| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tadalafil perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tadalafil_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GRB10 | growth factor receptor-bound protein 10 | 0.181838 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.134259 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.133289 |
| FAM13A | family with sequence similarity 13, member A | 0.11268 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.105529 |
| MEF2A | myocyte enhancer factor 2A | 0.102916 |
| FNDC3B | fibronectin type III domain containing 3B | 0.102553 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.100727 |
| ATP13A3 | ATPase type 13A3 | 0.100389 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.095022 |
| RBM39 | RNA binding motif protein 39 | 0.0933477 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0836443 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0820696 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0723154 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0715336 |
| USP3 | ubiquitin specific peptidase 3 | 0.0711936 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0705935 |
| SPAG9 | sperm associated antigen 9 | 0.0687822 |
| NGLY1 | N-glycanase 1 | 0.0673425 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0668231 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0654116 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0642101 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0635728 |
| SIK3 | SIK family kinase 3 | 0.0614873 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0599601 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.059336 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0591614 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0583853 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0582857 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0577946 |
| HELZ | helicase with zinc finger | 0.0575779 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0566227 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0563576 |
| PARD3 | par-3 family cell polarity regulator | 0.0553328 |
| ZNF292 | zinc finger protein 292 | 0.0545223 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0544366 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0543198 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0542347 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.054038 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0524882 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.052099 |
| MYO1B | myosin IB | 0.0517623 |
| QKI | QKI, KH domain containing, RNA binding | 0.0510123 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0506883 |
| SETD5 | SET domain containing 5 | 0.0505274 |
| GPC6 | glypican 6 | 0.0502464 |
| TMSB10 | thymosin beta 10 | 0.0488659 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0481309 |
| RIOK3 | RIO kinase 3 | 0.0469225 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0448628 |
| CD109 | CD109 molecule | 0.043547 |
| OXSR1 | oxidative stress responsive 1 | 0.0435057 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0428993 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0426264 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0424866 |
| CDC73 | cell division cycle 73 | 0.0413231 |
| OGA | O-GlcNAcase | 0.041266 |
| INSIG2 | insulin induced gene 2 | 0.0406412 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0401594 |
| NUP58 | nucleoporin 58 | 0.0399218 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0394417 |
| FLNB | filamin B, beta | 0.0387672 |
| USP15 | ubiquitin specific peptidase 15 | 0.0383941 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0380886 |
| GOLGA4 | golgin A4 | 0.0379168 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0376981 |
| RNF145 | ring finger protein 145 | 0.0374942 |
| POU2F1 | POU class 2 homeobox 1 | 0.0373735 |
| SRP54 | signal recognition particle 54kDa | 0.0372549 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.037151 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0363805 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0362531 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0358634 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0358016 |
| RUNX2 | runt-related transcription factor 2 | 0.0355302 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0350696 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0349527 |
| RPL35A | ribosomal protein L35a | 0.0347808 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | 0.0347749 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0347253 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0340333 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0337136 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0335608 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0334851 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0333469 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0329521 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.032803 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0327771 |
| CORO1C | coronin, actin binding protein, 1C | 0.0324149 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0323511 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0323455 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0321292 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0320578 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0319927 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.031949 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0316884 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.03158 |
| RPL23 | ribosomal protein L23 | 0.0315234 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0313638 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0313059 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.108611 |
| CD44 | CD44 molecule (Indian blood group) | -0.1074 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0943137 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0934442 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0895217 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0860769 |
| SMAD3 | SMAD family member 3 | -0.083373 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0744685 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0718555 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0708026 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0706741 |
| TGM2 | transglutaminase 2 | -0.0699584 |
| STC1 | stanniocalcin 1 | -0.0644346 |
| LOX | lysyl oxidase | -0.0601132 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0546184 |
| EFNA5 | ephrin-A5 | -0.0527682 |
| MT2A | metallothionein 2A | -0.0518069 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0516634 |
| OSMR | oncostatin M receptor | -0.0504335 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0497516 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0477665 |
| GLCCI1 | glucocorticoid induced 1 | -0.0471756 |
| CANX | calnexin | -0.0463153 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0459771 |
| TMSB4X | thymosin beta 4, X-linked | -0.0458585 |
| RAD51B | RAD51 paralog B | -0.0453603 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0447794 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0444003 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0443744 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.043585 |
| CDCP1 | CUB domain containing protein 1 | -0.0435546 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.043201 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0419194 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0418761 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0411173 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0396992 |
| NRP1 | neuropilin 1 | -0.0382098 |
| EHBP1 | EH domain binding protein 1 | -0.0371016 |
| ECE1 | endothelin converting enzyme 1 | -0.0364095 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0363155 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0354091 |
| FRMD4A | FERM domain containing 4A | -0.0350451 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0341823 |
| FNBP1 | formin binding protein 1 | -0.0331017 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0326556 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0324417 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0324214 |
| SLFN5 | schlafen family member 5 | -0.0317178 |
| LOXL2 | lysyl oxidase-like 2 | -0.0315066 |
| CEP350 | centrosomal protein 350kDa | -0.0305019 |
| ETV6 | ets variant 6 | -0.030327 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0303162 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.030192 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0298069 |
| EGFR | epidermal growth factor receptor | -0.0294849 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0293914 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0293848 |
| UBC | ubiquitin C | -0.0290272 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | -0.0286738 |
| MYO9A | myosin IXA | -0.0284064 |
| SYAP1 | synapse associated protein 1 | -0.0283556 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0282545 |
| BPTF | bromodomain PHD finger transcription factor | -0.0282311 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0282065 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0278001 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0271685 |
| MIB1 | mindbomb E3 ubiquitin protein ligase 1 | -0.0270055 |
| RPL37 | ribosomal protein L37 | -0.0269913 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | -0.0267468 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0264748 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0264317 |
| IFI44L | interferon-induced protein 44-like | -0.026104 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | -0.0256881 |
| GOLGB1 | golgin B1 | -0.0256036 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0255928 |
| SEPTIN9 | septin 9 | -0.0250376 |
| MCL1 | myeloid cell leukemia 1 | -0.0248533 |
| SCAPER | S-phase cyclin A-associated protein in the ER | -0.024764 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0246389 |
| FHL2 | four and a half LIM domains 2 | -0.0246346 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0245995 |
| KIAA1328 | KIAA1328 | -0.0245867 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0244186 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0243276 |
| LDHA | lactate dehydrogenase A | -0.0242991 |
| VEGFA | vascular endothelial growth factor A | -0.0241148 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0240572 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0238789 |
| KIAA1217 | KIAA1217 | -0.0238513 |
| BRD2 | bromodomain containing 2 | -0.0236623 |
| MYO9B | myosin IXB | -0.0234652 |
| R3HDM2 | R3H domain containing 2 | -0.0233848 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0232686 |
| ZNF609 | zinc finger protein 609 | -0.0228654 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | -0.0226872 |
| COPZ1 | coatomer protein complex, subunit zeta 1 | -0.0226598 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.0225454 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0223988 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0220412 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0219904 |
