Talc_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Talc perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Talc_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS3 ribosomal protein S3 0.129672
H1-0 H1.0 linker histone 0.0929666
EGFR epidermal growth factor receptor 0.086656
MT2A metallothionein 2A 0.0799421
PTMA prothymosin, alpha 0.0744165
RPL4 ribosomal protein L4 0.0733096
ANXA2 annexin A2 0.0634492
RPL37A ribosomal protein L37a 0.061484
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0591195
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0483763
RPS8 ribosomal protein S8 0.0481234
EIF1 eukaryotic translation initiation factor 1 0.0479217
FTL ferritin, light polypeptide 0.047849
NDE1 nudE neurodevelopment protein 1 0.0447832
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.044502
MKI67 marker of proliferation Ki-67 0.0444943
RPS12 ribosomal protein S12 0.0407163
RPS6 ribosomal protein S6 0.0403816
RPL7 ribosomal protein L7 0.0401219
CAV1 caveolin 1, caveolae protein, 22kDa 0.0396448
RPS2 ribosomal protein S2 0.0373038
DSPP dentin sialophosphoprotein 0.037217
TKT transketolase 0.036495
RPS25 ribosomal protein S25 0.0364598
MCTP1 multiple C2 domains, transmembrane 1 0.035973
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0358193
GRAMD1B GRAM domain containing 1B 0.0348162
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0347982
FAM13A family with sequence similarity 13, member A 0.0347266
LAMB3 laminin, beta 3 0.0344721
TPT1 tumor protein, translationally-controlled 1 0.0317358
RPL6 ribosomal protein L6 0.0314283
RPL19 ribosomal protein L19 0.0310419
RACK1 receptor for activated C kinase 1 0.0309973
ERRFI1 ERBB receptor feedback inhibitor 1 0.0305907
ANKRD10 ankyrin repeat domain 10 0.0303753
ATF4 activating transcription factor 4 0.0303465
RPS17 ribosomal protein S17 0.030314
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0300709
RPS29 ribosomal protein S29 0.030001
RPS27A ribosomal protein S27a 0.0297074
AHNAK AHNAK nucleoprotein 0.0296368
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0292594
RPL31 ribosomal protein L31 0.0290082
SPTSSA serine palmitoyltransferase, small subunit A 0.0281646
CSDE1 cold shock domain containing E1, RNA-binding 0.0281466
PGK1 phosphoglycerate kinase 1 0.0281008
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0279765
RPL11 ribosomal protein L11 0.0279487
B2M beta-2-microglobulin 0.0277334
HDLBP high density lipoprotein binding protein 0.0275389
GCLC glutamate-cysteine ligase, catalytic subunit 0.0270116
PUM2 pumilio RNA-binding family member 2 0.0269757
RSL1D1 ribosomal L1 domain containing 1 0.0265656
MXI1 MAX interactor 1, dimerization protein 0.0264961
SPIRE1 spire-type actin nucleation factor 1 0.026127
CTTN cortactin 0.0259104
RPS27 ribosomal protein S27 0.0257671
BACE2 beta-site APP-cleaving enzyme 2 0.0255333
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0254858
RPL3 ribosomal protein L3 0.0253915
RPL32 ribosomal protein L32 0.0251721
ENO1 enolase 1, (alpha) 0.0250196
SLC38A1 solute carrier family 38, member 1 0.0249033
NCKAP1 NCK-associated protein 1 0.0248193
CREBRF CREB3 regulatory factor 0.0245963
RPL26 ribosomal protein L26 0.0243178
NIPBL Nipped-B homolog (Drosophila) 0.023665
RPS14 ribosomal protein S14 0.0231777
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0225972
PTPRM protein tyrosine phosphatase, receptor type, M 0.0225403
RPL12 ribosomal protein L12 0.022488
RPL34 ribosomal protein L34 0.0224109
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0220828
SQSTM1 sequestosome 1 0.0212465
BZW1 basic leucine zipper and W2 domains 1 0.0209915
S100P S100 calcium binding protein P 0.0208443
DENND4A DENN/MADD domain containing 4A 0.020799
RPL18 ribosomal protein L18 0.0206072
CPE carboxypeptidase E 0.0200936
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0198026
TBC1D22A TBC1 domain family, member 22A 0.0197299
GOLGB1 golgin B1 0.0195734
ADAR adenosine deaminase, RNA-specific 0.0193704
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0192062
RPL5 ribosomal protein L5 0.0190162
HSPA8 heat shock 70kDa protein 8 0.018934
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0187501
TPM3 tropomyosin 3 0.0185882
ANKLE2 ankyrin repeat and LEM domain containing 2 0.0185728
PMM2 phosphomannomutase 2 0.018563
RPL27 ribosomal protein L27 0.0183962
ACTG1 actin gamma 1 0.0183194
RPL9 ribosomal protein L9 0.0180739
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0179037
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0178298
RPS7 ribosomal protein S7 0.0175403
FNIP1 folliculin interacting protein 1 0.0173782
TTC17 tetratricopeptide repeat domain 17 0.0173445
RPL13A ribosomal protein L13a 0.0171637

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.491268
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.277968
TXNRD1 thioredoxin reductase 1 -0.144761
