Tadalafil_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tadalafil perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Tadalafil_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0733654
DST dystonin 0.072326
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0627986
TP63 tumor protein p63 0.0586802
FMNL2 formin-like 2 0.0586483
PTMA prothymosin, alpha 0.0578106
DLG1 discs, large homolog 1 (Drosophila) 0.0506476
EFNA5 ephrin-A5 0.0487156
TSC22D1 TSC22 domain family, member 1 0.0477847
RPL35A ribosomal protein L35a 0.0471291
RPS19 ribosomal protein S19 0.0463921
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.041669
ZNF292 zinc finger protein 292 0.0407
PIAS2 protein inhibitor of activated STAT, 2 0.0397663
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0373947
RPS6 ribosomal protein S6 0.0360089
CCNL1 cyclin L1 0.0354236
WSB1 WD repeat and SOCS box containing 1 0.0343674
RPS12 ribosomal protein S12 0.0340066
TXNIP thioredoxin interacting protein 0.0336132
RPL36 ribosomal protein L36 0.0336123
PTK2 protein tyrosine kinase 2 0.0315053
DPYD dihydropyrimidine dehydrogenase 0.0314731
RBM39 RNA binding motif protein 39 0.0309552
CAPRIN2 caprin family member 2 0.0302743
RPS2 ribosomal protein S2 0.030168
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0295823
RPS8 ribosomal protein S8 0.0282115
ENO2 enolase 2 (gamma, neuronal) 0.027489
RPL37A ribosomal protein L37a 0.0271341
SPAG9 sperm associated antigen 9 0.0268472
ADAM17 ADAM metallopeptidase domain 17 0.0262725
FNIP1 folliculin interacting protein 1 0.0257812
ERRFI1 ERBB receptor feedback inhibitor 1 0.0257621
PARD3 par-3 family cell polarity regulator 0.0255087
EPHA4 EPH receptor A4 0.0248379
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0248342
ZDHHC14 zinc finger, DHHC-type containing 14 0.0245147
TTC28 tetratricopeptide repeat domain 28 0.0243706
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0242721
RPS3 ribosomal protein S3 0.0240089
RAD51B RAD51 paralog B 0.0237379
RPS23 ribosomal protein S23 0.0231665
VCL vinculin 0.0230421
ESYT2 extended synaptotagmin-like protein 2 0.0226065
TOP1 topoisomerase (DNA) I 0.0222946
PGAP1 post-GPI attachment to proteins 1 0.0222732
COL5A2 collagen, type V, alpha 2 0.0215604
ANKRD11 ankyrin repeat domain 11 0.0212555
JMJD1C jumonji domain containing 1C 0.0207476
CADM2 cell adhesion molecule 2 0.0205666
RPL23 ribosomal protein L23 0.0203927
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0203103
RPS29 ribosomal protein S29 0.0199576
TENT2 terminal nucleotidyltransferase 2 0.019955
LGALS3 lectin, galactoside-binding, soluble, 3 0.0198426
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0198328
XPO1 exportin 1 0.0194963
WAC WW domain containing adaptor with coiled-coil 0.019449
EPB41 erythrocyte membrane protein band 4.1 0.0192995
RPS17 ribosomal protein S17 0.0192953
AKAP10 A kinase (PRKA) anchor protein 10 0.0190585
PRELID2 PRELI domain containing 2 0.0189563
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0188564
SRPK2 SRSF protein kinase 2 0.0187668
PTBP2 polypyrimidine tract binding protein 2 0.0187488
SLK STE20-like kinase 0.0186881
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0186045
RCOR1 REST corepressor 1 0.0185711
B2M beta-2-microglobulin 0.0182158
RPL19 ribosomal protein L19 0.0181618
KMT2C lysine (K)-specific methyltransferase 2C 0.0180874
RPL31 ribosomal protein L31 0.0180583
SDK1 sidekick cell adhesion molecule 1 0.0180482
PHIP pleckstrin homology domain interacting protein 0.0179249
IFI6 interferon, alpha-inducible protein 6 0.0178877
RBM26 RNA binding motif protein 26 0.017684
RPS10 ribosomal protein S10 0.0175876
PICALM phosphatidylinositol binding clathrin assembly protein 0.0175182
PNISR PNN-interacting serine/arginine-rich protein 0.0172349
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.017026
RREB1 ras responsive element binding protein 1 0.01686
RPS27 ribosomal protein S27 0.0168379
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0168336
CD109 CD109 molecule 0.0168136
FAM13B family with sequence similarity 13, member B 0.0167656
FTL ferritin, light polypeptide 0.0167058
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0165844
DCAF6 DDB1 and CUL4 associated factor 6 0.016498
FAR1 fatty acyl CoA reductase 1 0.0164667
ECPAS Ecm29 proteasome adaptor and scaffold 0.0164638
FNBP1L formin binding protein 1-like 0.0164561
LPP LIM domain containing preferred translocation partner in lipoma 0.0164034
PDE8A phosphodiesterase 8A 0.0163473
NCOR1 nuclear receptor corepressor 1 0.0163236
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0161793
HELZ helicase with zinc finger 0.0161094
CAMTA1 calmodulin binding transcription activator 1 0.0159659
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0157722
TRA2A transformer 2 alpha homolog (Drosophila) 0.0157043

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.254819
TM4SF1 transmembrane 4 L six family member 1 -0.141366
