Tadalafil_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tadalafil perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

145 genes differentially expressed following the Tadalafil_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.19746
SPAG9 sperm associated antigen 9 0.143069
FNDC3B fibronectin type III domain containing 3B 0.12546
FAM13A family with sequence similarity 13, member A 0.12488
PRKCA protein kinase C, alpha 0.104365
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.102866
NAMPT nicotinamide phosphoribosyltransferase 0.0974871
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0909871
KLF5 Kruppel-like factor 5 (intestinal) 0.0850899
UBA6 ubiquitin-like modifier activating enzyme 6 0.083384
HOOK2 hook microtubule-tethering protein 2 0.07837
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0765758
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0707954
RTN4 reticulon 4 0.0703241
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0674913
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.067252
ERRFI1 ERBB receptor feedback inhibitor 1 0.0644748
LPP LIM domain containing preferred translocation partner in lipoma 0.0644446
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0636679
DST dystonin 0.0624617
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0604283
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0585852
JARID2 jumonji, AT rich interactive domain 2 0.0571673
YAP1 Yes-associated protein 1 0.056844
DSCAM Down syndrome cell adhesion molecule 0.0540085
ANKRD12 ankyrin repeat domain 12 0.0478589
LRP1B low density lipoprotein receptor-related protein 1B 0.0464699
ERBIN erbb2 interacting protein 0.0446647
APP amyloid beta (A4) precursor protein 0.0441532
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0421653
PRELID2 PRELI domain containing 2 0.0418953
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.041796
EGFR epidermal growth factor receptor 0.040793
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0380163
BHLHE40 basic helix-loop-helix family, member e40 0.0368939
PDE10A phosphodiesterase 10A 0.0363135
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0361385
KMT2C lysine (K)-specific methyltransferase 2C 0.0356794
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0354429
MYOF myoferlin 0.0333811
NABP1 nucleic acid binding protein 1 0.0333129
PDLIM5 PDZ and LIM domain 5 0.0324089
ZFAND3 zinc finger, AN1-type domain 3 0.0320245
ZNF292 zinc finger protein 292 0.0317497
BIRC6 baculoviral IAP repeat containing 6 0.0315612
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0305485
MAML3 mastermind-like 3 (Drosophila) 0.0299278
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0294056
PTK2 protein tyrosine kinase 2 0.0284865
CNKSR3 CNKSR family member 3 0.0279216
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0262545
NAV2 neuron navigator 2 0.0252847
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0232353
SND1 staphylococcal nuclease and tudor domain containing 1 0.0226352
PARD3 par-3 family cell polarity regulator 0.0206315
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0202499
FLNB filamin B, beta 0.0195576
FOXP1 forkhead box P1 0.0182649
ARHGAP12 Rho GTPase activating protein 12 0.015936
SMYD3 SET and MYND domain containing 3 0.0152153
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0152001
RB1CC1 RB1-inducible coiled-coil 1 0.0151494
GOLGA4 golgin A4 0.0145989
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0136271
WAC WW domain containing adaptor with coiled-coil 0.0128558
PTPRG protein tyrosine phosphatase, receptor type, G 0.0117794
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.010947
TBC1D22A TBC1 domain family, member 22A 0.00945779
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.00782028
PUM2 pumilio RNA-binding family member 2 0.00659409
KMT2E lysine (K)-specific methyltransferase 2E 0.00533197
RBM39 RNA binding motif protein 39 0.00454279
OGA O-GlcNAcase 0.00361874
EFNA5 ephrin-A5 0.00248872
THOC2 THO complex 2 0.00175343
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 7.26976E-4

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.261199
PDE4D phosphodiesterase 4D, cAMP-specific -0.121494
FTL ferritin, light polypeptide -0.104534
RPL35A ribosomal protein L35a -0.0984859
RPS6 ribosomal protein S6 -0.0925636
VIM vimentin -0.0823952
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0782973
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0756332
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0742472
NAP1L1 nucleosome assembly protein 1-like 1 -0.0740364
IGFBP3 insulin-like growth factor binding protein 3 -0.0736208
RPS12 ribosomal protein S12 -0.0733894
RPL37A ribosomal protein L37a -0.0708518
RPS8 ribosomal protein S8 -0.0705844
ASPH aspartate beta-hydroxylase -0.0693994
FTH1 ferritin, heavy polypeptide 1 -0.0667307
EEF2 eukaryotic translation elongation factor 2 -0.0657713
MCL1 myeloid cell leukemia 1 -0.0639998
PRRC2C proline-rich coiled-coil 2C -0.0637989
GPC6 glypican 6 -0.0609591
TPT1 tumor protein, translationally-controlled 1 -0.057807
MBD5 methyl-CpG binding domain protein 5 -0.0536152
FN1 fibronectin 1 -0.0523094
PTMA prothymosin, alpha -0.0515307
POTEF POTE ankyrin domain family, member F -0.0497815
MT2A metallothionein 2A -0.0491605
JMJD1C jumonji domain containing 1C -0.0481482
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0479213
TMSB10 thymosin beta 10 -0.0474959
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0468628
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0463326
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0422302
VCL vinculin -0.0416339
USP34 ubiquitin specific peptidase 34 -0.0411103
RPL38 ribosomal protein L38 -0.0386228
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0364852
LDHA lactate dehydrogenase A -0.0361417
SLC38A2 solute carrier family 38, member 2 -0.0352229
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0350191
AKAP9 A kinase (PRKA) anchor protein 9 -0.0295033
EIF1 eukaryotic translation initiation factor 1 -0.0281745
LMO7 LIM domain 7 -0.0273478
RPS3 ribosomal protein S3 -0.0269196
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0264436
ACTG1 actin gamma 1 -0.0262525
PKM pyruvate kinase, muscle -0.0257667
COL6A3 collagen, type VI, alpha 3 -0.025703
RPS19 ribosomal protein S19 -0.0252933
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0250362
SBF2 SET binding factor 2 -0.0240159
RUNX1 runt-related transcription factor 1 -0.0236872
RIGI RNA sensor RIG-I -0.023173
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0226766
PTPRM protein tyrosine phosphatase, receptor type, M -0.0213708
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0211401
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0197547
TRIO trio Rho guanine nucleotide exchange factor -0.0187496
ANKRD28 ankyrin repeat domain 28 -0.0166877
TRA2A transformer 2 alpha homolog (Drosophila) -0.016527
SDK1 sidekick cell adhesion molecule 1 -0.0151397
MAML2 mastermind-like 2 (Drosophila) -0.0148246
TAS2R14 taste receptor, type 2, member 14 -0.0127398
EXT1 exostosin glycosyltransferase 1 -0.0122104
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.00914833
CAMKMT calmodulin-lysine N-methyltransferase -0.00856017
ANO6 anoctamin 6 -0.00854519
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.00765669
RNF213 ring finger protein 213 -0.00762386
COL5A2 collagen, type V, alpha 2 -0.0055849