Talc_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Talc perturbation in HS-578T cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Talc_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.136607
COL1A1 collagen, type I, alpha 1 0.103457
VIM vimentin 0.101503
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.100369
FTH1 ferritin, heavy polypeptide 1 0.0981557
RPS8 ribosomal protein S8 0.0883646
FTL ferritin, light polypeptide 0.0849344
EIF1 eukaryotic translation initiation factor 1 0.0820704
PTMA prothymosin, alpha 0.0766
RPS6 ribosomal protein S6 0.0764325
TGFBI transforming growth factor, beta-induced, 68kDa 0.0714758
CADM1 cell adhesion molecule 1 0.0681093
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0646301
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0592441
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0584912
ACTG1 actin gamma 1 0.0563092
RPS3 ribosomal protein S3 0.0510436
RPL12 ribosomal protein L12 0.0492572
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.04817
RPS19 ribosomal protein S19 0.048013
CDH13 cadherin 13 0.0474935
RACK1 receptor for activated C kinase 1 0.0463224
PDE10A phosphodiesterase 10A 0.0461663
ATP13A3 ATPase type 13A3 0.0449224
GOLGA4 golgin A4 0.0429134
RPL36 ribosomal protein L36 0.0419113
TMSB10 thymosin beta 10 0.0418145
FMNL2 formin-like 2 0.0415511
RPL23 ribosomal protein L23 0.0407832
HLA-A major histocompatibility complex, class I, A 0.0403439
RPS12 ribosomal protein S12 0.0391485
NAP1L1 nucleosome assembly protein 1-like 1 0.0388147
RPL26 ribosomal protein L26 0.0385065
B2M beta-2-microglobulin 0.0384286
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0383005
RPS2 ribosomal protein S2 0.0382375
PCBP2 poly(rC) binding protein 2 0.0380493
RPL11 ribosomal protein L11 0.0377541
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0375098
RPL18 ribosomal protein L18 0.0373989
RPL8 ribosomal protein L8 0.0370667
ENO1 enolase 1, (alpha) 0.0358223
RPL19 ribosomal protein L19 0.0356258
WSB1 WD repeat and SOCS box containing 1 0.0355132
RPL37A ribosomal protein L37a 0.0351732
RPLP1 ribosomal protein, large, P1 0.0345215
TRIO trio Rho guanine nucleotide exchange factor 0.034481
ZFAND3 zinc finger, AN1-type domain 3 0.0330896
RPS14 ribosomal protein S14 0.0326513
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0324099
FOSL1 FOS-like antigen 1 0.0320093
RPL5 ribosomal protein L5 0.0314738
LGALS1 lectin, galactoside-binding, soluble, 1 0.0309511
ANKRD11 ankyrin repeat domain 11 0.0306576
MTDH metadherin 0.0304917
FOXJ3 forkhead box J3 0.0300647
RPL37 ribosomal protein L37 0.0297295
PDE8A phosphodiesterase 8A 0.0295468
RPL28 ribosomal protein L28 0.0290557
TMEM165 transmembrane protein 165 0.0286508
ZSWIM6 zinc finger, SWIM-type containing 6 0.0285836
CLINT1 clathrin interactor 1 0.0283273
YBX1 Y box binding protein 1 0.0282368
CCNL1 cyclin L1 0.0277901
RPL30 ribosomal protein L30 0.0276786
EEF2 eukaryotic translation elongation factor 2 0.0276625
RAB1A RAB1A, member RAS oncogene family 0.0276345
IGFBP3 insulin-like growth factor binding protein 3 0.0272749
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0270963
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0269184
RAB7A RAB7A, member RAS oncogene family 0.0268263
RPLP0 ribosomal protein, large, P0 0.0267725
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 0.0266551
RPL35A ribosomal protein L35a 0.026638
PARD3 par-3 family cell polarity regulator 0.0264155
CAMTA1 calmodulin binding transcription activator 1 0.0262554
RPS5 ribosomal protein S5 0.0259714
WAC WW domain containing adaptor with coiled-coil 0.0259616
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0259377
SEC24D SEC24 family member D 0.025544
HIPK2 homeodomain interacting protein kinase 2 0.0254532
ZCCHC7 zinc finger, CCHC domain containing 7 0.0254054
RPL7 ribosomal protein L7 0.0253955
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0248865
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0248172
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0246391
ATF4 activating transcription factor 4 0.0244331
RPL9 ribosomal protein L9 0.0243105
WASF2 WAS protein family, member 2 0.0242599
S100A9 S100 calcium binding protein A9 0.0241417
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0241018
DLG1 discs, large homolog 1 (Drosophila) 0.0239304
RPS25 ribosomal protein S25 0.0238787
CSPP1 centrosome and spindle pole associated protein 1 0.0237391
QKI QKI, KH domain containing, RNA binding 0.0232202
KIF1B kinesin family member 1B 0.0229323
CHD1 chromodomain helicase DNA binding protein 1 0.0224445
CSDE1 cold shock domain containing E1, RNA-binding 0.0222515
RAB6A RAB6A, member RAS oncogene family 0.0221078
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0220496

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.415947
