Talc_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Talc perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Talc_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.197247
AKAP12 A kinase (PRKA) anchor protein 12 0.0735836
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0707841
MAP1B microtubule-associated protein 1B 0.0619611
MEIS2 Meis homeobox 2 0.0599566
MEF2A myocyte enhancer factor 2A 0.0594463
FAM13A family with sequence similarity 13, member A 0.0585455
NAMPT nicotinamide phosphoribosyltransferase 0.0561535
CENPF centromere protein F, 350/400kDa 0.0433067
COL3A1 collagen, type III, alpha 1 0.0424963
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0423077
FNDC3B fibronectin type III domain containing 3B 0.0397194
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0388011
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0376427
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0344716
FNBP1 formin binding protein 1 0.034292
HELZ helicase with zinc finger 0.0325305
TPR translocated promoter region, nuclear basket protein 0.032135
NRG1 neuregulin 1 0.0316323
HILPDA hypoxia inducible lipid droplet-associated 0.0315491
ZNF654 zinc finger protein 654 0.0313904
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0313881
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0303895
KLF6 Kruppel-like factor 6 0.0302073
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0297819
SLITRK6 SLIT and NTRK-like family, member 6 0.0295739
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0294313
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.029381
MED13 mediator complex subunit 13 0.0292804
DSCAM Down syndrome cell adhesion molecule 0.029058
RPTOR regulatory associated protein of MTOR, complex 1 0.0289383
RBMS3 RNA binding motif, single stranded interacting protein 3 0.028902
CRH corticotropin releasing hormone 0.028559
PLPP1 phospholipid phosphatase 1 0.0284777
ADGRG6 adhesion G protein-coupled receptor G6 0.028184
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.0281752
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0281338
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0266276
PUM2 pumilio RNA-binding family member 2 0.0265009
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0264768
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0255758
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0255548
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0254603
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0254052
ITPRID2 ITPR interacting domain containing 2 0.0246516
PTBP1 polypyrimidine tract binding protein 1 0.0244574
THSD4 thrombospondin, type I, domain containing 4 0.0242744
CSDE1 cold shock domain containing E1, RNA-binding 0.0235219
SOCS5 suppressor of cytokine signaling 5 0.0233668
YME1L1 YME1-like 1 ATPase 0.0230324
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0227206
RAB30 RAB30, member RAS oncogene family 0.022699
RGS5 regulator of G-protein signaling 5 0.0225868
ETNK1 ethanolamine kinase 1 0.0225117
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.022391
PCDH9 protocadherin 9 0.0220836
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.021973
MKI67 marker of proliferation Ki-67 0.0217482
PLAT plasminogen activator, tissue 0.0216772
FOXO3 forkhead box O3 0.0213972
CDK19 cyclin-dependent kinase 19 0.0213173
WDR45B WD repeat domain 45B 0.0212893
CEP152 centrosomal protein 152kDa 0.0211313
LUM lumican 0.0209664
GARS1 glycyl-tRNA synthetase 1 0.0208939
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0208037
WDPCP WD repeat containing planar cell polarity effector 0.020794
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.020703
TCF12 transcription factor 12 0.0206799
TIMP3 TIMP metallopeptidase inhibitor 3 0.0205301
MXI1 MAX interactor 1, dimerization protein 0.0204404
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0201875
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0201795
ZNF638 zinc finger protein 638 0.0200595
CDC73 cell division cycle 73 0.019957
SOS1 son of sevenless homolog 1 (Drosophila) 0.0199041
MBD5 methyl-CpG binding domain protein 5 0.0198495
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0196869
ZNF292 zinc finger protein 292 0.0196666
RNGTT RNA guanylyltransferase and 5'-phosphatase 0.0195996
ANGPT1 angiopoietin 1 0.0192834
RPL3 ribosomal protein L3 0.0192056
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0192013
POU2F1 POU class 2 homeobox 1 0.0190553
SCLT1 sodium channel and clathrin linker 1 0.0186518
CXXC5 CXXC finger protein 5 0.0186403
CPNE8 copine VIII 0.0186099
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0184674
RBM26 RNA binding motif protein 26 0.0184444
PDCD6IP programmed cell death 6 interacting protein 0.0183932
ANKRD28 ankyrin repeat domain 28 0.0182697
TPM3 tropomyosin 3 0.0181698
TLE4 transducin-like enhancer of split 4 0.0181161
KIF5B kinesin family member 5B 0.0179316
