| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/11001318 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Tafamidis relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SBSN | suprabasin | 1.6 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 1.49 |
| PIP | prolactin-induced protein | 1.4 |
| ECM1 | extracellular matrix protein 1 | 1.31 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 1.05 |
| PIGQ | phosphatidylinositol glycan anchor biosynthesis, class Q | 0.69 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | 0.67 |
| TCIRG1 | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 | 0.65 |
| SLC45A1 | solute carrier family 45, member 1 | 0.58 |
| ARL13B | ADP-ribosylation factor-like 13B | 0.48 |
| SH3RF2 | SH3 domain containing ring finger 2 | 0.47 |
| PIP4P2 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 | 0.44 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 0.44 |
| TAF10 | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa | 0.44 |
| RTL8C | retrotransposon Gag like 8C | 0.44 |
| ERICH5 | glutamate-rich 5 | 0.42 |
| MAST3 | microtubule associated serine/threonine kinase 3 | 0.42 |
| CST6 | cystatin E/M | 0.42 |
| ABHD18 | abhydrolase domain containing 18 | 0.41 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.39 |
| BORCS7 | BLOC-1 related complex subunit 7 | 0.39 |
| CCDC85B | coiled-coil domain containing 85B | 0.39 |
| TCTEX1D2 | Tctex1 domain containing 2 | 0.37 |
| CCDC71 | coiled-coil domain containing 71 | 0.37 |
| C19ORF54 | chromosome 19 open reading frame 54 | 0.37 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.36 |
| FEM1C | fem-1 homolog c (C. elegans) | 0.36 |
| TIPE1 | TNF alpha induced protein 8 like 1 | 0.35 |
| OAF | OAF homolog (Drosophila) | 0.35 |
| MGA | MGA, MAX dimerization protein | 0.34 |
| STARD10 | StAR-related lipid transfer (START) domain containing 10 | 0.33 |
| GLI4 | GLI family zinc finger 4 | 0.33 |
| GLRX | glutaredoxin (thioltransferase) | 0.33 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.32 |
| TAF9B | TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa | 0.32 |
| ZNF668 | zinc finger protein 668 | 0.32 |
| GBA2 | glucosidase, beta (bile acid) 2 | 0.32 |
| MYT1 | myelin transcription factor 1 | 0.31 |
| MON1A | MON1 secretory trafficking family member A | 0.31 |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 | 0.31 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.31 |
| ZMAT5 | zinc finger, matrin-type 5 | 0.3 |
| FIG4 | FIG4 phosphoinositide 5-phosphatase | 0.3 |
| FN3K | fructosamine 3 kinase | 0.29 |
| ELFN1 | extracellular leucine-rich repeat and fibronectin type III domain containing 1 | 0.29 |
| RAB17 | RAB17, member RAS oncogene family | 0.29 |
| MTMR9 | myotubularin related protein 9 | 0.29 |
| RXRG | retinoid X receptor, gamma | 0.28 |
| MNT | MAX network transcriptional repressor | 0.28 |
| SLC25A30 | solute carrier family 25, member 30 | 0.28 |
| ZNF236 | zinc finger protein 236 | 0.28 |
| GM2A | GM2 ganglioside activator | 0.28 |
| N4BP3 | NEDD4 binding protein 3 | 0.27 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.27 |
| GDE1 | glycerophosphodiester phosphodiesterase 1 | 0.27 |
| TULP3 | tubby like protein 3 | 0.27 |
| AMPD1 | adenosine monophosphate deaminase 1 | 0.27 |
| SUCO | SUN domain containing ossification factor | 0.27 |
| ALMS1 | Alstrom syndrome protein 1 | 0.27 |
| KMT5B | lysine methyltransferase 5B | 0.26 |
| TSPAN4 | tetraspanin 4 | 0.26 |
| IFT57 | intraflagellar transport 57 | 0.26 |
| TRIM13 | tripartite motif containing 13 | 0.26 |
| B4GALT3 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 | 0.25 |
| STYX | serine/threonine/tyrosine interacting protein | 0.25 |
