Talc_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Talc perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Talc_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.170282
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.170019
TPT1 tumor protein, translationally-controlled 1 0.0848466
TIMP1 TIMP metallopeptidase inhibitor 1 0.0746855
RPL37A ribosomal protein L37a 0.0670569
RPS12 ribosomal protein S12 0.062001
RPS8 ribosomal protein S8 0.0593639
RPL11 ribosomal protein L11 0.0590006
RPL23 ribosomal protein L23 0.0571747
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0570312
RPL26 ribosomal protein L26 0.0569701
AKAP12 A kinase (PRKA) anchor protein 12 0.0537193
APOA2 apolipoprotein A-II 0.0526768
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0515597
RPS19 ribosomal protein S19 0.0500723
RPLP1 ribosomal protein, large, P1 0.0468391
RPS27A ribosomal protein S27a 0.0463699
RPL12 ribosomal protein L12 0.0447601
RPS6 ribosomal protein S6 0.0440299
RPL9 ribosomal protein L9 0.043803
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0434112
GPC3 glypican 3 0.0418557
RPL34 ribosomal protein L34 0.040012
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0397866
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0392675
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0384684
RPS24 ribosomal protein S24 0.03663
RPL31 ribosomal protein L31 0.0361342
PTMA prothymosin, alpha 0.0352594
ENO1 enolase 1, (alpha) 0.0343341
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0333418
RPLP2 ribosomal protein, large, P2 0.0330828
KDM3A lysine (K)-specific demethylase 3A 0.0329592
RPL4 ribosomal protein L4 0.0326047
FTL ferritin, light polypeptide 0.0305512
PDGFB platelet-derived growth factor beta polypeptide 0.0288417
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0287856
RPS21 ribosomal protein S21 0.028321
RPL5 ribosomal protein L5 0.0282953
RPS14 ribosomal protein S14 0.0282777
RPL35A ribosomal protein L35a 0.0279982
RPL18 ribosomal protein L18 0.027784
RPL10A ribosomal protein L10a 0.0277132
RPLP0 ribosomal protein, large, P0 0.0275835
TMSB10 thymosin beta 10 0.0274191
RPS29 ribosomal protein S29 0.0270281
RBM39 RNA binding motif protein 39 0.0269895
TM4SF1 transmembrane 4 L six family member 1 0.026454
NAP1L1 nucleosome assembly protein 1-like 1 0.026245
RPL27 ribosomal protein L27 0.0258638
RPS3 ribosomal protein S3 0.0247814
RPS16 ribosomal protein S16 0.0242387
RPL32 ribosomal protein L32 0.0242077
RPL37 ribosomal protein L37 0.0241484
PRELID2 PRELI domain containing 2 0.0240513
GOLGA4 golgin A4 0.0239005
H1-0 H1.0 linker histone 0.0238184
MACF1 microtubule-actin crosslinking factor 1 0.0237585
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.023593
EIF1 eukaryotic translation initiation factor 1 0.0234417
RPL7 ribosomal protein L7 0.0233886
RACK1 receptor for activated C kinase 1 0.0232929
APOE apolipoprotein E 0.0231043
SLC38A1 solute carrier family 38, member 1 0.0229929
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0229183
ATF4 activating transcription factor 4 0.0227426
CANX calnexin 0.022583
FTH1 ferritin, heavy polypeptide 1 0.0220081
CCL20 chemokine (C-C motif) ligand 20 0.0219783
MXI1 MAX interactor 1, dimerization protein 0.0216099
RPL19 ribosomal protein L19 0.0215839
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0212048
RPS23 ribosomal protein S23 0.021185
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0203788
RPS25 ribosomal protein S25 0.0203169
DTNA dystrobrevin, alpha 0.0202726
KIF1B kinesin family member 1B 0.0199566
RPL38 ribosomal protein L38 0.0196168
RPL13A ribosomal protein L13a 0.0195708
RPS17 ribosomal protein S17 0.0193089
HLA-A major histocompatibility complex, class I, A 0.0192423
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0191955
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0191205
RPS13 ribosomal protein S13 0.0191195
RPL7A ribosomal protein L7a 0.0190757
CAMTA1 calmodulin binding transcription activator 1 0.0190498
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0188634
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0184884
APOA1 apolipoprotein A-I 0.0182898
FNDC3B fibronectin type III domain containing 3B 0.0182505
PCCA propionyl CoA carboxylase, alpha polypeptide 0.018167
HDLBP high density lipoprotein binding protein 0.0181266
KLF6 Kruppel-like factor 6 0.018112
S100A9 S100 calcium binding protein A9 0.0180292
WSB1 WD repeat and SOCS box containing 1 0.0177349
ACTG1 actin gamma 1 0.0176974
NDRG1 N-myc downstream regulated 1 0.0175859
ISG15 ISG15 ubiquitin-like modifier 0.0175828
EEF1B2 eukaryotic translation elongation factor 1 beta 2 0.0175565
RPL36 ribosomal protein L36 0.0175168

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.226371
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0897418
NKD1 naked cuticle homolog 1 (Drosophila) -0.0639562
