Tadalafil_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tadalafil perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tadalafil_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRB10 growth factor receptor-bound protein 10 0.0727993
TSC22D2 TSC22 domain family, member 2 0.0514159
RPL35A ribosomal protein L35a 0.043866
FNDC3B fibronectin type III domain containing 3B 0.0418539
FXR1 fragile X mental retardation, autosomal homolog 1 0.0411108
FAM13A family with sequence similarity 13, member A 0.0396806
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0392383
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0350433
PGK1 phosphoglycerate kinase 1 0.0326756
PLAU plasminogen activator, urokinase 0.028432
TOP1 topoisomerase (DNA) I 0.0271591
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0253742
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0245694
GARS1 glycyl-tRNA synthetase 1 0.0227433
LPP LIM domain containing preferred translocation partner in lipoma 0.0222562
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0219036
MSI2 musashi RNA-binding protein 2 0.0214556
RYBP RING1 and YY1 binding protein 0.0214176
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0211956
SSBP2 single-stranded DNA binding protein 2 0.0202579
PTK2 protein tyrosine kinase 2 0.0200354
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0198838
KDM5B lysine (K)-specific demethylase 5B 0.0197565
QKI QKI, KH domain containing, RNA binding 0.0196655
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0193207
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0191099
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0190567
WSB1 WD repeat and SOCS box containing 1 0.0189904
CD109 CD109 molecule 0.0185643
CCNL1 cyclin L1 0.0182132
EPS8 epidermal growth factor receptor pathway substrate 8 0.0180862
SPOPL speckle-type POZ protein-like 0.0180664
RPL23 ribosomal protein L23 0.0176881
FAM168A family with sequence similarity 168, member A 0.0176138
UBA6 ubiquitin-like modifier activating enzyme 6 0.017231
ISG15 ISG15 ubiquitin-like modifier 0.0172115
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0171436
F3 coagulation factor III (thromboplastin, tissue factor) 0.0171137
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 0.0170078
WAC WW domain containing adaptor with coiled-coil 0.0161778
LRRC1 leucine rich repeat containing 1 0.0160267
RREB1 ras responsive element binding protein 1 0.0155263
ENO2 enolase 2 (gamma, neuronal) 0.0154554
MRPS6 mitochondrial ribosomal protein S6 0.0152338
FHIT fragile histidine triad 0.0150888
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0150563
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0148672
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0145963
RNF145 ring finger protein 145 0.0145182
STRN3 striatin, calmodulin binding protein 3 0.0144737
ZNF292 zinc finger protein 292 0.0140585
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0136271
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0136197
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0136067
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.0133232
TRA2B transformer 2 beta homolog (Drosophila) 0.0131783
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0131704
YME1L1 YME1-like 1 ATPase 0.0128739
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0128533
WDFY2 WD repeat and FYVE domain containing 2 0.0127879
RPS3 ribosomal protein S3 0.0125867
ZNF451 zinc finger protein 451 0.0125361
IFI6 interferon, alpha-inducible protein 6 0.0124042
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 0.0123246
FERMT2 fermitin family member 2 0.0122626
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0122379
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.01216
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains 0.0116676
TFG TRK-fused gene 0.0116081
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0115863
USP3 ubiquitin specific peptidase 3 0.0115264
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.011464
NT5C2 5'-nucleotidase, cytosolic II 0.0114522
CDC73 cell division cycle 73 0.011395
MAML3 mastermind-like 3 (Drosophila) 0.0113337
RIGI RNA sensor RIG-I 0.0112933
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0112925
GRID1 glutamate receptor, ionotropic, delta 1 0.0111478
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0111106
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.010967
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0109617
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0109589
RNASE3 ribonuclease, RNase A family, 3 0.0109258
PHIP pleckstrin homology domain interacting protein 0.0109163
HSPH1 heat shock 105kDa/110kDa protein 1 0.0108993
MORF4L1 mortality factor 4 like 1 0.01077
PDS5B PDS5 cohesin associated factor B 0.0106943
SOX4 SRY (sex determining region Y)-box 4 0.0106635
MXD1 MAX dimerization protein 1 0.0105678
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0105444
HOOK1 hook microtubule-tethering protein 1 0.0104814
AGFG1 ArfGAP with FG repeats 1 0.0104622
FAM162A family with sequence similarity 162, member A 0.0104216