| PPP1R35 | protein phosphatase 1, regulatory subunit 35 | 0.25 |
| MZT2B | mitotic spindle organizing protein 2B | 0.25 |
| ZBTB45 | zinc finger and BTB domain containing 45 | 0.25 |
| CARD19 | caspase recruitment domain family member 19 | 0.25 |
| S100A2 | S100 calcium binding protein A2 | 0.25 |
| HEXIM2 | hexamethylene bis-acetamide inducible 2 | 0.25 |
| PKHD1L1 | polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 | 0.24 |
| KIAA0355 | KIAA0355 | 0.24 |
| ARMT1 | acidic residue methyltransferase 1 | 0.24 |
| LYSMD1 | LysM, putative peptidoglycan-binding, domain containing 1 | 0.24 |
| PRMT9 | protein arginine methyltransferase 9 | 0.24 |
| HSPBAP1 | HSPB (heat shock 27kDa) associated protein 1 | 0.24 |
| RPGR | retinitis pigmentosa GTPase regulator | 0.24 |
| RPP25 | ribonuclease P/MRP 25kDa subunit | 0.24 |
| ZNF286B | zinc finger protein 286B | 0.24 |
| ZNF724 | zinc finger protein 724 | 0.23 |
| GALNT4 | polypeptide N-acetylgalactosaminyltransferase 4 | 0.23 |
| TDG | thymine-DNA glycosylase | 0.23 |
| ZNF200 | zinc finger protein 200 | 0.23 |
| LARGE2 | LARGE xylosyl- and glucuronyltransferase 2 | 0.23 |
| JUN | jun proto-oncogene | 0.23 |
| FBXO44 | F-box protein 44 | 0.22 |
| CIC | capicua transcriptional repressor | 0.22 |
| GAS2L3 | growth arrest-specific 2 like 3 | 0.22 |
| SIRT2 | sirtuin 2 | 0.22 |
| SELENBP1 | selenium binding protein 1 | 0.22 |
| ASTE1 | asteroid homolog 1 (Drosophila) | 0.22 |
| ENTPD4 | ectonucleoside triphosphate diphosphohydrolase 4 | 0.22 |
| CLCN2 | chloride channel, voltage-sensitive 2 | 0.22 |
| CRY2 | cryptochrome circadian clock 2 | 0.22 |
| CDC25B | cell division cycle 25B | 0.22 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | 0.22 |
| BBS10 | Bardet-Biedl syndrome 10 | 0.21 |
| CFAP410 | cilia and flagella associated protein 410 | 0.21 |
| ATG2B | autophagy related 2B | 0.21 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZNF616 | zinc finger protein 616 | -1.83 |
| WDR20 | WD repeat domain 20 | -0.77 |
| PLSCR3 | phospholipid scramblase 3 | -0.72 |
| CNTNAP3 | contactin associated protein-like 3 | -0.7 |
| PMS1 | PMS1 postmeiotic segregation increased 1 (S. cerevisiae) | -0.52 |
| BAG4 | BCL2-associated athanogene 4 | -0.52 |
| SH3D19 | SH3 domain containing 19 | -0.48 |
| MYH6 | myosin, heavy chain 6, cardiac muscle, alpha | -0.48 |
| CNKSR1 | connector enhancer of kinase suppressor of Ras 1 | -0.47 |
| MYCBP | MYC binding protein | -0.44 |
| RPGRIP1L | RPGRIP1-like | -0.42 |
| ARHGEF39 | Rho guanine nucleotide exchange factor (GEF) 39 | -0.42 |
| ADSS1 | adenylosuccinate synthase 1 | -0.41 |
| IFT140 | intraflagellar transport 140 | -0.41 |
| ZSCAN29 | zinc finger and SCAN domain containing 29 | -0.41 |
| POLR2K | polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa | -0.4 |
| RIC1 | RAB6A GEF complex partner 1 | -0.4 |
| MYZAP | myocardial zonula adherens protein | -0.4 |
| TMEM222 | transmembrane protein 222 | -0.39 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.38 |
| APBA3 | amyloid beta (A4) precursor protein-binding, family A, member 3 | -0.38 |
| ZNF639 | zinc finger protein 639 | -0.37 |
| TBC1D31 | TBC1 domain family, member 31 | -0.37 |
| ZNF239 | zinc finger protein 239 | -0.36 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.36 |
| CYP4F22 | cytochrome P450, family 4, subfamily F, polypeptide 22 | -0.36 |
| APOE | apolipoprotein E | -0.35 |
| LTBP3 | latent transforming growth factor beta binding protein 3 | -0.34 |
| CASZ1 | castor zinc finger 1 | -0.34 |
| GPATCH11 | G patch domain containing 11 | -0.33 |
| MLXIPL | MLX interacting protein-like | -0.32 |
