Tafluprost Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/9868491
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Genes

198 proteins with high or low expression in Tafluprost relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
SLC26A11 solute carrier family 26 (anion exchanger), member 11 1.39
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 1.02
MDM1 Mdm1 nuclear protein homolog (mouse) 1.0
TRIM29 tripartite motif containing 29 0.99
DCHS1 dachsous cadherin-related 1 0.98
LRP1 low density lipoprotein receptor-related protein 1 0.97
KSR2 kinase suppressor of ras 2 0.89
B2M beta-2-microglobulin 0.87
CFAP57 cilia and flagella associated protein 57 0.75
PTPRB protein tyrosine phosphatase, receptor type, B 0.74
ADCK1 aarF domain containing kinase 1 0.73
CALHM2 calcium homeostasis modulator 2 0.59
MT2A metallothionein 2A 0.55
FGG fibrinogen gamma chain 0.55
LRRC46 leucine rich repeat containing 46 0.53
KMT2B lysine (K)-specific methyltransferase 2B 0.52
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 0.51
ISCA2 iron-sulfur cluster assembly 2 0.5
ADCY9 adenylate cyclase 9 0.48
TMEM14C transmembrane protein 14C 0.48
PDIK1L PDLIM1 interacting kinase 1 like 0.46
FAT4 FAT atypical cadherin 4 0.45
TPGS2 tubulin polyglutamylase complex subunit 2 0.45
HOXA10 homeobox A10 0.45
ANKRD20A4 ankyrin repeat domain 20 family, member A4 0.44
ABHD2 abhydrolase domain containing 2 0.43
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 0.43
DES desmin 0.42
TTN titin 0.42
ZNF22 zinc finger protein 22 0.41
CCDC85B coiled-coil domain containing 85B 0.39
DST dystonin 0.38
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha 0.38
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.38
TUBAL3 tubulin, alpha-like 3 0.38
ACE angiotensin I converting enzyme 0.38
RNFT2 ring finger protein, transmembrane 2 0.37
ANKRD22 ankyrin repeat domain 22 0.37
TMEM260 transmembrane protein 260 0.37
DEPDC1B DEP domain containing 1B 0.37
ABHD15 abhydrolase domain containing 15 0.37
ATXN1L ataxin 1-like 0.36
MTF1 metal-regulatory transcription factor 1 0.36
ADPRH ADP-ribosylarginine hydrolase 0.36
GPN2 GPN-loop GTPase 2 0.36
PRELID1 PRELI domain containing 1 0.35
CARD8 caspase recruitment domain family, member 8 0.35
CD320 CD320 molecule 0.35
MDM4 MDM4, p53 regulator 0.35
FKBP1A FK506 binding protein 1A, 12kDa 0.35
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.34
FDXACB1 ferredoxin-fold anticodon binding domain containing 1 0.34
ZNF114 zinc finger protein 114 0.34
HIST2H2AA3 histone cluster 2, H2aa3 0.34
TRIM23 tripartite motif containing 23 0.34
ZNF100 zinc finger protein 100 0.33
C17ORF53 chromosome 17 open reading frame 53 0.33
KIAA0586 KIAA0586 0.32
ZNF555 zinc finger protein 555 0.31
TACC3 transforming, acidic coiled-coil containing protein 3 0.31
RPL30 ribosomal protein L30 0.31
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria 0.31
ZNF616 zinc finger protein 616 0.3
TP73 tumor protein p73 0.3
OASL 2'-5'-oligoadenylate synthetase-like 0.3
EHF ets homologous factor 0.3
ZNF367 zinc finger protein 367 0.3
TCHP trichoplein, keratin filament binding 0.3
MT1E metallothionein 1E 0.29
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.29
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.29
ABLIM3 actin binding LIM protein family, member 3 0.29
PCLAF PCNA clamp associated factor 0.29
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 0.29
ALMS1 Alstrom syndrome protein 1 0.29
LRRC45 leucine rich repeat containing 45 0.28
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.28
RNF126 ring finger protein 126 0.28
MAT1A methionine adenosyltransferase I, alpha 0.28
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.28
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.28
BIRC5 baculoviral IAP repeat containing 5 0.28
MT1F metallothionein 1F 0.28
TMEM179B transmembrane protein 179B 0.28
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.28
PRELID3B PRELI domain containing 3B 0.27
ZNF724 zinc finger protein 724 0.27
REXO5 RNA exonuclease 5 0.27
ARG2 arginase 2 0.27
ZWINT ZW10 interacting kinetochore protein 0.27
MT-ATP6 ATP synthase F0 subunit 6 0.27
HGFAC HGF activator 0.26
FUBP1 far upstream element (FUSE) binding protein 1 0.26
ADAM19 ADAM metallopeptidase domain 19 0.26
DCAF12 DDB1 and CUL4 associated factor 12 0.26
EFCAB7 EF-hand calcium binding domain 7 0.26
C11ORF98 chromosome 11 open reading frame 98 0.26
BRCC3 BRCA1/BRCA2-containing complex, subunit 3 0.26
MIEF2 mitochondrial elongation factor 2 0.26
HIST2H2BF histone cluster 2, H2bf 0.26

