Tadalafil_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tadalafil perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tadalafil_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0645601
RBM39 RNA binding motif protein 39 0.0645336
ZNF292 zinc finger protein 292 0.0589529
CCNL1 cyclin L1 0.057405
ZFAND3 zinc finger, AN1-type domain 3 0.0548501
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0494769
RTN4 reticulon 4 0.0480779
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0478722
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0452148
WAC WW domain containing adaptor with coiled-coil 0.0444067
ADAM17 ADAM metallopeptidase domain 17 0.0443096
WDR43 WD repeat domain 43 0.0436603
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0426372
FNBP1L formin binding protein 1-like 0.0419061
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0411092
PUM2 pumilio RNA-binding family member 2 0.0405263
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0403416
PUM1 pumilio RNA-binding family member 1 0.0393685
USP3 ubiquitin specific peptidase 3 0.0385812
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0382998
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0382661
RNF145 ring finger protein 145 0.0382098
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0380033
NAMPT nicotinamide phosphoribosyltransferase 0.0375042
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.036977
PDIA6 protein disulfide isomerase family A, member 6 0.0368971
RPS12 ribosomal protein S12 0.0360933
CHN1 chimerin 1 0.03548
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0349105
CYRIB CYFIP related Rac1 interactor B 0.0342814
RICTOR RPTOR independent companion of MTOR, complex 2 0.0342019
NCKAP1 NCK-associated protein 1 0.0338239
BCLAF1 BCL2-associated transcription factor 1 0.0337923
TPD52 tumor protein D52 0.0337854
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0336477
YME1L1 YME1-like 1 ATPase 0.0330972
NUP58 nucleoporin 58 0.0329805
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0327182
MTMR3 myotubularin related protein 3 0.0322651
TRA2A transformer 2 alpha homolog (Drosophila) 0.0315155
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0313997
ECT2 epithelial cell transforming 2 0.031329
PAWR PRKC, apoptosis, WT1, regulator 0.0309461
COPA coatomer protein complex, subunit alpha 0.0307077
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0306304
QKI QKI, KH domain containing, RNA binding 0.0304401
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0298879
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.0295266
FMNL2 formin-like 2 0.0293003
NCEH1 neutral cholesterol ester hydrolase 1 0.0292181
CASC3 cancer susceptibility candidate 3 0.0292151
NOP58 NOP58 ribonucleoprotein 0.0290235
ADAM9 ADAM metallopeptidase domain 9 0.0289493
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0288374
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0288095
MARCHF6 membrane associated ring-CH-type finger 6 0.0284494
TPM3 tropomyosin 3 0.0282587
TFG TRK-fused gene 0.0280572
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0279258
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0273837
RPS3 ribosomal protein S3 0.0272322
UBA6 ubiquitin-like modifier activating enzyme 6 0.0272104
KMT2E lysine (K)-specific methyltransferase 2E 0.0271135
RPS2 ribosomal protein S2 0.026706
EWSR1 EWS RNA-binding protein 1 0.0265488
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0264357
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 0.0263943
CDC73 cell division cycle 73 0.0263218
SPOPL speckle-type POZ protein-like 0.0260493
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0258343
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0257651
YBX3 Y box binding protein 3 0.0255549
SP3 Sp3 transcription factor 0.0253419
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0252898
CHD1 chromodomain helicase DNA binding protein 1 0.0252199
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0251603
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0249463
ERRFI1 ERBB receptor feedback inhibitor 1 0.0249218
MATR3 matrin 3 0.0248299
PARD3 par-3 family cell polarity regulator 0.0248111
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0242653
ENAH enabled homolog (Drosophila) 0.0240285
MTF2 metal response element binding transcription factor 2 0.0239703
VEZT vezatin, adherens junctions transmembrane protein 0.0239627
YTHDC1 YTH domain containing 1 0.0237778
RPL23 ribosomal protein L23 0.0236944
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.0236736
BMPR1B bone morphogenetic protein receptor, type IB 0.0235663
UGCG UDP-glucose ceramide glucosyltransferase 0.0235532
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.0233748
AGFG1 ArfGAP with FG repeats 1 0.0232342
PTK2 protein tyrosine kinase 2 0.0232101
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0230814
TRA2B transformer 2 beta homolog (Drosophila) 0.0230612
AKAP13 A kinase (PRKA) anchor protein 13 0.0228312
CFAP73 cilia and flagella associated protein 73 0.0227293