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.125328
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.119275
TXNRD1 thioredoxin reductase 1 -0.118274
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.116235
EEF2 eukaryotic translation elongation factor 2 -0.0962448
LOC112694756 uncharaterized LOC112694756 -0.0850108
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0829884
UBC ubiquitin C -0.0629038
LDHA lactate dehydrogenase A -0.0567807
ACTG1 actin gamma 1 -0.0517258
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0513437
AHNAK AHNAK nucleoprotein -0.0431057
JUN jun proto-oncogene -0.0427105
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0421519
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0392925
CANX calnexin -0.0385469
EMP1 epithelial membrane protein 1 -0.0380391
HDLBP high density lipoprotein binding protein -0.0377837
RAI1 retinoic acid induced 1 -0.0376204
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0368463
TMSB4X thymosin beta 4, X-linked -0.0363547
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -0.0350639
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0298578
SPRY4 sprouty homolog 4 (Drosophila) -0.0272997
ZMYND8 zinc finger, MYND-type containing 8 -0.0259117
MACF1 microtubule-actin crosslinking factor 1 -0.0257203
BZW1 basic leucine zipper and W2 domains 1 -0.0256448
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0239516
ZBTB38 zinc finger and BTB domain containing 38 -0.0236058
WWTR1 WW domain containing transcription regulator 1 -0.023507
TPT1 tumor protein, translationally-controlled 1 -0.0234712
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.023418
TMSB10 thymosin beta 10 -0.0233923
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0231345
CAPN2 calpain 2, (m/II) large subunit -0.0220486
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0216203
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 -0.0214342
HSPA8 heat shock 70kDa protein 8 -0.0212272
BIRC3 baculoviral IAP repeat containing 3 -0.0208293
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0207857
FTH1 ferritin, heavy polypeptide 1 -0.0204364
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0201106
EZR ezrin -0.0199613
SRGN serglycin -0.0199434
EREG epiregulin -0.0198148
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0197211
PRRC2B proline-rich coiled-coil 2B -0.0196123
RGS4 regulator of G-protein signaling 4 -0.0194549
CDCP1 CUB domain containing protein 1 -0.0191231
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0188717
GCLM glutamate-cysteine ligase, modifier subunit -0.0187875
CALU calumenin -0.0187561
NT5E 5'-nucleotidase, ecto (CD73) -0.0187182
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.018714
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0186996
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0185487
APP amyloid beta (A4) precursor protein -0.0182194
ARF1 ADP-ribosylation factor 1 -0.017825
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0176905
ZEB1 zinc finger E-box binding homeobox 1 -0.0174398
PODXL podocalyxin-like -0.0174121
ANXA2 annexin A2 -0.0173194
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0171993
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0171928
OSMR oncostatin M receptor -0.0171227
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0170608
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0169393
MYH9 myosin, heavy chain 9, non-muscle -0.0169393
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0169079
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0167768
CAVIN1 caveolae associated protein 1 -0.0167669
ERCC1 excision repair cross-complementation group 1 -0.0167095
KRT18 keratin 18, type I -0.0166547
PYGB phosphorylase, glycogen; brain -0.0165916
HOOK2 hook microtubule-tethering protein 2 -0.0162271
LOXL2 lysyl oxidase-like 2 -0.016133
SRRM2 serine/arginine repetitive matrix 2 -0.0160785
RPS27A ribosomal protein S27a -0.0159312
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0158678
ENO1 enolase 1, (alpha) -0.0156101
AHNAK2 AHNAK nucleoprotein 2 -0.0154363
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.015361
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0152438
TRIP12 thyroid hormone receptor interactor 12 -0.0151637
S100A6 S100 calcium binding protein A6 -0.0150961
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 -0.0150152
ANXA1 annexin A1 -0.0149768
CFLAR CASP8 and FADD-like apoptosis regulator -0.0148395
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.0145313
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.014489
RRBP1 ribosome binding protein 1 -0.014477
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0141568
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0140837
NPAS2 neuronal PAS domain protein 2 -0.0139601
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0138478
BPTF bromodomain PHD finger transcription factor -0.0137879
GAN gigaxonin -0.0137088
PRRC2A proline-rich coiled-coil 2A -0.0136699