low expression

Symbol Name Standardized Value
CNTLN centlein, centrosomal protein -1.01
HMOX1 heme oxygenase 1 -0.75
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.64
EGR1 early growth response 1 -0.63
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -0.61
SQSTM1 sequestosome 1 -0.6
MUC16 mucin 16, cell surface associated -0.59
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 -0.58
RGPD8 RANBP2-like and GRIP domain containing 8 -0.58
AKR1C2 aldo-keto reductase family 1, member C2 -0.54
SULF2 sulfatase 2 -0.53
DNASE1L1 deoxyribonuclease I-like 1 -0.52
LACC1 laccase (multicopper oxidoreductase) domain containing 1 -0.51
GGT2 gamma-glutamyltransferase 2 -0.5
REX1BD required for excision 1-B domain containing -0.5
ANKS6 ankyrin repeat and sterile alpha motif domain containing 6 -0.47
PLXNB1 plexin B1 -0.46
SHC4 SHC (Src homology 2 domain containing) family, member 4 -0.46
PALM3 paralemmin 3 -0.44
C14ORF93 chromosome 14 open reading frame 93 -0.44
SVIP small VCP/p97-interacting protein -0.44
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 -0.44
JOSD1 Josephin domain containing 1 -0.44
ZNF227 zinc finger protein 227 -0.44
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 -0.43
JPT1 Jupiter microtubule associated homolog 1 -0.43
TET2 tet methylcytosine dioxygenase 2 -0.43
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 -0.42
HKDC1 hexokinase domain containing 1 -0.42
TDRD9 tudor domain containing 9 -0.4
ZNF484 zinc finger protein 484 -0.4
SLC26A6 solute carrier family 26 (anion exchanger), member 6 -0.4
BPTF bromodomain PHD finger transcription factor -0.4
SERINC5 serine incorporator 5 -0.39
GPC1 glypican 1 -0.39
UNC13A unc-13 homolog A (C. elegans) -0.38
ABHD4 abhydrolase domain containing 4 -0.38
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D -0.37
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 -0.37
TTC9 tetratricopeptide repeat domain 9 -0.37
EPHX4 epoxide hydrolase 4 -0.37
HBA1 hemoglobin, alpha 1 -0.36
MAP2 microtubule-associated protein 2 -0.36
SRCIN1 SRC kinase signaling inhibitor 1 -0.35
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -0.35
BMP4 bone morphogenetic protein 4 -0.35
BMP1 bone morphogenetic protein 1 -0.35
CPN1 carboxypeptidase N, polypeptide 1 -0.34
TOR2A torsin family 2, member A -0.34
ZDHHC8 zinc finger, DHHC-type containing 8 -0.34
ZNF341 zinc finger protein 341 -0.33
ERICH5 glutamate-rich 5 -0.33
ZDHHC18 zinc finger, DHHC-type containing 18 -0.33
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.33
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 -0.33
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.32
ZBTB38 zinc finger and BTB domain containing 38 -0.32
HOXA9 homeobox A9 -0.32
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.32
UBXN8 UBX domain protein 8 -0.31
ZNF516 zinc finger protein 516 -0.31
ZNF275 zinc finger protein 275 -0.31
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.31
AZGP1 alpha-2-glycoprotein 1, zinc-binding -0.31
PLSCR3 phospholipid scramblase 3 -0.31
PEX19 peroxisomal biogenesis factor 19 -0.31
ICAM5 intercellular adhesion molecule 5, telencephalin -0.3
NUMBL numb homolog (Drosophila)-like -0.3
TENM2 teneurin transmembrane protein 2 -0.3
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 -0.29
GDF15 growth differentiation factor 15 -0.29
TTC30A tetratricopeptide repeat domain 30A -0.29
SYNE1 spectrin repeat containing, nuclear envelope 1 -0.29
OSGIN1 oxidative stress induced growth inhibitor 1 -0.29
ENO1 enolase 1, (alpha) -0.29
TRIML2 tripartite motif family-like 2 -0.29
CARHSP1 calcium regulated heat stable protein 1, 24kDa -0.29
SLC22A18 solute carrier family 22, member 18 -0.28
FBLIM1 filamin binding LIM protein 1 -0.28
MTUS2 microtubule associated tumor suppressor candidate 2 -0.28
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 -0.28
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.28
IER5 immediate early response 5 -0.28
NEU3 sialidase 3 (membrane sialidase) -0.28
ZNF808 zinc finger protein 808 -0.28
ABHD17C abhydrolase domain containing 17C -0.28
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) -0.28
IFI30 interferon, gamma-inducible protein 30 -0.27
RABEP2 rabaptin, RAB GTPase binding effector protein 2 -0.27
NCKAP5L NCK-associated protein 5-like -0.27
ALS2CL ALS2 C-terminal like -0.27
LRP6 low density lipoprotein receptor-related protein 6 -0.27
MID2 midline 2 -0.27
FBXL14 F-box and leucine-rich repeat protein 14 -0.27
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.27
TMEM159 transmembrane protein 159 -0.27
FRS2 fibroblast growth factor receptor substrate 2 -0.27
ZDHHC12 zinc finger, DHHC-type containing 12 -0.27