Tadalafil_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tadalafil perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tadalafil_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.105238
IGFBP3 insulin-like growth factor binding protein 3 0.0872107
NRXN3 neurexin 3 0.0747981
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0635255
VEGFC vascular endothelial growth factor C 0.0603394
ERRFI1 ERBB receptor feedback inhibitor 1 0.05782
PRELID2 PRELI domain containing 2 0.0526548
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0507368
COG5 component of oligomeric golgi complex 5 0.0494186
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0465641
PRSS23 protease, serine, 23 0.0465406
TRIO trio Rho guanine nucleotide exchange factor 0.0432369
TNS3 tensin 3 0.0431361
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0424311
ZBTB20 zinc finger and BTB domain containing 20 0.0423811
CDH13 cadherin 13 0.0415956
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.040248
CENPF centromere protein F, 350/400kDa 0.0399916
APOLD1 apolipoprotein L domain containing 1 0.0397458
PSD3 pleckstrin and Sec7 domain containing 3 0.0396044
CDK13 cyclin-dependent kinase 13 0.0388014
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0387709
CXCL8 chemokine (C-X-C motif) ligand 8 0.037056
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0357284
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0347017
SND1 staphylococcal nuclease and tudor domain containing 1 0.0346324
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0344761
MACF1 microtubule-actin crosslinking factor 1 0.0344375
COL5A1 collagen, type V, alpha 1 0.0342835
DNAH11 dynein, axonemal, heavy chain 11 0.0342775
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0329112
TUT4 terminal uridylyl transferase 4 0.0315977
ZSWIM6 zinc finger, SWIM-type containing 6 0.0308116
SCLT1 sodium channel and clathrin linker 1 0.0304047
SDK1 sidekick cell adhesion molecule 1 0.0299137
F3 coagulation factor III (thromboplastin, tissue factor) 0.0298661
TPM1 tropomyosin 1 (alpha) 0.029756
YEATS2 YEATS domain containing 2 0.0297175
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0293668
WNT5A wingless-type MMTV integration site family, member 5A 0.0287031
NIPBL Nipped-B homolog (Drosophila) 0.0279124
SMYD3 SET and MYND domain containing 3 0.0273472
DPYD dihydropyrimidine dehydrogenase 0.0270808
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0268082
ANLN anillin, actin binding protein 0.026115
ANO6 anoctamin 6 0.0259372
TIMP3 TIMP metallopeptidase inhibitor 3 0.0258276
N4BP2L2 NEDD4 binding protein 2-like 2 0.0257884
ATXN1 ataxin 1 0.0254333
CCDC14 coiled-coil domain containing 14 0.0253622
SEC24A SEC24 family member A 0.0253134
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0252996
AHR aryl hydrocarbon receptor 0.0250285
FAM20C family with sequence similarity 20, member C 0.0249226
BIRC3 baculoviral IAP repeat containing 3 0.0247953
KAZN kazrin, periplakin interacting protein 0.0245687
HIPK2 homeodomain interacting protein kinase 2 0.024513
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0245099
ARB2A ARB2 cotranscriptional regulator A 0.0241905
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0241647
ITCH itchy E3 ubiquitin protein ligase 0.0241126
LPP LIM domain containing preferred translocation partner in lipoma 0.0240672
HOOK2 hook microtubule-tethering protein 2 0.0239489
ATG7 autophagy related 7 0.0237166
BIRC6 baculoviral IAP repeat containing 6 0.0232125
KDM6A lysine (K)-specific demethylase 6A 0.022819
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0227871
AKAP9 A kinase (PRKA) anchor protein 9 0.0224618
EIF4B eukaryotic translation initiation factor 4B 0.0223939
THBS1 thrombospondin 1 0.0223088
SLC30A7 solute carrier family 30 (zinc transporter), member 7 0.0222539
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0219938
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0215844
STARD13 StAR-related lipid transfer (START) domain containing 13 0.0212335
SRPK2 SRSF protein kinase 2 0.0211136
RNF145 ring finger protein 145 0.0209041
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0207778
COL6A2 collagen, type VI, alpha 2 0.0206289
PRICKLE2 prickle homolog 2 (Drosophila) 0.0204583
CCNB1 cyclin B1 0.0202425
TGFB2 transforming growth factor, beta 2 0.0201826
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0201744
NLN neurolysin (metallopeptidase M3 family) 0.0200747
NAV1 neuron navigator 1 0.0199844
TRRAP transformation/transcription domain-associated protein 0.0198812
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 0.0198647
MYH9 myosin, heavy chain 9, non-muscle 0.0195451
PDIA5 protein disulfide isomerase family A, member 5 0.0194131
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0192263
KIDINS220 kinase D-interacting substrate, 220kDa 0.0192205
AOPEP aminopeptidase O (putative) 0.0192111
KIAA2026 KIAA2026 0.0191924
RAI14 retinoic acid induced 14 0.0191556
