| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tadalafil perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tadalafil_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RAD51B | RAD51 paralog B | 0.0902133 |
| PRELID2 | PRELI domain containing 2 | 0.0778621 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0749029 |
| CCNL1 | cyclin L1 | 0.0722871 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0645768 |
| BBX | bobby sox homolog (Drosophila) | 0.0592646 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0571036 |
| USP34 | ubiquitin specific peptidase 34 | 0.0539363 |
| ATXN1 | ataxin 1 | 0.0529397 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0499361 |
| RBM39 | RNA binding motif protein 39 | 0.0498005 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0493198 |
| CEP192 | centrosomal protein 192kDa | 0.0485768 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0476394 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0454603 |
| TPM3 | tropomyosin 3 | 0.0441573 |
| HELZ | helicase with zinc finger | 0.0436181 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0423347 |
| PREPL | prolyl endopeptidase-like | 0.0418864 |
| XPO1 | exportin 1 | 0.0394681 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0391915 |
| PHF20 | PHD finger protein 20 | 0.0381287 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0377821 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0374316 |
| COPA | coatomer protein complex, subunit alpha | 0.0371818 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0364064 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0363636 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0362454 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0357167 |
| ENO1 | enolase 1, (alpha) | 0.0352842 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.034794 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0343807 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | 0.0342854 |
| GOLGA4 | golgin A4 | 0.0342697 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0336374 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0333114 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0331825 |
| PHF21A | PHD finger protein 21A | 0.032346 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0321761 |
| TNPO3 | transportin 3 | 0.0319751 |
| PCM1 | pericentriolar material 1 | 0.0318858 |
| RNF38 | ring finger protein 38 | 0.0318789 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0317666 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0317665 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | 0.0317452 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0316227 |
| ZNF292 | zinc finger protein 292 | 0.031543 |
| RSF1 | remodeling and spacing factor 1 | 0.0314862 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0314527 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0311743 |
| FAM168A | family with sequence similarity 168, member A | 0.0310633 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0309301 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0302601 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0299062 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0298007 |
| TBK1 | TANK-binding kinase 1 | 0.0297382 |
| PDS5B | PDS5 cohesin associated factor B | 0.0296473 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0294979 |
| VMP1 | vacuole membrane protein 1 | 0.0294242 |
| WWOX | WW domain containing oxidoreductase | 0.0292066 |
| CDK19 | cyclin-dependent kinase 19 | 0.0290077 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.028661 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0285141 |
| TFG | TRK-fused gene | 0.0283481 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0282807 |
| OGA | O-GlcNAcase | 0.0280863 |
| CUL3 | cullin 3 | 0.0278743 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0277394 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0277055 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0274238 |
| ANKRD36 | ankyrin repeat domain 36 | 0.027399 |
| THOC1 | THO complex 1 | 0.0273863 |
| ZNF148 | zinc finger protein 148 | 0.0273296 |
| MED13L | mediator complex subunit 13-like | 0.0272968 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0272274 |
| TMEM165 | transmembrane protein 165 | 0.0268396 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0267603 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0267018 |
| RBM33 | RNA binding motif protein 33 | 0.0266106 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0261158 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0260922 |
| NOP58 | NOP58 ribonucleoprotein | 0.0259215 |
| NCKAP1 | NCK-associated protein 1 | 0.0254482 |
| RLIM | ring finger protein, LIM domain interacting | 0.0253883 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0251694 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0250965 |
| SRP54 | signal recognition particle 54kDa | 0.0247862 |
| SBF2 | SET binding factor 2 | 0.0246414 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0245476 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0245321 |
| CDYL | chromodomain protein, Y-like | 0.0241922 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0241726 |
| SMAP1 | small ArfGAP 1 | 0.0240025 |
| JMJD1C | jumonji domain containing 1C | 0.0239148 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0237916 |
| CPNE8 | copine VIII | 0.0237795 |
| GPBP1L1 | GC-rich promoter binding protein 1-like 1 | 0.0236579 |
| PARD3 | par-3 family cell polarity regulator | 0.023612 |
| TMEM39A | transmembrane protein 39A | 0.0235066 |