MEX3A mex-3 RNA binding family member A 0.017918
EYA1 EYA transcriptional coactivator and phosphatase 1 0.017825
LDHB lactate dehydrogenase B 0.0177816
SRP54 signal recognition particle 54kDa 0.0177297
TMCO1 transmembrane and coiled-coil domains 1 0.0176584
RNASEH2A ribonuclease H2, subunit A 0.0176542

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.127835
TPT1 tumor protein, translationally-controlled 1 -0.109499
VIM vimentin -0.0912345
RPS6 ribosomal protein S6 -0.0798692
RPL23 ribosomal protein L23 -0.0763631
TMSB10 thymosin beta 10 -0.072516
NDRG1 N-myc downstream regulated 1 -0.0662986
BPTF bromodomain PHD finger transcription factor -0.0647909
VCL vinculin -0.0645563
LSAMP limbic system-associated membrane protein -0.0602886
RPL35A ribosomal protein L35a -0.0601421
FTL ferritin, light polypeptide -0.0545911
SYT1 synaptotagmin I -0.0538613
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0534291
RPL31 ribosomal protein L31 -0.0530782
RPL9 ribosomal protein L9 -0.0529732
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0504232
NALF1 NALCN channel auxiliary factor 1 -0.050251
VDAC1 voltage-dependent anion channel 1 -0.0500002
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0490646
RPL34 ribosomal protein L34 -0.0464365
RPS14 ribosomal protein S14 -0.0451471
ZFAND3 zinc finger, AN1-type domain 3 -0.0442537
EXT1 exostosin glycosyltransferase 1 -0.0440874
RPS23 ribosomal protein S23 -0.0439617
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0435575
RPS24 ribosomal protein S24 -0.0434376
RPLP1 ribosomal protein, large, P1 -0.0419324
RPS16 ribosomal protein S16 -0.0415757
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0411883
RPS20 ribosomal protein S20 -0.0405763
KTN1 kinectin 1 (kinesin receptor) -0.0400827
RPS8 ribosomal protein S8 -0.0397521
RPS13 ribosomal protein S13 -0.038706
RPL37A ribosomal protein L37a -0.0385786
PDIA3 protein disulfide isomerase family A, member 3 -0.0376389
ACTG1 actin gamma 1 -0.0374084
PA2G4 proliferation-associated 2G4, 38kDa -0.0363711
RPS3 ribosomal protein S3 -0.0363504
ZNF609 zinc finger protein 609 -0.0362558
FMNL2 formin-like 2 -0.0360943
RPS17 ribosomal protein S17 -0.035883
RPLP2 ribosomal protein, large, P2 -0.0358555
ANKRD11 ankyrin repeat domain 11 -0.0357504
SAMD4A sterile alpha motif domain containing 4A -0.0349859
RPL27A ribosomal protein L27a -0.0342235
RPL5 ribosomal protein L5 -0.0341563
GOLGB1 golgin B1 -0.0339702
MCL1 myeloid cell leukemia 1 -0.0338615
RPS19 ribosomal protein S19 -0.0333864
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0332452
RPL11 ribosomal protein L11 -0.0321994
TRA2A transformer 2 alpha homolog (Drosophila) -0.0320613
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0318109
FRMD4A FERM domain containing 4A -0.0314307
RPS21 ribosomal protein S21 -0.0312554
ATXN1 ataxin 1 -0.0312091
AEBP2 AE binding protein 2 -0.030986
GOSR1 golgi SNAP receptor complex member 1 -0.0308162
DPH6 diphthamine biosynthesis 6 -0.0305273
APLP2 amyloid beta (A4) precursor-like protein 2 -0.029675
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0293773
MATR3 matrin 3 -0.0292367
DTNA dystrobrevin, alpha -0.0291912
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.0291432
RPL38 ribosomal protein L38 -0.029114
GREM2 gremlin 2, DAN family BMP antagonist -0.0290844
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0288873
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0287886
BBX bobby sox homolog (Drosophila) -0.0286642
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0282985
MED13L mediator complex subunit 13-like -0.0281955
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.028118
RPL19 ribosomal protein L19 -0.0280657
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0280046
FN1 fibronectin 1 -0.0276756
NF1 neurofibromin 1 -0.0276127
RPS12 ribosomal protein S12 -0.0274822
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0272439
RPL7A ribosomal protein L7a -0.0271394
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0271365
ANXA2 annexin A2 -0.0270512
PITPNB phosphatidylinositol transfer protein, beta -0.0269099
ANKRD12 ankyrin repeat domain 12 -0.0267701
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0267628
RPL26 ribosomal protein L26 -0.0261285
SPAG9 sperm associated antigen 9 -0.025981
RPL12 ribosomal protein L12 -0.0259091
GNAS GNAS complex locus -0.0257415
RPS29 ribosomal protein S29 -0.0256633
DSTN destrin (actin depolymerizing factor) -0.0255797
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0254612
RTN3 reticulon 3 -0.0254307
YY1 YY1 transcription factor -0.0251751
FOXK1 forkhead box K1 -0.0251215
RPL13A ribosomal protein L13a -0.0251132
NPAS2 neuronal PAS domain protein 2 -0.0251019
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0250874
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0250456
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.024791