| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tadalafil perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tadalafil_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FNDC3B | fibronectin type III domain containing 3B | 0.121573 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0892769 |
| ZNF292 | zinc finger protein 292 | 0.0586495 |
| PTK2 | protein tyrosine kinase 2 | 0.0580519 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0532044 |
| EGFR | epidermal growth factor receptor | 0.0504196 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0498488 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0497526 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0489239 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0487711 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0479537 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0477032 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0466795 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0466569 |
| PARD3 | par-3 family cell polarity regulator | 0.0456484 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0452891 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0448882 |
| USP3 | ubiquitin specific peptidase 3 | 0.0446775 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0445746 |
| DNER | delta/notch-like EGF repeat containing | 0.0445615 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0441649 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0438475 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0427086 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0422521 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0418414 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0399016 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0393737 |
| NAV3 | neuron navigator 3 | 0.0386217 |
| FLNB | filamin B, beta | 0.0383203 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0375785 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0367821 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0366964 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.036156 |
| OXSR1 | oxidative stress responsive 1 | 0.0354605 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0354003 |
| NPTN | neuroplastin | 0.0351921 |
| RBM26 | RNA binding motif protein 26 | 0.0349459 |
| DTNA | dystrobrevin, alpha | 0.0349355 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.0344414 |
| INSIG2 | insulin induced gene 2 | 0.0343373 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0342072 |
| NBAS | neuroblastoma amplified sequence | 0.0341803 |
| NHSL1 | NHS-like 1 | 0.0340543 |
| FMNL2 | formin-like 2 | 0.0334249 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0332019 |
| ATXN1 | ataxin 1 | 0.0330545 |
| INSIG1 | insulin induced gene 1 | 0.0330129 |
| HMGA2 | high mobility group AT-hook 2 | 0.0326828 |
| PYGL | phosphorylase, glycogen, liver | 0.0325902 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0321409 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0320189 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0319531 |
| TTK | TTK protein kinase | 0.031697 |
| NALCN | sodium leak channel, non selective | 0.0313872 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0308593 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0307414 |
| FOXO3 | forkhead box O3 | 0.0301225 |
| NEK6 | NIMA-related kinase 6 | 0.0299227 |
| AHNAK | AHNAK nucleoprotein | 0.0299158 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.029706 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.029217 |
| RTN4 | reticulon 4 | 0.0288265 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0286338 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0283129 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0283097 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0283084 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0281259 |
| RBM6 | RNA binding motif protein 6 | 0.0280194 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0279247 |
| TFG | TRK-fused gene | 0.0278564 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0277199 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0276535 |
| DNAJC10 | DnaJ (Hsp40) homolog, subfamily C, member 10 | 0.0275813 |
| CNOT8 | CCR4-NOT transcription complex, subunit 8 | 0.0274042 |
| KIF16B | kinesin family member 16B | 0.0273267 |
| RAI14 | retinoic acid induced 14 | 0.0272304 |
| QKI | QKI, KH domain containing, RNA binding | 0.0271707 |
| AHR | aryl hydrocarbon receptor | 0.0269879 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.0268615 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0267898 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0267628 |
| NAA35 | N(alpha)-acetyltransferase 35, NatC auxiliary subunit | 0.0266547 |
| UBP1 | upstream binding protein 1 (LBP-1a) | 0.0265644 |
| SNX9 | sorting nexin 9 | 0.0259424 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0259047 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0257648 |
| SVIL | supervillin | 0.0256578 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.0252907 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0251697 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0251449 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0249924 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.0249824 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0249515 |
| RNF145 | ring finger protein 145 | 0.0249483 |
| BTRC | beta-transducin repeat containing E3 ubiquitin protein ligase | 0.0249317 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0249035 |