| CAND1 | cullin-associated and neddylation-dissociated 1 | 0.0232471 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TFPI2 | tissue factor pathway inhibitor 2 | -0.198483 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.167638 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.109795 |
| TXNRD1 | thioredoxin reductase 1 | -0.089705 |
| VIM | vimentin | -0.0819919 |
| OSMR | oncostatin M receptor | -0.080839 |
| ACTG1 | actin gamma 1 | -0.0804975 |
| STC1 | stanniocalcin 1 | -0.0651843 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0632063 |
| YBX3 | Y box binding protein 3 | -0.0631392 |
| EGR1 | early growth response 1 | -0.0603296 |
| GRAMD1B | GRAM domain containing 1B | -0.0582182 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0564085 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0515083 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0493092 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0486685 |
| NABP1 | nucleic acid binding protein 1 | -0.0483886 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0472884 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0468173 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0462113 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0443681 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0441299 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0427015 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0425357 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0417974 |
| TMSB10 | thymosin beta 10 | -0.041507 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0414248 |
| KLF6 | Kruppel-like factor 6 | -0.0401159 |
| SLC38A2 | solute carrier family 38, member 2 | -0.03942 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0393321 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0383975 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.038011 |
| PLSCR1 | phospholipid scramblase 1 | -0.0367251 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0361121 |
| HMGA2 | high mobility group AT-hook 2 | -0.0360804 |
| CCND1 | cyclin D1 | -0.0358111 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0356536 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0349291 |
| RPLP1 | ribosomal protein, large, P1 | -0.0342972 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0340574 |
| EGFR | epidermal growth factor receptor | -0.0337676 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0329374 |
| CAVIN1 | caveolae associated protein 1 | -0.032889 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.032387 |
| MCL1 | myeloid cell leukemia 1 | -0.0318846 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0317516 |
| NRG1 | neuregulin 1 | -0.0316587 |
| RIGI | RNA sensor RIG-I | -0.0309845 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0309416 |
| PDE10A | phosphodiesterase 10A | -0.0302203 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0299346 |
| HLA-B | major histocompatibility complex, class I, B | -0.0298342 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0296649 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0296617 |
| VDAC1 | voltage-dependent anion channel 1 | -0.029355 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0289067 |
| RPL36A | ribosomal protein L36a | -0.0288565 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0285941 |
| POTEF | POTE ankyrin domain family, member F | -0.0281919 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0279731 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0276994 |
| IER3 | immediate early response 3 | -0.0276691 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0275644 |
| CDK17 | cyclin-dependent kinase 17 | -0.027549 |
| RACK1 | receptor for activated C kinase 1 | -0.0272892 |
| TPI1 | triosephosphate isomerase 1 | -0.0262785 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.0259429 |
| FHL2 | four and a half LIM domains 2 | -0.0255507 |
| MT2A | metallothionein 2A | -0.0253463 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0251697 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -0.0250234 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0247269 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0246575 |
| ATP11A | ATPase, class VI, type 11A | -0.0245402 |
| DUSP6 | dual specificity phosphatase 6 | -0.0242953 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0241095 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0236332 |
| PMP22 | peripheral myelin protein 22 | -0.0235973 |
| GPHN | gephyrin | -0.0233004 |
| GOLM2 | golgi membrane protein 2 | -0.0230091 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0229332 |
| CD44 | CD44 molecule (Indian blood group) | -0.0217953 |
| S100A6 | S100 calcium binding protein A6 | -0.0217253 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0216988 |
| S100A11 | S100 calcium binding protein A11 | -0.0216085 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0215345 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0215092 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0212979 |
| TCIM | transcriptional and immune response regulator | -0.0212389 |
| TMEM41B | transmembrane protein 41B | -0.0208778 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0206965 |
| B2M | beta-2-microglobulin | -0.0205207 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0205007 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.020492 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0204253 |
| ANXA2 | annexin A2 | -0.0203892 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0203623 |
| CLDN1 | claudin 1 | -0.0203133 |
| TUBA1B | tubulin, alpha 1b | -0.0202174 |
| RBBP6 | retinoblastoma binding protein 6 | -0.0202098 |
