Tadalafil_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tadalafil perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tadalafil_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.0735552
RPL35A ribosomal protein L35a 0.0694962
FAM13A family with sequence similarity 13, member A 0.0657285
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.043948
SEC61G Sec61 gamma subunit 0.0438261
TSC22D2 TSC22 domain family, member 2 0.040203
RPL37A ribosomal protein L37a 0.0396372
RPS3 ribosomal protein S3 0.0364738
PDE8A phosphodiesterase 8A 0.035729
RPS2 ribosomal protein S2 0.0343628
MT2A metallothionein 2A 0.0340341
KMT2E lysine (K)-specific methyltransferase 2E 0.0338527
GPC6 glypican 6 0.0330479
TMEM165 transmembrane protein 165 0.0322412
NGLY1 N-glycanase 1 0.0283633
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.028238
RPS12 ribosomal protein S12 0.027617
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0266898
S100P S100 calcium binding protein P 0.0265807
RNF145 ring finger protein 145 0.0262795
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0244651
CD163L1 CD163 molecule-like 1 0.0242279
WASF2 WAS protein family, member 2 0.0241291
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0238301
RPS23 ribosomal protein S23 0.023688
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.023171
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0231027
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0230452
TPD52 tumor protein D52 0.022522
ANKRD37 ankyrin repeat domain 37 0.0213659
RPS6 ribosomal protein S6 0.0199339
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0197188
FNDC3B fibronectin type III domain containing 3B 0.0191856
SLMAP sarcolemma associated protein 0.0190327
NCKAP1 NCK-associated protein 1 0.0189562
RPS8 ribosomal protein S8 0.0188006
WAC WW domain containing adaptor with coiled-coil 0.0187908
CAMTA1 calmodulin binding transcription activator 1 0.0185177
ERRFI1 ERBB receptor feedback inhibitor 1 0.0183843
RICTOR RPTOR independent companion of MTOR, complex 2 0.018205
PTPRM protein tyrosine phosphatase, receptor type, M 0.0181402
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0178433
RPS29 ribosomal protein S29 0.0176051
RPL36 ribosomal protein L36 0.0167507
RPL34 ribosomal protein L34 0.0167335
TFG TRK-fused gene 0.0164607
UBA6 ubiquitin-like modifier activating enzyme 6 0.0163574
MXI1 MAX interactor 1, dimerization protein 0.0161852
HELZ helicase with zinc finger 0.0160273
GRB10 growth factor receptor-bound protein 10 0.0158859
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0155272
KCMF1 potassium channel modulatory factor 1 0.0154332
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0152962
NPTN neuroplastin 0.0151028
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0148796
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0148578
RPS27 ribosomal protein S27 0.0147927
RAB6A RAB6A, member RAS oncogene family 0.0147799
ZNF292 zinc finger protein 292 0.0146332
RPS19 ribosomal protein S19 0.0146178
GSK3B glycogen synthase kinase 3 beta 0.0145515
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0143885
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0140423
ATP13A3 ATPase type 13A3 0.0139567
BAIAP2L1 BAI1-associated protein 2-like 1 0.0138379
RPL32 ribosomal protein L32 0.013677
ESYT2 extended synaptotagmin-like protein 2 0.0135801
RAP1B RAP1B, member of RAS oncogene family 0.0134729
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.013342
QKI QKI, KH domain containing, RNA binding 0.0128203
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0126849
RPL21 ribosomal protein L21 0.0124347
FBXL5 F-box and leucine-rich repeat protein 5 0.0123573
FA2H fatty acid 2-hydroxylase 0.0117149
CCNL1 cyclin L1 0.0116509
BACE2 beta-site APP-cleaving enzyme 2 0.011357
ATF4 activating transcription factor 4 0.0111828
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0110992
RPS14 ribosomal protein S14 0.0110607
RASA2 RAS p21 protein activator 2 0.0110302
ATG7 autophagy related 7 0.0109707
RPS16 ribosomal protein S16 0.0109179
BRWD3 bromodomain and WD repeat domain containing 3 0.0107631
RPS13 ribosomal protein S13 0.0106501
FTL ferritin, light polypeptide 0.0106249
CCNY cyclin Y 0.0103961
SREBF2 sterol regulatory element binding transcription factor 2 0.0103102
RPL35 ribosomal protein L35 0.0103074
MT1X metallothionein 1X 0.0101798
TMSB10 thymosin beta 10 0.0101392
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 0.0100964
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0100521
LAMC2 laminin, gamma 2 0.00985593
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.00975104
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.00968124
PIAS2 protein inhibitor of activated STAT, 2 0.00962126
WDFY2 WD repeat and FYVE domain containing 2 0.00960952
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.00952705
CIB1 calcium and integrin binding 1 (calmyrin) 0.00950833
UBE2K ubiquitin-conjugating enzyme E2K 0.00948946

decreased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 -0.255461