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa 0.0100649
ARHGAP12 Rho GTPase activating protein 12 0.0099677
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.00993974
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 0.00991475
PGAP1 post-GPI attachment to proteins 1 0.00989094
WFDC2 WAP four-disulfide core domain 2 0.00973382
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.00972234

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.311738
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.278018
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.210772
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.210604
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.173114
POTEF POTE ankyrin domain family, member F -0.155583
ACTG1 actin gamma 1 -0.134771
NDRG1 N-myc downstream regulated 1 -0.128749
LAMC2 laminin, gamma 2 -0.102597
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.097364
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0966296
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0927357
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0780589
GOLGA4 golgin A4 -0.0753907
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0752029
ALCAM activated leukocyte cell adhesion molecule -0.0750685
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0727145
HMGA1 high mobility group AT-hook 1 -0.0696824
UBC ubiquitin C -0.0692827
LDHA lactate dehydrogenase A -0.067743
S100A6 S100 calcium binding protein A6 -0.0676758
RPS6 ribosomal protein S6 -0.0639379
TXNRD1 thioredoxin reductase 1 -0.0602694
EEF2 eukaryotic translation elongation factor 2 -0.0584407
TMSB4X thymosin beta 4, X-linked -0.0577339
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0567925
ASPH aspartate beta-hydroxylase -0.0566585
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.052177
LOC112694756 uncharaterized LOC112694756 -0.050824
RACK1 receptor for activated C kinase 1 -0.0507721
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0502275
FBXO32 F-box protein 32 -0.0490774
ANXA2 annexin A2 -0.0474084
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0472349
SQSTM1 sequestosome 1 -0.0472146
MYH9 myosin, heavy chain 9, non-muscle -0.0468209
EIF1 eukaryotic translation initiation factor 1 -0.0462368
CAPN2 calpain 2, (m/II) large subunit -0.0461717
TPT1 tumor protein, translationally-controlled 1 -0.0461209
RPL37 ribosomal protein L37 -0.0456926
RPLP0 ribosomal protein, large, P0 -0.045623
ERBIN erbb2 interacting protein -0.0449973
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0447338
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0446533
KRT18 keratin 18, type I -0.0446223
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0443501
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0438703
MKI67 marker of proliferation Ki-67 -0.0435885
DSG2 desmoglein 2 -0.04317
ELL2 elongation factor, RNA polymerase II, 2 -0.0421509
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0407007
RPL11 ribosomal protein L11 -0.040506
HSPA8 heat shock 70kDa protein 8 -0.0391436
BRD2 bromodomain containing 2 -0.0390633
VIM vimentin -0.0385312
DSTN destrin (actin depolymerizing factor) -0.0382125
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0371319
TPM3 tropomyosin 3 -0.0367935
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0367201
RPL7 ribosomal protein L7 -0.0365911
MAP1B microtubule-associated protein 1B -0.0365367
CD44 CD44 molecule (Indian blood group) -0.0360221
CCND1 cyclin D1 -0.0358093
RPL27A ribosomal protein L27a -0.0356194
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0355585
YBX1 Y box binding protein 1 -0.0353723
PLEC plectin -0.0353588
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0348707
EXT1 exostosin glycosyltransferase 1 -0.0347171
FTH1 ferritin, heavy polypeptide 1 -0.0342579
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0337808
CENPF centromere protein F, 350/400kDa -0.0336187
SLC38A1 solute carrier family 38, member 1 -0.0333073
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0332154
NAV2 neuron navigator 2 -0.0331847
EZR ezrin -0.0330981
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0330669
CDCP1 CUB domain containing protein 1 -0.0329101
MSN moesin -0.0324893
PRRC2C proline-rich coiled-coil 2C -0.0322597
ATXN1 ataxin 1 -0.0322077
PKM pyruvate kinase, muscle -0.0322024
EPCAM epithelial cell adhesion molecule -0.0321755
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0313713
RPL8 ribosomal protein L8 -0.0313453
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0313139
RPL26 ribosomal protein L26 -0.0312114
VEGFA vascular endothelial growth factor A -0.0306333
CSNK1A1 casein kinase 1, alpha 1 -0.0304965
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0303958
LMNA lamin A/C -0.0302383
DST dystonin -0.0301742
ZFR zinc finger RNA binding protein -0.030026
EFNA5 ephrin-A5 -0.030024
RUNX1 runt-related transcription factor 1 -0.0299666
FLNB filamin B, beta -0.0299122
MYO1E myosin IE -0.0298686
ANO6 anoctamin 6 -0.0298449
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0296205
RPLP1 ribosomal protein, large, P1 -0.0292011