NDRG1 N-myc downstream regulated 1 -0.138855
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.123854
LOC112694756 uncharaterized LOC112694756 -0.108082
EGR1 early growth response 1 -0.0944213
OSMR oncostatin M receptor -0.0746627
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0735906
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0703783
LMO7 LIM domain 7 -0.0618536
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0617957
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0597896
SPAG9 sperm associated antigen 9 -0.0584396
PKM pyruvate kinase, muscle -0.056349
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0509127
TSC22D2 TSC22 domain family, member 2 -0.0508341
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0494769
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0491568
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.045822
ASPH aspartate beta-hydroxylase -0.0449845
DOCK5 dedicator of cytokinesis 5 -0.0447839
KCMF1 potassium channel modulatory factor 1 -0.0435678
SEC61G Sec61 gamma subunit -0.0433964
CES1 carboxylesterase 1 -0.0416369
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.041256
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0409549
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0403827
NABP1 nucleic acid binding protein 1 -0.0377184
LAMA4 laminin, alpha 4 -0.0360111
PDIA3 protein disulfide isomerase family A, member 3 -0.0346314
ADAM9 ADAM metallopeptidase domain 9 -0.0326711
TJP1 tight junction protein 1 -0.0323489
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.03224
CSNK1E casein kinase 1, epsilon -0.0322219
KMT2E lysine (K)-specific methyltransferase 2E -0.031377
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0307058
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) -0.0303482
WDR45B WD repeat domain 45B -0.029769
PDE8A phosphodiesterase 8A -0.0297488
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0297409
LAMC2 laminin, gamma 2 -0.0293511
IGFBP3 insulin-like growth factor binding protein 3 -0.0288556
TMEM165 transmembrane protein 165 -0.0283972
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0282957
RAP1B RAP1B, member of RAS oncogene family -0.0282947
ZNF638 zinc finger protein 638 -0.0281441
KDM2A lysine (K)-specific demethylase 2A -0.0270902
JMJD1C jumonji domain containing 1C -0.0270791
GSK3B glycogen synthase kinase 3 beta -0.0270327
RAB10 RAB10, member RAS oncogene family -0.026909
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0268962
INSIG2 insulin induced gene 2 -0.0266463
ANKRD37 ankyrin repeat domain 37 -0.0262855
TOP1 topoisomerase (DNA) I -0.0261052
HYOU1 hypoxia up-regulated 1 -0.0260984
BTG1 B-cell translocation gene 1, anti-proliferative -0.0259061
OFD1 oral-facial-digital syndrome 1 -0.0254009
MON2 MON2 homolog (S. cerevisiae) -0.0251561
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.0248366
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0247273
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0242401
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.024099
POTEF POTE ankyrin domain family, member F -0.024035
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0238751
CDCP1 CUB domain containing protein 1 -0.0238429
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.023606
RAB6A RAB6A, member RAS oncogene family -0.0235725
PHF21A PHD finger protein 21A -0.0235012
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0233567
AFF4 AF4/FMR2 family, member 4 -0.0233506
BRD2 bromodomain containing 2 -0.0232867
UBC ubiquitin C -0.0232354
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0227757
OGA O-GlcNAcase -0.0226751
HILPDA hypoxia inducible lipid droplet-associated -0.0226746
GPC6 glypican 6 -0.0225134
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.022278
BLZF1 basic leucine zipper nuclear factor 1 -0.0221632
FNDC3B fibronectin type III domain containing 3B -0.0221582
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0220989
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.021943
ZNF207 zinc finger protein 207 -0.0217237
PRRC2C proline-rich coiled-coil 2C -0.0215872
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0215321
KRT8 keratin 8, type II -0.0214753
MRPS6 mitochondrial ribosomal protein S6 -0.021423
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0213776
LDHA lactate dehydrogenase A -0.0212929
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0211344
BPTF bromodomain PHD finger transcription factor -0.021111
STRN3 striatin, calmodulin binding protein 3 -0.0207099
AGO2 argonaute RISC catalytic component 2 -0.020341
MGAT4C MGAT4 family, member C -0.0201775
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0199329
ARF4 ADP-ribosylation factor 4 -0.0199022
MCL1 myeloid cell leukemia 1 -0.0197747
BMAL2 basic helix-loop-helix ARNT like 2 -0.0197273
AREG amphiregulin -0.0197101
MED13L mediator complex subunit 13-like -0.0197014