UBC ubiquitin C -0.210444
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.1885
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.162122
ASPH aspartate beta-hydroxylase -0.116268
LOC112694756 uncharaterized LOC112694756 -0.111399
LDHA lactate dehydrogenase A -0.0853417
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0847407
PKM pyruvate kinase, muscle -0.0703462
PCBP2 poly(rC) binding protein 2 -0.0675714
FTH1 ferritin, heavy polypeptide 1 -0.0656803
ENO1 enolase 1, (alpha) -0.0644331
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0640513
CES1 carboxylesterase 1 -0.0618063
MCL1 myeloid cell leukemia 1 -0.0597793
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0584341
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0575399
EEF2 eukaryotic translation elongation factor 2 -0.0564421
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0553505
CANX calnexin -0.0552059
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0527323
DSCAM Down syndrome cell adhesion molecule -0.0519555
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.050692
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0470461
MYH9 myosin, heavy chain 9, non-muscle -0.045309
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0450498
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0441362
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0430188
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0419112
GRAMD1B GRAM domain containing 1B -0.0414351
HDLBP high density lipoprotein binding protein -0.0406187
USP34 ubiquitin specific peptidase 34 -0.0403469
PLEC plectin -0.0400225
SOD2 superoxide dismutase 2, mitochondrial -0.0385714
RPS27A ribosomal protein S27a -0.0383713
AKR1C1 aldo-keto reductase family 1, member C1 -0.037255
GCLC glutamate-cysteine ligase, catalytic subunit -0.0365106
PRRC2C proline-rich coiled-coil 2C -0.0364337
MKI67 marker of proliferation Ki-67 -0.0354045
AHNAK AHNAK nucleoprotein -0.0352681
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0350273
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0342953
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0342676
MGST1 microsomal glutathione S-transferase 1 -0.0342387
STC1 stanniocalcin 1 -0.0341792
AGO2 argonaute RISC catalytic component 2 -0.0340243
KIAA1217 KIAA1217 -0.0337134
RBM25 RNA binding motif protein 25 -0.03366
SLC38A1 solute carrier family 38, member 1 -0.0336334
TBC1D22A TBC1 domain family, member 22A -0.0326123
MYOF myoferlin -0.0325184
SMAD3 SMAD family member 3 -0.0318352
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0315995
SRRM2 serine/arginine repetitive matrix 2 -0.0315931
ZC3H11A zinc finger CCCH-type containing 11A -0.0313942
SP100 SP100 nuclear antigen -0.0313195
RNF213 ring finger protein 213 -0.0305966
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0305407
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0300016
ARRDC3 arrestin domain containing 3 -0.0299927
ANKRD17 ankyrin repeat domain 17 -0.0293347
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0292706
TES testin LIM domain protein -0.0290606
EGFR epidermal growth factor receptor -0.0288474
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0288265
SLTM SAFB-like, transcription modulator -0.0287612
CAV1 caveolin 1, caveolae protein, 22kDa -0.0286084
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.028596
OSMR oncostatin M receptor -0.0284317
LRP1B low density lipoprotein receptor-related protein 1B -0.0283119
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0279075
ADAR adenosine deaminase, RNA-specific -0.0277904
KDM2A lysine (K)-specific demethylase 2A -0.0272208
SPDYA speedy/RINGO cell cycle regulator family member A -0.0271315
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0267472
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0265701
ANXA2 annexin A2 -0.0265444
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.0261292
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0259477
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0251567
DOCK5 dedicator of cytokinesis 5 -0.0250763
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0250147
ANKRD11 ankyrin repeat domain 11 -0.0250079
TKT transketolase -0.0249221
PATJ PATJ crumbs cell polarity complex component -0.0244584
JMJD1C jumonji domain containing 1C -0.0244341
SFPQ splicing factor proline/glutamine-rich -0.0243619
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0243564
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0242609
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0242475
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0240628
APP amyloid beta (A4) precursor protein -0.0236597
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0236545
GCLM glutamate-cysteine ligase, modifier subunit -0.023562
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0235501
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0235193
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0231472
BRD2 bromodomain containing 2 -0.0231246
EZR ezrin -0.0230578
KRT18 keratin 18, type I -0.0228736