| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tadalafil perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tadalafil_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.181123 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.104464 |
| PATJ | PATJ crumbs cell polarity complex component | 0.101813 |
| ATP13A3 | ATPase type 13A3 | 0.0956447 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0953908 |
| PTK2 | protein tyrosine kinase 2 | 0.0876889 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0869082 |
| PHF3 | PHD finger protein 3 | 0.0803462 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.074286 |
| RPS25 | ribosomal protein S25 | 0.0684231 |
| RBM39 | RNA binding motif protein 39 | 0.064536 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0625969 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0622584 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0613134 |
| RPL15 | ribosomal protein L15 | 0.0612994 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0612284 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0611918 |
| SPTSSA | serine palmitoyltransferase, small subunit A | 0.0609053 |
| C1ORF21 | chromosome 1 open reading frame 21 | 0.0598681 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0593174 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0593027 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0584392 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0584143 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0579403 |
| TNPO3 | transportin 3 | 0.0569715 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0559263 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0522323 |
| TRIM2 | tripartite motif containing 2 | 0.0521321 |
| TASOR2 | transcription activation suppressor family member 2 | 0.0520816 |
| KIF16B | kinesin family member 16B | 0.0519711 |
| TUSC3 | tumor suppressor candidate 3 | 0.0501702 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0482569 |
| ASPH | aspartate beta-hydroxylase | 0.0477994 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0477857 |
| USP53 | ubiquitin specific peptidase 53 | 0.0472529 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0465868 |
| TMF1 | TATA element modulatory factor 1 | 0.0463037 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0460456 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0458126 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0449355 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0440391 |
| NAV2 | neuron navigator 2 | 0.0431886 |
| GOLGB1 | golgin B1 | 0.042551 |
| CDC42SE2 | CDC42 small effector 2 | 0.0425085 |
| RPS8 | ribosomal protein S8 | 0.0424803 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0419408 |
| AREG | amphiregulin | 0.0419154 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0416421 |
| BRD4 | bromodomain containing 4 | 0.0414091 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0410887 |
| MSI2 | musashi RNA-binding protein 2 | 0.0410013 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0409283 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0403905 |
| ZNF207 | zinc finger protein 207 | 0.0401243 |
| AFF1 | AF4/FMR2 family, member 1 | 0.039828 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0397811 |
| RPL9 | ribosomal protein L9 | 0.0392448 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0389202 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0387976 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0381795 |
| PGK1 | phosphoglycerate kinase 1 | 0.0377942 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.03739 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0372769 |
| TXNRD1 | thioredoxin reductase 1 | 0.0366649 |
| PKP4 | plakophilin 4 | 0.0342542 |
| SQSTM1 | sequestosome 1 | 0.0342187 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0341498 |
| AEBP2 | AE binding protein 2 | 0.0339487 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0337134 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0337009 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0330559 |
| EPB41 | erythrocyte membrane protein band 4.1 | 0.0328587 |
| ANKRD12 | ankyrin repeat domain 12 | 0.032772 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0325729 |
| LAMA4 | laminin, alpha 4 | 0.0324718 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0324499 |
| MYO6 | myosin VI | 0.0324299 |
| PTMA | prothymosin, alpha | 0.0318966 |
| MAP7 | microtubule-associated protein 7 | 0.0314555 |
| ZNF292 | zinc finger protein 292 | 0.0312048 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0311899 |
| WDR45B | WD repeat domain 45B | 0.0311654 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0310328 |
| DEK | DEK proto-oncogene | 0.0307418 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.030481 |
| MATR3 | matrin 3 | 0.0303798 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0300816 |
| HMGB1 | high mobility group box 1 | 0.0300003 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0296319 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0292392 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0291454 |
| CERT1 | ceramide transporter 1 | 0.0291181 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.0290503 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0288204 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0284147 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0274629 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0274364 |
| VMP1 | vacuole membrane protein 1 | 0.0274224 |
| FAM13A | family with sequence similarity 13, member A | 0.027039 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0270168 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.23704 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.215688 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.129515 |
| LAMB3 | laminin, beta 3 | -0.128708 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.122791 |
| NDRG1 | N-myc downstream regulated 1 | -0.11514 |
| MYO1E | myosin IE | -0.0999742 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0934206 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0919568 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0872069 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0806471 |
| KRT17 | keratin 17, type I | -0.0786022 |
| SPAG9 | sperm associated antigen 9 | -0.0770637 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0744531 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0706118 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.068894 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0682479 |
| VIM | vimentin | -0.0681831 |
| ANXA1 | annexin A1 | -0.0678313 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0676687 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0675494 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0659111 |
| IGF2 | insulin-like growth factor 2 | -0.0654016 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0643881 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0641086 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0625025 |
| MXD1 | MAX dimerization protein 1 | -0.0620679 |
| CANX | calnexin | -0.0610467 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0560873 |
| TSC22D2 | TSC22 domain family, member 2 | -0.05552 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0551536 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0539501 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0536633 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0515344 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0509145 |
| PLAUR | plasminogen activator, urokinase receptor | -0.050506 |
| KYNU | kynureninase | -0.0504657 |
| VCL | vinculin | -0.0493412 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0488586 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0488101 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.048607 |
| OGA | O-GlcNAcase | -0.0464437 |
| RTN4 | reticulon 4 | -0.0457068 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0447806 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0429934 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0421692 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0419572 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0416527 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0412196 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0404766 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.040201 |
| PARD3 | par-3 family cell polarity regulator | -0.0400074 |
| GRB10 | growth factor receptor-bound protein 10 | -0.039323 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0390111 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.038659 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.038593 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0383216 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0380012 |
| HELZ | helicase with zinc finger | -0.0379847 |
| EZR | ezrin | -0.0376028 |
| PCBP2 | poly(rC) binding protein 2 | -0.0375201 |
| PKM | pyruvate kinase, muscle | -0.0365913 |
| RPS6 | ribosomal protein S6 | -0.0358235 |
| MEF2A | myocyte enhancer factor 2A | -0.0358136 |
| FLNB | filamin B, beta | -0.0355629 |
| RND3 | Rho family GTPase 3 | -0.0346053 |
| FN1 | fibronectin 1 | -0.0344145 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0338423 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0332928 |
| RUNX1 | runt-related transcription factor 1 | -0.0316372 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0313344 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0313306 |
| CALU | calumenin | -0.0307319 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0302616 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0299045 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0295205 |
| RPL23 | ribosomal protein L23 | -0.0292602 |
| RPS23 | ribosomal protein S23 | -0.029103 |
| QKI | QKI, KH domain containing, RNA binding | -0.0290112 |
| MORF4L2 | mortality factor 4 like 2 | -0.0287113 |
| TPM4 | tropomyosin 4 | -0.0283144 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0280742 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0280677 |
| GOLGA4 | golgin A4 | -0.0275235 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0265217 |
| OSMR | oncostatin M receptor | -0.0264498 |
| S100A9 | S100 calcium binding protein A9 | -0.0263445 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0262963 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0242721 |
| JMJD1C | jumonji domain containing 1C | -0.024208 |
| MED13 | mediator complex subunit 13 | -0.0241342 |
| CD44 | CD44 molecule (Indian blood group) | -0.0241077 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0234064 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0231083 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0230521 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0229549 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0228376 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0227408 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0221291 |
| RPL37A | ribosomal protein L37a | -0.0220819 |
