| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tadalafil perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tadalafil_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.062492 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0527283 |
| FNDC3B | fibronectin type III domain containing 3B | 0.046813 |
| NCKAP1 | NCK-associated protein 1 | 0.0439641 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0421781 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.039637 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0386057 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0383365 |
| WDR43 | WD repeat domain 43 | 0.0367536 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0337151 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0330469 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0323027 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0320928 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0315861 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.029414 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0286961 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0286807 |
| CRY1 | cryptochrome circadian clock 1 | 0.0286755 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0284778 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.0278857 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0278131 |
| TPM3 | tropomyosin 3 | 0.0272983 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0272902 |
| YME1L1 | YME1-like 1 ATPase | 0.0269112 |
| YAP1 | Yes-associated protein 1 | 0.0259222 |
| TFG | TRK-fused gene | 0.025744 |
| GOLGA4 | golgin A4 | 0.0250357 |
| USP3 | ubiquitin specific peptidase 3 | 0.0249921 |
| STAM | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 | 0.0249583 |
| MED13L | mediator complex subunit 13-like | 0.0241708 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0241297 |
| MATR3 | matrin 3 | 0.0238928 |
| MTMR3 | myotubularin related protein 3 | 0.0238012 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0229653 |
| UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | 0.0228436 |
| STRN | striatin, calmodulin binding protein | 0.0228252 |
| FNIP1 | folliculin interacting protein 1 | 0.0226942 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0225365 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0220402 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.02196 |
| CDK6 | cyclin-dependent kinase 6 | 0.0218977 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0218544 |
| RPRD1B | regulation of nuclear pre-mRNA domain containing 1B | 0.0218129 |
| U2SURP | U2 snRNP-associated SURP domain containing | 0.0217002 |
| RBM39 | RNA binding motif protein 39 | 0.0213543 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0213047 |
| CEP95 | centrosomal protein 95kDa | 0.0212823 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0211785 |
| TOP1 | topoisomerase (DNA) I | 0.021095 |
| ZNF638 | zinc finger protein 638 | 0.0208887 |
| SLMAP | sarcolemma associated protein | 0.0206626 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0202064 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.020163 |
| ATM | ATM serine/threonine kinase | 0.0200683 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0199581 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0196567 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0194622 |
| SCAF8 | SR-related CTD-associated factor 8 | 0.0194338 |
| CLIC4 | chloride intracellular channel 4 | 0.019336 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0192964 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0192922 |
| AMBRA1 | autophagy/beclin-1 regulator 1 | 0.0192521 |
| MAPRE1 | microtubule-associated protein, RP/EB family, member 1 | 0.0190531 |
| MCL1 | myeloid cell leukemia 1 | 0.0189395 |
| NRAS | neuroblastoma RAS viral (v-ras) oncogene homolog | 0.0188563 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0187541 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0186861 |
| SIK3 | SIK family kinase 3 | 0.0185997 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0185821 |
| MEMO1 | mediator of cell motility 1 | 0.0185102 |
| NOP58 | NOP58 ribonucleoprotein | 0.0184161 |
| MBIP | MAP3K12 binding inhibitory protein 1 | 0.0184143 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.018362 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0182897 |
| FAM168A | family with sequence similarity 168, member A | 0.0182748 |
| SUGT1 | SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) | 0.0181914 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0181787 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0179373 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0178959 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 0.0178375 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.017659 |
| NFIB | nuclear factor I/B | 0.0175264 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0174909 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0174653 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0173703 |
| TBC1D12 | TBC1 domain family, member 12 | 0.0173206 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0171956 |
| PDGFC | platelet derived growth factor C | 0.0171853 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 0.0171778 |
| RNF145 | ring finger protein 145 | 0.0171605 |
| DENND4A | DENN/MADD domain containing 4A | 0.0170931 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0170614 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0170113 |
| AHCTF1 | AT hook containing transcription factor 1 | 0.0170095 |
| ZDHHC20 | zinc finger, DHHC-type containing 20 | 0.0169882 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.0169371 |