| TRIM2 | tripartite motif containing 2 | -0.32 |
| SIGIRR | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain | -0.32 |
| SERINC1 | serine incorporator 1 | -0.32 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -0.32 |
| GLCCI1 | glucocorticoid induced 1 | -0.31 |
| MUS81 | MUS81 structure-specific endonuclease subunit | -0.31 |
| FN1 | fibronectin 1 | -0.3 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -0.3 |
| FGB | fibrinogen beta chain | -0.29 |
| TRAF3 | TNF receptor-associated factor 3 | -0.29 |
| MFAP3L | microfibrillar-associated protein 3-like | -0.29 |
| COA6 | cytochrome c oxidase assembly factor 6 | -0.28 |
| BSPRY | B-box and SPRY domain containing | -0.28 |
| REX1BD | required for excision 1-B domain containing | -0.28 |
| PRUNE2 | prune homolog 2 (Drosophila) | -0.28 |
| TCP11L1 | t-complex 11, testis-specific-like 1 | -0.28 |
| FURIN | furin (paired basic amino acid cleaving enzyme) | -0.28 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.27 |
| SFR1 | SWI5-dependent recombination repair 1 | -0.27 |
| FAT3 | FAT atypical cadherin 3 | -0.27 |
| BEND7 | BEN domain containing 7 | -0.27 |
| CLASP1 | cytoplasmic linker associated protein 1 | -0.27 |
| SKIL | SKI-like proto-oncogene | -0.27 |
| SEPTIN5 | septin 5 | -0.27 |
| TYSND1 | trypsin domain containing 1 | -0.26 |
| PLEC | plectin | -0.26 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.26 |
| CCDC130 | coiled-coil domain containing 130 | -0.26 |
| ASB3 | ankyrin repeat and SOCS box containing 3 | -0.25 |
| R3HCC1L | R3H domain and coiled-coil containing 1-like | -0.25 |
| PRR36 | proline rich 36 | -0.25 |
| PSMG2 | proteasome (prosome, macropain) assembly chaperone 2 | -0.25 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.24 |
| SRR | serine racemase | -0.24 |
| TP53 | tumor protein p53 | -0.24 |
| DGKQ | diacylglycerol kinase, theta 110kDa | -0.24 |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | -0.24 |
| SLC25A39 | solute carrier family 25, member 39 | -0.24 |
| NEIL1 | nei endonuclease VIII-like 1 (E. coli) | -0.24 |
| ZNF526 | zinc finger protein 526 | -0.24 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.23 |
| MSH5 | mutS homolog 5 | -0.23 |
| VWDE | von Willebrand factor D and EGF domains | -0.23 |
| MSL2 | male-specific lethal 2 homolog (Drosophila) | -0.23 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | -0.23 |
| FBXO42 | F-box protein 42 | -0.23 |
| CHSY3 | chondroitin sulfate synthase 3 | -0.23 |
| PPP1R3D | protein phosphatase 1, regulatory subunit 3D | -0.23 |
| ANKRD46 | ankyrin repeat domain 46 | -0.23 |
| RASSF7 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 | -0.23 |
| CLCN5 | chloride channel, voltage-sensitive 5 | -0.23 |
| C12ORF73 | chromosome 12 open reading frame 73 | -0.23 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.23 |
| ATG2A | autophagy related 2A | -0.23 |
| ETV6 | ets variant 6 | -0.22 |
| ACTBL2 | actin, beta-like 2 | -0.22 |
| ZNF184 | zinc finger protein 184 | -0.22 |
| ATG4D | autophagy related 4D, cysteine peptidase | -0.22 |
| ARHGEF35 | Rho guanine nucleotide exchange factor (GEF) 35 | -0.22 |
| DEAF1 | DEAF1 transcription factor | -0.22 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | -0.22 |
| SERAC1 | serine active site containing 1 | -0.22 |
| KDM4D | lysine (K)-specific demethylase 4D | -0.22 |
| ZFYVE19 | zinc finger, FYVE domain containing 19 | -0.22 |
| FKBP7 | FK506 binding protein 7 | -0.21 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.21 |
| AEN | apoptosis enhancing nuclease | -0.21 |
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | -0.21 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | -0.21 |
