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0298029 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.029645 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0295925 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0295251 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0288316 |
| PLIN2 | perilipin 2 | 0.0277163 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0275617 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0274405 |
| ASPH | aspartate beta-hydroxylase | 0.027228 |
| PARD3 | par-3 family cell polarity regulator | 0.026434 |
| DSPP | dentin sialophosphoprotein | 0.0263015 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.026283 |
| MYO1B | myosin IB | 0.0260213 |
| FAM107B | family with sequence similarity 107, member B | 0.0256719 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.025452 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0242215 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0239098 |
| KIF1B | kinesin family member 1B | 0.0237038 |
| USP47 | ubiquitin specific peptidase 47 | 0.0234258 |
| QKI | QKI, KH domain containing, RNA binding | 0.023226 |
| CCNL1 | cyclin L1 | 0.0230939 |
| HELZ | helicase with zinc finger | 0.0228447 |
| FLNB | filamin B, beta | 0.0227094 |
| USP34 | ubiquitin specific peptidase 34 | 0.0224392 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0219722 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0216409 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0212306 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0211113 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0211078 |
| PCGF5 | polycomb group ring finger 5 | 0.0210935 |
| WWC2 | WW and C2 domain containing 2 | 0.0210551 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0210538 |
| ANO6 | anoctamin 6 | 0.0210522 |
| MYO6 | myosin VI | 0.0209249 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0208144 |
| RYBP | RING1 and YY1 binding protein | 0.0206366 |
| NDRG1 | N-myc downstream regulated 1 | 0.0203995 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0202854 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0201626 |
| ARFGEF3 | ARFGEF family member 3 | 0.0201193 |
| CUL3 | cullin 3 | 0.0200271 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.019859 |
| FERMT2 | fermitin family member 2 | 0.0197499 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0195973 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.019582 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.019574 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0195221 |
| GRK3 | G protein-coupled receptor kinase 3 | 0.0194237 |
| TOP1 | topoisomerase (DNA) I | 0.0193661 |
| ITGAV | integrin, alpha V | 0.0192153 |
| GPC6 | glypican 6 | 0.0191093 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0188812 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0188435 |
| JMJD1C | jumonji domain containing 1C | 0.0188399 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0186622 |
| AHR | aryl hydrocarbon receptor | 0.0185802 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0185052 |
| CCNY | cyclin Y | 0.0184572 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0184497 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0183694 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0183319 |
| TNS1 | tensin 1 | 0.0181285 |
| VEGFA | vascular endothelial growth factor A | 0.0179469 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0177613 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0177558 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.017693 |
| ATXN1 | ataxin 1 | 0.0175808 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0175714 |
| VCL | vinculin | 0.0175645 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0175389 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.0172576 |
| RANBP9 | RAN binding protein 9 | 0.0171615 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.0171285 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0169573 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0168749 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0167281 |
| USP6NL | USP6 N-terminal like | 0.016656 |
| CLIC4 | chloride intracellular channel 4 | 0.0166245 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0166107 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.209811 |
| APOB | apolipoprotein B | -0.162573 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.134978 |
| C3 | complement component 3 | -0.133544 |
| FN1 | fibronectin 1 | -0.102813 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0957368 |
| MT2A | metallothionein 2A | -0.0910748 |
| GPC3 | glypican 3 | -0.0845219 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0652826 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.063166 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0594932 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0532967 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0530609 |
| FTL | ferritin, light polypeptide | -0.0473654 |
| RPS6 | ribosomal protein S6 | -0.0457647 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0428545 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0391118 |
| APOA2 | apolipoprotein A-II | -0.0388393 |
| RPS8 | ribosomal protein S8 | -0.0388031 |
| RPLP1 | ribosomal protein, large, P1 | -0.0386665 |
| RPS24 | ribosomal protein S24 | -0.0383958 |
| RRBP1 | ribosome binding protein 1 | -0.037937 |
| TRIM26 | tripartite motif containing 26 | -0.0368305 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0364094 |
| RPL11 | ribosomal protein L11 | -0.0343842 |
| RPL31 | ribosomal protein L31 | -0.0334963 |
| RPL35A | ribosomal protein L35a | -0.0328633 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0313644 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0307013 |
| A2M | alpha-2-macroglobulin | -0.0306545 |
| RPS19 | ribosomal protein S19 | -0.0293953 |
| RPLP2 | ribosomal protein, large, P2 | -0.0291026 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0290643 |
| RPL37A | ribosomal protein L37a | -0.0287797 |
| TMSB10 | thymosin beta 10 | -0.0280585 |
| APOE | apolipoprotein E | -0.0276349 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0272858 |
| EHBP1 | EH domain binding protein 1 | -0.0270038 |
| RPL26 | ribosomal protein L26 | -0.0264636 |
| RPS27A | ribosomal protein S27a | -0.0264374 |
| RPS12 | ribosomal protein S12 | -0.0260719 |
| ACTN4 | actinin, alpha 4 | -0.0259595 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0252226 |
| RPLP0 | ribosomal protein, large, P0 | -0.0251992 |
| OSMR | oncostatin M receptor | -0.025108 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0250559 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0247739 |
| PEG10 | paternally expressed 10 | -0.0240193 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0239852 |
| RPS21 | ribosomal protein S21 | -0.0238722 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0237026 |
| RACK1 | receptor for activated C kinase 1 | -0.0235718 |
| RPL12 | ribosomal protein L12 | -0.0231073 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0230307 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0230019 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0228777 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0228306 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0222767 |
| RPL23 | ribosomal protein L23 | -0.0221165 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0220256 |
| RPL34 | ribosomal protein L34 | -0.021693 |
| RPL32 | ribosomal protein L32 | -0.0216055 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0210019 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.020975 |
| KRT18 | keratin 18, type I | -0.0207266 |
| KRT8 | keratin 8, type II | -0.0206329 |
| RPL37 | ribosomal protein L37 | -0.0205972 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.02052 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0204732 |
| RPL9 | ribosomal protein L9 | -0.0201043 |
| PTMA | prothymosin, alpha | -0.0197248 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0192664 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0184098 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0182076 |
| RPL19 | ribosomal protein L19 | -0.0177741 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0177334 |
| PEG3 | paternally expressed 3 | -0.0177226 |
| RPS13 | ribosomal protein S13 | -0.0176538 |
| GDF15 | growth differentiation factor 15 | -0.0176143 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0175317 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0174587 |
| GNAS | GNAS complex locus | -0.0172415 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0172225 |
| IER3 | immediate early response 3 | -0.0171744 |
| CTSB | cathepsin B | -0.0168721 |
| RPL36A | ribosomal protein L36a | -0.0166147 |
| LCN2 | lipocalin 2 | -0.0165717 |
| PTCHD4 | patched domain containing 4 | -0.0164751 |
| APOA1 | apolipoprotein A-I | -0.0164116 |
| RPS29 | ribosomal protein S29 | -0.0163125 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0163046 |
| RPL30 | ribosomal protein L30 | -0.0161662 |
| RPL13A | ribosomal protein L13a | -0.016083 |
| ANGPTL8 | angiopoietin like 8 | -0.0160366 |
| ITGB5 | integrin, beta 5 | -0.0159589 |
| BCL2L1 | BCL2-like 1 | -0.0159261 |
| CFB | complement factor B | -0.0158814 |
| RPL10A | ribosomal protein L10a | -0.0158729 |
| RBM25 | RNA binding motif protein 25 | -0.01579 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0155148 |
