Talc_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Talc perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Talc_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.208069
MT2A metallothionein 2A 0.156817
PTMA prothymosin, alpha 0.155193
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.110368
TM4SF1 transmembrane 4 L six family member 1 0.0857427
FTH1 ferritin, heavy polypeptide 1 0.0689846
ERRFI1 ERBB receptor feedback inhibitor 1 0.0668911
CD44 CD44 molecule (Indian blood group) 0.0635813
RPL12 ribosomal protein L12 0.0564373
RAI1 retinoic acid induced 1 0.0552897
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0524925
FMNL2 formin-like 2 0.051821
BIRC2 baculoviral IAP repeat containing 2 0.0509538
PODXL podocalyxin-like 0.0493563
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0493058
ZFP36L1 ZFP36 ring finger protein-like 1 0.048822
RUNX1 runt-related transcription factor 1 0.0477038
FTL ferritin, light polypeptide 0.0462037
RPS8 ribosomal protein S8 0.0454033
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0441098
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0396169
ARHGAP5 Rho GTPase activating protein 5 0.039152
ACTG1 actin gamma 1 0.0391171
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0381074
RPS3 ribosomal protein S3 0.036748
EHBP1 EH domain binding protein 1 0.0363809
RACK1 receptor for activated C kinase 1 0.036189
WWTR1 WW domain containing transcription regulator 1 0.0356593
HDAC9 histone deacetylase 9 0.0356277
MACF1 microtubule-actin crosslinking factor 1 0.0352344
RPS12 ribosomal protein S12 0.0348741
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0347863
EIF1 eukaryotic translation initiation factor 1 0.0342465
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0327064
RAB7A RAB7A, member RAS oncogene family 0.0326284
TMSB10 thymosin beta 10 0.0324713
ANKRD12 ankyrin repeat domain 12 0.0323525
KLF6 Kruppel-like factor 6 0.0316982
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0307098
MT1E metallothionein 1E 0.0295356
MT1X metallothionein 1X 0.0287368
JUN jun proto-oncogene 0.0285045
CLIP2 CAP-GLY domain containing linker protein 2 0.0283952
ANGPTL4 angiopoietin-like 4 0.0282764
ANXA2 annexin A2 0.0272383
CMIP c-Maf inducing protein 0.0272373
EREG epiregulin 0.0270983
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0270571
RPL19 ribosomal protein L19 0.0269372
RPL18 ribosomal protein L18 0.0266035
CSMD3 CUB and Sushi multiple domains 3 0.0261875
AHNAK2 AHNAK nucleoprotein 2 0.0253437
ZDHHC14 zinc finger, DHHC-type containing 14 0.0243797
ZBTB38 zinc finger and BTB domain containing 38 0.0241333
HPCAL1 hippocalcin-like 1 0.0240889
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.023699
RPL36 ribosomal protein L36 0.0234839
RPS19 ribosomal protein S19 0.0234496
CXCL8 chemokine (C-X-C motif) ligand 8 0.0234365
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0233892
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.022719
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0224919
CAPRIN2 caprin family member 2 0.0221315
SQSTM1 sequestosome 1 0.0215472
RPS2 ribosomal protein S2 0.021403
HLA-A major histocompatibility complex, class I, A 0.0213827
SDCCAG8 serologically defined colon cancer antigen 8 0.0211206
RPL4 ribosomal protein L4 0.0210186
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0209736
LOC102724023 ES1 protein homolog, mitochondrial 0.0209649
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.020766
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0204984
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0200911
JMJD1C jumonji domain containing 1C 0.0197228
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.019696
SRGN serglycin 0.0193825
PSD3 pleckstrin and Sec7 domain containing 3 0.0192791
RPL26 ribosomal protein L26 0.019168
SOX9 SRY (sex determining region Y)-box 9 0.0188162
DOCK11 dedicator of cytokinesis 11 0.0184417
MYOF myoferlin 0.0183833
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0181458
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0178267
TGM2 transglutaminase 2 0.0177971
PATJ PATJ crumbs cell polarity complex component 0.0176495
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0173896
EFNA5 ephrin-A5 0.01725
ZEB1 zinc finger E-box binding homeobox 1 0.0171556
RPL37A ribosomal protein L37a 0.0171544
RPL31 ribosomal protein L31 0.0170655
NBEAL1 neurobeachin-like 1 0.0170518
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0169204
RAD51B RAD51 paralog B 0.0168792
RPL27 ribosomal protein L27 0.0168262
FLNB filamin B, beta 0.0167262
LRRC49 leucine rich repeat containing 49 0.0167041
RPS14 ribosomal protein S14 0.0166022
ANXA1 annexin A1 0.0165425
ATF4 activating transcription factor 4 0.0165231
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0164846

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.089134
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0767331
POTEF POTE ankyrin domain family, member F -0.0737306