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0226161
WTAP Wilms tumor 1 associated protein 0.0223833
FOXJ3 forkhead box J3 0.022373
NUP153 nucleoporin 153kDa 0.022254

decreased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B -0.212569
VIM vimentin -0.17767
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.166775
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.129737
THSD4 thrombospondin, type I, domain containing 4 -0.11519
PDE4D phosphodiesterase 4D, cAMP-specific -0.100593
ACTG1 actin gamma 1 -0.0820848
IGF2 insulin-like growth factor 2 -0.0796991
TM4SF1 transmembrane 4 L six family member 1 -0.0773261
TFPI2 tissue factor pathway inhibitor 2 -0.0754201
PM20D1 peptidase M20 domain containing 1 -0.0723918
AKAP12 A kinase (PRKA) anchor protein 12 -0.069096
FTH1 ferritin, heavy polypeptide 1 -0.065244
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0641046
CMIP c-Maf inducing protein -0.0595092
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0572667
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0521899
IGFBP3 insulin-like growth factor binding protein 3 -0.0516216
OSMR oncostatin M receptor -0.0509905
ASPH aspartate beta-hydroxylase -0.0440468
POTEF POTE ankyrin domain family, member F -0.0424576
STC1 stanniocalcin 1 -0.0422301
PYGL phosphorylase, glycogen, liver -0.0420159
SVIL supervillin -0.0409004
KYNU kynureninase -0.0396199
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0386519
HDAC9 histone deacetylase 9 -0.036885
WWOX WW domain containing oxidoreductase -0.0366876
TPM4 tropomyosin 4 -0.0356001
BICC1 BicC family RNA binding protein 1 -0.035043
S100A6 S100 calcium binding protein A6 -0.034615
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0345731
ZBTB20 zinc finger and BTB domain containing 20 -0.0344798
LDHA lactate dehydrogenase A -0.0344615
EFNA5 ephrin-A5 -0.034449
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.034397
MAML3 mastermind-like 3 (Drosophila) -0.0340811
GLIS3 GLIS family zinc finger 3 -0.0338109
EGR1 early growth response 1 -0.0337076
DOCK5 dedicator of cytokinesis 5 -0.0329026
EGFR epidermal growth factor receptor -0.0320708
IER3 immediate early response 3 -0.0319172
BASP1 brain abundant, membrane attached signal protein 1 -0.0316639
MCL1 myeloid cell leukemia 1 -0.0311555
EHBP1 EH domain binding protein 1 -0.0304234
LOC112694756 uncharaterized LOC112694756 -0.0301843
ATXN1 ataxin 1 -0.0297837
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.029586
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0285474
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0281243
NAV3 neuron navigator 3 -0.0281146
TPT1 tumor protein, translationally-controlled 1 -0.0275699
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0270977
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0270759
C15ORF48 chromosome 15 open reading frame 48 -0.0269884
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0267265
BICD1 bicaudal D homolog 1 (Drosophila) -0.0266903
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0263418
MKI67 marker of proliferation Ki-67 -0.0258246
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0256491
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0253811
LOC102724023 ES1 protein homolog, mitochondrial -0.0250237
RNF213 ring finger protein 213 -0.0247856
USP34 ubiquitin specific peptidase 34 -0.0244848
TMSB10 thymosin beta 10 -0.0243541
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0233223
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0231049
S100A10 S100 calcium binding protein A10 -0.0230746
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.022387
CENPF centromere protein F, 350/400kDa -0.0223746
DOCK4 dedicator of cytokinesis 4 -0.0223392
AGO2 argonaute RISC catalytic component 2 -0.0222644
ANXA2 annexin A2 -0.0220635
ACTN1 actinin, alpha 1 -0.0218797
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0217955
CAVIN1 caveolae associated protein 1 -0.0214711
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.021255
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0212191
DST dystonin -0.0210499
MT2A metallothionein 2A -0.0209998
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0209071
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0209061
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0204326
ALCAM activated leukocyte cell adhesion molecule -0.0203494
CDK12 cyclin-dependent kinase 12 -0.0203109
TUBB tubulin, beta class I -0.0202134
RSPO3 R-spondin 3 -0.0201822
TBC1D5 TBC1 domain family, member 5 -0.0201625
TRIP11 thyroid hormone receptor interactor 11 -0.0201015
TRAPPC9 trafficking protein particle complex 9 -0.0200935
CUX1 cut-like homeobox 1 -0.0199956
TAS2R14 taste receptor, type 2, member 14 -0.0198631
FLNB filamin B, beta -0.0198173
MYO9A myosin IXA -0.0198157
PCNX4 pecanex 4 -0.0197844
EXOC6B exocyst complex component 6B -0.0197013
RAD51B RAD51 paralog B -0.0194438
ZMYND8 zinc finger, MYND-type containing 8 -0.0193137
NCOA7 nuclear receptor coactivator 7 -0.0191096
UBC ubiquitin C -0.0189109