| PGGT1B | protein geranylgeranyltransferase type I, beta subunit | 0.0248855 |
| ATXN2 | ataxin 2 | 0.0248807 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0248805 |
| MORF4L1 | mortality factor 4 like 1 | 0.0247297 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.107883 |
| VIM | vimentin | -0.104515 |
| SMYD3 | SET and MYND domain containing 3 | -0.0968443 |
| GOLGA4 | golgin A4 | -0.0743898 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0718843 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.066347 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0656231 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0645678 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0635867 |
| LDHA | lactate dehydrogenase A | -0.063102 |
| RPLP1 | ribosomal protein, large, P1 | -0.0616989 |
| CENPF | centromere protein F, 350/400kDa | -0.05582 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0510654 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0509993 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0470413 |
| CENPP | centromere protein P | -0.0469869 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0466241 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0442631 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0429828 |
| SQSTM1 | sequestosome 1 | -0.0429102 |
| RPL15 | ribosomal protein L15 | -0.0428282 |
| ANO6 | anoctamin 6 | -0.0426441 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.042443 |
| DEK | DEK proto-oncogene | -0.0423341 |
| YBX3 | Y box binding protein 3 | -0.0418883 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0412526 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0412259 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0400724 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0399065 |
| RPS12 | ribosomal protein S12 | -0.039788 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0394476 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0392761 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0378549 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0377389 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0376723 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0376713 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0376367 |
| GNAS | GNAS complex locus | -0.0375888 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0374776 |
| ZC3H13 | zinc finger CCCH-type containing 13 | -0.0367991 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0365992 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0365358 |
| VMP1 | vacuole membrane protein 1 | -0.0364669 |
| ERBIN | erbb2 interacting protein | -0.0363736 |
| SET | SET nuclear proto-oncogene | -0.0363705 |
| RRBP1 | ribosome binding protein 1 | -0.0363351 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | -0.0359319 |
| NUP98 | nucleoporin 98kDa | -0.0356727 |
| SON | SON DNA binding protein | -0.0354017 |
| CPNE1 | copine I | -0.0351956 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0344763 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0339017 |
| CALU | calumenin | -0.0337752 |
| WDR45B | WD repeat domain 45B | -0.0337475 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.033555 |
| RPL36 | ribosomal protein L36 | -0.033487 |
| TFRC | transferrin receptor | -0.0332805 |
| TPX2 | TPX2, microtubule-associated | -0.0332775 |
| RAD51B | RAD51 paralog B | -0.0331565 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0323945 |
| RPL9 | ribosomal protein L9 | -0.0320683 |
| PCBP2 | poly(rC) binding protein 2 | -0.0320197 |
| FUS | FUS RNA binding protein | -0.0314697 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0308945 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0305611 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0302945 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0301216 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0301147 |
| BRD2 | bromodomain containing 2 | -0.0301132 |
| UBB | ubiquitin B | -0.0300488 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0300279 |
| ZC3H6 | zinc finger CCCH-type containing 6 | -0.0300277 |
| TPR | translocated promoter region, nuclear basket protein | -0.0298109 |
| DSTN | destrin (actin depolymerizing factor) | -0.0297304 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0296519 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0296414 |
| KIF20B | kinesin family member 20B | -0.029527 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0294492 |
| AHCTF1 | AT hook containing transcription factor 1 | -0.0293047 |
| H3-3B | H3.3 histone B | -0.0292011 |
| RPS17 | ribosomal protein S17 | -0.0288219 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0286722 |
| OGA | O-GlcNAcase | -0.0286442 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0281804 |
| RPL35 | ribosomal protein L35 | -0.0281054 |
| VPS13A | vacuolar protein sorting 13 homolog A (S. cerevisiae) | -0.0278616 |
| BRD8 | bromodomain containing 8 | -0.0276297 |
| RPL26 | ribosomal protein L26 | -0.0275468 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.027422 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0274219 |
| GOLGB1 | golgin B1 | -0.027405 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0272892 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0272583 |
| BRD4 | bromodomain containing 4 | -0.0271438 |
| YEATS2 | YEATS domain containing 2 | -0.0271103 |
| SSH2 | slingshot protein phosphatase 2 | -0.0270488 |
| B2M | beta-2-microglobulin | -0.0265836 |
| RACK1 | receptor for activated C kinase 1 | -0.0265103 |
| RPS20 | ribosomal protein S20 | -0.0263711 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0262111 |