TXNRD1 thioredoxin reductase 1 -0.067836
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0647182
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0637593
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0600404
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0580374
EEF2 eukaryotic translation elongation factor 2 -0.0573902
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0569176
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0544039
LOC112694756 uncharaterized LOC112694756 -0.0510263
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0466281
MATR3 matrin 3 -0.0460179
SLC38A2 solute carrier family 38, member 2 -0.0453957
SPAG9 sperm associated antigen 9 -0.044371
XPO1 exportin 1 -0.0431038
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0424872
PKM pyruvate kinase, muscle -0.0403271
HMGA1 high mobility group AT-hook 1 -0.0399385
TMSB4X thymosin beta 4, X-linked -0.0391068
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0367891
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0367541
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0354975
ZFAND3 zinc finger, AN1-type domain 3 -0.0348366
ZNF207 zinc finger protein 207 -0.0346977
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0346078
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0344934
ZNF217 zinc finger protein 217 -0.0343994
ADGRG6 adhesion G protein-coupled receptor G6 -0.0337142
SMC4 structural maintenance of chromosomes 4 -0.0335986
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0328034
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0326515
SFPQ splicing factor proline/glutamine-rich -0.0326215
WARS1 tryptophanyl-tRNA synthetase 1 -0.0308905
RBM25 RNA binding motif protein 25 -0.0305871
DST dystonin -0.0302455
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0301951
RBM39 RNA binding motif protein 39 -0.0301158
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0294344
OLA1 Obg-like ATPase 1 -0.0282383
YBX1 Y box binding protein 1 -0.0275457
TAPBP TAP binding protein (tapasin) -0.0274553
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0274008
KMT2E lysine (K)-specific methyltransferase 2E -0.0265239
TNPO1 transportin 1 -0.0265165
NUP58 nucleoporin 58 -0.0258888
DIAPH3 diaphanous-related formin 3 -0.0257039
CENPF centromere protein F, 350/400kDa -0.0254901
ADAM9 ADAM metallopeptidase domain 9 -0.0253698
SOD2 superoxide dismutase 2, mitochondrial -0.0246649
LDHA lactate dehydrogenase A -0.0244409
KCMF1 potassium channel modulatory factor 1 -0.0241893
CALR calreticulin -0.0241574
TRA2B transformer 2 beta homolog (Drosophila) -0.0241093
PRRC2C proline-rich coiled-coil 2C -0.0238311
SPRY4 sprouty homolog 4 (Drosophila) -0.0237528
SF3B3 splicing factor 3b, subunit 3, 130kDa -0.023342
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0230582
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0229911
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0226583
TUBB tubulin, beta class I -0.0225524
PDIA3 protein disulfide isomerase family A, member 3 -0.0222945
TENT4A terminal nucleotidyltransferase 4A -0.0219133
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0217704
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0215759
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0214985
MYADM myeloid-associated differentiation marker -0.0209272
WDR45B WD repeat domain 45B -0.0207725
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0206633
FXR1 fragile X mental retardation, autosomal homolog 1 -0.02058
PTK2 protein tyrosine kinase 2 -0.0205451
AHCTF1 AT hook containing transcription factor 1 -0.0204972
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0204472
ECT2 epithelial cell transforming 2 -0.0204434
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0204212
RTN4 reticulon 4 -0.0203985
MARCHF6 membrane associated ring-CH-type finger 6 -0.0201741
ZNF121 zinc finger protein 121 -0.0201621
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.0199867
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.019844
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0197728
CAPRIN1 cell cycle associated protein 1 -0.0196226
FUBP1 far upstream element (FUSE) binding protein 1 -0.0195982
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0195859
GARS1 glycyl-tRNA synthetase 1 -0.019551
SINHCAF SIN3-HDAC complex associated factor -0.0195505
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0195144
TRA2A transformer 2 alpha homolog (Drosophila) -0.019504
RLF rearranged L-myc fusion -0.0193173
PDE10A phosphodiesterase 10A -0.0192356
ADAM17 ADAM metallopeptidase domain 17 -0.0192291
RLIM ring finger protein, LIM domain interacting -0.0191518
XPO6 exportin 6 -0.0190216
EZR ezrin -0.0189795
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0189056
ANLN anillin, actin binding protein -0.0188736
ADAM10 ADAM metallopeptidase domain 10 -0.0187095
ZNF148 zinc finger protein 148 -0.0185519
MTF2 metal response element binding transcription factor 2 -0.0184479