Talc_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Talc perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Talc_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.11819
TMSB10 thymosin beta 10 0.059345
AREG amphiregulin 0.0544337
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.047779
BIRC2 baculoviral IAP repeat containing 2 0.0449828
RPS12 ribosomal protein S12 0.0396285
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0394408
VIM vimentin 0.0392642
ACTG1 actin gamma 1 0.0384331
FTL ferritin, light polypeptide 0.0377248
MKI67 marker of proliferation Ki-67 0.0361728
MTAP methylthioadenosine phosphorylase 0.0349612
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0347485
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0341723
RPS8 ribosomal protein S8 0.0333051
RPL4 ribosomal protein L4 0.0322178
RPL12 ribosomal protein L12 0.0315752
RPS2 ribosomal protein S2 0.0301042
RACK1 receptor for activated C kinase 1 0.0291948
RPLP1 ribosomal protein, large, P1 0.0291633
YAP1 Yes-associated protein 1 0.0281991
TAS2R14 taste receptor, type 2, member 14 0.0270458
RPL37A ribosomal protein L37a 0.02682
RPL23 ribosomal protein L23 0.0262873
TMEM41B transmembrane protein 41B 0.0262315
EIF1 eukaryotic translation initiation factor 1 0.026105
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0254265
KLF6 Kruppel-like factor 6 0.0250582
RPS19 ribosomal protein S19 0.0249883
VCL vinculin 0.0237949
H1-0 H1.0 linker histone 0.0237229
RPL26 ribosomal protein L26 0.0236412
RPS27A ribosomal protein S27a 0.0231776
RPS3 ribosomal protein S3 0.0231228
YBX3 Y box binding protein 3 0.0225225
RRM2 ribonucleotide reductase M2 0.0220592
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0215456
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0214159
CNRIP1 cannabinoid receptor interacting protein 1 0.021218
PDGFC platelet derived growth factor C 0.0209918
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0205091
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.020092
CELF2 CUGBP, Elav-like family member 2 0.019973
SQSTM1 sequestosome 1 0.0199002
TPT1 tumor protein, translationally-controlled 1 0.019822
RPL36 ribosomal protein L36 0.0194894
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0194686
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0184502
EDARADD EDAR-associated death domain 0.0183346
SMC4 structural maintenance of chromosomes 4 0.0183035
MYPN myopalladin 0.0172744
CENPF centromere protein F, 350/400kDa 0.0172698
NAP1L1 nucleosome assembly protein 1-like 1 0.0171624
RPL19 ribosomal protein L19 0.0168887
RPL37 ribosomal protein L37 0.0167424
NPC1 Niemann-Pick disease, type C1 0.0165956
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0164783
RPL11 ribosomal protein L11 0.0162781
NFE2L2 nuclear factor, erythroid 2-like 2 0.0159685
RAD21 RAD21 homolog (S. pombe) 0.0159018
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 0.0157425
ATF4 activating transcription factor 4 0.0157401
RPL18 ribosomal protein L18 0.0156485
ATAD2 ATPase family, AAA domain containing 2 0.0156138
RPL6 ribosomal protein L6 0.015465
RPLP0 ribosomal protein, large, P0 0.015356
ERRFI1 ERBB receptor feedback inhibitor 1 0.015354
AHNAK AHNAK nucleoprotein 0.0153324
MYL12B myosin, light chain 12B, regulatory 0.0151131
RPS29 ribosomal protein S29 0.0150787
BCHE butyrylcholinesterase 0.0148663
IQCB1 IQ motif containing B1 0.0146993
RPL7 ribosomal protein L7 0.0145411
ATP5F1E ATP synthase F1 subunit epsilon 0.0142058
IMMT inner membrane protein, mitochondrial 0.0141482
RPL34 ribosomal protein L34 0.0139558
FTH1 ferritin, heavy polypeptide 1 0.0139506
GASK1B golgi associated kinase 1B 0.0139185
DLC1 DLC1 Rho GTPase activating protein 0.0138863
SCLT1 sodium channel and clathrin linker 1 0.0138238
PDE4B phosphodiesterase 4B, cAMP-specific 0.0137695
HSPA8 heat shock 70kDa protein 8 0.0137417
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0137122
RPL9 ribosomal protein L9 0.0136943
PCNX4 pecanex 4 0.0135444
RSL1D1 ribosomal L1 domain containing 1 0.0135129
SERINC1 serine incorporator 1 0.0133272
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 0.0132293
CLTC clathrin, heavy chain (Hc) 0.0131654
RPS27 ribosomal protein S27 0.0130862
CAVIN1 caveolae associated protein 1 0.0130699
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0130649
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0130036
MAPK8 mitogen-activated protein kinase 8 0.0129989
WWOX WW domain containing oxidoreductase 0.012885
RPL13A ribosomal protein L13a 0.0127638
RPLP2 ribosomal protein, large, P2 0.0125948
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0125584
ICE1 interactor of little elongation complex ELL subunit 1 0.0124868
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) 0.0124802

decreased expression

Symbol Name Standardized Value
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.143377
USP34 ubiquitin specific peptidase 34 -0.0794497
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0698844
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0659725
