| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/135565082 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Talazoparib relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TNKS2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | 3.13 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 2.67 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 2.38 |
| AMOTL1 | angiomotin like 1 | 2.24 |
| AMOT | angiomotin | 1.85 |
| AMOTL2 | angiomotin like 2 | 1.8 |
| RNF146 | ring finger protein 146 | 1.58 |
| PHLDA3 | pleckstrin homology-like domain, family A, member 3 | 1.43 |
| C11ORF95 | chromosome 11 open reading frame 95 | 1.3 |
| TROAP | trophinin associated protein | 1.28 |
| SMTN | smoothelin | 1.27 |
| LAMA3 | laminin, alpha 3 | 1.26 |
| DENND5A | DENN/MADD domain containing 5A | 1.26 |
| RRM2 | ribonucleotide reductase M2 | 1.26 |
| E2F7 | E2F transcription factor 7 | 1.22 |
| TP53I3 | tumor protein p53 inducible protein 3 | 1.16 |
| CASC3 | cancer susceptibility candidate 3 | 1.15 |
| TP53 | tumor protein p53 | 1.15 |
| GMNN | geminin, DNA replication inhibitor | 1.14 |
| TP73 | tumor protein p73 | 1.13 |
| PARP3 | poly (ADP-ribose) polymerase family, member 3 | 1.12 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 1.12 |
| PCLAF | PCNA clamp associated factor | 1.09 |
| ANLN | anillin, actin binding protein | 1.08 |
| CDCA5 | cell division cycle associated 5 | 1.07 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | 1.06 |
| CCNA1 | cyclin A1 | 1.05 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | 1.04 |
| CKAP2 | cytoskeleton associated protein 2 | 1.04 |
| CCNA2 | cyclin A2 | 1.04 |
| AKAP6 | A kinase (PRKA) anchor protein 6 | 1.02 |
| FAS | Fas cell surface death receptor | 1.02 |
| GDF15 | growth differentiation factor 15 | 1.02 |
| SEMA3F | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F | 1.01 |
| PIMREG | PICALM interacting mitotic regulator | 1.01 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.99 |
| TK1 | thymidine kinase 1, soluble | 0.99 |
| SGO1 | shugoshin 1 | 0.98 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.97 |
| SLC26A11 | solute carrier family 26 (anion exchanger), member 11 | 0.95 |
| TPX2 | TPX2, microtubule-associated | 0.95 |
| SASS6 | spindle assembly 6 homolog (C. elegans) | 0.93 |
| LMOD1 | leiomodin 1 (smooth muscle) | 0.92 |
| PRC1 | protein regulator of cytokinesis 1 | 0.91 |
| SYN2 | synapsin II | 0.91 |
| CCNE1 | cyclin E1 | 0.9 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.9 |
| NGFR | nerve growth factor receptor | 0.89 |
| GTSE1 | G-2 and S-phase expressed 1 | 0.88 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 0.87 |
| KIFC1 | kinesin family member C1 | 0.85 |
| CCNE2 | cyclin E2 | 0.84 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | 0.84 |
| RRM2B | ribonucleotide reductase M2 B (TP53 inducible) | 0.83 |
| FDXR | ferredoxin reductase | 0.82 |
| KSR2 | kinase suppressor of ras 2 | 0.82 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.82 |
| DONSON | downstream neighbor of SON | 0.81 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.81 |
| LZTS1 | leucine zipper, putative tumor suppressor 1 | 0.81 |
| INCENP | inner centromere protein antigens 135/155kDa | 0.78 |
| BLM | Bloom syndrome, RecQ helicase-like | 0.76 |
| POLH | polymerase (DNA directed), eta | 0.76 |
| HAPLN3 | hyaluronan and proteoglycan link protein 3 | 0.76 |
| SGO2 | shugoshin 2 | 0.74 |
| ADAMTS7 | ADAM metallopeptidase with thrombospondin type 1 motif, 7 | 0.74 |