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.116299
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.11362
COL1A2 collagen, type I, alpha 2 -0.0788068
STC1 stanniocalcin 1 -0.0779892
CD44 CD44 molecule (Indian blood group) -0.0745073
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0675721
LOXL2 lysyl oxidase-like 2 -0.0623568
EXT1 exostosin glycosyltransferase 1 -0.0618724
INHBA inhibin, beta A -0.0519154
TM4SF1 transmembrane 4 L six family member 1 -0.0483252
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0478124
ASPH aspartate beta-hydroxylase -0.0472602
LTBP1 latent transforming growth factor beta binding protein 1 -0.0458996
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0452794
IL6ST interleukin 6 signal transducer -0.0443019
CLIC4 chloride intracellular channel 4 -0.0434728
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0431249
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0411493
VCAN versican -0.0408207
MAP1B microtubule-associated protein 1B -0.0401036
LOX lysyl oxidase -0.0368937
ECE1 endothelin converting enzyme 1 -0.0331772
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.032841
COL6A3 collagen, type VI, alpha 3 -0.0324756
TMSB4X thymosin beta 4, X-linked -0.0315889
F3 coagulation factor III (thromboplastin, tissue factor) -0.0313586
FAT1 FAT atypical cadherin 1 -0.0304438
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0302716
SAMD9 sterile alpha motif domain containing 9 -0.0301774
POSTN periostin, osteoblast specific factor -0.0297398
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0297062
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0295798
VEGFA vascular endothelial growth factor A -0.0287693
DPYSL3 dihydropyrimidinase-like 3 -0.0279446
VCL vinculin -0.0279211
ZBTB20 zinc finger and BTB domain containing 20 -0.0268922
MX2 MX dynamin-like GTPase 2 -0.0268675
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0267399
SMAD3 SMAD family member 3 -0.0255381
ADAM12 ADAM metallopeptidase domain 12 -0.0250486
CALR calreticulin -0.0249762
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0245797
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0244088
PSD3 pleckstrin and Sec7 domain containing 3 -0.024054
PALLD palladin, cytoskeletal associated protein -0.023999
MTSS1 metastasis suppressor 1 -0.0232387
TPM1 tropomyosin 1 (alpha) -0.0231751
FBN1 fibrillin 1 -0.022814
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0226636
CALU calumenin -0.0224448
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0221757
ALCAM activated leukocyte cell adhesion molecule -0.0221084
PRELID2 PRELI domain containing 2 -0.0220987
OSMR oncostatin M receptor -0.0220096
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0218427
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0212375
TAPBP TAP binding protein (tapasin) -0.0204188
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0203037
CNTN5 contactin 5 -0.0202838
PDE4D phosphodiesterase 4D, cAMP-specific -0.0201694
NT5E 5'-nucleotidase, ecto (CD73) -0.0196148
RIGI RNA sensor RIG-I -0.0193919
TPM4 tropomyosin 4 -0.0193672
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0191657
ADAM9 ADAM metallopeptidase domain 9 -0.0186897
IER3 immediate early response 3 -0.018689
CTSB cathepsin B -0.0186704
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0186389
PLSCR1 phospholipid scramblase 1 -0.0183833
CD82 CD82 molecule -0.0180923
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0179865
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0178634
DST dystonin -0.0176959
ARHGAP29 Rho GTPase activating protein 29 -0.0176876
GLIS3 GLIS family zinc finger 3 -0.0176412
EHD2 EH-domain containing 2 -0.0176398
NAV1 neuron navigator 1 -0.0175826
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0173034
DPYD dihydropyrimidine dehydrogenase -0.017073
MAML2 mastermind-like 2 (Drosophila) -0.0166709
UGDH UDP-glucose 6-dehydrogenase -0.016484
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 -0.016448
SOD2 superoxide dismutase 2, mitochondrial -0.0163026
EGFR epidermal growth factor receptor -0.0162616
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0161896
LMAN1 lectin, mannose-binding, 1 -0.0161762
ELL2 elongation factor, RNA polymerase II, 2 -0.0160367
ZBTB38 zinc finger and BTB domain containing 38 -0.0160285
RNF169 ring finger protein 169 -0.0158041
SACS sacsin molecular chaperone -0.0157887
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0156149
HMGA2 high mobility group AT-hook 2 -0.0155116
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0153713
LMO7 LIM domain 7 -0.0153446
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0151564
FNDC3B fibronectin type III domain containing 3B -0.0150857
CPQ carboxypeptidase Q -0.014914
FBXO32 F-box protein 32 -0.0148723
FRMD4A FERM domain containing 4A -0.0145955