TARS1 threonyl-tRNA synthetase 1 0.0191338
NOTCH2 notch 2 0.0190635
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0189156
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 0.0187925
CUL1 cullin 1 0.0187646
XRN1 5'-3' exoribonuclease 1 0.0186782
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0186251

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.330091
MT2A metallothionein 2A -0.175358
VIM vimentin -0.118845
TMSB10 thymosin beta 10 -0.116872
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0891299
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0860506
HLA-B major histocompatibility complex, class I, B -0.0859613
PTMA prothymosin, alpha -0.0818541
STC1 stanniocalcin 1 -0.0676516
FTL ferritin, light polypeptide -0.063876
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.062352
B2M beta-2-microglobulin -0.0576911
WSB1 WD repeat and SOCS box containing 1 -0.0569147
H3-3B H3.3 histone B -0.0558596
S100A6 S100 calcium binding protein A6 -0.0505009
TPT1 tumor protein, translationally-controlled 1 -0.0489128
RPLP1 ribosomal protein, large, P1 -0.0475146
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.047361
ADM adrenomedullin -0.0465944
SDC4 syndecan 4 -0.0461173
RPS6 ribosomal protein S6 -0.0452451
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0423057
RPL11 ribosomal protein L11 -0.0421239
ENO1 enolase 1, (alpha) -0.0418878
NAMPT nicotinamide phosphoribosyltransferase -0.0415441
LOC112694756 uncharaterized LOC112694756 -0.0410548
HLA-C major histocompatibility complex, class I, C -0.0408688
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0390005
EEF2 eukaryotic translation elongation factor 2 -0.0383724
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0372547
RPS24 ribosomal protein S24 -0.0360739
CCNI cyclin I -0.0358976
PDE10A phosphodiesterase 10A -0.0353633
FMNL2 formin-like 2 -0.0350036
PNRC1 proline-rich nuclear receptor coactivator 1 -0.034702
RPL36 ribosomal protein L36 -0.0339364
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0338592
ZFAND3 zinc finger, AN1-type domain 3 -0.0334225
RPS8 ribosomal protein S8 -0.0331424
RPS19 ribosomal protein S19 -0.0330401
PRRC2C proline-rich coiled-coil 2C -0.0327371
RPL26 ribosomal protein L26 -0.0325896
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0324949
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0322243
S100A9 S100 calcium binding protein A9 -0.0318169
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0316691
HLA-A major histocompatibility complex, class I, A -0.0316371
ASPH aspartate beta-hydroxylase -0.0309808
UBC ubiquitin C -0.0308071
SEPTIN7 septin 7 -0.0307634
EIF1 eukaryotic translation initiation factor 1 -0.0306133
MAP1B microtubule-associated protein 1B -0.0304199
ALCAM activated leukocyte cell adhesion molecule -0.0294535
MATR3 matrin 3 -0.0293042
EGR1 early growth response 1 -0.0285411
PFN1 profilin 1 -0.0283359
RACK1 receptor for activated C kinase 1 -0.0280692
RPL23 ribosomal protein L23 -0.0279629
GPC6 glypican 6 -0.0275573
YBX1 Y box binding protein 1 -0.0275467
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0275248
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -0.0275148
LMNA lamin A/C -0.0274694
RPS12 ribosomal protein S12 -0.0271639
RPL28 ribosomal protein L28 -0.026937
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0269078
ADAM9 ADAM metallopeptidase domain 9 -0.0266563
RPL7 ribosomal protein L7 -0.0262742
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0259421
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0258867
LOX lysyl oxidase -0.0255711
DDIT4 DNA-damage-inducible transcript 4 -0.0254931
CBX3 chromobox homolog 3 -0.0254501
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0253428
CD44 CD44 molecule (Indian blood group) -0.0251324
CALR calreticulin -0.0250932
QKI QKI, KH domain containing, RNA binding -0.0249225
POTEF POTE ankyrin domain family, member F -0.024795
MT1X metallothionein 1X -0.0247602
PDIA3 protein disulfide isomerase family A, member 3 -0.0246316
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0246059
IRF1 interferon regulatory factor 1 -0.024495
RBM39 RNA binding motif protein 39 -0.0244023
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0240245
RPL12 ribosomal protein L12 -0.0238629
CALU calumenin -0.0237863
RPS4X ribosomal protein S4, X-linked -0.0237038
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0235298
ANXA2 annexin A2 -0.0235059
ANXA1 annexin A1 -0.02346
ATP5F1E ATP synthase F1 subunit epsilon -0.0234356
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0234134
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0233289
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0232357
WTAP Wilms tumor 1 associated protein -0.0231317
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0227779
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0227041
RPL37A ribosomal protein L37a -0.0226528
FOSL1 FOS-like antigen 1 -0.0225569
SPDYA speedy/RINGO cell cycle regulator family member A -0.0223491