| CCNB1 | cyclin B1 | 0.74 |
| CDCA3 | cell division cycle associated 3 | 0.74 |
| CKAP2L | cytoskeleton associated protein 2-like | 0.74 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | 0.73 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 0.73 |
| MYLK | myosin light chain kinase | 0.72 |
| RAD54L | RAD54-like (S. cerevisiae) | 0.72 |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | 0.72 |
| AURKB | aurora kinase B | 0.72 |
| FOXM1 | forkhead box M1 | 0.71 |
| SHCBP1 | SHC SH2-domain binding protein 1 | 0.7 |
| RAD51 | RAD51 recombinase | 0.7 |
| KIF11 | kinesin family member 11 | 0.7 |
| CLSPN | claspin | 0.7 |
| DGKA | diacylglycerol kinase, alpha 80kDa | 0.69 |
| RINL | Ras and Rab interactor-like | 0.69 |
| RIBC2 | RIB43A domain with coiled-coils 2 | 0.69 |
| TLR3 | toll-like receptor 3 | 0.67 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.67 |
| PTPRU | protein tyrosine phosphatase, receptor type, U | 0.67 |
| MAP3K12 | mitogen-activated protein kinase kinase kinase 12 | 0.67 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.66 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.66 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.65 |
| CENPF | centromere protein F, 350/400kDa | 0.65 |
| SAT2 | spermidine/spermine N1-acetyltransferase family member 2 | 0.65 |
| ASF1B | anti-silencing function 1B histone chaperone | 0.65 |
| KIF18A | kinesin family member 18A | 0.64 |
| CES2 | carboxylesterase 2 | 0.64 |
| EPS8L2 | EPS8-like 2 | 0.64 |
| KIF18B | kinesin family member 18B | 0.63 |
| AURKA | aurora kinase A | 0.62 |
| CENPP | centromere protein P | 0.62 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NABP1 | nucleic acid binding protein 1 | -1.11 |
| CDT1 | chromatin licensing and DNA replication factor 1 | -1.06 |
| STC2 | stanniocalcin 2 | -0.99 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.88 |
| H1-2 | H1.2 linker histone, cluster member | -0.83 |
| KMT5A | lysine methyltransferase 5A | -0.81 |
| FGB | fibrinogen beta chain | -0.79 |
| ZNF417 | zinc finger protein 417 | -0.78 |
| ORC1 | origin recognition complex, subunit 1 | -0.76 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.74 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | -0.71 |
| MID1IP1 | MID1 interacting protein 1 | -0.67 |
| PRDM4 | PR domain containing 4 | -0.66 |
| VIM | vimentin | -0.66 |
| ZNF485 | zinc finger protein 485 | -0.65 |
| SLC38A2 | solute carrier family 38, member 2 | -0.63 |
| ZNF34 | zinc finger protein 34 | -0.63 |
| H1-5 | H1.5 linker histone, cluster member | -0.63 |
| CCDC170 | coiled-coil domain containing 170 | -0.61 |
| ALDH1L2 | aldehyde dehydrogenase 1 family, member L2 | -0.59 |
| SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 | -0.59 |
| HIST1H1T | histone cluster 1, H1t | -0.57 |
| ACTN4 | actinin, alpha 4 | -0.57 |
| ABCB4 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | -0.57 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -0.56 |
| IFRD1 | interferon-related developmental regulator 1 | -0.56 |
| ZSCAN31 | zinc finger and SCAN domain containing 31 | -0.55 |
| ODC1 | ornithine decarboxylase 1 | -0.55 |
| ZNF587B | zinc finger protein 587B | -0.54 |
| SMAD3 | SMAD family member 3 | -0.54 |
| AZIN1 | antizyme inhibitor 1 | -0.54 |
| TMEM106C | transmembrane protein 106C | -0.53 |
| EGR1 | early growth response 1 | -0.52 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.52 |
| PIP | prolactin-induced protein | -0.52 |