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0630569
BIRC6 baculoviral IAP repeat containing 6 -0.0622036
EHBP1 EH domain binding protein 1 -0.055893
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0553547
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0523745
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0506002
SYT1 synaptotagmin I -0.047083
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0440966
CARD16 caspase recruitment domain family, member 16 -0.0410579
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0402577
HMGA1 high mobility group AT-hook 1 -0.0394772
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0381877
EEF2 eukaryotic translation elongation factor 2 -0.0369909
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0366439
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0355041
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0353615
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0349562
EGR1 early growth response 1 -0.0348236
RASAL2 RAS protein activator like 2 -0.0344982
PICALM phosphatidylinositol binding clathrin assembly protein -0.0334829
BPTF bromodomain PHD finger transcription factor -0.0327478
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0327425
DST dystonin -0.0324027
MED13L mediator complex subunit 13-like -0.0321501
SBF2 SET binding factor 2 -0.0317159
VDAC1 voltage-dependent anion channel 1 -0.0310736
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0308452
RHOA ras homolog family member A -0.0305856
DPYD dihydropyrimidine dehydrogenase -0.0303672
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0301824
KDM2A lysine (K)-specific demethylase 2A -0.0299756
MGAT4C MGAT4 family, member C -0.0299608
TBC1D5 TBC1 domain family, member 5 -0.0299147
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0296666
PCBP2 poly(rC) binding protein 2 -0.0295432
NF1 neurofibromin 1 -0.0295174
MMP12 matrix metallopeptidase 12 -0.0284447
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0282793
SLC38A2 solute carrier family 38, member 2 -0.0280052
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0277933
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0276804
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0275024
ZFAND3 zinc finger, AN1-type domain 3 -0.0260801
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0260309
FBXO11 F-box protein 11 -0.0259343
TRIO trio Rho guanine nucleotide exchange factor -0.0257819
TAOK1 TAO kinase 1 -0.0256925
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0256853
NHSL1 NHS-like 1 -0.0253632
PFN1 profilin 1 -0.0252437
GSK3B glycogen synthase kinase 3 beta -0.0252052
POTEF POTE ankyrin domain family, member F -0.0250443
PRKCI protein kinase C, iota -0.0243894
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0242993
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0240699
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0239826
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0238414
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0237624
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0236966
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0234874
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0231476
KMT2C lysine (K)-specific methyltransferase 2C -0.0229061
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0226799
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0225673
FSTL5 follistatin-like 5 -0.0221176
GARS1 glycyl-tRNA synthetase 1 -0.0220408
BCAS3 breast carcinoma amplified sequence 3 -0.0218412
SPATS2 spermatogenesis associated, serine-rich 2 -0.0217476
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0214188
PHF21A PHD finger protein 21A -0.0214043
SPAG9 sperm associated antigen 9 -0.0213669
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0213185
SBNO1 strawberry notch homolog 1 (Drosophila) -0.0211998
PLK2 polo-like kinase 2 -0.0211168
TMEM135 transmembrane protein 135 -0.020834
TXNRD1 thioredoxin reductase 1 -0.0207503
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0205999
ZNF292 zinc finger protein 292 -0.0205991
CPOX coproporphyrinogen oxidase -0.0205856
WNK1 WNK lysine deficient protein kinase 1 -0.0204654
TSPAN5 tetraspanin 5 -0.0203649
ASXL2 additional sex combs like transcriptional regulator 2 -0.0203637
FAM168A family with sequence similarity 168, member A -0.0203211
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0199295
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) -0.0199045
NCOR1 nuclear receptor corepressor 1 -0.0198936
CCN2 cellular communication network factor 2 -0.0198644
NECTIN3 nectin cell adhesion molecule 3 -0.0197899
MAP4 microtubule-associated protein 4 -0.019566
FRYL FRY-like -0.0194792
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0194749
VMP1 vacuole membrane protein 1 -0.0193943
KMT2E lysine (K)-specific methyltransferase 2E -0.0192963
MBNL1 muscleblind-like splicing regulator 1 -0.0190287
SPDYA speedy/RINGO cell cycle regulator family member A -0.0189261
PRR16 proline rich 16 -0.0188241