| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tadalafil perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tadalafil_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | 0.193404 |
| FNDC3B | fibronectin type III domain containing 3B | 0.162579 |
| CADM1 | cell adhesion molecule 1 | 0.155701 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.152156 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0908188 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 0.0781778 |
| NAV2 | neuron navigator 2 | 0.0746836 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0733508 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0716485 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0704612 |
| FRMD4A | FERM domain containing 4A | 0.0686138 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0629948 |
| FNIP1 | folliculin interacting protein 1 | 0.0618259 |
| DIAPH2 | diaphanous-related formin 2 | 0.0540324 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0518506 |
| FMNL2 | formin-like 2 | 0.0505676 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0476946 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0475874 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0475236 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0470241 |
| RPL35A | ribosomal protein L35a | 0.0464809 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0458174 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0457375 |
| PRELID2 | PRELI domain containing 2 | 0.0428561 |
| PRR16 | proline rich 16 | 0.0426012 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0411971 |
| ATXN1 | ataxin 1 | 0.0406391 |
| NGLY1 | N-glycanase 1 | 0.0371942 |
| GPC6 | glypican 6 | 0.0369118 |
| CENPF | centromere protein F, 350/400kDa | 0.0367738 |
| HELZ | helicase with zinc finger | 0.0360717 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0353319 |
| TMEM178B | transmembrane protein 178B | 0.0348864 |
| FRMPD4 | FERM and PDZ domain containing 4 | 0.0342572 |
| FTL | ferritin, light polypeptide | 0.0341294 |
| WTAP | Wilms tumor 1 associated protein | 0.0327131 |
| FOXO3 | forkhead box O3 | 0.0327101 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0317856 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0315418 |
| ERBIN | erbb2 interacting protein | 0.0312919 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0305834 |
| NKTR | natural killer cell triggering receptor | 0.0305241 |
| QKI | QKI, KH domain containing, RNA binding | 0.0303317 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0301781 |
| JMJD1C | jumonji domain containing 1C | 0.0300851 |
| PDGFC | platelet derived growth factor C | 0.02992 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0299097 |
| LRRC7 | leucine rich repeat containing 7 | 0.0297815 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0290781 |
| CCBE1 | collagen and calcium binding EGF domains 1 | 0.0290306 |
| CDK19 | cyclin-dependent kinase 19 | 0.0289323 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0283859 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0283109 |
| TNS3 | tensin 3 | 0.028195 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0281505 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0280452 |
| ATP11B | ATPase, class VI, type 11B | 0.0275638 |
| DIAPH3 | diaphanous-related formin 3 | 0.0273038 |
| PCBP3 | poly(rC) binding protein 3 | 0.0272803 |
| FBXO11 | F-box protein 11 | 0.0272682 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0272313 |
| KIF4A | kinesin family member 4A | 0.0270843 |
| EXT1 | exostosin glycosyltransferase 1 | 0.02705 |
| SMC4 | structural maintenance of chromosomes 4 | 0.026954 |
| RPL36 | ribosomal protein L36 | 0.0269297 |
| MYOF | myoferlin | 0.0261326 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0257317 |
| AFDN | afadin, adherens junction formation factor | 0.025669 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0256378 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0255912 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0254559 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0254399 |
| WDR26 | WD repeat domain 26 | 0.0253502 |
| RYBP | RING1 and YY1 binding protein | 0.0251848 |
| SNX14 | sorting nexin 14 | 0.0251707 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0250843 |
| PLIN2 | perilipin 2 | 0.0249151 |
| CD109 | CD109 molecule | 0.0248042 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0247945 |
| NLGN1 | neuroligin 1 | 0.0245981 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0244 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0243077 |
| SETD5 | SET domain containing 5 | 0.0240297 |
| NR3C2 | nuclear receptor subfamily 3, group C, member 2 | 0.023942 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0239268 |
| RUNX1 | runt-related transcription factor 1 | 0.0238029 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0233802 |
| TLE4 | transducin-like enhancer of split 4 | 0.0233184 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0230739 |
| ANKRD11 | ankyrin repeat domain 11 | 0.023065 |
| KAZN | kazrin, periplakin interacting protein | 0.0230134 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | 0.0229026 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0227658 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0227417 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0226786 |
| ZNF638 | zinc finger protein 638 | 0.0225701 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0225508 |