| ZNF33A | zinc finger protein 33A | -0.51 |
| MCTS2P | malignant T cell amplified sequence 2, pseudogene | -0.51 |
| IKZF5 | IKAROS family zinc finger 5 (Pegasus) | -0.5 |
| H1FX | H1 histone family, member X | -0.5 |
| POLR2M | polymerase (RNA) II (DNA directed) polypeptide M | -0.5 |
| ZNF12 | zinc finger protein 12 | -0.49 |
| NKAPD1 | NKAP domain containing 1 | -0.48 |
| DCDC1 | doublecortin domain containing 1 | -0.48 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | -0.48 |
| PAH | phenylalanine hydroxylase | -0.47 |
| REV1 | REV1, polymerase (DNA directed) | -0.47 |
| EREG | epiregulin | -0.47 |
| SHC4 | SHC (Src homology 2 domain containing) family, member 4 | -0.46 |
| SLC6A9 | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | -0.46 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -0.46 |
| RNF115 | ring finger protein 115 | -0.46 |
| FDXACB1 | ferredoxin-fold anticodon binding domain containing 1 | -0.46 |
| PHF19 | PHD finger protein 19 | -0.45 |
| NEO1 | neogenin 1 | -0.45 |
| H1-4 | H1.4 linker histone, cluster member | -0.45 |
| USP22 | ubiquitin specific peptidase 22 | -0.45 |
| CRPPA | CDP-L-ribitol pyrophosphorylase A | -0.44 |
| ARL4A | ADP-ribosylation factor-like 4A | -0.44 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.44 |
| CNTROB | centrobin, centrosomal BRCA2 interacting protein | -0.44 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.44 |
| SHANK3 | SH3 and multiple ankyrin repeat domains 3 | -0.44 |
| H1-3 | H1.3 linker histone, cluster member | -0.44 |
| MDC1 | mediator of DNA-damage checkpoint 1 | -0.44 |
| ZNF627 | zinc finger protein 627 | -0.43 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | -0.43 |
| HIST2H3A | histone cluster 2, H3a | -0.43 |
| JPT1 | Jupiter microtubule associated homolog 1 | -0.43 |
| SQSTM1 | sequestosome 1 | -0.42 |
| HIST3H2A | histone cluster 3, H2a | -0.42 |
| GABPB2 | GA binding protein transcription factor, beta subunit 2 | -0.42 |
| RNF6 | ring finger protein (C3H2C3 type) 6 | -0.42 |
| MARK2 | MAP/microtubule affinity-regulating kinase 2 | -0.42 |
| SREBF1 | sterol regulatory element binding transcription factor 1 | -0.42 |
| MARVELD3 | MARVEL domain containing 3 | -0.42 |
| NOP53 | NOP53 ribosome biogenesis factor | -0.41 |
| NDST2 | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 | -0.41 |
| SOX12 | SRY (sex determining region Y)-box 12 | -0.41 |
| RASSF1 | Ras association (RalGDS/AF-6) domain family member 1 | -0.41 |
| SUN2 | Sad1 and UNC84 domain containing 2 | -0.41 |
| NECTIN3 | nectin cell adhesion molecule 3 | -0.41 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | -0.41 |
| ATMIN | ATM interactor | -0.4 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.4 |
| ANKRD10 | ankyrin repeat domain 10 | -0.4 |
| SET | SET nuclear proto-oncogene | -0.4 |
| ZNF460 | zinc finger protein 460 | -0.4 |
| USP53 | ubiquitin specific peptidase 53 | -0.4 |
| GPSM2 | G-protein signaling modulator 2 | -0.4 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.39 |
| JRKL | JRK-like | -0.39 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | -0.39 |
| HIST3H2BB | histone cluster 3, H2bb | -0.39 |
| UPP1 | uridine phosphorylase 1 | -0.39 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -0.39 |
| ERMARD | ER membrane-associated RNA degradation | -0.39 |
| AJUBA | ajuba LIM protein | -0.39 |
| JADE1 | jade family PHD finger 1 | -0.39 |
| KLF10 | Kruppel-like factor 10 | -0.39 |
| ANKRD36 | ankyrin repeat domain 36 | -0.38 |