GPC6 glypican 6 -0.0518705
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0506026
FN1 fibronectin 1 -0.0462461
MAML2 mastermind-like 2 (Drosophila) -0.0440325
SLC38A2 solute carrier family 38, member 2 -0.0413545
DST dystonin -0.0368018
EGR1 early growth response 1 -0.0338635
PTCHD4 patched domain containing 4 -0.0319079
A2M alpha-2-macroglobulin -0.0307683
ITGAV integrin, alpha V -0.0300776
VCL vinculin -0.0279301
RUNX1 runt-related transcription factor 1 -0.027519
DNAH17 dynein, axonemal, heavy chain 17 -0.0268562
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0254405
USP34 ubiquitin specific peptidase 34 -0.0245785
SAMD4A sterile alpha motif domain containing 4A -0.0244945
FAT1 FAT atypical cadherin 1 -0.0240367
SOD2 superoxide dismutase 2, mitochondrial -0.0239653
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0234884
VEGFA vascular endothelial growth factor A -0.023341
DOCK4 dedicator of cytokinesis 4 -0.0229959
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0227403
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0226314
ZNF644 zinc finger protein 644 -0.022544
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0223621
FNDC3A fibronectin type III domain containing 3A -0.0221484
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0216288
UBASH3B ubiquitin associated and SH3 domain containing B -0.0208451
FBF1 Fas (TNFRSF6) binding factor 1 -0.0207235
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0205122
NPAS2 neuronal PAS domain protein 2 -0.0201314
GSK3B glycogen synthase kinase 3 beta -0.0188308
LRMDA leucine rich melanocyte differentiation associated -0.0185684
CADM1 cell adhesion molecule 1 -0.0182505
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.018152
MBNL2 muscleblind-like splicing regulator 2 -0.0178984
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0171898
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0169733
TPM4 tropomyosin 4 -0.0169079
EHBP1 EH domain binding protein 1 -0.0166829
ANKRD17 ankyrin repeat domain 17 -0.0166245
PICALM phosphatidylinositol binding clathrin assembly protein -0.0165412
FOXP1 forkhead box P1 -0.016524
C3 complement component 3 -0.0164011
PDLIM5 PDZ and LIM domain 5 -0.016393
TNS3 tensin 3 -0.0163246
SESTD1 SEC14 and spectrin domains 1 -0.0157245
GSPT1 G1 to S phase transition 1 -0.01536
MALT1 MALT1 paracaspase -0.0148528
PPP1R9A protein phosphatase 1, regulatory subunit 9A -0.014792
HDAC4 histone deacetylase 4 -0.0146882
PEG3 paternally expressed 3 -0.0146477
FKTN fukutin -0.0144653
GK glycerol kinase -0.0144336
OSBPL10 oxysterol binding protein-like 10 -0.0142832
SKIL SKI-like proto-oncogene -0.014161
PHF3 PHD finger protein 3 -0.0139609
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.013946
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0137632
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0137479
FCHSD2 FCH and double SH3 domains 2 -0.0133619
PTPRM protein tyrosine phosphatase, receptor type, M -0.0133617
PPP4R2 protein phosphatase 4, regulatory subunit 2 -0.0133143
RNASEH2A ribonuclease H2, subunit A -0.0129807
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0129669
LMCD1 LIM and cysteine-rich domains 1 -0.0128899
SORBS1 sorbin and SH3 domain containing 1 -0.0128549
EML4 echinoderm microtubule associated protein like 4 -0.012797
LCOR ligand dependent nuclear receptor corepressor -0.0127923
PKM pyruvate kinase, muscle -0.0127087
RNF11 ring finger protein 11 -0.0126917
PDIA3 protein disulfide isomerase family A, member 3 -0.0126674
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0125426
MBNL3 muscleblind-like splicing regulator 3 -0.012498
CAPZB capping protein (actin filament) muscle Z-line, beta -0.0123438
LARP4 La ribonucleoprotein domain family, member 4 -0.0123244
FGL1 fibrinogen-like 1 -0.0122862
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0122822
GRB2 growth factor receptor-bound protein 2 -0.0121678
OSMR oncostatin M receptor -0.0121483
HSPG2 heparan sulfate proteoglycan 2 -0.0121411
TXNRD1 thioredoxin reductase 1 -0.0120396
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0119197
ZNF207 zinc finger protein 207 -0.0118935
PRDM2 PR domain containing 2, with ZNF domain -0.011867
LYZ lysozyme -0.0116726
ZMYM4 zinc finger, MYM-type 4 -0.0116457
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0116352
JMJD1C jumonji domain containing 1C -0.0116006
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0115819
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0115505
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0115215
PTBP3 polypyrimidine tract binding protein 3 -0.0115029
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -0.01145
CDPF1 cysteine-rich, DPF motif domain containing 1 -0.0113775
ENAH enabled homolog (Drosophila) -0.0111813
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0111582