| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tadalafil perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tadalafil_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FLNB | filamin B, beta | 0.179243 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.168896 |
| FOXO1 | forkhead box O1 | 0.0924276 |
| MEF2A | myocyte enhancer factor 2A | 0.0906838 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0864714 |
| NDRG1 | N-myc downstream regulated 1 | 0.0834301 |
| SULF1 | sulfatase 1 | 0.0720682 |
| ITGA6 | integrin, alpha 6 | 0.0673659 |
| EZR | ezrin | 0.0654501 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0634131 |
| BCL2L1 | BCL2-like 1 | 0.0632032 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0621508 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0601341 |
| AHNAK | AHNAK nucleoprotein | 0.0591285 |
| MYOF | myoferlin | 0.0551234 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0539403 |
| ANLN | anillin, actin binding protein | 0.0470464 |
| MSN | moesin | 0.0468204 |
| NEK7 | NIMA-related kinase 7 | 0.0447828 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.043879 |
| RBM39 | RNA binding motif protein 39 | 0.0437413 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0429812 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.042764 |
| MYO10 | myosin X | 0.0426553 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0422403 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0417065 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0414275 |
| PODXL | podocalyxin-like | 0.0394647 |
| CD44 | CD44 molecule (Indian blood group) | 0.0392074 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0391124 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0384771 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0384255 |
| SPAG9 | sperm associated antigen 9 | 0.0381365 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0377453 |
| LNPEP | leucyl/cystinyl aminopeptidase | 0.0369219 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0368841 |
| OGA | O-GlcNAcase | 0.0363319 |
| MTSS1 | metastasis suppressor 1 | 0.0357161 |
| EMP1 | epithelial membrane protein 1 | 0.0353035 |
| NRG1 | neuregulin 1 | 0.035188 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0345062 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0341906 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.033759 |
| PGK1 | phosphoglycerate kinase 1 | 0.0335129 |
| PTK2 | protein tyrosine kinase 2 | 0.032844 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | 0.0327387 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0327134 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.032277 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0320976 |
| ZNF292 | zinc finger protein 292 | 0.0316464 |
| CAPRIN2 | caprin family member 2 | 0.0312121 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.031142 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0303923 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.030054 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0296361 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0293622 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.0291316 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0288699 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0288348 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.028712 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0285617 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0282998 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.028034 |
| AOPEP | aminopeptidase O (putative) | 0.0274062 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0273838 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | 0.0273531 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0273028 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0272454 |
| CUL4B | cullin 4B | 0.0271493 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0270093 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0268724 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0266363 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0266064 |
| MKI67 | marker of proliferation Ki-67 | 0.0265429 |
| H1-0 | H1.0 linker histone | 0.0265234 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0263998 |
| NBAS | neuroblastoma amplified sequence | 0.0263233 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0262495 |
| GOLGA4 | golgin A4 | 0.0261397 |
| TXNRD1 | thioredoxin reductase 1 | 0.0261295 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0260331 |
| HELZ | helicase with zinc finger | 0.0260317 |
| INSIG2 | insulin induced gene 2 | 0.0257722 |
| HYCC2 | hyccin PI4KA lipid kinase complex subunit 2 | 0.0256649 |
| ANXA11 | annexin A11 | 0.025379 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0252908 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0252098 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0250826 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0250266 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0250255 |
| SBF2 | SET binding factor 2 | 0.0248222 |
| NF1 | neurofibromin 1 | 0.0247342 |
| PHF21A | PHD finger protein 21A | 0.0247283 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0246376 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0244851 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0242594 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0237317 |