| CUL4B | cullin 4B | 0.0168647 |
| ZFHX4 | zinc finger homeobox 4 | 0.016759 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0166955 |
| BNC2 | basonuclin 2 | 0.0166386 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.192622 |
| VIM | vimentin | -0.176177 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.153743 |
| GPC3 | glypican 3 | -0.138332 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.120471 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.105657 |
| TMSB10 | thymosin beta 10 | -0.0972053 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0956338 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0938024 |
| RPS16 | ribosomal protein S16 | -0.0900673 |
| COL11A1 | collagen, type XI, alpha 1 | -0.0899512 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0895552 |
| CADM2 | cell adhesion molecule 2 | -0.0866568 |
| PTMA | prothymosin, alpha | -0.0854592 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0841419 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0816592 |
| PCDH9 | protocadherin 9 | -0.0811262 |
| RPS8 | ribosomal protein S8 | -0.0805534 |
| NTM | neurotrimin | -0.077369 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0662409 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.0654626 |
| ACTG1 | actin gamma 1 | -0.0636474 |
| RPS6 | ribosomal protein S6 | -0.0624209 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0611502 |
| SNX6 | sorting nexin 6 | -0.06094 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0607163 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0579609 |
| RPLP1 | ribosomal protein, large, P1 | -0.0558732 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0545213 |
| LRRC4C | leucine rich repeat containing 4C | -0.054082 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0540112 |
| GNAS | GNAS complex locus | -0.0525209 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0521572 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.051315 |
| ENO1 | enolase 1, (alpha) | -0.0482567 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0478954 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0464605 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0460309 |
| RPL35A | ribosomal protein L35a | -0.0458479 |
| TENM3 | teneurin transmembrane protein 3 | -0.0451914 |
| RPL23 | ribosomal protein L23 | -0.044018 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0435102 |
| RAD51B | RAD51 paralog B | -0.0435042 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0411522 |
| COL3A1 | collagen, type III, alpha 1 | -0.0408639 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0405503 |
| RPLP0 | ribosomal protein, large, P0 | -0.0398498 |
| TENM2 | teneurin transmembrane protein 2 | -0.0387049 |
| HDAC9 | histone deacetylase 9 | -0.03809 |
| RPL12 | ribosomal protein L12 | -0.0378083 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0377541 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0376342 |
| TPR | translocated promoter region, nuclear basket protein | -0.0371504 |
| TMSB4X | thymosin beta 4, X-linked | -0.0360464 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0354904 |
| RPS12 | ribosomal protein S12 | -0.0352339 |
| RPS19 | ribosomal protein S19 | -0.0352163 |
| RPS27A | ribosomal protein S27a | -0.0351392 |
| TUBA1B | tubulin, alpha 1b | -0.0349279 |
| CALR | calreticulin | -0.0338187 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0335615 |
| SOX2 | SRY (sex determining region Y)-box 2 | -0.0332014 |
| RPS3 | ribosomal protein S3 | -0.0329443 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0327471 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0326037 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.0324561 |
| RPL31 | ribosomal protein L31 | -0.0323268 |
| RPL26 | ribosomal protein L26 | -0.0318294 |
| MAP4 | microtubule-associated protein 4 | -0.0315583 |
| RFPL4B | ret finger protein-like 4B | -0.0310933 |
| COL5A2 | collagen, type V, alpha 2 | -0.0310239 |
| HMCN1 | hemicentin 1 | -0.0306977 |
| RPL30 | ribosomal protein L30 | -0.0306969 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.030638 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0306233 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0305751 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.030504 |
| LDHA | lactate dehydrogenase A | -0.0302022 |
| HMGB2 | high mobility group box 2 | -0.030172 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0300813 |
| HMGB1 | high mobility group box 1 | -0.0297129 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0296392 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0295479 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0293437 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0293213 |
| RACK1 | receptor for activated C kinase 1 | -0.0293164 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0291185 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0289645 |
| COL1A2 | collagen, type I, alpha 2 | -0.028789 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0287612 |
| RPLP2 | ribosomal protein, large, P2 | -0.0287366 |
| RPS4X | ribosomal protein S4, X-linked | -0.0283835 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0280996 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0279058 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0278155 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0275215 |
| RPL11 | ribosomal protein L11 | -0.0274122 |
| RPL37A | ribosomal protein L37a | -0.0272366 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0270422 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0270079 |
