| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tadalafil perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tadalafil_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.216165 |
| EFNA5 | ephrin-A5 | 0.155402 |
| GDA | guanine deaminase | 0.119119 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0922544 |
| ASPH | aspartate beta-hydroxylase | 0.082928 |
| RPL37A | ribosomal protein L37a | 0.082753 |
| RPS3 | ribosomal protein S3 | 0.0802264 |
| NRCAM | neuronal cell adhesion molecule | 0.0797053 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0786015 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0756408 |
| PCBP3 | poly(rC) binding protein 3 | 0.0752809 |
| PTMA | prothymosin, alpha | 0.0719512 |
| COL5A2 | collagen, type V, alpha 2 | 0.0708913 |
| RPS2 | ribosomal protein S2 | 0.0702491 |
| RPS8 | ribosomal protein S8 | 0.0701446 |
| RPS12 | ribosomal protein S12 | 0.0682437 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0661806 |
| RPL23 | ribosomal protein L23 | 0.0631151 |
| PDE10A | phosphodiesterase 10A | 0.0612311 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0569171 |
| RPL35A | ribosomal protein L35a | 0.0566703 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0566464 |
| GRAMD1B | GRAM domain containing 1B | 0.0563343 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0552089 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0550972 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0550292 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0510452 |
| RPL26 | ribosomal protein L26 | 0.0509446 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0505707 |
| RPL36 | ribosomal protein L36 | 0.05011 |
| MT2A | metallothionein 2A | 0.0498025 |
| TMSB10 | thymosin beta 10 | 0.0496264 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0489649 |
| RPS19 | ribosomal protein S19 | 0.0473222 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0470695 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0462193 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0460411 |
| NPAS2 | neuronal PAS domain protein 2 | 0.04532 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0444114 |
| RPL12 | ribosomal protein L12 | 0.0412867 |
| SMYD3 | SET and MYND domain containing 3 | 0.0411964 |
| AUTS2 | autism susceptibility candidate 2 | 0.0411523 |
| RPL32 | ribosomal protein L32 | 0.0409335 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.040851 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0387212 |
| FLNB | filamin B, beta | 0.0384113 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0380796 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0378934 |
| RPS29 | ribosomal protein S29 | 0.0375682 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0369227 |
| RPS23 | ribosomal protein S23 | 0.0361698 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.035766 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.035728 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0345834 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0341575 |
| CD109 | CD109 molecule | 0.0339681 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0332082 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0331786 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0330314 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0329432 |
| CTSC | cathepsin C | 0.0325957 |
| RPS6 | ribosomal protein S6 | 0.0325331 |
| RPL34 | ribosomal protein L34 | 0.0320595 |
| GLIS3 | GLIS family zinc finger 3 | 0.0313848 |
| BMERB1 | bMERB domain containing 1 | 0.0311238 |
| RPS13 | ribosomal protein S13 | 0.0304274 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0302021 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | 0.0301014 |
| RPL9 | ribosomal protein L9 | 0.029888 |
| ATP13A3 | ATPase type 13A3 | 0.0298076 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.02971 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0294725 |
| RPL31 | ribosomal protein L31 | 0.0287302 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0282583 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0280942 |
| RPS27A | ribosomal protein S27a | 0.028091 |
| RPL5 | ribosomal protein L5 | 0.0279705 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0277223 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0275008 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0273371 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0273282 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0271509 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0269859 |
| RPL18 | ribosomal protein L18 | 0.0268711 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0266691 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0266593 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0266564 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0262358 |
| RPS17 | ribosomal protein S17 | 0.0258655 |
| USP34 | ubiquitin specific peptidase 34 | 0.0256762 |
| COL4A5 | collagen, type IV, alpha 5 | 0.0254891 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0252298 |
| RPS10 | ribosomal protein S10 | 0.0250364 |
| BDNF | brain-derived neurotrophic factor | 0.0246475 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0245302 |
| FMNL2 | formin-like 2 | 0.0243806 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0239683 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0238309 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0237552 |
| RPS21 | ribosomal protein S21 | 0.0233437 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.277145 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.173077 |
| FN1 | fibronectin 1 | -0.152909 |
| VIM | vimentin | -0.118244 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0928761 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0879437 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0787481 |
| LDHA | lactate dehydrogenase A | -0.0741247 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.071691 |
| UBC | ubiquitin C | -0.0666643 |
| CANX | calnexin | -0.0554675 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0546686 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.054012 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0539545 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.050405 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.050377 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.048685 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0484804 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0454514 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0448349 |
| PCBP2 | poly(rC) binding protein 2 | -0.0436113 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.0403713 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0380209 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0379657 |
| RPLP0 | ribosomal protein, large, P0 | -0.037702 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0373839 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0373809 |
| ANXA1 | annexin A1 | -0.0369623 |
| MCL1 | myeloid cell leukemia 1 | -0.036892 |
| ANXA2 | annexin A2 | -0.0366455 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0357853 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0357489 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0342244 |
| EGR1 | early growth response 1 | -0.0324047 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0322205 |
| PYGL | phosphorylase, glycogen, liver | -0.0321903 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0321881 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0321153 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0316818 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0315335 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0313023 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.030572 |
| PKM | pyruvate kinase, muscle | -0.0305098 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0299915 |
| PERP | PERP, TP53 apoptosis effector | -0.0298024 |
| POTEF | POTE ankyrin domain family, member F | -0.0292481 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0291302 |
| MORF4L2 | mortality factor 4 like 2 | -0.0290979 |
| EZR | ezrin | -0.0289647 |
| STC1 | stanniocalcin 1 | -0.0282907 |
| RTN4 | reticulon 4 | -0.0278135 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0277667 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.027017 |
| TSC22D2 | TSC22 domain family, member 2 | -0.026873 |
| RPL39 | ribosomal protein L39 | -0.0259946 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.025798 |
| RPS24 | ribosomal protein S24 | -0.0248152 |
| SPAG9 | sperm associated antigen 9 | -0.0248087 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 | -0.0247445 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0246501 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.0243075 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0242478 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0242392 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0239947 |
| MAGT1 | magnesium transporter 1 | -0.0238148 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.0235955 |
| ATF3 | activating transcription factor 3 | -0.0235894 |
| ZNF207 | zinc finger protein 207 | -0.0235573 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0232366 |
| BSG | basigin (Ok blood group) | -0.023231 |
| S100A6 | S100 calcium binding protein A6 | -0.0232255 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0230606 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0229026 |
| TKT | transketolase | -0.0228306 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0226299 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0224171 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0221986 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0220757 |
| TUBA1B | tubulin, alpha 1b | -0.0220729 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0219492 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0218453 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -0.0216928 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0215231 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0213197 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0211832 |
| NABP1 | nucleic acid binding protein 1 | -0.0206837 |
| DSTN | destrin (actin depolymerizing factor) | -0.0204383 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0204188 |
| ARF1 | ADP-ribosylation factor 1 | -0.0203781 |
| NUP58 | nucleoporin 58 | -0.0201894 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0199398 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0198898 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.0197009 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0195437 |
| S100A10 | S100 calcium binding protein A10 | -0.0194357 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0194183 |
| RPL37 | ribosomal protein L37 | -0.0193419 |
| WDR45B | WD repeat domain 45B | -0.0192735 |
| USP15 | ubiquitin specific peptidase 15 | -0.0190049 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0189595 |