| ABI1 | abl-interactor 1 | 0.0224352 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0224266 |
| DENND5A | DENN/MADD domain containing 5A | 0.0224113 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.158738 |
| VIM | vimentin | -0.152273 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.145536 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.11492 |
| FN1 | fibronectin 1 | -0.100981 |
| CD44 | CD44 molecule (Indian blood group) | -0.0906669 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0869237 |
| TMSB4X | thymosin beta 4, X-linked | -0.0848596 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0844982 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0832917 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0805946 |
| STC1 | stanniocalcin 1 | -0.0805336 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0794853 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0778135 |
| BICC1 | BicC family RNA binding protein 1 | -0.0710853 |
| CANX | calnexin | -0.0663648 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0661121 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.064815 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0598326 |
| LDHA | lactate dehydrogenase A | -0.0596854 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0582503 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0545793 |
| THBS1 | thrombospondin 1 | -0.0538652 |
| LAMP2 | lysosomal-associated membrane protein 2 | -0.0535025 |
| VCAN | versican | -0.052951 |
| POTEF | POTE ankyrin domain family, member F | -0.0522201 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0518239 |
| GLIS3 | GLIS family zinc finger 3 | -0.0510487 |
| DSTN | destrin (actin depolymerizing factor) | -0.0491855 |
| UBC | ubiquitin C | -0.048938 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0486499 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0485466 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0485132 |
| SFTPA2 | surfactant protein A2 | -0.0481874 |
| ANXA2 | annexin A2 | -0.0479864 |
| APP | amyloid beta (A4) precursor protein | -0.0468211 |
| CLTC | clathrin, heavy chain (Hc) | -0.0464576 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0434142 |
| HLA-E | major histocompatibility complex, class I, E | -0.0432642 |
| SET | SET nuclear proto-oncogene | -0.0432207 |
| MSN | moesin | -0.0431369 |
| HMGA2 | high mobility group AT-hook 2 | -0.041622 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0414318 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0410721 |
| RPLP0 | ribosomal protein, large, P0 | -0.0407578 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0401248 |
| CDCP1 | CUB domain containing protein 1 | -0.0400997 |
| RPS4X | ribosomal protein S4, X-linked | -0.039536 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0389302 |
| RPS2 | ribosomal protein S2 | -0.0386214 |
| SDC4 | syndecan 4 | -0.038112 |
| GNAS | GNAS complex locus | -0.0374053 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0370942 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0365267 |
| RPL26 | ribosomal protein L26 | -0.0363915 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0352962 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0351877 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0351822 |
| RPS6 | ribosomal protein S6 | -0.0350493 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0347327 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0346898 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0341797 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0334817 |
| PCBP2 | poly(rC) binding protein 2 | -0.0334811 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0330589 |
| RPL39 | ribosomal protein L39 | -0.0325459 |
| RPS24 | ribosomal protein S24 | -0.0323389 |
| PGK1 | phosphoglycerate kinase 1 | -0.0320909 |
| DST | dystonin | -0.031656 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0315816 |
| FLNA | filamin A, alpha | -0.0315711 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0313184 |
| CUL4B | cullin 4B | -0.031121 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0310284 |
| TKT | transketolase | -0.03081 |
| CTSB | cathepsin B | -0.030772 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0306542 |
| RRBP1 | ribosome binding protein 1 | -0.03041 |
| VEGFA | vascular endothelial growth factor A | -0.0303503 |
| MATR3 | matrin 3 | -0.0303274 |
| MAP1B | microtubule-associated protein 1B | -0.0302372 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0296612 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 | -0.0293516 |
| TAF1 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | -0.0291721 |
| CALR | calreticulin | -0.0289292 |
| NONO | non-POU domain containing, octamer-binding | -0.028647 |
| SLC38A1 | solute carrier family 38, member 1 | -0.028571 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0284941 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0284786 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0283507 |
| IPO7 | importin 7 | -0.0282862 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0282615 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0279778 |
| RPL7 | ribosomal protein L7 | -0.0276436 |
| TPM1 | tropomyosin 1 (alpha) | -0.027609 |
| HDAC8 | histone deacetylase 8 | -0.0275817 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0275168 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0270982 |
| EHBP1 | EH domain binding protein 1 | -0.0270867 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.0270259 |