| PDLIM1 | PDZ and LIM domain 1 | 0.0237018 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0236937 |
| THOC2 | THO complex 2 | 0.0236296 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0819805 |
| INTS6 | integrator complex subunit 6 | -0.0811775 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0749637 |
| RPS8 | ribosomal protein S8 | -0.0629007 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0592734 |
| MT2A | metallothionein 2A | -0.0521307 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0518097 |
| RPS6 | ribosomal protein S6 | -0.046938 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0465797 |
| HLA-B | major histocompatibility complex, class I, B | -0.0454471 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0451188 |
| RPL35A | ribosomal protein L35a | -0.037826 |
| RPS13 | ribosomal protein S13 | -0.0375898 |
| TMSB10 | thymosin beta 10 | -0.0375444 |
| STC1 | stanniocalcin 1 | -0.0372536 |
| RPL11 | ribosomal protein L11 | -0.0368719 |
| RPS12 | ribosomal protein S12 | -0.0367064 |
| RPS3 | ribosomal protein S3 | -0.0350112 |
| LDHA | lactate dehydrogenase A | -0.0346222 |
| RPS21 | ribosomal protein S21 | -0.0342635 |
| RPL34 | ribosomal protein L34 | -0.0337585 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0336563 |
| RPL26 | ribosomal protein L26 | -0.0336091 |
| B2M | beta-2-microglobulin | -0.033347 |
| RPLP1 | ribosomal protein, large, P1 | -0.0333387 |
| RPL37 | ribosomal protein L37 | -0.0328541 |
| RPS24 | ribosomal protein S24 | -0.0325958 |
| SQSTM1 | sequestosome 1 | -0.0325476 |
| RPL23 | ribosomal protein L23 | -0.0318858 |
| TMSB4X | thymosin beta 4, X-linked | -0.0318096 |
| RPS25 | ribosomal protein S25 | -0.0314396 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0311812 |
| RPL37A | ribosomal protein L37a | -0.0301266 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.030061 |
| RPL12 | ribosomal protein L12 | -0.0291929 |
| RPLP2 | ribosomal protein, large, P2 | -0.0283223 |
| RPL31 | ribosomal protein L31 | -0.0281694 |
| RPS19 | ribosomal protein S19 | -0.0278746 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0265653 |
| S100A10 | S100 calcium binding protein A10 | -0.0257703 |
| RPLP0 | ribosomal protein, large, P0 | -0.0255475 |
| PTMA | prothymosin, alpha | -0.0255144 |
| RPS27A | ribosomal protein S27a | -0.0240464 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0237543 |
| LOC112694756 | uncharaterized LOC112694756 | -0.023368 |
| RPL9 | ribosomal protein L9 | -0.0229538 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0228532 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0226709 |
| FTL | ferritin, light polypeptide | -0.0226611 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.022641 |
| RPL7A | ribosomal protein L7a | -0.0225304 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0223942 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0222756 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0222549 |
| RPL5 | ribosomal protein L5 | -0.0220608 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0220387 |
| RACK1 | receptor for activated C kinase 1 | -0.0218842 |
| RPL19 | ribosomal protein L19 | -0.0215362 |
| RPL36 | ribosomal protein L36 | -0.0214425 |
| RPS14 | ribosomal protein S14 | -0.021352 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0208535 |
| HM13 | histocompatibility (minor) 13 | -0.02057 |
| CNTNAP3 | contactin associated protein-like 3 | -0.0203329 |
| HLA-E | major histocompatibility complex, class I, E | -0.0200301 |
| RPS27 | ribosomal protein S27 | -0.0198494 |
| RPS17 | ribosomal protein S17 | -0.0197432 |
| RPL30 | ribosomal protein L30 | -0.019617 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0196034 |
| RPL27A | ribosomal protein L27a | -0.0195421 |
| RPL39 | ribosomal protein L39 | -0.0192951 |
| RPL8 | ribosomal protein L8 | -0.0192752 |
| RPL13A | ribosomal protein L13a | -0.0191465 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0188817 |
| CSMD2 | CUB and Sushi multiple domains 2 | -0.0188427 |
| RPL28 | ribosomal protein L28 | -0.0188291 |
| CSTB | cystatin B (stefin B) | -0.0186551 |
| RPS29 | ribosomal protein S29 | -0.0186021 |
| S100A9 | S100 calcium binding protein A9 | -0.018464 |
| RPL36A | ribosomal protein L36a | -0.0183242 |
| MT1E | metallothionein 1E | -0.0182477 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.0181828 |
| ATF4 | activating transcription factor 4 | -0.0181576 |
| RPS23 | ribosomal protein S23 | -0.0180792 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0178374 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0177133 |
| RPS16 | ribosomal protein S16 | -0.0176219 |
| RPL7 | ribosomal protein L7 | -0.0175931 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.0175123 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | -0.0172639 |
| CANX | calnexin | -0.0171385 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0170183 |
| S100A2 | S100 calcium binding protein A2 | -0.0166687 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0164691 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0162713 |
| S100A6 | S100 calcium binding protein A6 | -0.0162624 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0162597 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0161199 |
| UBC | ubiquitin C | -0.015973 |
| ANGPTL4 | angiopoietin-like 4 | -0.0157916 |
| GNAS | GNAS complex locus | -0.0157471 |
